{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:13:17Z","timestamp":1791400397702,"version":"4.3.3"},"reference-count":249,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,3]],"date-time":"2027-09-03T00:00:00Z","timestamp":1819929600000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA288743-01A1"],"award-info":[{"award-number":["1R01CA288743-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NCI 1R01CA251698-01"],"award-info":[{"award-number":["NCI 1R01CA251698-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.molcel.2026.07.004","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:47:36Z","timestamp":1784818056000},"page":"3367-3393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["BRD4: From molecular understanding to therapeutics development"],"prefix":"10.1016","volume":"86","author":[{"given":"Shwu-Yuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-3282","authenticated-orcid":false,"given":"Cheng-Ming","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.07.004_bib1","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1074\/jbc.R700001200","article-title":"The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation","volume":"282","author":"Wu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13742","article-title":"Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span","volume":"22","author":"Garcia","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.devcel.2019.05.037","article-title":"Brd4 and p300 confer transcriptional competency during zygotic genome activation","volume":"49","author":"Chan","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41573-024-01080-6","article-title":"Targeting lysine acetylation readers and writers","volume":"24","author":"Zhou","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molcel.2026.07.004_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cell.2012.02.013","article-title":"Histone recognition and large-scale structural analysis of the human bromodomain family","volume":"149","author":"Filippakopoulos","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib6","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.331231.119","article-title":"Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity","volume":"33","author":"Kim","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.07.004_bib7","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nature09589","article-title":"Suppression of inflammation by a synthetic histone mimic","volume":"468","author":"Nicodeme","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib9","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1021\/acs.jmedchem.0c01487","article-title":"Targeting bromodomain and extraterminal proteins for drug discovery: From current progress to technological development","volume":"64","author":"Tang","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib10","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.chembiol.2014.07.003","article-title":"Nonequivalent response to bromodomain-targeting BET inhibitors in oligodendrocyte cell fate decision","volume":"21","author":"Chiang","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.molcel.2005.06.027","article-title":"The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription","volume":"19","author":"Jang","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2005.06.029","article-title":"Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4","volume":"19","author":"Yang","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib13","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1101\/gad.1448206","article-title":"Brd4 links chromatin targeting to HPV transcriptional silencing","volume":"20","author":"Wu","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.07.004_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3410\/B1-98","article-title":"Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4","volume":"1","author":"Chiang","year":"2009","journal-title":"F1000 Biol. Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","article-title":"Selective inhibition of tumor oncogenes by disruption of super-enhancers","volume":"153","author":"Lov\u00e9n","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib16","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.cell.2013.10.056","article-title":"Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release","volume":"155","author":"Liu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2012.12.006","article-title":"Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting","volume":"49","author":"Wu","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf7346","article-title":"Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome","volume":"7","author":"Kim","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.07.004_bib19","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1016\/j.molcel.2023.10.004","article-title":"Transcriptional elongation control in developmental gene expression, aging, and disease","volume":"83","author":"Aoi","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-025-02887-3","article-title":"CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci","author":"Liu","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.07.004_bib21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/nar\/gkw729","article-title":"The bromodomain protein BRD4 regulates splicing during heat shock","volume":"45","author":"Hussong","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib22","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.celrep.2019.10.066","article-title":"The bromodomain protein 4 contributes to the regulation of alternative splicing","volume":"29","author":"Uppal","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib23","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1016\/j.molcel.2021.06.026","article-title":"A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3\u2032-processing and termination","volume":"81","author":"Arnold","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib24","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41419-023-06273-2","article-title":"The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells","volume":"14","author":"Luo","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2026.07.004_bib25","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1128\/MCB.22.18.6509-6520.2002","article-title":"A mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase","volume":"22","author":"Maruyama","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003777","article-title":"Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA","volume":"9","author":"Sakakibara","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2026.07.004_bib27","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1128\/JVI.03068-12","article-title":"Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA","volume":"87","author":"Wang","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.07.004_bib28","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.celrep.2016.07.001","article-title":"BRD4 phosphorylation regulates HPV E2-mediated viral transcription, origin replication, and cellular MMP-9 expression","volume":"16","author":"Wu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib29","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1016\/j.celrep.2019.08.051","article-title":"Functional analysis of the replication fork proteome identifies BET proteins as PCNA regulators","volume":"28","author":"Wessel","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib30","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1016\/j.celrep.2019.11.114","article-title":"PCNA unloading is negatively regulated by BET proteins","volume":"29","author":"Kang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17503-y","article-title":"BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage","volume":"11","author":"Lam","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108166","article-title":"BRD4 