{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:43:54Z","timestamp":1793119434182,"version":"4.5.0"},"reference-count":150,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI087846"],"award-info":[{"award-number":["AI087846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI165502"],"award-info":[{"award-number":["AI165502"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI169444"],"award-info":[{"award-number":["AI169444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI186249"],"award-info":[{"award-number":["AI186249"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.molcel.2025.09.008","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:49:19Z","timestamp":1760636959000},"page":"3793-3806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["The RIG-I-like receptor family of immune proteins"],"prefix":"10.1016","volume":"85","author":[{"given":"Mariska","family":"van Huizen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-2598","authenticated-orcid":false,"given":"Michaela U.","family":"Gack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2025.09.008_bib1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nri.2016.78","article-title":"Discriminating self from non-self in nucleic acid sensing","volume":"16","author":"Schlee","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and type III interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2025.09.008_bib3","doi-asserted-by":"crossref","first-page":"17264","DOI":"10.1073\/pnas.0407639101","article-title":"The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter","volume":"101","author":"Andrejeva","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses","volume":"441","author":"Kato","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib6","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.1132505","article-title":"5\u2032-Triphosphate RNA is the ligand for RIG-I","volume":"314","author":"Hornung","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.09.008_bib7","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1126\/science.1132998","article-title":"RIG-I-mediated antiviral responses to single-stranded RNA bearing 5\u2032-phosphates","volume":"314","author":"Pichlmair","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.09.008_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2011.09.039","article-title":"Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA","volume":"147","author":"Kowalinski","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature10537","article-title":"Structural basis of RNA recognition and activation by innate immune receptor RIG-I","volume":"479","author":"Jiang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib10","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.4049\/jimmunol.175.8.5260","article-title":"The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I","volume":"175","author":"Rothenfusser","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1243","article-title":"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction","volume":"6","author":"Kawai","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nature04193","article-title":"Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus","volume":"437","author":"Meylan","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","article-title":"Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3","volume":"122","author":"Seth","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.molcel.2005.08.014","article-title":"VISA is an adapter protein required for virus-triggered IFN-beta signaling","volume":"19","author":"Xu","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib15","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cell.2010.04.018","article-title":"Peroxisomes are signaling platforms for antiviral innate immunity","volume":"141","author":"Dixit","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib16","doi-asserted-by":"crossref","first-page":"14590","DOI":"10.1073\/pnas.1110133108","article-title":"Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus","volume":"108","author":"Horner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.chom.2012.04.006","article-title":"The mitochondrial targeting chaperone 14\u20133-3epsilon regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity","volume":"11","author":"Liu","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molcel.2025.09.008_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007582","article-title":"The 14-3-3eta chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution","volume":"15","author":"Lin","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2025.09.008_bib19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ni.2915","article-title":"Diverse intracellular pathogens activate type III interferon expression from peroxisomes","volume":"15","author":"Odendall","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib20","doi-asserted-by":"crossref","first-page":"17717","DOI":"10.1073\/pnas.0508531102","article-title":"Hepatitis C virus protease NS3\/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005264","article-title":"Activation of type I and III interferon response by mitochondrial and peroxisomal MAVS and inhibition by hepatitis C virus","volume":"11","author":"Bender","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2025.09.008_bib22","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/jcmm.12801","article-title":"Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response","volume":"20","author":"Ferreira","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molcel.2025.09.008_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.871977","article-title":"Human cytomegalovirus vMIA inhibits MAVS oligomerization at peroxisomes in an MFF-dependent manner","volume":"10","author":"Ferreira","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.molcel.2025.09.008_bib24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-virology-092818-015756","article-title":"Interferon-stimulated genes: What do they all do?","volume":"6","author":"Schoggins","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41577-020-0288-3","article-title":"RIG-I-like receptors: their regulation and roles in RNA sensing","volume":"20","author":"Rehwinkel","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.it.2023.04.002","article-title":"The RNA polymerase III-RIG-I axis in antiviral immunity and inflammation","volume":"44","author":"Naesens","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.virol.2015.02.017","article-title":"RIG-I in RNA virus recognition","volume":"479\u2013480","author":"Kell","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.molcel.2025.09.008_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adm8185","article-title":"Human life within a narrow range: The lethal ups and downs of type I interferons","volume":"9","author":"Crow","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib29","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1073\/pnas.0603082103","article-title":"Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus","volume":"103","author":"Gitlin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/JVI.00631-09","article-title":"MDA5 and MAVS mediate type I interferon responses to coxsackie B virus","volume":"84","author":"Wang","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tim.2018.08.007","article-title":"A balancing act: MDA5 in antiviral immunity and