{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T14:13:36Z","timestamp":1792937616340,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.molcel.2026.07.026","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:07:40Z","timestamp":1786979260000},"page":"3529-3544.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Excess intracellular lactate represses mRNA translation and tumor progression through lactate-tRNA charging"],"prefix":"10.1016","volume":"86","author":[{"given":"Xinyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biru","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengtao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8423-4150","authenticated-orcid":false,"given":"Yichen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.07.026_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1042\/bj3120163","article-title":"A hierarchy of ATP-consuming processes in mammalian cells","volume":"312","author":"Buttgereit","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.molcel.2026.07.026_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jbior.2017.11.001","article-title":"Dysregulation of mRNA translation and energy metabolism in cancer","volume":"67","author":"Leibovitch","year":"2018","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.molcel.2026.07.026_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/sqb.2011.76.010785","article-title":"mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways","volume":"76","author":"Topisirovic","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib4","first-page":"309","article-title":"On the metabolism of carcinoma cells","volume":"152","author":"Warburg","year":"1924","journal-title":"Biochem. Z."},{"key":"10.1016\/j.molcel.2026.07.026_bib5","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.cell.2023.01.038","article-title":"What is cancer metabolism?","volume":"186","author":"Finley","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41568-021-00380-y","article-title":"The plasticity of mRNA translation during cancer progression and therapy resistance","volume":"21","author":"Fabbri","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.07.026_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molcel.2012.11.028","article-title":"Widespread regulation of translation by elongation pausing in heat shock","volume":"49","author":"Shalgi","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200408003","article-title":"Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response","volume":"167","author":"Lu","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature15377","article-title":"Dynamic m(6)A mRNA methylation directs translational control of heat shock response","volume":"526","author":"Zhou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib10","doi-asserted-by":"crossref","first-page":"aad3867","DOI":"10.1126\/science.aad3867","article-title":"Translation from the 5\u2032 untranslated region shapes the integrated stress response","volume":"351","author":"Starck","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.026_bib11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molcel.2007.10.019","article-title":"A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer","volume":"28","author":"Braunstein","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbagrm.2014.11.002","article-title":"Stress-mediated translational control in cancer cells","volume":"1849","author":"Leprivier","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molcel.2026.07.026_bib13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2006.01.010","article-title":"Hypoxia-induced energy stress regulates mRNA translation and cell growth","volume":"21","author":"Liu","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib14","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2013.04.055","article-title":"The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation","volume":"153","author":"Leprivier","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: the ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.molcel.2026.07.026_bib16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cell.2015.12.034","article-title":"Metabolic Heterogeneity in Human Lung Tumors","volume":"164","author":"Hensley","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41589-024-01680-8","article-title":"Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis","volume":"21","author":"Zhang","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib20","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.ccell.2024.09.006","article-title":"Lactylation in cancer: Current understanding and challenges","volume":"42","author":"Li","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41586-024-07620-9","article-title":"NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance","volume":"631","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.cell.2023.11.022","article-title":"Metabolic regulation of homologous recombination repair by MRE11 lactylation","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2024.10.015","article-title":"ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion","volume":"37","author":"Zhu","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2026.07.026_bib24","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41586-024-07992-y","article-title":"AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases","volume":"634","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s42255-022-00710-w","article-title":"Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma","volume":"5","author":"Yang","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.molcel.2026.07.026_bib26","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.cell.2024.04.002","article-title":"Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis","volume":"187","author":"Zong","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.micro.091208.073210","article-title":"Aminoacyl-tRNA synthesis and translational quality control","volume":"63","author":"Ling","year":"2009","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.molcel.2026.07.026_bib28","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cell.2009.01.036","article-title":"Fidelity at the Molecular Level: Lessons from Protein Synthesis","volume":"136","author":"Zaher","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.molcel.2004.10.030","article-title":"Uniform binding of aminoacylated transfer RNAs to the ribosomal A and P sites","volume":"16","author":"Fahlman","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib30","doi-asserted-by":"crossref","first-page":"e174587","DOI":"10.1172\/JCI174587","article-title":"The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer","volume":"134","author":"Ju","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.molcel.2026.07.026_bib31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41590-023-01738-0","article-title":"Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria","volume":"25","author":"Ma","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2026.07.026_bib32","doi-asserted-by":"crossref","first-page":"gkaf327","DOI":"10.1093\/nar\/gkaf327","article-title":"Monitoring monomer-specific acyl-tRNA levels in cells with PARTI","volume":"53","author":"Pressimone","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.026_bib33","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/acs.analchem.4c04692","article-title":"Simultaneous Profiling of Multiple Phosphorylated Metabolites in Typical Biological Matrices via Ion-Pair Reversed-Phase Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry","volume":"97","author":"Wang","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.molcel.2026.07.026_bib34","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0003-2697(75)90612-0","article-title":"Estimation of in vivo aminoacylation by periodate oxidation: tRNA alterations and iodate inhibition","volume":"66","author":"Rizzino","year":"1975","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molcel.2026.07.026_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.embor.7400341","article-title":"Selective charging of tRNA isoacceptors induced by amino-acid