prevents R-loop formation and transcription-replication conflicts by ensuring efficient transcription elongation","volume":"32","author":"Edwards","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.molcel.2023.11.022","article-title":"IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors","volume":"84","author":"Wu","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature12147","article-title":"The bromodomain protein Brd4 insulates chromatin from DNA damage signalling","volume":"498","author":"Floyd","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molcel.2014.05.018","article-title":"Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining","volume":"55","author":"Stanlie","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib36","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.celrep.2017.12.078","article-title":"BRD4 promotes DNA repair and mediates the formation of TMPRSS2-ERG gene rearrangements in prostate cancer","volume":"22","author":"Li","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ccell.2018.01.019","article-title":"BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency","volume":"33","author":"Sun","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30787-6","article-title":"BRD4 promotes resection and homology-directed repair of DNA double-strand breaks","volume":"13","author":"Barrows","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109797","article-title":"Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage","volume":"27","author":"Wu","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.molcel.2026.07.004_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55637-5","article-title":"KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency","volume":"16","author":"Awwad","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib41","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1074\/jbc.M111.323493","article-title":"Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib42","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nsmb.3228","article-title":"BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin","volume":"23","author":"Devaiah","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib43","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1093\/nar\/gkx561","article-title":"BRD4 inhibitors block telomere elongation","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib44","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2019.08.037","article-title":"Organization of chromatin by intrinsic and regulated phase separation","volume":"179","author":"Gibson","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib45","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/s41588-021-00934-8","article-title":"BRD4 orchestrates genome folding to promote neural crest differentiation","volume":"53","author":"Linares-Saldana","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.07.004_bib46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41586-021-04116-8","article-title":"ecDNA hubs drive cooperative intermolecular oncogene expression","volume":"600","author":"Hung","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib47","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.abk3512","article-title":"Nested epistasis enhancer networks for robust genome regulation","volume":"377","author":"Lin","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.004_bib48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/cells15020118","article-title":"BRD4 phosphorylation regulates the structure of chromatin nanodomains","volume":"15","author":"Seitz","year":"2026","journal-title":"Cells"},{"key":"10.1016\/j.molcel.2026.07.004_bib49","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/.20.17.6537-6549.2000","article-title":"A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G2-to-M transition","volume":"20","author":"Dey","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib50","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1128\/MCB.01020-07","article-title":"Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression","volume":"28","author":"Yang","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib51","doi-asserted-by":"crossref","first-page":"9040","DOI":"10.1074\/jbc.M707603200","article-title":"The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase","volume":"283","author":"Mochizuki","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib52","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ncb2341","article-title":"Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation","volume":"13","author":"Zhao","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib53","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.celrep.2019.03.057","article-title":"Interrogating histone acetylation and BRD4 as mitotic bookmarks of transcription","volume":"27","author":"Behera","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib54","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.molcel.2020.04.034","article-title":"Opposing functions of BRD4 isoforms in breast cancer","volume":"78","author":"Wu","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib55","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.molcel.2020.04.027","article-title":"Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer","volume":"78","author":"Shu","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib56","article-title":"Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib57","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1128\/MCB.22.11.3794-3802.2002","article-title":"Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4","volume":"22","author":"Houzelstein","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib58","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.celrep.2014.08.055","article-title":"Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes","volume":"9","author":"Di Micco","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib60","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12864-016-2414-y","article-title":"Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells","volume":"17","author":"Gonzales-Cope","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molcel.2026.07.004_bib61","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.celrep.2018.10.003","article-title":"Brd4\u2019s bromodomains mediate histone H3 acetylation and chromatin remodeling in pluripotent cells through p300 and Brg1","volume":"25","author":"Wu","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib62","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41589-020-00716-z","article-title":"BET bromodomain inhibitors regulate keratinocyte plasticity","volume":"17","author":"Schutzius","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib63","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/stem.3454","article-title":"Emerging roles of bromodomain protein 4 in regulation of stem cell identity","volume":"39","author":"Dey","year":"2021","journal-title":"Stem Cells (Dayt. Ohio)"},{"key":"10.1016\/j.molcel.2026.07.004_bib64","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202357032","article-title":"Loss of BRD4 induces cell senescence in HSC\/HPCs by deregulating histone H3 clipping","volume":"24","author":"Yang","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib65","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1161\/CIRCULATIONAHA.120.047239","article-title":"Epigenetic reader BRD4 (bromodomain-containing protein 4) governs nucleus-encoded mitochondrial transcriptome to regulate cardiac function","volume":"142","author":"Kim","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.molcel.2026.07.004_bib66","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-024-08085-6","article-title":"Chromatin