autoinflammation","volume":"27","author":"Dias Junior","year":"2019","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.molcel.2025.09.008_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01586","article-title":"Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5","volume":"10","author":"Brisse","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41577-021-00633-9","article-title":"The type I interferonopathies: 10 years on","volume":"22","author":"Crow","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib34","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature13590","article-title":"Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5\u2032-diphosphates","volume":"514","author":"Goubau","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib35","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.celrep.2019.01.107","article-title":"RIG-I selectively discriminates against 5\u2032-monophosphate RNA","volume":"26","author":"Ren","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib36","doi-asserted-by":"crossref","first-page":"11893","DOI":"10.1093\/nar\/gkad835","article-title":"A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA","volume":"51","author":"de Regt","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.09.008_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.immuni.2015.06.015","article-title":"A conserved histidine in the RNA sensor RIG-I controls immune tolerance to N1-2'O-methylated self RNA","volume":"43","author":"Schuberth-Wagner","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2025.09.008_bib38","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chembiol.2023.12.004","article-title":"Modifying the antiviral innate immune response by selective writing, erasing, and reading of m(6)A on viral and cellular RNA","volume":"31","author":"Aufgebauer","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2025.09.008_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2009.05.008","article-title":"Recognition of 5\u2032 triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus","volume":"31","author":"Schlee","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2025.09.008_bib40","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1073\/pnas.0900971106","article-title":"5\u2032-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I","volume":"106","author":"Schmidt","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1042\/BST20230724","article-title":"Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA","volume":"52","author":"Solotchi","year":"2024","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.molcel.2025.09.008_bib42","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1016\/j.molcel.2022.09.029","article-title":"The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands","volume":"82","author":"Wang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib43","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109782","article-title":"The intrinsically disordered CARDs-Helicase linker in RIG-I is a molecular gate for RNA proofreading","volume":"41","author":"Schweibenz","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib44","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/nar\/gkp059","article-title":"The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA","volume":"37","author":"Pippig","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.09.008_bib45","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.molcel.2016.04.021","article-title":"Structural analysis of dsRNA binding to anti-viral pattern recognition receptors LGP2 and MDA5","volume":"62","author":"Uchikawa","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib46","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20080091","article-title":"Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5","volume":"205","author":"Kato","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2025.09.008_bib47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.cell.2012.11.048","article-title":"Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5","volume":"152","author":"Wu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib48","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2010.01.020","article-title":"RIG-I detects viral genomic RNA during negative-strand RNA virus infection","volume":"140","author":"Rehwinkel","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib49","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1128\/JVI.00232-15","article-title":"Influenza A virus panhandle structure is directly involved in RIG-I activation and interferon induction","volume":"89","author":"Liu","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib50","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.celrep.2018.06.047","article-title":"RIG-I recognizes the 5\u2032 region of dengue and Zika virus genomes","volume":"24","author":"Chazal","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib51","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/eji.201847483","article-title":"Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling","volume":"48","author":"Hertzog","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib52","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.molcel.2025.01.015","article-title":"Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virus","volume":"85","author":"Genoyer","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib53","doi-asserted-by":"crossref","first-page":"109091","DOI":"10.1016\/j.celrep.2021.109091","article-title":"METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection","volume":"35","author":"Li","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib54","doi-asserted-by":"crossref","first-page":"e01939-20","DOI":"10.1128\/JVI.01939-20","article-title":"Nonsegmented negative-sense RNA viruses utilize N(6)-methyladenosine (m(6)A) as a common strategy to evade host innate immunity","volume":"95","author":"Lu","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib55","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41564-019-0653-9","article-title":"N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I","volume":"5","author":"Lu","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.molcel.2025.09.008_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21904-y","article-title":"N(6)-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA","volume":"12","author":"Qiu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.09.008_bib57","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.aac7049","article-title":"RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself","volume":"349","author":"Liddicoat","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.09.008_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2123338119","article-title":"5-methylcytosine (m(5)C) RNA modification controls the innate immune response to virus infection by regulating type I interferons","volume":"119","author":"Zhang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib59","doi-asserted-by":"crossref","first-page":"16303","DOI":"10.1073\/pnas.1005077107","article-title":"Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing","volume":"107","author":"Baum","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004081","article-title":"In vivo ligands of MDA5 and RIG-I in measles virus-infected cells","volume":"10","author":"Runge","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2025.09.008_bib61","doi-asserted-by":"crossref","first-page":"e00643-17","DOI":"10.1128\/JVI.00643-17","article-title":"Nonencapsidated 