{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:56:15Z","timestamp":1790870175134,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170572"],"award-info":[{"award-number":["32170572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32570705"],"award-info":[{"award-number":["32570705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530006"],"award-info":[{"award-number":["82530006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470597"],"award-info":[{"award-number":["32470597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172641"],"award-info":[{"award-number":["82172641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2023ZD0500600"],"award-info":[{"award-number":["2023ZD0500600"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82122006"],"award-info":[{"award-number":["82122006"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.molcel.2026.08.019","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:09:54Z","timestamp":1789571394000},"page":"3968-3985.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A dual-module ECAS complex couples transcription elongation and RNA processing"],"prefix":"10.1016","volume":"86","author":[{"given":"Ying","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoshi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8126-383X","authenticated-orcid":false,"given":"Kaiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-2830","authenticated-orcid":false,"given":"Pingping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-353X","authenticated-orcid":false,"given":"Kaiwei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.08.019_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nrg3662","article-title":"Coupling mRNA processing with transcription in time and space","volume":"15","author":"Bentley","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molcel.2026.08.019_bib2","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.cell.2021.04.012","article-title":"Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection","volume":"184","author":"Wan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41580-024-00706-2","article-title":"Co-transcriptional gene regulation in eukaryotes and prokaryotes","volume":"25","author":"Shine","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-biochem-091719-064225","article-title":"RNA Splicing by the Spliceosome","volume":"89","author":"Wilkinson","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2026.08.019_bib5","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1016\/j.molcel.2024.08.036","article-title":"Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing","volume":"84","author":"Carrocci","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib6","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1016\/j.molcel.2023.11.004","article-title":"A direct interaction between CPF and RNA Pol II links RNA 3\u2032 end processing to transcription","volume":"83","author":"Carminati","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1126\/science.abf1870","article-title":"Structure of a transcribing RNA polymerase II-U1 snRNP complex","volume":"371","author":"Zhang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.08.019_bib8","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.tig.2023.04.008","article-title":"Pre-mRNA splicing and its cotranscriptional connections","volume":"39","author":"Shenasa","year":"2023","journal-title":"Trends Genet."},{"key":"10.1016\/j.molcel.2026.08.019_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molcel.2018.09.004","article-title":"RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing","volume":"72","author":"Nojima","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib10","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1016\/j.jmb.2016.04.017","article-title":"Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing","volume":"428","author":"Saldi","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-019-1464-0","article-title":"Pol II phosphorylation regulates a switch between transcriptional and splicing condensates","volume":"572","author":"Guo","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.019_bib12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cell.2015.03.027","article-title":"Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing","volume":"161","author":"Nojima","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib13","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.molcel.2023.06.002","article-title":"Structural insights into human co-transcriptional capping","volume":"83","author":"Garg","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41580-024-00739-7","article-title":"Splicing regulation through biomolecular condensates and membraneless organelles","volume":"25","author":"Giudice","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105740","article-title":"RNA polymerase II speed: a key player in controlling and adapting transcriptome composition","volume":"40","author":"Muniz","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.08.019_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/science.adj9141","article-title":"Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing","volume":"389","author":"Shao","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.08.019_bib17","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a032227","article-title":"Nascent RNA and the Coordination of Splicing with Transcription","volume":"11","author":"Neugebauer","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib18","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1101\/gad.252106.114","article-title":"Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate","volume":"28","author":"Fong","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.08.019_bib19","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.molcel.2021.02.016","article-title":"Efficient RNA polymerase II pause release requires U2 snRNP function","volume":"81","author":"Caizzi","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib20","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.molcel.2023.03.002","article-title":"U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes","volume":"83","author":"Mimoso","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrm3953","article-title":"Getting up to speed with transcription elongation by RNA polymerase II","volume":"16","author":"Jonkers","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib22","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41580-018-0010-5","article-title":"Born to run: control of transcription elongation by RNA polymerase II","volume":"19","author":"Chen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib23","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molcel.2010.04.013","article-title":"HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription","volume":"38","author":"He","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.molcel.2010.01.026","article-title":"AFF4, a component of the ELL\/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia","volume":"37","author":"Lin","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib25","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cell.2018.09.027","article-title":"Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy","volume":"175","author":"Liang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2016.12.011","article-title":"Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia","volume":"168","author":"Liang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib27","article-title":"The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.08.019_bib28","first-page":"7219","article-title":"Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing","volume":"14","author":"Wuarin","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09652","article-title":"Nascent transcript sequencing visualizes transcription at nucleotide resolution","volume":"469","author":"Churchman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.019_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molcel.2011.10.022","article-title":"Functional association of Gdown1 with RNA polymerase II poised on human genes","volume":"45","author":"Cheng","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nsmb.2951","article-title":"The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes","volume":"22","author":"De","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib32","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41586-023-06049-w","article-title":"Structural basis of catalytic activation in human splicing","volume":"617","author":"Schmitzov\u00e1","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.019_bib33","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1016\/j.molcel.2021.06.019","article-title":"Allosteric transcription stimulation by RNA polymerase II super elongation