{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:27:21Z","timestamp":1787624841535,"version":"build-2736575974"},"reference-count":66,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.molcel.2026.06.033","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:07:33Z","timestamp":1784128053000},"page":"3332-3343.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["SMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis"],"prefix":"10.1016","volume":"86","author":[{"given":"Wei-Ying","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Xia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangchan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-2200","authenticated-orcid":false,"given":"Jian-Huang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.06.033_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41576-020-00295-8","article-title":"The epitranscriptome beyond m6A","volume":"22","author":"Wiener","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2026.06.033_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2023.10.008","article-title":"Why U matters: detection and functions of pseudouridine modifications in mRNAs","volume":"49","author":"Rodell","year":"2024","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molcel.2026.06.033_bib3","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41580-023-00622-x","article-title":"Regulation and functions of non-m6A mRNA modifications","volume":"24","author":"Sun","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.aad8711","article-title":"Messenger RNA modifications: Form, distribution, and function","volume":"352","author":"Gilbert","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.06.033_bib5","article-title":"Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine","volume":"7","author":"Xue","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molcel.2026.06.033_bib6","article-title":"RNA modifications: importance in immune cell biology and related diseases","volume":"7","author":"Cui","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molcel.2026.06.033_bib7","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1038\/s41380-022-01570-2","article-title":"Epitranscriptomic dynamics in brain development and disease","volume":"27","author":"Shafik","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.molcel.2026.06.033_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.immuni.2005.06.008","article-title":"Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA","volume":"23","author":"Karik\u00f3","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2026.06.033_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-genet-112618-043830","article-title":"Regulation and Function of RNA Pseudouridylation in Human Cells","volume":"54","author":"Borchardt","year":"2020","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.molcel.2026.06.033_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41576-022-00534-0","article-title":"Biological roles of adenine methylation in RNA","volume":"24","author":"Boulias","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2026.06.033_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41571-023-00774-x","article-title":"The roles and implications of RNA m6A modification in cancer","volume":"20","author":"Deng","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.molcel.2026.06.033_bib12","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41589-023-01304-7","article-title":"Quantitative profiling of pseudouridylation landscape in the human transcriptome","volume":"19","author":"Zhang","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-35858-w","article-title":"Semi-quantitative detection of pseudouridine modifications and type I\/II hypermodifications in human mRNAs using direct long-read sequencing","volume":"14","author":"Tavakoli","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.06.033_bib14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41587-022-01505-w","article-title":"Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution","volume":"41","author":"Dai","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.06.033_bib15","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/s41592-024-02439-8","article-title":"Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome","volume":"21","author":"Xu","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.06.033_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2021.12.023","article-title":"Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing","volume":"82","author":"Martinez","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev-biochem-013118-111024","article-title":"How Is Precursor Messenger RNA Spliced by the Spliceosome?","volume":"89","author":"Wan","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2026.06.033_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s13238-021-00856-5","article-title":"Emerging roles of spliceosome in cancer and immunity","volume":"13","author":"Yang","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrm.2017.86","article-title":"Mechanistic insights into precursor messenger RNA splicing by the spliceosome","volume":"18","author":"Shi","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-biochem-052521-035949","article-title":"mRNA Regulation by RNA Modifications","volume":"92","author":"Gilbert","year":"2023","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2026.06.033_bib21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.033_bib23","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib26","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1021\/jacs.4c17659","article-title":"Quantitative Proteomics Identifies Profilin-1 as a Pseudouridine-Binding Protein","volume":"147","author":"Wei","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.molcel.2026.06.033_bib27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.molcel.2013.07.024","article-title":"RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner","volume":"51","author":"Peisley","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib28","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/nar\/gkaa1178","article-title":"Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase","volume":"49","author":"Levi","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.06.033_bib29","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nature09956","article-title":"Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis","volume":"473","author":"Leung","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.033_bib30","article-title":"Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC\/Spliceosome Program in Hepatocellular Carcinoma","volume":"11","author":"Chang","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.molcel.2026.06.033_bib31","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrm.2017.63","article-title":"Splicing and transcription touch base: co-transcriptional spliceosome assembly and function","volume":"18","author":"Herzel","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib32","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrm3525","article-title":"Alternative splicing: a pivotal step between eukaryotic