{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:34:50Z","timestamp":1790897690657,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015127","name":"Commonwealth Foundation for Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"National Institutes of Health Office of Extramural Research","doi-asserted-by":"publisher","award":["R01CA204232"],"award-info":[{"award-number":["R01CA204232"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"National Institutes of Health Office of Extramural Research","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA204232"],"award-info":[{"award-number":["R01CA204232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA258622"],"award-info":[{"award-number":["R01CA258622"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.molcel.2025.08.006","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T14:34:46Z","timestamp":1756132486000},"page":"3333-3342.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Endocytosis is essential for cysteine-deprivation-induced ferroptosis"],"prefix":"10.1016","volume":"85","author":[{"given":"Xuesong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad A.","family":"Benthani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deguang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2025.08.006_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib2","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.08.006_bib7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2025.08.006_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2025.08.006_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-physiol-012110-142317","article-title":"Lysosomal acidification mechanisms","volume":"74","author":"Mindell","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.molcel.2025.08.006_bib10","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1080\/15548627.2024.2319901","article-title":"International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis","volume":"20","author":"Chen","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2025.08.006_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib12","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1073\/pnas.1819728116","article-title":"Chaperone-mediated autophagy is involved in the execution of ferroptosis","volume":"116","author":"Wu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.08.006_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0076-6879(08)03606-9","article-title":"Assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using monodansylcadaverine (MDC) and DQ-BSA","volume":"452","author":"V\u00e1zquez","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2025.08.006_bib14","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.03.034","article-title":"Endosome maturation, transport and functions","volume":"31","author":"Scott","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature01451","article-title":"Regulated portals of entry into the cell","volume":"422","author":"Conner","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.08.006_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1126\/science.285.5425.215","article-title":"The structural era of endocytosis","volume":"285","author":"Marsh","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.08.006_bib18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbagen.2011.09.009","article-title":"The intracellular trafficking pathway of transferrin","volume":"1820","author":"Mayle","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molcel.2025.08.006_bib19","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1021\/jm900036m","article-title":"Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles","volume":"52","author":"Hill","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.molcel.2025.08.006_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0092-8674(02)00735-3","article-title":"Molecular architecture and functional model of the endocytic AP2 complex","volume":"109","author":"Collins","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100575","article-title":"Generation of locus-specific degradable tag knock-ins in mouse and human cell lines","volume":"2","author":"Damhofer","year":"2021","journal-title":"Star Protoc."},{"key":"10.1016\/j.molcel.2025.08.006_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41589-018-0021-8","article-title":"The dTAG system for immediate and target-specific protein degradation","volume":"14","author":"Nabet","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18377-w","article-title":"Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules","volume":"11","author":"Nabet","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.08.006_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2020.01.003","article-title":"Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation","volume":"77","author":"Weber","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2023.10.011","article-title":"Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest","volume":"31","author":"Rodencal","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib26","article-title":"Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.08.006_bib27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib28","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1039\/C7MT00143F","article-title":"The transferrin receptor: the cellular iron gate","volume":"9","author":"Gammella","year":"2017","journal-title":"Metallomics"},{"key":"10.1016\/j.molcel.2025.08.006_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","article-title":"Mechanisms controlling cellular and systemic iron homeostasis","volume":"25","author":"Galy","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2018.10.413","article-title":"Non-transferrin-bound iron transporters","volume":"133","author":"Knutson","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.molcel.2025.08.006_bib31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of Mitochondria in Ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.08.006_bib33","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.chembiol.2022.06.004","article-title":"Context-dependent regulation of ferroptosis sensitivity","volume":"29","author":"Magtanong","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2025.08.006_bib34","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.molcel.2025.08.006_bib35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41586-025-08974-4","article-title":"Activation of lysosomal iron triggers ferroptosis in cancer","volume":"642","author":"Ca\u00f1eque","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.08.006_bib36","doi-asserted-by":"crossref","first-page":"12297","DOI":"10.1074\/jbc.M900573200","article-title":"ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy","volume":"284","author":"Ganley","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.08.006_bib37","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s13238-018-0584-x","article-title":"Unc-51-like kinase (ULK) complex-independent autophagy induced by hypoxia","volume":"10","author":"Feng","year":"2019","journal-title":"Protein Cell"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276525006562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276525006562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:03:02Z","timestamp":1764046982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276525006562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1097276525006562"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2025.08.006","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocytosis is essential for cysteine-deprivation-induced ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2025.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}