remodelling drives immune cell-fibroblast communication in heart failure","volume":"635","author":"Alexanian","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib67","doi-asserted-by":"crossref","first-page":"10772","DOI":"10.1128\/JVI.00804-06","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2\/RING3-induced G1 cell cycle arrest","volume":"80","author":"Ottinger","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.07.004_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005950","article-title":"An epigenetic compound library screen identifies BET inhibitors that promote HSV-1 and -2 replication by bridging P-TEFb to viral gene promoters through BRD4","volume":"12","author":"Ren","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2026.07.004_bib69","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.molcel.2017.07.025","article-title":"The short isoform of BRD4 promotes HIV-1 latency by engaging repressive SWI\/SNF chromatin-remodeling complexes","volume":"67","author":"Conrad","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006100","article-title":"BET-inhibitors disrupt Rad21-dependent conformational control of KSHV latency","volume":"13","author":"Chen","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2026.07.004_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007012","article-title":"The KAT5-acetyl-histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency","volume":"14","author":"Li","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molcel.2026.07.004_bib72","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1093\/nar\/gky659","article-title":"TIP60 represses activation of endogenous retroviral elements","volume":"46","author":"Rajagopalan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib73","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/v13030454","article-title":"Discovery of RSV-induced BRD4 protein interactions using native immunoprecipitation and parallel accumulation-serial fragmentation (PASEF) mass spectrometry","volume":"13","author":"Mann","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.molcel.2026.07.004_bib74","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023025118","article-title":"Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention","volume":"118","author":"Groves","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib75","article-title":"ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription","volume":"13","author":"Yu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib76","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.str.2022.05.020","article-title":"Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection","volume":"30","author":"Vann","year":"2022","journal-title":"Structure"},{"key":"10.1016\/j.molcel.2026.07.004_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111088","article-title":"Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2","volume":"40","author":"Chen","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib78","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12977-024-00639-w","article-title":"The cell biology of HIV-1 latency and rebound","volume":"21","author":"Mbonye","year":"2024","journal-title":"Retrovirology"},{"key":"10.1016\/j.molcel.2026.07.004_bib79","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature10334","article-title":"RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia","volume":"478","author":"Zuber","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib80","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ccr.2013.11.003","article-title":"Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma","volume":"24","author":"Chapuy","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib81","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.celrep.2014.08.025","article-title":"Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition","volume":"8","author":"Bolden","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib82","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1073\/pnas.1422165112","article-title":"An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma","volume":"112","author":"Baratta","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib83","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature16508","article-title":"Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer","volume":"529","author":"Shu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib84","first-page":"E5352","article-title":"Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma","volume":"114","author":"Wang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib85","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41388-018-0457-z","article-title":"TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial-mesenchymal transition and metastasis in liver cancer","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2026.07.004_bib86","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1158\/1541-7786.MCR-18-1279","article-title":"BRD4 regulates metastatic potential of castration-resistant prostate cancer through AHNAK","volume":"17","author":"Shafran","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib87","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41418-019-0353-2","article-title":"Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail","volume":"27","author":"Lu","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.molcel.2026.07.004_bib88","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41586-020-1930-8","article-title":"Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer","volume":"578","author":"Faivre","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib89","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/s41388-020-01625-0","article-title":"Supercharging BRD4 with NUT in carcinoma","volume":"40","author":"Eagen","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2026.07.004_bib90","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41389-021-00316-z","article-title":"Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4","volume":"10","author":"Calder","year":"2021","journal-title":"Oncogenesis"},{"key":"10.1016\/j.molcel.2026.07.004_bib91","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151851","article-title":"Targeting ESR1 mutation-induced transcriptional addiction in breast cancer with BET inhibition","volume":"7","author":"Udden","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.molcel.2026.07.004_bib92","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112614","article-title":"YAP\/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperproliferation in pancreatic cancer","volume":"42","author":"Yamazaki","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.07.004_bib93","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s44319-023-00033-1","article-title":"BRD4 isoforms have distinct roles in tumour progression and metastasis in rhabdomyosarcoma","volume":"25","author":"Das","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib94","doi-asserted-by":"crossref","DOI":"10.31083\/FBL46158","article-title":"BRD4-S drives colorectal cancer progression via DDX27-regulated splicing and MAPK signaling