5\u2032 copy-back defective interfering genomes produced by recombinant measles viruses are recognized by RIG-I and LGP2 but not MDA5","volume":"91","author":"Mura","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.595390","article-title":"Defective interfering genomes and the full-length viral genome trigger RIG-I after infection with vesicular stomatitis virus in a replication dependent manner","volume":"12","author":"Linder","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib63","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41564-018-0240-5","article-title":"Mini viral RNAs act as innate immune agonists during influenza virus infection","volume":"3","author":"Te Velthuis","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.molcel.2025.09.008_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adw8034","article-title":"A two-step mechanism for RIG-I activation by influenza virus mvRNAs","volume":"11","author":"Pitr\u00e9","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2025.09.008_bib65","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1038\/sj.emboj.7601314","article-title":"EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN","volume":"25","author":"Samanta","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib66","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ni.1779","article-title":"RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate","volume":"10","author":"Ablasser","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib67","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cell.2009.06.015","article-title":"RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway","volume":"138","author":"Chiu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib68","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1128\/JVI.02160-10","article-title":"Adenovirus virus-associated RNAs induce type I interferon expression through a RIG-I-mediated pathway","volume":"85","author":"Minamitani","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41590-017-0005-y","article-title":"Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity","volume":"19","author":"Chiang","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abq4531","article-title":"GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141","volume":"7","author":"Naesens","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07314-7","article-title":"RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.09.008_bib72","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1080\/15476286.2017.1306169","article-title":"DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells","volume":"14","author":"Burke","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.molcel.2025.09.008_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104599","article-title":"Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1","volume":"25","author":"Vabret","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.molcel.2025.09.008_bib74","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1101\/gad.340604.120","article-title":"DUSP11-mediated control of 5\u2032-triphosphate RNA regulates RIG-I sensitivity","volume":"34","author":"Choi","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2025.09.008_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105415","article-title":"Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme","volume":"299","author":"Law","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.09.008_bib76","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2018.03.064","article-title":"Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response","volume":"173","author":"Jiang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01711","article-title":"A human long non-coding RNA lncATV promotes virus replication through restricting RIG-I-mediated innate immunity","volume":"10","author":"Fan","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib78","doi-asserted-by":"crossref","first-page":"16743","DOI":"10.1073\/pnas.0804947105","article-title":"Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction","volume":"105","author":"Gack","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib79","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.cell.2014.01.021","article-title":"A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity","volume":"156","author":"Brubaker","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib80","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2012.11.018","article-title":"Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling","volume":"38","author":"Wies","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2025.09.008_bib81","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib82","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.chom.2010.11.008","article-title":"The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection","volume":"8","author":"Oshiumi","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molcel.2025.09.008_bib83","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1073\/pnas.1401674111","article-title":"Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity","volume":"111","author":"Kuniyoshi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib84","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jmcb\/mju005","article-title":"TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination","volume":"6","author":"Yan","year":"2014","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.09.008_bib85","doi-asserted-by":"crossref","first-page":"e00725-19","DOI":"10.1128\/JVI.00725-19","article-title":"Hepatitis C Virus Infection Is Inhibited by a Noncanonical Antiviral Signaling Pathway Targeted by NS3-NS4A","volume":"93","author":"Vazquez","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2025.09.008_bib86","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202254844","article-title":"K63-linked polyubiquitination of LGP2 by Riplet regulates RIG-I-dependent innate immune response","volume":"24","author":"Kouwaki","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006145","article-title":"TRIM25 enhances the antiviral action of zinc-finger antiviral protein (ZAP)","volume":"13","author":"Li","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2025.09.008_bib88","article-title":"The structural basis of TRIM25-mediated regulation of RIG-I","volume":"301","author":"Li","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.09.008_bib89","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.20160592","article-title":"TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity","volume":"214","author":"Lang","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2025.09.008_bib90","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41564-021-00884-1","article-title":"ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity","volume":"6","author":"Liu","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.molcel.2025.09.008_bib91","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2420190122","article-title":"MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis","volume":"122","author":"Sarkar","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib92","doi-asserted-by":"crossref","first-page":"351","DOI":"10.15252\/embj.201796781","article-title":"LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation","volume":"37","author":"Du","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib93","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1084\/jem.20161015","article-title":"Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5","volume":"214","author":"Hu","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2025.09.008_bib94","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119531119","article-title":"Signaling