{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:21:53Z","timestamp":1791915713178,"version":"4.3.4"},"reference-count":68,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,4]],"date-time":"2027-06-04T00:00:00Z","timestamp":1812067200000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA260249"],"award-info":[{"award-number":["R01CA260249"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA251726"],"award-info":[{"award-number":["R01CA251726"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK063720"],"award-info":[{"award-number":["P30 DK063720"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032560","name":"Arc Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001021","name":"Damon Runyon Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["DP2CA239597"],"award-info":[{"award-number":["DP2CA239597"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["R01CA290875"],"award-info":[{"award-number":["R01CA290875"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P500PB_221997"],"award-info":[{"award-number":["P500PB_221997"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.molcel.2026.05.005","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:42:53Z","timestamp":1780065773000},"page":"2141-2156.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer"],"prefix":"10.1016","volume":"86","author":[{"given":"Marine","family":"Berquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Luy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Venida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"McDowall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"O\u2019Loughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Rademaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilash","family":"Barpanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun P.","family":"Wiita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-2273","authenticated-orcid":false,"given":"Rushika M.","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.05.005_bib1","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.molcel.2022.03.023","article-title":"Autophagy in cancer cell remodeling and quality control","volume":"82","author":"Hernandez","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib2","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021110031","article-title":"The multifaceted role of autophagy in cancer","volume":"41","author":"Russell","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.05.005_bib3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1158\/2159-8290.CD-17-0952","article-title":"Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms","volume":"8","author":"Yang","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.05.005_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1101\/gad.2016111","article-title":"Pancreatic cancers require autophagy for tumor growth","volume":"25","author":"Yang","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.05.005_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature14587","article-title":"Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism","volume":"524","author":"Perera","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.05.005_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41580-023-00676-x","article-title":"Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology","volume":"25","author":"Settembre","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27088-9","article-title":"Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression","volume":"13","author":"Cheung","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.05.005_bib8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1158\/2159-8290.CD-23-0584","article-title":"Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer","volume":"14","author":"Sang","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.05.005_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41586-020-2229-5","article-title":"Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I","volume":"581","author":"Yamamoto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.05.005_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature24627","article-title":"Structure of the human MHC-I peptide-loading complex","volume":"551","author":"Blees","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.05.005_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1179846","article-title":"Chaperone function in antigen presentation by MHC class I molecules-tapasin in the PLC and TAPBPR beyond","volume":"14","author":"Margulies","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-biophys-121219-081643","article-title":"Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity","volume":"49","author":"Trowitzsch","year":"2020","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.molcel.2026.05.005_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32841-9","article-title":"Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity","volume":"13","author":"M\u00fcller","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.05.005_bib14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/ni1485","article-title":"Selective loading of high-affinity peptides onto major histocompatibility complex class I molecules by the tapasin-ERp57 heterodimer","volume":"8","author":"Wearsch","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni859","article-title":"An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides","volume":"3","author":"Saric","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib16","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni1208","article-title":"Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum","volume":"6","author":"Saveanu","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23049","article-title":"TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway","volume":"6","author":"Neerincx","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.05.005_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature14498","article-title":"Regulation of endoplasmic reticulum turnover by selective autophagy","volume":"522","author":"Khaminets","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.05.005_bib19","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00038.2021","article-title":"ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum","volume":"102","author":"Reggiori","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.molcel.2026.05.005_bib20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tcb.2020.02.001","article-title":"ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum","volume":"30","author":"Chino","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib21","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.molcel.2022.02.018","article-title":"ER remodeling via ER-phagy","volume":"82","author":"Gubas","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib22","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899847","article-title":"A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex","volume":"38","author":"Forrester","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.05.005_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202052289","article-title":"Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control","volume":"22","author":"Reggio","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2026.05.005_bib24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.molcel.2019.03.034","article-title":"TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress","volume":"74","author":"An","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.molcel.2019.03.033","article-title":"Intrinsically Disordered Protein TEX264 Mediates ER-phagy","volume":"74","author":"Chino","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib26","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.4049\/jimmunol.178.6.3612","article-title":"Stimulation of an unfolded protein response impairs MHC class I expression","volume":"178","author":"de Almeida","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2172-10-10","article-title":"ER stress affects processing of MHC class I-associated peptides","volume":"10","author":"Granados","year":"2009","journal-title":"BMC Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao4908","article-title":"Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases","volume":"360","author":"Pommier","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.05.005_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nmeth.1928","article-title":"Synchronization of secretory protein traffic in populations of cells","volume":"9","author":"Boncompain","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.05.005_bib30","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1080\/15548627.2020.1719746","article-title":"Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy","volume":"16","author":"Stefely","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2026.05.005_bib31","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202208092","article-title":"NBR1: The archetypal selective autophagy receptor","volume":"221","author":"Rasmussen","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/tra.12279","article-title":"Release from endoplasmic reticulum matrix