activation","volume":"30","author":"Wang","year":"2025","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.molcel.2026.07.004_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-06483-7","article-title":"BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis","volume":"7","author":"Roberts","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib96","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02403-5","article-title":"Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis","volume":"8","author":"Lee","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib97","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molcel.2016.03.028","article-title":"Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain","volume":"62","author":"Li","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib98","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152774","article-title":"Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism","volume":"22","author":"Nitsch","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib99","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.str.2015.08.004","article-title":"A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications","volume":"23","author":"Flynn","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.molcel.2026.07.004_bib100","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1128\/MCB.01365-08","article-title":"Brd4 coactivates transcriptional activation of NF-\u03baB via specific binding to acetylated RelA","volume":"29","author":"Huang","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib101","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.molcel.2018.11.006","article-title":"Interactome rewiring following pharmacological targeting of BET bromodomains","volume":"73","author":"Lambert","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib102","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1021\/acs.biochem.0c00816","article-title":"BET-family bromodomains can recognize diacetylated sequences from transcription factors using a conserved mechanism","volume":"60","author":"Patel","year":"2021","journal-title":"Biochemistry"},{"key":"10.1016\/j.molcel.2026.07.004_bib103","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ccr.2014.01.028","article-title":"Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer","volume":"25","author":"Shi","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib104","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948795","article-title":"PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition","volume":"21","author":"Wang","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib105","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111473","article-title":"BRD4-PRC2 represses transcription of T-helper 2-specific negative regulators during T-cell differentiation","volume":"42","author":"Zhao","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.07.004_bib106","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1074\/jbc.M111.282855","article-title":"Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes","volume":"287","author":"Schr\u00f6der","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib107","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13148-019-0696-z","article-title":"Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism","volume":"11","author":"Tsujikawa","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.molcel.2026.07.004_bib108","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1021\/acsptsci.3c00219","article-title":"Apabetalone (RVX-208): A potential epigenetic therapy for the treatment of cardiovascular, renal, neurological, viral, and cancer disorders","volume":"7","author":"Dhulkifle","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.molcel.2026.07.004_bib109","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.chembiol.2014.05.009","article-title":"Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression","volume":"21","author":"Gacias","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib110","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1021\/acs.jmedchem.1c01851","article-title":"Discovery, X-ray crystallography, and anti-inflammatory activity of bromodomain-containing protein 4 (BRD4) BD1 inhibitors targeting a distinct new binding site","volume":"65","author":"Liu","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib111","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/s42003-021-02750-6","article-title":"Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins","volume":"4","author":"Malvezzi","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib112","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1128\/MCB.01341-10","article-title":"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3","volume":"31","author":"Rahman","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib113","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41594-020-0394-8","article-title":"Roles of the BRD4 short isoform in phase separation and active gene transcription","volume":"27","author":"Han","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib114","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1248\/bpb.b12-00527","article-title":"The conserved 12-amino acid stretch in the inter-bromodomain region of BET family proteins functions as a nuclear localization signal","volume":"35","author":"Fukazawa","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.molcel.2026.07.004_bib115","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1242\/jcs.105841","article-title":"Association of bromodomain BET proteins with chromatin requires dimerization through the conserved motif B","volume":"125","author":"Garcia-Gutierrez","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.molcel.2026.07.004_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101326","article-title":"The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains","volume":"297","author":"Weissman","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2020.194604","article-title":"SAGA and TFIID: Friends of TBP drifting apart","volume":"1864","author":"Timmers","year":"2021","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.molcel.2026.07.004_bib118","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1158\/0008-5472.CAN-10-4417","article-title":"Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion","volume":"71","author":"Alsarraj","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib119","article-title":"A natural product targets BRD4 to inhibit phase separation and gene transcription","volume":"25","author":"Wang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.molcel.2026.07.004_bib120","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar3958","article-title":"Coactivator condensation at super-enhancers links phase separation and gene control","volume":"361","author":"Sabari","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.004_bib121","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41421-023-00544-0","article-title":"BRD4-targeting PROTAC as a unique tool to study biomolecular condensates","volume":"9","author":"Shi","year":"2023","journal-title":"Cell Discov."},{"key":"10.1016\/j.molcel.2026.07.004_bib122","doi-asserted-by":"crossref","first-page":"13690","DOI":"10.1073\/pnas.0705053104","article-title":"Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription","volume":"104","author":"Bisgrove","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib123","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0092-8674(04)00402-7","article-title":"Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes","volume":"117","author":"You","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib124","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.modgep.2004.03.002","article-title":"Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis","volume":"4","author":"Shang","year":"2004","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.molcel.2026.07.004_bib125","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/nn.4095","article-title":"BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice","volume":"18","author":"Korb","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molcel.2026.07.004_bib126","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gr.213611.116","article-title":"Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly","volume":"27","author":"Schneider","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib127","doi-asserted-by":"crossref","first-page":"D948","DOI":"10.1093\/nar\/gkae1071","article-title":"Ensembl 