starvation","volume":"6","author":"Dittmar","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molcel.2026.07.026_bib36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41556-022-00856-5","article-title":"Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics","volume":"24","author":"Passarelli","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41586-023-05908-w","article-title":"mRNA decoding in human is kinetically and structurally distinct from bacteria","volume":"617","author":"Holm","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib38","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.270.5241.1464","article-title":"Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog","volume":"270","author":"Nissen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.026_bib39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"Ingolia","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.026_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2017.03.003","article-title":"eIF5A Functions Globally in Translation Elongation and Termination","volume":"66","author":"Schuller","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib41","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/s41556-025-01750-6","article-title":"Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control","volume":"27","author":"Zhang","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc.2017.104","article-title":"Ribosome biogenesis in cancer: new players and therapeutic avenues","volume":"18","author":"Pelletier","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.07.026_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11083","article-title":"A unifying model for mTORC1-mediated regulation of mRNA translation","volume":"485","author":"Thoreen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib44","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.cell.2020.10.036","article-title":"Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy","volume":"183","author":"Krug","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41588-020-00753-3","article-title":"The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer","volume":"53","author":"Najumudeen","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.07.026_bib46","doi-asserted-by":"crossref","first-page":"32061","DOI":"10.1074\/jbc.272.51.32061","article-title":"Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site","volume":"272","author":"Nanbru","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.026_bib47","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1126\/science.1123835","article-title":"Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita","volume":"312","author":"Yoon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.026_bib48","doi-asserted-by":"crossref","first-page":"eaat5314","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: From mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.026_bib49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.07.026_bib50","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/emboj.2010.81","article-title":"The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation","volume":"29","author":"Ye","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.07.026_bib51","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/s41556-019-0415-1","article-title":"Translational reprogramming marks adaptation to asparagine restriction in cancer","volume":"21","author":"Pathria","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib52","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41568-023-00611-4","article-title":"Transfer RNAs as dynamic and critical regulators of cancer progression","volume":"23","author":"Pinzaru","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.07.026_bib53","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1093\/nar\/gkp787","article-title":"tRNA over-expression in breast cancer and functional consequences","volume":"37","author":"Pavon-Eternod","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.026_bib54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41580-021-00342-0","article-title":"The expanding world of tRNA modifications and their disease relevance","volume":"22","author":"Suzuki","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.07.026_bib55","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41586-022-04499-2","article-title":"Tryptophan depletion results in tryptophan-to-phenylalanine substitutants","volume":"603","author":"Pataskar","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib56","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature08576","article-title":"Innate immune and chemically triggered oxidative stress modifies translational fidelity","volume":"462","author":"Netzer","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib57","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1016\/S0021-9258(18)81724-0","article-title":"Canavanine Incorporation into the Antibacterial Proteins of the Fly, Phormia Terranovae (Diptera), and Its Effect on Biological Activity","volume":"264","author":"Rosenthal","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.07.026_bib58","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1126\/science.286.5446.1893","article-title":"Quality control mechanisms during translation","volume":"286","author":"Ibba","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.07.026_bib59","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1093\/nar\/gkx514","article-title":"Determination of tRNA aminoacylation levels by high-throughput sequencing","volume":"45","author":"Evans","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.026_bib60","doi-asserted-by":"crossref","first-page":"RP91554","DOI":"10.7554\/eLife.91554.3","article-title":"A robust method for measuring aminoacylation through tRNA-Seq","volume":"12","author":"Davidsen","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.07.026_bib61","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.07.026_bib62","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.07.026_bib63","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.07.026_bib64","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients","volume":"123","author":"Gy\u00f6rffy","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.molcel.2026.07.026_bib65","first-page":"100625","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innovation (Camb.)"},{"key":"10.1016\/j.molcel.2026.07.026_bib66","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41586-021-04244-1","article-title":"Valine tRNA levels and availability regulate complex I assembly in leukaemia","volume":"601","author":"Thandapani","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib67","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1093\/nar\/gkae1134","article-title":"Simultaneous determination of cytosolic aminoacyl-tRNA synthetase activities by LC-MS\/MS","volume":"52","author":"Mendes","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.07.026_bib68","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41590-025-02183-x","article-title":"The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation","volume":"26","author":"Yu","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molcel.2026.07.026_bib69","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature10912","article-title":"The translational landscape of mTOR signalling steers cancer initiation and metastasis","volume":"485","author":"Hsieh","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.07.026_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042882","article-title":"Selective depletion of rRNA enables whole transcriptome profiling of archival fixed tissue","volume":"7","author":"Morlan","year":"2012","journal-title":"PLOS One"},{"key":"10.1016\/j.molcel.2026.07.026_bib71","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.07.026_bib72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526005125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526005125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:15:25Z","timestamp":1790655325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526005125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":72,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1097276526005125"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.07.026","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excess intracellular lactate represses mRNA translation and tumor progression through lactate-tRNA charging","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}