from the RNA sensor RIG-I is regulated by ufmylation","volume":"119","author":"Snider","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib95","article-title":"Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform","volume":"6","author":"Nguyen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib96","doi-asserted-by":"crossref","first-page":"429","DOI":"10.15252\/embj.201592586","article-title":"HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I","volume":"35","author":"Choi","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib97","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ebiom.2016.06.015","article-title":"Regulation of retinoic acid inducible gene-I (RIG-I) activation by the histone deacetylase 6","volume":"9","author":"Liu","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.molcel.2025.09.008_bib98","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molcel.2015.01.036","article-title":"Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production","volume":"58","author":"He","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01030","article-title":"Regulation of MAVS expression and signaling function in the antiviral innate immune response","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib100","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41594-023-00988-8","article-title":"MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation","volume":"30","author":"Dai","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2025.09.008_bib101","article-title":"Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity","volume":"121","author":"Liu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib102","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.4049\/jimmunol.178.10.6444","article-title":"Loss of DExD\/H box RNA helicase LGP2 manifests disparate antiviral responses","volume":"178","author":"Venkataraman","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib103","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1073\/pnas.0912986107","article-title":"LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses","volume":"107","author":"Satoh","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib104","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.molcel.2014.07.003","article-title":"The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly","volume":"55","author":"Bruns","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib105","doi-asserted-by":"crossref","first-page":"11664","DOI":"10.1093\/nar\/gkaa935","article-title":"Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes","volume":"48","author":"Duic","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.09.008_bib106","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109760","article-title":"RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency","volume":"41","author":"Stok","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib107","article-title":"HOIL1 mediates MDA5 activation through ubiquitination of LGP2","author":"Cheng","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.molcel.2025.09.008_bib108","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jhep.2022.08.041","article-title":"Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication","volume":"78","author":"Gillich","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.molcel.2025.09.008_bib109","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201745176","article-title":"RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling","volume":"19","author":"Parisien","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110175","article-title":"Immune regulator LGP2 targets Ubc13\/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-kappaB activation","volume":"37","author":"Lenoir","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib111","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1128\/MCB.01368-10","article-title":"DDX60, a DEXD\/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling","volume":"31","author":"Miyashita","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2025.09.008_bib112","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1073\/pnas.1400139111","article-title":"Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system","volume":"111","author":"Sugimoto","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2025.09.008_bib113","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.celrep.2015.04.047","article-title":"DDX60 is involved in RIG-I-dependent and independent antiviral responses, and its function is attenuated by virus-induced EGFR activation","volume":"11","author":"Oshiumi","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib114","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19071877","article-title":"The RNA helicase DDX6 associates with RIG-I to augment induction of antiviral signaling","volume":"19","author":"N\u00fa\u00f1ez","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molcel.2025.09.008_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006886","article-title":"DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity","volume":"14","author":"Zhu","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2025.09.008_bib116","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/jir.2018.0163","article-title":"DHX15 is a coreceptor for RLR signaling that promotes antiviral defense against RNA virus infection","volume":"39","author":"Pattabhi","year":"2019","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.molcel.2025.09.008_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110434","article-title":"The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity","volume":"38","author":"Hage","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib118","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.chom.2011.03.007","article-title":"The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response","volume":"9","author":"Kok","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molcel.2025.09.008_bib119","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.4049\/jimmunol.1601493","article-title":"PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization","volume":"199","author":"Lui","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib120","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.immuni.2018.08.014","article-title":"The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors","volume":"49","author":"Lian","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2025.09.008_bib121","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-48524-6","article-title":"ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection","volume":"15","author":"Bazzone","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.09.008_bib122","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq0660","article-title":"Endosomes serve as signaling platforms for RIG-I ubiquitination and activation","volume":"10","author":"Chen","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2025.09.008_bib123","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrmicro2574","article-title":"Subversion