2025","volume":"53","author":"Dyer","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib128","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1158\/1541-7786.MCR-20-0413","article-title":"Defects in emerin-nucleoskeleton binding disrupt nuclear structure and promote breast cancer cell motility and metastasis","volume":"19","author":"Liddane","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib129","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1128\/MCB.19.8.5383","article-title":"Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure","volume":"19","author":"Kimura","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib130","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.devcel.2011.09.008","article-title":"Animal transcription networks as highly connected, quantitative continua","volume":"21","author":"Biggin","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib131","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.celrep.2016.06.074","article-title":"Signal-dependent recruitment of BRD4 to cardiomyocyte super-enhancers is suppressed by a microRNA","volume":"16","author":"Stratton","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib132","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.molcel.2018.06.036","article-title":"DUB3 promotes BET inhibitor resistance and cancer progression by deubiquitinating BRD4","volume":"71","author":"Jin","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib133","article-title":"Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification","volume":"5","author":"Wala","year":"2025","journal-title":"Cell Genom."},{"key":"10.1016\/j.molcel.2026.07.004_bib134","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1074\/jbc.M805835200","article-title":"Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/10409230600648736","article-title":"The general transcription machinery and general cofactors","volume":"41","author":"Thomas","year":"2006","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib136","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ddtec.2016.05.003","article-title":"Phospho-BRD4: transcription plasticity and drug targeting","volume":"19","author":"Chiang","year":"2016","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.molcel.2026.07.004_bib137","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-20378-8","article-title":"BRD4-mediated repression of p53 is a target for combination therapy in AML","volume":"12","author":"Latif","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib138","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.molcel.2017.04.027","article-title":"Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function","volume":"66","author":"Sakamaki","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib139","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.molcel.2015.04.011","article-title":"BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia","volume":"58","author":"Roe","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib140","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41594-018-0102-0","article-title":"RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation","volume":"25","author":"Rahnamoun","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib141","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1016\/j.molcel.2021.07.024","article-title":"Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation","volume":"81","author":"Lee","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib142","first-page":"33","article-title":"Bromodomain and extra-terminal family proteins BRD2, BRD3, and BRD4 contribute to H19-dependent transcriptional regulation of cell adhesion molecules, modulating metastatic dissemination program in prostate cancer","volume":"11","author":"Pecci","year":"2025","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.molcel.2026.07.004_bib143","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41589-025-01900-9","article-title":"Nuclear m6A modification regulates satellite transcription and chromosome segregation","volume":"22","author":"Huang","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib144","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf1406","article-title":"The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation","volume":"53","author":"Lambrechts","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib145","first-page":"86","article-title":"BRD4 binds the nucleosome via both histone and DNA interactions","author":"Zhu","year":"2026","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib146","article-title":"GLTSCR1 negatively regulates BRD4-dependent transcription elongation and inhibits CRC metastasis","volume":"6","author":"Han","year":"2019","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.molcel.2026.07.004_bib147","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16588-8","article-title":"Structural mechanism of the oxygenase JMJD6 recognition by the extraterminal (ET) domain of BRD4","volume":"7","author":"Konuma","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib148","article-title":"Characterization of subcellular localization of eukaryotic clamp loader\/unloader and its regulatory mechanism","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib149","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1073\/pnas.1516813113","article-title":"Structure of the Brd4 ET domain bound to a C-terminal motif from \u03b3-retroviral integrases reveals a conserved mechanism of interaction","volume":"113","author":"Crowe","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib150","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1158\/0008-5472.CAN-23-2888","article-title":"KDM5C-mediated recruitment of BRD4 to chromatin regulates enhancer activation and BET inhibitor sensitivity","volume":"84","author":"Qiang","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib151","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature17970","article-title":"Near-atomic resolution visualization of human transcription promoter opening","volume":"533","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib152","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41594-019-0287-x","article-title":"50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms","volume":"26","author":"Roeder","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib153","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1128\/MCB.23.17.6229-6242.2003","article-title":"Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors","volume":"23","author":"Wu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib154","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1074\/jbc.273.20.12492","article-title":"Properties of PC4 and an RNA polymerase II complex in directing activated and basal transcription in vitro","volume":"273","author":"Wu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib155","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1093\/emboj\/17.15.4478","article-title":"TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4","volume":"17","author":"Wu","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.07.004_bib156","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1097-2765(00)80092-1","article-title":"Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs","volume":"1","author":"Oelgeschl\u00e4ger","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib157","doi-asserted-by":"crossref","first-page":"23480","DOI":"10.1074\/jbc.274.33.23480","article-title":"Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription","volume":"274","author":"Wu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib158","doi-asserted-by":"crossref","first-page":"34235","DOI":"10.1074\/jbc.M102463200","article-title":"TATA-binding protein-associated factors enhance the