{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:29:03Z","timestamp":1790108943397,"version":"4.0.1"},"reference-count":92,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.molcel.2025.11.002","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T15:44:04Z","timestamp":1763999044000},"page":"4410-4425.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt"],"prefix":"10.1016","volume":"85","author":[{"given":"Annarita","family":"Miluzio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Scagliola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"D\u2019Andrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cassina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Oliveto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Boletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Biffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2025.11.002_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0968-0004(00)01776-X","article-title":"Translation control: bridging the gap between genomics and proteomics?","volume":"26","author":"Pradet-Balade","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molcel.2025.11.002_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib3","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.cmet.2024.07.022","article-title":"The crosstalk between metabolism and translation","volume":"36","author":"Biffo","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2025.11.002_bib4","doi-asserted-by":"crossref","first-page":"e00070-18","DOI":"10.1128\/MCB.00070-18","article-title":"Signaling pathways involved in the regulation of mRNA translation","volume":"38","author":"Roux","year":"2018","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41568-021-00380-y","article-title":"The plasticity of mRNA translation during cancer progression and therapy resistance","volume":"21","author":"Fabbri","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2025.11.002_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: From mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.11.002_bib7","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.06.006","article-title":"Ribosome collisions trigger general stress responses to regulate cell fate","volume":"182","author":"Wu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib9","doi-asserted-by":"crossref","first-page":"a013706","DOI":"10.1101\/cshperspect.a013706","article-title":"The elongation, termination, and recycling phases of translation in eukaryotes","volume":"4","author":"Dever","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib10","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cmet.2018.08.009","article-title":"The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling","volume":"28","author":"Ricciardi","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2025.11.002_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2022.10.012","article-title":"Translation\u2014a tug of war during viral infection","volume":"83","author":"Rozman","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1101\/gad.350752.123","article-title":"Translational regulation by uORFs and start codon selection stringency","volume":"37","author":"Dever","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2025.11.002_bib13","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1074\/jbc.M110.216093","article-title":"Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation","volume":"286","author":"Palam","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.11.002_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature18282","article-title":"Stem cell function and stress response are controlled by protein synthesis","volume":"534","author":"Blanco","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature13035","article-title":"Haematopoietic stem cells require a highly regulated protein synthesis rate","volume":"509","author":"Signer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature02160","article-title":"Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly","volume":"426","author":"Ceci","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib17","doi-asserted-by":"crossref","first-page":"8796","DOI":"10.1016\/S0021-9258(19)86768-6","article-title":"Purification and characterization of a ribosome dissociation factor (eukaryotic initiation factor 6) from wheat germ","volume":"254","author":"Russell","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.11.002_bib18","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.1211204","article-title":"Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6","volume":"334","author":"Klinge","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.11.002_bib19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1083\/jcb.144.5.823","article-title":"The \u03b24 integrin interactor p27BBP\/eIF6 is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly","volume":"144","author":"Sanvito","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib20","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nature07267","article-title":"Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation","volume":"455","author":"Gandin","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ccr.2011.04.018","article-title":"Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth","volume":"19","author":"Miluzio","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib22","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1074\/jbc.RA120.013324","article-title":"Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3","volume":"295","author":"Jungers","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.11.002_bib23","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gky1159","article-title":"15 years of PhosphoSitePlus\u00ae: integrating post-translationally modified sites, disease variants and isoforms","volume":"47","author":"Hornbeck","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib24","article-title":"Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.11.002_bib25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17237-x","article-title":"Structural snapshots of human pre-60S ribosomal particles before and after nuclear export","volume":"11","author":"Liang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.11.002_bib27","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1128\/MCB.25.4.1258-1271.2005","article-title":"Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function","volume":"25","author":"Korgaonkar","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccr.2009.09.024","article-title":"Signaling to p53: ribosomal proteins find their way","volume":"16","author":"Zhang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2016.02.066","article-title":"Ribosome footprint profiling of translation throughout the genome","volume":"165","author":"Ingolia","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.molcel.2020.06.005","article-title":"Selective 40S footprinting reveals cap-tethered ribosome scanning in human cells","volume":"79","author":"Bohlen","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202100269","article-title":"Rebirth of the translational machinery: The importance of recycling ribosomes","volume":"44","author":"Young","year":"2022","journal-title":"BioEssays"},{"key":"10.1016\/j.molcel.2025.11.002_bib32","doi-asserted-by":"crossref","first-page":"D529","DOI":"10.1093\/nar\/gky1079","article-title":"The