of the actin cytoskeleton during viral infection","volume":"9","author":"Taylor","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.molcel.2025.09.008_bib124","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1016\/j.cell.2022.08.011","article-title":"Actin cytoskeleton remodeling primes RIG-I-like receptor activation","volume":"185","author":"Acharya","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib125","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1038\/s41590-024-02004-7","article-title":"UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling","volume":"25","author":"Harrison","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib126","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1038\/s44319-024-00256-w","article-title":"RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation","volume":"25","author":"Li","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib127","article-title":"RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways","volume":"16","author":"He","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.09.008_bib128","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41422-020-0362-1","article-title":"A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I\/MDA5 for degradation during viral infection","volume":"31","author":"Hou","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2025.09.008_bib129","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/15548627.2019.1615303","article-title":"LRRC59 modulates type I interferon signaling by restraining the SQSTM1\/p62-mediated autophagic degradation of pattern recognition receptor DDX58\/RIG-I","volume":"16","author":"Xian","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2025.09.008_bib130","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.molcel.2017.09.005","article-title":"Tetherin suppresses type I interferon signaling by targeting MAVS for NDP52-mediated selective autophagic degradation in human cells","volume":"68","author":"Jin","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib131","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100978","article-title":"RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation","volume":"38","author":"He","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib132","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2016.24","article-title":"MAVS maintains mitochondrial homeostasis via autophagy","volume":"2","author":"Sun","year":"2016","journal-title":"Cell Discov."},{"key":"10.1016\/j.molcel.2025.09.008_bib133","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02096","article-title":"Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-Beclin-1 signaling axis","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib134","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/s42255-022-00652-3","article-title":"Innate metabolic responses against viral infections","volume":"4","author":"Palmer","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.molcel.2025.09.008_bib135","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1016\/j.molcel.2022.10.026","article-title":"AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity","volume":"82","author":"Zhang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib136","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/s41590-024-01848-3","article-title":"An IFNgamma-dependent immune-endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response","volume":"25","author":"\u0160estan","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib137","article-title":"MAVS integrates glucose metabolism and RIG-I-like receptor signaling","volume":"14","author":"He","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.09.008_bib138","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2025.09.008_bib139","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2019.05.003","article-title":"Lactate is a natural suppressor of RLR signaling by targeting MAVS","volume":"178","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.09.008_bib140","article-title":"Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition","volume":"12","author":"Zhou","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.09.008_bib141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011371","article-title":"Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I","volume":"19","author":"Li","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2025.09.008_bib142","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.chom.2018.11.001","article-title":"O-GlcNAc transferase links glucose metabolism to MAVS-mediated antiviral innate immunity","volume":"24","author":"Li","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molcel.2025.09.008_bib143","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.celrep.2019.07.085","article-title":"MAVS O-GlcNAcylation is essential for host antiviral immunity against lethal RNA viruses","volume":"28","author":"Song","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.09.008_bib144","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib145","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/s42255-024-01145-1","article-title":"Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase","volume":"6","author":"O'Carroll","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.molcel.2025.09.008_bib146","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41586-018-0363-0","article-title":"Mitochondrial double-stranded RNA triggers antiviral signalling in humans","volume":"560","author":"Dhir","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib147","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-023-05720-6","article-title":"Macrophage fumarate hydratase restrains mtRNA-mediated interferon production","volume":"615","author":"Hooftman","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.09.008_bib148","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/s41564-025-01985-x","article-title":"Metabolic remodelling produces fumarate via the aspartate-argininosuccinate shunt in macrophages as an antiviral defence","volume":"10","author":"Xia","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.molcel.2025.09.008_bib149","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103285","article-title":"SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation","volume":"39","author":"Liu","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2025.09.008_bib150","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tips.2018.12.003","article-title":"Therapeutic targeting of RIG-I and MDA5 might not lead to the same Rome","volume":"40","author":"Kasumba","year":"2019","journal-title":"Trends Pharmacol. Sci."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109727652500749X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109727652500749X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:54:59Z","timestamp":1783148099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109727652500749X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":150,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S109727652500749X"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2025.09.008","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The RIG-I-like receptor family of immune proteins","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2025.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}