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J. Mol. Sci."},{"key":"10.1016\/j.molcel.2026.06.040_bib112","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41589-021-00772-z","article-title":"Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly","volume":"17","author":"Bennett","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.06.040_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101092","article-title":"Dissecting lipid metabolism alterations in SARS-CoV-2","volume":"82","author":"Casari","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.molcel.2026.06.040_bib114","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.02282-24","article-title":"Perturbation of de novo lipogenesis hinders MERS-CoV assembly and release, but not the biogenesis of viral replication organelles","volume":"99","author":"Soultsioti","year":"2025","journal-title":"J. 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Chem."},{"key":"10.1016\/j.molcel.2026.06.040_bib118","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1002\/1873-3468.12743","article-title":"Plasmalogen homeostasis - regulation of plasmalogen biosynthesis and its physiological consequence in mammals","volume":"591","author":"Honsho","year":"2017","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molcel.2026.06.040_bib119","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-60204-8_1","article-title":"Peroxisome: Metabolic Functions and Biogenesis","volume":"1299","author":"Okumoto","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molcel.2026.06.040_bib120","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s41586-025-08773-x","article-title":"A coronavirus assembly inhibitor that targets the viral membrane protein","volume":"640","author":"Laporte","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.040_bib121","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-04835-6","article-title":"The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle","volume":"606","author":"Ricciardi","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.06.040_bib122","article-title":"Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. 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Rep."},{"key":"10.1016\/j.molcel.2026.06.040_bib129","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2018.10.014","article-title":"Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells","volume":"29","author":"Bajzikova","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2026.06.040_bib130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41589-024-01689-z","article-title":"Phospholipid biosynthesis modulates nucleotide metabolism and reductive capacity","volume":"21","author":"Zhu","year":"2024","journal-title":"Nat. Chem. 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Chem."},{"key":"10.1016\/j.molcel.2026.06.040_bib133","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2009.05.036","article-title":"Identification of a Physiologically Relevant Endogenous Ligand for PPAR\u03b1 in Liver","volume":"138","author":"Chakravarthy","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.06.040_bib134","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.673917","article-title":"Potential Role of Plasmalogens in the Modulation of Biomembrane Morphology","volume":"9","author":"Almsherqi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.molcel.2026.06.040_bib135","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.tibs.2023.08.004","article-title":"Membrane homeostasis beyond fluidity: control of membrane compressibility","volume":"48","author":"Renne","year":"2023","journal-title":"Trends Biochem. 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Cell Biol."},{"key":"10.1016\/j.molcel.2026.06.040_bib141","article-title":"Synthesis, insertion, and characterization of SARS-CoV-2 membrane protein within lipid bilayers","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.06.040_bib142","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1128\/JVI.79.24.15043-15053.2005","article-title":"A Vesicular Stomatitis Virus Recombinant Expressing Granulocyte-Macrophage Colony-Stimulating Factor Induces Enhanced T-Cell Responses and Is Highly Attenuated for Replication in Animals","volume":"79","author":"Ramsburg","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.06.040_bib143","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.06.040_bib144","doi-asserted-by":"crossref","DOI":"10.21105\/joss.02410","article-title":"Viime: Visualization and Integration of Metabolomics Experiments","volume":"5","author":"Choudhury","year":"2020","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.molcel.2026.06.040_bib145","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.06.040_bib146","first-page":"158","article-title":"A modified method for lead staining of thin sections","volume":"17","author":"Sato","year":"1968","journal-title":"J. Electron Microsc. 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