complex","volume":"81","author":"Chen","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14076","article-title":"Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription","volume":"8","author":"Qi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.08.019_bib35","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1038\/s41556-025-01809-4","article-title":"Proximal proteomics reveals a landscape of human nuclear condensates","volume":"27","author":"Li","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1101\/gad.346106.120","article-title":"Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression","volume":"35","author":"Zheng","year":"2021","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.08.019_bib37","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ccell.2018.10.004","article-title":"A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis","volume":"34","author":"Volk","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41586-023-05812-3","article-title":"The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia","volume":"615","author":"Issa","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.019_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41568-019-0132-x","article-title":"Targeting chromatin complexes in fusion protein-driven malignancies","volume":"19","author":"Brien","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.08.019_bib40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1535-6108(03)00003-5","article-title":"Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification","volume":"3","author":"Armstrong","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib41","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1182\/blood.2024025886","article-title":"FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells","volume":"145","author":"Ara\u00fajo","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.molcel.2026.08.019_bib42","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1073\/pnas.94.8.3639","article-title":"ELL2, a new member of an ELL family of RNA polymerase II elongation factors","volume":"94","author":"Shilatifard","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.08.019_bib43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-biochem-052610-095910","article-title":"RNA polymerase II elongation control","volume":"81","author":"Zhou","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molcel.2026.08.019_bib44","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1016\/j.molcel.2023.10.004","article-title":"Transcriptional elongation control in developmental gene expression, aging, and disease","volume":"83","author":"Aoi","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib45","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a032235","article-title":"U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation","volume":"11","author":"Venters","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib46","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.molcel.2019.08.007","article-title":"A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells","volume":"76","author":"So","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2024.168743","article-title":"Multiple Forms and Functions of Premature Termination by RNA Polymerase II","volume":"437","author":"Bentley","year":"2025","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib48","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2022.12.006","article-title":"P-TEFb: The master regulator of transcription elongation","volume":"83","author":"Fujinaga","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib49","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.molcel.2026.03.031","article-title":"Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles","volume":"86","author":"Liu","year":"2026","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib50","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/s41586-024-07429-6","article-title":"Genome organization around nuclear speckles drives mRNA splicing efficiency","volume":"629","author":"Bhat","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.019_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.gde.2020.11.002","article-title":"Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision","volume":"67","author":"Gordon","year":"2021","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.molcel.2026.08.019_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/15476286.2016.1231359","article-title":"Cajal bodies and snRNPs - friends with benefits","volume":"14","author":"Stan\u011bk","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib53","doi-asserted-by":"crossref","first-page":"E2564","DOI":"10.1073\/pnas.1604935113","article-title":"biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes","volume":"113","author":"Weissmann","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.08.019_bib54","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.stem.2025.01.013","article-title":"Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation","volume":"32","author":"Song","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib55","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1038\/s41596-018-0068-8","article-title":"A cross-linking\/mass spectrometry workflow based on MS-cleavable cross-linkers and the MeroX software for studying protein structures and protein-protein interactions","volume":"13","author":"Iacobucci","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molcel.2026.08.019_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2024.168656","article-title":"xiVIEW: Visualisation of Crosslinking Mass Spectrometry Data","volume":"436","author":"Combe","year":"2024","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib57","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.019_bib58","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.molcel.2023.03.022","article-title":"INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II","volume":"83","author":"Hu","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib59","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nbt.4201","article-title":"Efficient proximity labeling in living cells and organisms with TurboID","volume":"36","author":"Branon","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.08.019_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf8698","article-title":"CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation","volume":"9","author":"Qiu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.08.019_bib61","doi-asserted-by":"crossref","first-page":"W187","DOI":"10.1093\/nar\/gku365","article-title":"deepTools: a flexible platform for exploring deep-sequencing data","volume":"42","author":"Ram\u00edrez","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.08.019_bib62","article-title":"A rapid, sensitive, scalable method for Precision Run-On sequencing (PRO-seq)","author":"Judd","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.molcel.2026.08.019_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.08.019_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib65","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.08.019_bib66","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.molcel.2025.02.006","article-title":"Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II","volume":"85","author":"Dai","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.08.019_bib67","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.08.019_bib68","doi-asserted-by":"crossref","first-page":"E5593","DOI":"10.1073\/pnas.1419161111","article-title":"rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data","volume":"111","author":"Shen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.08.019_bib70","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/cyto.a.24041","article-title":"Phenotypic Analysis of the Mouse Hematopoietic Hierarchy Using Spectral Cytometry: From Stem Cell Subsets to Early Progenitor Compartments","volume":"97","author":"Solomon","year":"2020","journal-title":"Cytometry A"},{"key":"10.1016\/j.molcel.2026.08.019_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102289","article-title":"High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline","volume":"4","author":"Wang","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.molcel.2026.08.019_bib72","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","article-title":"ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Hu","year":"2009","journal-title":"J. Immunol. Methods"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526005885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526005885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:14:44Z","timestamp":1790867684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526005885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":71,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1097276526005885"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.08.019","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual-module ECAS complex couples transcription elongation and RNA processing","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}