proteins controls cell surface transport of MHC class I molecules","volume":"16","author":"Fritzsche","year":"2015","journal-title":"Traffic"},{"key":"10.1016\/j.molcel.2026.05.005_bib33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41587-022-01566-x","article-title":"High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform","volume":"41","author":"Bruno","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.05.005_bib34","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.4049\/jimmunol.155.4.2232","article-title":"Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein","volume":"155","author":"Dupuis","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib35","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2013.06.044","article-title":"CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes","volume":"154","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib37","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cell.2024.11.028","article-title":"Global organelle profiling reveals subcellular localization and remodeling at proteome scale","volume":"188","author":"Hein","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s11689-016-9146-9","article-title":"An investigation of NFXL1, a gene implicated in a study of specific language impairment","volume":"8","author":"Nudel","year":"2016","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.molcel.2026.05.005_bib39","article-title":"The Role of Membrane-Associated E3 Ubiquitin Ligases in Cancer","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molcel.2026.05.005_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/biology10040279","article-title":"NFX1, Its Isoforms and Roles in Biology, Disease and Cancer","volume":"10","author":"Chintala","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.molcel.2026.05.005_bib41","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.ccell.2024.09.010","article-title":"The hallmarks of cancer immune evasion","volume":"42","author":"Galassi","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib42","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1800162","article-title":"Anti-tumor immunity influences cancer cell reliance upon ATG7","volume":"9","author":"Arensman","year":"2020","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.molcel.2026.05.005_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s43018-021-00208-6","article-title":"ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer","volume":"2","author":"Deng","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.molcel.2026.05.005_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29412-3","article-title":"Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing","volume":"13","author":"Frey","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.05.005_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-020-2746-2","article-title":"Functional genomic landscape of cancer-intrinsic evasion of killing by T cells","volume":"586","author":"Lawson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.05.005_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax7881","article-title":"Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1\/PD-L1 immunotherapy","volume":"6","author":"Noman","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.05.005_bib47","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s43018-020-00110-7","article-title":"Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response","volume":"1","author":"Poillet-Perez","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.molcel.2026.05.005_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb9561","article-title":"Autophagy protects tumors from T cell-mediated cytotoxicity via inhibition of TNFalpha-induced apoptosis","volume":"5","author":"Young","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib49","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.celrep.2019.03.037","article-title":"Autophagy Regulation of Metabolism Is Required for CD8(+) T Cell Anti-tumor Immunity","volume":"27","author":"DeVorkin","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.05.005_bib50","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41589-018-0096-2","article-title":"Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle","volume":"14","author":"McShan","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib51","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1038\/s44318-024-00280-5","article-title":"Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration","volume":"43","author":"Bauer","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.05.005_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25572-w","article-title":"Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation","volume":"12","author":"Turco","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.05.005_bib53","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1016\/j.cell.2024.09.048","article-title":"IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion","volume":"187","author":"Herhaus","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib54","doi-asserted-by":"crossref","first-page":"E9353","DOI":"10.1073\/pnas.1809465115","article-title":"Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules","volume":"115","author":"Ilca","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.05.005_bib55","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.ccell.2022.07.005","article-title":"A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy","volume":"40","author":"Zhang","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.05.005_bib56","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.molimm.2015.07.005","article-title":"Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I","volume":"68","author":"van den Boomen","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molcel.2026.05.005_bib57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.200611063","article-title":"Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3","volume":"177","author":"Wang","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib58","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1074\/jbc.M513920200","article-title":"The viral E3 ubiquitin ligase mK3 uses the Derlin\/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.05.005_bib59","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1002\/j.1460-2075.1996.tb00689.x","article-title":"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47","volume":"15","author":"Ahn","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.05.005_bib60","doi-asserted-by":"crossref","first-page":"30365","DOI":"10.1074\/jbc.M603000200","article-title":"Structure and dynamics of membrane-associated ICP47, a viral inhibitor of the MHC I antigen-processing machinery","volume":"281","author":"Aisenbrey","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.05.005_bib61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1083\/jcb.201503075","article-title":"NBR1 enables autophagy-dependent focal adhesion turnover","volume":"212","author":"Kenific","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib62","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41586-023-06985-7","article-title":"Stress response silencing by an E3 ligase mutated in neurodegeneration","volume":"626","author":"Haakonsen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.05.005_bib63","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41556-021-00644-7","article-title":"Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth","volume":"23","author":"Gupta","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.05.005_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19760","article-title":"Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation","volume":"5","author":"Horlbeck","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.05.005_bib65","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73982","article-title":"Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells","volume":"11","author":"Kirkemo","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.05.005_bib66","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1074\/mcp.RA117.000314","article-title":"Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results","volume":"16","author":"Bruderer","year":"2017","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.molcel.2026.05.005_bib67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.05.005_bib68","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1021\/acs.jproteome.2c00646","article-title":"Integrative Proteomic and Pharmacological Analysis of Colon Cancer Reveals the Classical Lipogenic Pathway with Prognostic and Therapeutic Opportunities","volume":"22","author":"Barpanda","year":"2023","journal-title":"J. Proteome Res."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526003114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526003114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:57:21Z","timestamp":1783187841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526003114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1097276526003114"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.05.005","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}