recruitment of RNA polymerase II by transcriptional activators","volume":"276","author":"Wu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib159","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.molcel.2020.03.008","article-title":"TFIID enables RNA polymerase II promoter-proximal pausing","volume":"78","author":"Fant","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib160","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.molcel.2009.09.011","article-title":"Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome","volume":"35","author":"Koerber","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib161","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1101\/gad.14.8.951","article-title":"Bromodomain factor 1 corresponds to a missing piece of yeast TFIID","volume":"14","author":"Matangkasombut","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.07.004_bib162","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.7824954","article-title":"Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators","volume":"267","author":"Chiang","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.004_bib163","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1126\/science.288.5470.1422","article-title":"Structure and function of a human TAFII250 double bromodomain module","volume":"288","author":"Jacobson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.004_bib164","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cell.2007.08.016","article-title":"Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4","volume":"131","author":"Vermeulen","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib165","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41586-024-07861-8","article-title":"Coordinated inheritance of extrachromosomal DNAs in cancer cells","volume":"635","author":"Hung","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib166","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/j.molcel.2025.06.013","article-title":"Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance","volume":"85","author":"Nichols","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib167","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00782-23","article-title":"Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function","volume":"97","author":"Prabhakar","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.07.004_bib168","article-title":"Epstein-Barr virus expressed long non-coding RNA (lncBARTs) regulate EBV latent genome replication","volume":"13","author":"Liu","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.molcel.2026.07.004_bib169","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1128\/JVI.00502-06","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes","volume":"80","author":"You","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.07.004_bib170","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cell.2010.03.030","article-title":"c-Myc regulates transcriptional pause release","volume":"141","author":"Rahl","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib171","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbagrm.2012.11.007","article-title":"Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond","volume":"1829","author":"Yamaguchi","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molcel.2026.07.004_bib172","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41586-018-0442-2","article-title":"Structure of paused transcription complex Pol II-DSIF-NELF","volume":"560","author":"Vos","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.004_bib173","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1016\/j.molcel.2021.08.006","article-title":"SPT5 stabilization of promoter-proximal RNA polymerase II","volume":"81","author":"Aoi","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105106","article-title":"Assessment of the roles of Spt5-nucleic acid contacts in promoter proximal pausing of RNA polymerase II","volume":"299","author":"Dollinger","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib175","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.molcel.2024.01.023","article-title":"Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing","volume":"84","author":"Su","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib176","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1093\/nar\/gkaa531","article-title":"A unified view of the sequence and functional organization of the human RNA polymerase II promoter","volume":"48","author":"Luse","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib177","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1093\/nar\/gkw571","article-title":"Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II","volume":"44","author":"Lu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib178","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2022.12.006","article-title":"P-TEFb: The master regulator of transcription elongation","volume":"83","author":"Fujinaga","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib179","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.molcel.2023.06.032","article-title":"Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation","volume":"83","author":"Zheng","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib180","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41594-024-01384-6","article-title":"Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity","volume":"32","author":"Zhang","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib181","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1093\/nar\/gkw585","article-title":"Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb","volume":"44","author":"C Quaresma","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib182","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2016.02.036","article-title":"RNA polymerase II regulates topoisomerase 1 activity to favor efficient transcription","volume":"165","author":"Baranello","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib183","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1101\/gad.325142.119","article-title":"Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation","volume":"33","author":"Core","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.07.004_bib184","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1016\/j.molcel.2021.06.023","article-title":"m6A RNA methylation regulates promoter-proximal pausing of RNA polymerase II","volume":"81","author":"Akhtar","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib185","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1016\/j.molcel.2023.09.020","article-title":"N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation","volume":"83","author":"Wang","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib186","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54993","article-title":"NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency","volume":"9","author":"Marques","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.07.004_bib187","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.molcel.2015.10.033","article-title":"NSD3-short is an adaptor protein that couples BRD4 to the CHD8 chromatin remodeler","volume":"60","author":"Shen","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib188","article-title":"The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib189","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1212770","article-title":"Bromodomain-containing protein 4 regulates innate inflammation via modulation of alternative splicing","volume":"14","author":"Mann","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molcel.2026.07.004_bib190","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade3876","article-title":"Cohesin regulates alternative