{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:17:12Z","timestamp":1792624632245,"version":"4.5.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01HL159062"],"award-info":[{"award-number":["R01HL159062"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R35CA209896"],"award-info":[{"award-number":["R35CA209896"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["837832"],"award-info":[{"award-number":["837832"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R21EY031483"],"award-info":[{"award-number":["R21EY031483"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01HL093671"],"award-info":[{"award-number":["R01HL093671"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01HL157319"],"award-info":[{"award-number":["R01HL157319"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01HL164772"],"award-info":[{"award-number":["R01HL164772"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32HL144456"],"award-info":[{"award-number":["T32HL144456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32GM007491"],"award-info":[{"award-number":["T32GM007491"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21EY031483"],"award-info":[{"award-number":["R21EY031483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35CA209896"],"award-info":[{"award-number":["R35CA209896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL159062"],"award-info":[{"award-number":["R01HL159062"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL164772"],"award-info":[{"award-number":["R01HL164772"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL157319"],"award-info":[{"award-number":["R01HL157319"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL093671"],"award-info":[{"award-number":["R01HL093671"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["PR191593"],"award-info":[{"award-number":["PR191593"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.molcel.2024.07.020","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T11:10:04Z","timestamp":1723547404000},"page":"3098-3114.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"title":["OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response"],"prefix":"10.1016","volume":"84","author":[{"given":"Felix G.","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Zandkarimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Axelrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Pekson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisang","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent R.","family":"Stockwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Kitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2024.07.020_bib1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-cancerbio-030518-055844","article-title":"The hallmarks of ferroptosis","volume":"3","author":"Dixon","year":"2019","journal-title":"Annu. Rev. Cancer Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2024.07.020_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent- and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00726-011-0867-5","article-title":"The oxidative stress-inducible cystine\/glutamate antiporter, system x (c) (-): cystine supplier and beyond","volume":"42","author":"Conrad","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.molcel.2024.07.020_bib10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/febs.15842","article-title":"Understanding the role of cysteine in ferroptosis: progress\u00a0& paradoxes","volume":"289","author":"Poltorack","year":"2022","journal-title":"FEBS Journal"},{"key":"10.1016\/j.molcel.2024.07.020_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2024.07.020_bib12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2024.07.020_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.molcel.2024.07.020_bib14","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib15","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1038\/s41418-021-00859-z","article-title":"Organelle-specific regulation of ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.molcel.2024.07.020_bib16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41589-022-01249-3","article-title":"Identification of essential sites of lipid peroxidation in ferroptosis","volume":"19","author":"von Krusenstiern","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.molcel.2024.07.020_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib19","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2018.01.019","article-title":"Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis","volume":"117","author":"Jelinek","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.molcel.2024.07.020_bib21","article-title":"Mitochondrial event as an ultimate step in ferroptosis","volume":"8","author":"Oh","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.molcel.2024.07.020_bib22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1021\/acscentsci.6b00199","article-title":"A mitochondrial-targeted nitroxide is a potent inhibitor of ferroptosis","volume":"2","author":"Krainz","year":"2016","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.molcel.2024.07.020_bib23","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2024.07.020_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.molcel.2024.07.020_bib25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2024.07.020_bib26","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121987119","article-title":"A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria","volume":"119","author":"Wu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2024.07.020_bib27","first-page":"246","article-title":"Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7","volume":"25","author":"Deshwal","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib28","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/jcs.159186","article-title":"OPA1 processing in cell death and disease - the long and short of it","volume":"129","author":"MacVicar","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.molcel.2024.07.020_bib29","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib30","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl.\u00a0Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2024.07.020_bib31","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1074\/jbc.M116.762567","article-title":"The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure","volume":"292","author":"Lee","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2024.07.020_bib32","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.celrep.2017.05.073","article-title":"OPA1 isoforms in the hierarchical organization of mitochondrial functions","volume":"19","author":"Del Dotto","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2024.07.020_bib33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.redox.2017.03.007","article-title":"BID links ferroptosis to mitochondrial cell death pathways","volume":"12","author":"Neitemeier","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib36","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s00439-001-0633-y","article-title":"Mutation spectrum and splicing variants in the OPA1 gene","volume":"109","author":"Delettre","year":"2001","journal-title":"Hum. Genet."},{"key":"10.1016\/j.molcel.2024.07.020_bib37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1083\/jcb.200704110","article-title":"OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L","volume":"178","author":"Song","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50973","article-title":"Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane","volume":"9","author":"Ge","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2024.07.020_bib39","article-title":"Mitochondrial membrane dynamics-functional positioning of OPA1","volume":"7","author":"Lee","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.molcel.2024.07.020_bib40","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib41","article-title":"mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2024.07.020_bib42","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1073\/pnas.1819728116","article-title":"Chaperone-mediated autophagy is involved in the execution of ferroptosis","volume":"116","author":"Wu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2024.07.020_bib43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41589-021-00915-2","article-title":"Characterization of a patient-derived variant of GPX4 for precision therapy","volume":"18","author":"Liu","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-dependent ferroptosis: machinery and regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66519","article-title":"OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21","volume":"10","author":"Pereira","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2024.07.020_bib46","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cmet.2020.04.007","article-title":"Developmental and tumor angiogenesis requires the mitochondria-shaping protein Opa1","volume":"31","author":"Herkenne","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib47","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","article-title":"Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence","volume":"25","author":"Tezze","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib48","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114351","article-title":"YAP\/TAZ and ATF4 drive resistance to sorafenib in hepatocellular carcinoma by preventing