BioGRID interaction database: 2019 update","volume":"47","author":"Oughtred","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib33","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nsmb.3112","article-title":"Mechanism of eIF6 release from the nascent 60S ribosomal subunit","volume":"22","author":"Weis","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib34","first-page":"3203","article-title":"GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae","volume":"11","author":"Foiani","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib35","doi-asserted-by":"crossref","first-page":"11269","DOI":"10.1073\/pnas.0400541101","article-title":"Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells","volume":"101","author":"Vattem","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.molcel.2025.11.002_bib36","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-\u03baB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib37","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.4049\/jimmunol.151.12.6986","article-title":"Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes","volume":"151","author":"Ziegler-Heitbrock","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molcel.2025.11.002_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib39","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1016\/j.molcel.2021.08.015","article-title":"AMPK: restoring metabolic homeostasis over space and time","volume":"81","author":"Trefts","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature25449","article-title":"Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders","volume":"554","author":"Calo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.11.002_bib41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0012-1606(73)90172-3","article-title":"Amino acid uptake and protein synthesis in preimplantation mouse embryos","volume":"33","author":"Epstein","year":"1973","journal-title":"Dev. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib42","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a032607","article-title":"Principles of Translational Control","volume":"11","author":"Hershey","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib43","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-biochem-013118-111042","article-title":"The organizing principles of eukaryotic ribosome recruitment","volume":"88","author":"Pelletier","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2025.11.002_bib44","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a032649","article-title":"Translation elongation and recoding in eukaryotes","volume":"10","author":"Dever","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib45","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41580-023-00624-9","article-title":"The molecular basis of translation initiation and its regulation in eukaryotes","volume":"25","author":"Brito Querido","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib46","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1158\/0008-5472.CAN-14-2789","article-title":"Targeting the eIF4F translation initiation complex: a critical nexus for cancer development","volume":"75","author":"Pelletier","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib47","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012252","article-title":"Regulation of mRNA translation by signaling pathways","volume":"4","author":"Roux","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2020.11.034","article-title":"Hallmarks of Health","volume":"184","author":"L\u00f3pez-Ot\u00edn","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib49","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41590-020-0714-5","article-title":"Dynamics in protein translation sustaining T cell preparedness","volume":"21","author":"Wolf","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2025.11.002_bib50","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2023.04.025","article-title":"A 360\u00b0 view of the inflammasome: Mechanisms of activation, cell death, and diseases","volume":"186","author":"Barnett","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcdb.2014.06.010","article-title":"Timing of developmental events in the early mouse embryo","volume":"34","author":"Kojima","year":"2014","journal-title":"Semin. Cell Dev. Biol. (Elsevier)"},{"key":"10.1016\/j.molcel.2025.11.002_bib52","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0012-1606(74)90105-5","article-title":"Development of preimplantation rabbit embryos in vivo and in vitro","volume":"40","author":"Van Blerkom","year":"1974","journal-title":"Dev. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib53","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","article-title":"Translational control is required for the unfolded protein response and in vivo glucose homeostasis","volume":"7","author":"Scheuner","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib54","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.1005320107","article-title":"eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression","volume":"107","author":"Furic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.molcel.2025.11.002_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36230-8","article-title":"Structural basis for clearing of ribosome collisions by the RQT complex","volume":"14","author":"Best","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.11.002_bib56","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S1097-2765(01)00403-8","article-title":"The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis","volume":"8","author":"Senger","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib57","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ng1994","article-title":"The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast","volume":"39","author":"Menne","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2025.11.002_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29214-7","article-title":"eIF6 rebinding dynamically couples ribosome maturation and translation","volume":"13","author":"Jaako","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.11.002_bib59","doi-asserted-by":"crossref","first-page":"30314","DOI":"10.1074\/jbc.272.48.30314","article-title":"Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells","volume":"272","author":"Biffo","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.11.002_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/srep15401","article-title":"Direct and high throughput (HT) interactions on the ribosomal surface by iRIA","volume":"5","author":"Pesce","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2025.11.002_bib61","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells","volume":"23","author":"Schwenk","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib62","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.20070725","article-title":"Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development","volume":"205","author":"Panattoni","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2025.11.002_bib63","doi-asserted-by":"crossref","first-page":"29617","DOI":"10.1074\/jbc.M204381200","article-title":"Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression","volume":"277","author":"Strezoska","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2025.11.002_bib64","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0076-6879(02)46074-0","article-title":"Transduction