splicing","volume":"9","author":"Singh","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.07.004_bib191","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.90993","article-title":"Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor","volume":"12","author":"Jablonowski","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.07.004_bib192","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adr1557","article-title":"Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma","volume":"18","author":"Holliday","year":"2026","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molcel.2026.07.004_bib193","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf253","article-title":"High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation","volume":"53","author":"Luteijn","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib194","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m6A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib195","doi-asserted-by":"crossref","first-page":"19408","DOI":"10.1073\/pnas.1216363109","article-title":"Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins","volume":"109","author":"Lockwood","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib196","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41419-022-05123-x","article-title":"BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia","volume":"13","author":"Zhong","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2026.07.004_bib197","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1016\/j.celrep.2016.08.032","article-title":"BET bromodomain inhibition promotes anti-tumor immunity by suppressing PD-L1 expression","volume":"16","author":"Zhu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib198","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07620-0","article-title":"SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4","volume":"9","author":"Tzelepis","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib199","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2014.08.069","article-title":"Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4","volume":"9","author":"Fernandez","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200826","article-title":"BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors","volume":"13","author":"Rhyasen","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.molcel.2026.07.004_bib201","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1128\/jvi.63.7.2967-2976.1989","article-title":"Identification of a novel constitutive enhancer element and an associated binding protein: implications for human papillomavirus type 11 enhancer regulation","volume":"63","author":"Chin","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.07.004_bib202","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.virusres.2016.11.005","article-title":"Control of viral replication and transcription by the papillomavirus E8^E2 protein","volume":"231","author":"Dreer","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib203","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/jvi.65.6.3317-3329.1991","article-title":"An E1M^E2C fusion protein encoded by human papillomavirus type 11 is asequence-specific transcription repressor","volume":"65","author":"Chiang","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.molcel.2026.07.004_bib204","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1128\/MCB.20.1.113-125.2000","article-title":"Alleviation of human papillomavirus E2-mediated transcriptional repression via formation of a TATA binding protein (or TFIID)-TFIIB-RNA polymerase II-TFIIF preinitiation complex","volume":"20","author":"Hou","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib205","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1073\/pnas.89.13.5799","article-title":"Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins","volume":"89","author":"Chiang","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib206","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.virusres.2016.12.006","article-title":"Involvement of Brd4 in different steps of the papillomavirus life cycle","volume":"231","author":"Iftner","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib207","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.725794","article-title":"Multiple roles of Brd4 in the infectious cycle of human papillomaviruses","volume":"8","author":"McBride","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.molcel.2026.07.004_bib208","doi-asserted-by":"crossref","first-page":"40974","DOI":"10.1074\/jbc.M111.290874","article-title":"Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib209","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.celrep.2017.05.016","article-title":"Replication-coupled dilution of H4K20me2 guides 53BP1 to pre-replicative chromatin","volume":"19","author":"Pellegrino","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib210","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10799-5","article-title":"Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis","volume":"10","author":"Penas","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib211","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3390\/cancers12061637","article-title":"Bromodomain-containing protein BRD4 is hyperphosphorylated in mitosis","volume":"12","author":"Wang","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.molcel.2026.07.004_bib212","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1016\/j.molcel.2024.09.030","article-title":"Phosphorylation by JNK switches BRD4 functions","volume":"84","author":"Devaiah","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib213","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1038\/onc.2017.137","article-title":"Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4","volume":"36","author":"Hu","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2026.07.004_bib214","article-title":"Stromal induction of BRD4 phosphorylation results in chromatin remodeling and BET inhibitor resistance in colorectal cancer","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.07.004_bib215","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/nm.4372","article-title":"Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors","volume":"23","author":"Janouskova","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2026.07.004_bib216","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nm.4379","article-title":"Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation","volume":"23","author":"Zhang","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2026.07.004_bib217","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nm.4378","article-title":"Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4","volume":"23","author":"Dai","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2026.07.004_bib218","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/emboj.2009.83","article-title":"Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding","volume":"28","author":"Wu","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.07.004_bib219","doi-asserted-by":"crossref","first-page":"45","DOI":"10.12703\/P5-45","article-title":"Sumoylation in gene regulation, human disease, and therapeutic action","volume":"5","author":"Yang","year":"2013","journal-title":"F1000Prime Rep."