ferroptosis","volume":"13","author":"Gao","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.molcel.2024.07.020_bib49","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.cmet.2022.08.017","article-title":"OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy","volume":"34","author":"Ahola","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib50","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2023.03.016","article-title":"ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis","volume":"79","author":"He","year":"2023","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.molcel.2024.07.020_bib51","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2024.07.020_bib52","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quir\u00f3s","year":"2017","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63326","article-title":"The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals","volume":"10","author":"Torrence","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2024.07.020_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2024.07.020_bib55","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2015.93","article-title":"Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation","volume":"23","author":"Hayano","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.molcel.2024.07.020_bib56","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41586-020-2078-2","article-title":"Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway","volume":"579","author":"Guo","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2024.07.020_bib57","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.molcel.2021.08.027","article-title":"Lipid metabolism in sickness and in health: emerging regulators of lipotoxicity","volume":"81","author":"Yoon","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib58","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ncb3560","article-title":"Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin","volume":"19","author":"Ban","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib59","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1038\/emboj.2011.365","article-title":"Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis","volume":"30","author":"Pidoux","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2024.07.020_bib60","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1021\/acs.jproteome.9b00081","article-title":"Lipidomics reveals triacylglycerol accumulation due to impaired fatty acid flux in Opa1-disrupted fibroblasts","volume":"18","author":"Bocca","year":"2019","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.molcel.2024.07.020_bib61","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.2337\/db22-0450","article-title":"OPA1 regulates lipid metabolism and cold-induced browning of White adipose tissue in mice","volume":"71","author":"Pereira","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.molcel.2024.07.020_bib62","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2024.07.020_bib63","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.molcel.2023.03.005","article-title":"Ferroptosis: A flexible constellation of related biochemical mechanisms","volume":"83","author":"Dixon","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib64","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib65","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib66","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.1074\/jbc.RA119.010983","article-title":"The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress","volume":"295","author":"Lee","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.molcel.2024.07.020_bib67","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.stem.2022.07.010","article-title":"The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells","volume":"29","author":"Baker","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib68","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.stem.2016.04.015","article-title":"Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program","volume":"19","author":"Khacho","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib69","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49178","article-title":"Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell","volume":"9","author":"Mick","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2024.07.020_bib70","article-title":"The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2024.07.020_bib71","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib72","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41589-021-00751-4","article-title":"A compendium of kinetic modulatory profiles identifies ferroptosis regulators","volume":"17","author":"Conlon","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2024.07.020_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05719-x","article-title":"PDIA4 confers resistance to ferroptosis via induction of ATF4\/SLC7A11 in renal cell carcinoma","volume":"14","author":"Kang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2024.07.020_bib74","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1016\/j.cell.2022.07.025","article-title":"Sublethal cytochrome c release generates drug-tolerant persister cells","volume":"185","author":"Kalkavan","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2024.07.020_bib75","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tem.2017.07.003","article-title":"Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells","volume":"28","author":"Wortel","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31204","article-title":"ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle","volume":"239","author":"Hinton","year":"2024","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.molcel.2024.07.020_bib77","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.bbamcr.2014.05.011","article-title":"At the right distance: ER-mitochondria juxtaposition in cell life and death","volume":"1843","author":"Naon","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molcel.2024.07.020_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118800","article-title":"Maintaining social contacts: the physiological relevance of organelle interactions","volume":"1867","author":"Silva","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.molcel.2024.07.020_bib79","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cmet.2017.05.016","article-title":"Mitochondrial dynamics in regulating the unique phenotypes of cancer and stem cells","volume":"26","author":"Chen","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib80","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.molcel.2024.07.020_bib81","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.tem.2022.07.003","article-title":"OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle","volume":"33","author":"Noone","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib82","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.15252\/embj.201696179","article-title":"OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance","volume":"36","author":"Pereira","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2024.07.020_bib83","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2018.06.014","article-title":"Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease","volume":"28","author":"Yamada","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2024.07.020_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103996","article-title":"Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver","volume":"25","author":"Yamada","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.molcel.2024.07.020_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-1678-y","article-title":"Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis","volume":"10","author":"Tsurusaki","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2024.07.020_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2334-2","article-title":"Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure","volume":"11","author":"Yamada","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2024.07.020_bib87","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02304-6","article-title":"Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth","volume":"41","author":"Zamberlan","year":"2022","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.molcel.2024.07.020_bib88","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.158429","article-title":"Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC","volume":"8","author":"Liu","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.molcel.2024.07.020_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010121","article-title":"Mitochondrial fusion via OPA1 and MFN1 supports liver tumor cell metabolism and growth","volume":"9","author":"Li","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.molcel.2024.07.020_bib90","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/2159-8290.CD-19-0117","article-title":"Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment","volume":"9","author":"Chen","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2024.07.020_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05768-2","article-title":"Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to gefitinib in a lung adenocarcinomaresistant cell line","volume":"14","author":"Noguchi","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2024.07.020_bib92","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21691-5","article-title":"Identification of novel prognosis-related genes associated with cancer using integrative network analysis","volume":"8","author":"Wee","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2024.07.020_bib93","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109727652400618X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109727652400618X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:09:05Z","timestamp":1778519345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109727652400618X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":93,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S109727652400618X"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2024.07.020","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2024.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}