transcription and translation","volume":"14","author":"Kornblihtt","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae1201","article-title":"BASAL: a universal mapping algorithm for nucleotide base-conversion sequencing","volume":"53","author":"Xu","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.06.033_bib35","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1093\/nar\/gkv386","article-title":"Splicing of many human genes involves sites embedded within introns","volume":"43","author":"Kelly","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.06.033_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ady3894","article-title":"Nuclear 2\u2032-O-methylation regulates RNA splicing through its binding protein FUBP1","volume":"11","author":"Gao","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.06.033_bib37","article-title":"IGF2BP3 promotes mRNA degradation through internal m7G modification","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.06.033_bib38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nature13566","article-title":"Crystal structure of the human COP9 signalosome","volume":"512","author":"Lingaraju","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.033_bib39","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/15548627.2018.1532262","article-title":"YKT6 as a second SNARE protein of mammalian autophagosomes","volume":"15","author":"Mizushima","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.molcel.2026.06.033_bib40","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41568-024-00750-2","article-title":"Steering research on mRNA splicing in cancer towards clinical translation","volume":"24","author":"Anczukow","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.06.033_bib41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41568-022-00541-7","article-title":"RNA splicing dysregulation and the hallmarks of cancer","volume":"23","author":"Bradley","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.06.033_bib42","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s43018-022-00384-z","article-title":"Dysregulation and therapeutic targeting of RNA splicing in cancer","volume":"3","author":"Stanley","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.molcel.2026.06.033_bib43","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbpa.2016.06.014","article-title":"Pseudouridine: the fifth RNA nucleotide with renewed interests","volume":"33","author":"Li","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib44","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.cell.2023.05.047","article-title":"QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism","volume":"186","author":"Zhao","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib45","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/cr.2014.152","article-title":"Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine","volume":"24","author":"Zhu","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2026.06.033_bib46","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/cr.2014.153","article-title":"Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition","volume":"24","author":"Li","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2026.06.033_bib47","doi-asserted-by":"crossref","first-page":"24902","DOI":"10.1074\/jbc.M115.680389","article-title":"Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins","volume":"290","author":"Xu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.06.033_bib48","doi-asserted-by":"crossref","first-page":"654","DOI":"10.15252\/embj.201593113","article-title":"Pseudouridines in U2 snRNA stimulate the ATPase activity of Prp5 during spliceosome assembly","volume":"35","author":"Wu","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.06.033_bib49","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1093\/emboj\/17.19.5783","article-title":"Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing","volume":"17","author":"Yu","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.06.033_bib50","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/cr.2017.55","article-title":"5-methylcytosine promotes mRNA export \u2013 NSUN2 as the methyltransferase and ALYREF as an m(5)C reader","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.molcel.2026.06.033_bib51","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1016\/j.molcel.2024.10.004","article-title":"m6Am sequesters PCF11 to suppress premature termination and drive neuroblastoma differentiation","volume":"84","author":"An","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib52","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1089\/cmb.2017.0096","article-title":"cutPrimers: A New Tool for Accurate Cutting of Primers from Reads of Targeted Next Generation Sequencing","volume":"24","author":"Kechin","year":"2017","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib53","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.06.033_bib54","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.molcel.2026.06.033_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.06.033_bib56","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib57","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb.)"},{"key":"10.1016\/j.molcel.2026.06.033_bib58","doi-asserted-by":"crossref","first-page":"E5593","DOI":"10.1073\/pnas.1419161111","article-title":"rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data","volume":"111","author":"Shen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.06.033_bib59","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib60","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41586-019-1160-0","article-title":"A vitamin-C-derived DNA modification catalysed by an algal TET homologue","volume":"569","author":"Xue","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.033_bib61","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.033_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and Metabolomic Characterization of COVID-19 Patient Sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.06.033_bib63","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.06.033_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib65","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-8-r79","article-title":"PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data","volume":"12","author":"Corcoran","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.06.033_bib66","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1093\/bioinformatics\/btx469","article-title":"ggseqlogo: a versatile R package for drawing sequence logos","volume":"33","author":"Wagih","year":"2017","journal-title":"Bioinformatics"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526004223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526004223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:24:15Z","timestamp":1787239455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526004223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":66,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1097276526004223"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.06.033","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}