},{"key":"10.1016\/j.molcel.2026.07.004_bib220","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1038\/s12276-024-01315-x","article-title":"Cbx4 SUMOylates BRD4 to regulate the expression of inflammatory cytokines in post-traumatic osteoarthritis","volume":"56","author":"Zhou","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.molcel.2026.07.004_bib221","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1158\/0008-5472.CAN-19-0442","article-title":"BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail","volume":"79","author":"Qin","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.molcel.2026.07.004_bib222","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf5374","article-title":"BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation","volume":"7","author":"Vershinin","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.07.004_bib223","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41419-023-06149-5","article-title":"Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2026.07.004_bib224","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401838R","article-title":"PRMT1-mediated BRD4 arginine methylation and phosphorylation promote partial epithelial-mesenchymal transformation and renal fibrosis","volume":"39","author":"Xiong","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.molcel.2026.07.004_bib225","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add8928","article-title":"Arginine methylation of BRD4 by PRMT2\/4 governs transcription and DNA repair","volume":"8","author":"Liu","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.07.004_bib226","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201483119","article-title":"Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6","volume":"119","author":"Cockman","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.07.004_bib227","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.1132516","article-title":"FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties","volume":"314","author":"Frey","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.004_bib228","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2012.04.017","article-title":"Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels","volume":"149","author":"Kato","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib229","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib230","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103179","article-title":"Biomolecular condensates at sites of DNA damage: More than just a phase","volume":"106","author":"Spegg","year":"2021","journal-title":"DNA Repair"},{"key":"10.1016\/j.molcel.2026.07.004_bib231","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1016\/j.molcel.2022.09.021","article-title":"\u201cStructure\u201d-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation","volume":"82","author":"Ferrie","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib232","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.molcel.2024.12.026","article-title":"The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators","volume":"85","author":"Ahn","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib233","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41580-024-00789-x","article-title":"Transcription regulation by biomolecular condensates","volume":"26","author":"Pei","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib234","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3390\/cancers13061246","article-title":"Expression of phosphorylated BRD4 is markedly associated with the activation status of the PP2A pathway and shows a strong prognostic value in triple negative breast cancer patients","volume":"13","author":"Sanz-\u00c1lvarez","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.molcel.2026.07.004_bib235","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2017.07.033","article-title":"Excess translation of epigenetic regulators contributes to fragile X syndrome and is alleviated by Brd4 inhibition","volume":"170","author":"Korb","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib236","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12808","article-title":"Role of BRD4 phosphorylation in the nucleus accumbens in relapse to cocaine-seeking behavior in mice","volume":"25","author":"Guo","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib237","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1016\/j.bmcl.2011.06.011","article-title":"Peptoid ligands that bind selectively to phosphoproteins","volume":"21","author":"Cai","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molcel.2026.07.004_bib238","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1021\/acsptsci.4c00057","article-title":"Novel BRD4-p53 inhibitor SDU-071 suppresses proliferation and migration of MDA-MB-231 triple-negative breast cancer cells","volume":"7","author":"Wang","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.molcel.2026.07.004_bib239","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm.2017.10","article-title":"The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain","volume":"18","author":"Harlen","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib240","article-title":"A natural product from Polygonum cuspidatum Sieb. Et Zucc. promotes Tat-dependent HIV latency reversal through triggering P-TEFb\u2019s release from 7SK snRNP","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.molcel.2026.07.004_bib241","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1016\/j.cell.2025.06.033","article-title":"Regulation of inflammatory responses by pH-dependent transcriptional condensates","volume":"188","author":"Wu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.004_bib242","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2026.118580","article-title":"Small-molecule modulators of the androgen receptor N-terminal domain: Advances in medicinal chemistry for prostate cancer","volume":"305","author":"Sekhon","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.molcel.2026.07.004_bib243","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41392-026-02642-3","article-title":"Drugging the intrinsically disordered transactivation domain of androgen receptor","volume":"11","author":"Obst","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molcel.2026.07.004_bib244","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1038\/sj.onc.1206641","article-title":"Low molecular weight inhibitors of Myc-Max interaction and function","volume":"22","author":"Yin","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2026.07.004_bib245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097285","article-title":"Targeting of the MYCN protein with small molecule c-MYC inhibitors","volume":"9","author":"M\u00fcller","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molcel.2026.07.004_bib246","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In vivo activation of the p53 pathway by small-molecule antagonists of MDM2","volume":"303","author":"Vassilev","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.004_bib247","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1021\/ml4000657","article-title":"Discovery of RG7112: A small-molecule MDM2 inhibitor in clinical development","volume":"4","author":"Vu","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.molcel.2026.07.004_bib248","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/s41589-025-01893-5","article-title":"Small-molecule dissolution of stress granules by redox modulation benefits ALS models","volume":"21","author":"Uechi","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.07.004_bib249","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.molcel.2021.01.031","article-title":"Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics","volume":"81","author":"Ma","year":"2021","journal-title":"Mol. Cell"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526004685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526004685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:15:11Z","timestamp":1790655311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526004685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":249,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1097276526004685"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.07.004","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BRD4: From molecular understanding to therapeutics development","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}