of a gene expression cassette using advanced generation lentiviral vectors","volume":"346","author":"De Palma","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.molcel.2025.11.002_bib65","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/hum.2005.16.741","article-title":"Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses","volume":"16","author":"Abordo-Adesida","year":"2005","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.molcel.2025.11.002_bib66","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1182\/blood-2015-11-683052","article-title":"Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice","volume":"127","author":"Choudhari","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.molcel.2025.11.002_bib67","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00018-012-1215-y","article-title":"RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency","volume":"70","author":"Volta","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.molcel.2025.11.002_bib68","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/dbio.1998.8874","article-title":"Na\/K-ATPase-Mediated86Rb+ Uptake and Asymmetrical Trophectoderm Localization of \u03b11 and \u03b13 Na\/K-ATPase Isoforms during Bovine Preattachment Development","volume":"197","author":"Betts","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104390","article-title":"Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2","volume":"87","author":"Miluzio","year":"2023","journal-title":"EBiomedicine"},{"key":"10.1016\/j.molcel.2025.11.002_bib70","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nprot.2009.191","article-title":"Protocols to detect senescence-associated beta-galactosidase (SA-\u03b2gal) activity, a biomarker of senescent cells in culture and in vivo","volume":"4","author":"Debacq-Chainiaux","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molcel.2025.11.002_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9261","article-title":"eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription","volume":"6","author":"Brina","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.11.002_bib72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.molcel.2025.11.002_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib74","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib75","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-370-7_2","article-title":"Design and construction of functional AAV vectors","volume":"807","author":"Gray","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib76","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.2732","article-title":"HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics","volume":"11","author":"Branca","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2025.11.002_bib77","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41608","article-title":"In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta","volume":"8","author":"Pernemalm","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2025.11.002_bib78","doi-asserted-by":"crossref","first-page":"13.24.1","DOI":"10.1002\/0471250953.bi1324s46","article-title":"Employing ProteoWizard to Convert Raw Mass Spectrometry Data","volume":"46","author":"Holman","year":"2014","journal-title":"Curr. Protoc. Bioinform."},{"key":"10.1016\/j.molcel.2025.11.002_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6277","article-title":"MS-GF+ makes progress towards a universal database search tool for proteomics","volume":"5","author":"Kim","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2025.11.002_bib80","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1021\/pr400937n","article-title":"Fast and accurate database searches with MS-GF+Percolator","volume":"13","author":"Granholm","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib81","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nbt.3134","article-title":"Multi-omic data analysis using Galaxy","volume":"33","author":"Boekel","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2025.11.002_bib83","doi-asserted-by":"crossref","first-page":"D1539","DOI":"10.1093\/nar\/gkac1040","article-title":"The ProteomeXchange consortium at 10 years: 2023 update","volume":"51","author":"Deutsch","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib82","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1016\/j.molcel.2021.09.015","article-title":"Proteome-wide mapping of short-lived proteins in human cells","volume":"81","author":"Li","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib84","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ymeth.2017.05.028","article-title":"Transcriptome-wide measurement of translation by ribosome profiling","volume":"126","author":"McGlincy","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.molcel.2025.11.002_bib85","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1093\/nar\/gkab1158","article-title":"Phospho-RNA sequencing with circAID-p-seq","volume":"50","author":"Del Piano","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2025.11.002_bib86","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2011.10.002","article-title":"Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes","volume":"147","author":"Ingolia","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib87","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a032698","article-title":"Ribosome profiling: global views of translation","volume":"11","author":"Ingolia","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib88","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2017.03.003","article-title":"eIF5A functions globally in translation elongation and termination","volume":"66","author":"Schuller","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2025.11.002_bib89","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2025.11.002_bib90","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2025.11.002_bib91","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1002\/cpmb.108","article-title":"deltaTE: detection of translationally regulated genes by integrative analysis of Ribo-seq and RNA-seq Data","volume":"129","author":"Chothani","year":"2019","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.molcel.2025.11.002_bib92","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/nar\/gkad135","article-title":"PRRC2 proteins impact translation initiation by promoting leaky scanning","volume":"51","author":"Bohlen","year":"2023","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276525008986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276525008986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T15:17:06Z","timestamp":1764947826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276525008986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":92,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1097276525008986"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2025.11.002","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2025.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}