{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:50:21Z","timestamp":1769154621605,"version":"3.49.0"},"reference-count":11,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Y011481\/1"],"award-info":[{"award-number":["BB\/Y011481\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Z517264\/1"],"award-info":[{"award-number":["BB\/Z517264\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.molcel.2025.12.021","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:27:33Z","timestamp":1769099253000},"page":"231-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Heavy Chain Reaction: Unraveling loop extrusion dynamics during VDJ recombination"],"prefix":"10.1016","volume":"86","author":[{"given":"Naiming","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushad","family":"Pavri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2025.12.021_bib11","first-page":"304","article-title":"Chromatin folding principles underlying the generation of antibody diversity","volume":"86","author":"Ollikainen","year":"2026","journal-title":"Molecular Cell."},{"key":"10.1016\/j.molcel.2025.12.021_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cell.2008.03.024","article-title":"The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions","volume":"133","author":"Jhunjhunwala","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.12.021_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1126\/science.1068768","article-title":"Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development","volume":"296","author":"Kosak","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.molcel.2025.12.021_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/gad.291504","article-title":"Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene","volume":"18","author":"Fuxa","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2025.12.021_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cell.2011.08.049","article-title":"Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus","volume":"147","author":"Guo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.12.021_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41586-020-2578-0","article-title":"CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning","volume":"586","author":"Ba","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.12.021_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-020-2454-y","article-title":"Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion","volume":"584","author":"Hill","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.12.021_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-1547-y","article-title":"The fundamental role of chromatin loop extrusion in physiological V(D)J recombination","volume":"573","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2025.12.021_bib8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cell.2018.04.035","article-title":"CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning","volume":"174","author":"Jain","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2025.12.021_bib9","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.celrep.2016.04.085","article-title":"Formation of Chromosomal Domains by Loop Extrusion","volume":"15","author":"Fudenberg","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2025.12.021_bib10","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1038\/s41467-023-37994-9","article-title":"Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells","volume":"14","author":"Hill","year":"2023","journal-title":"Nat. Commun."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276525010202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276525010202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:28:40Z","timestamp":1769099320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276525010202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1097276525010202"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2025.12.021","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Heavy Chain Reaction: Unraveling loop extrusion dynamics during VDJ recombination","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2025.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2025.12.023","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}