{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:53:13Z","timestamp":1791021193820,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001906","name":"Washington Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA056370"],"award-info":[{"award-number":["R01DA056370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.molcel.2026.08.024","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:13:15Z","timestamp":1790867595000},"page":"3864-3866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular glue everywhere: Metabolites join the party"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-817X","authenticated-orcid":false,"given":"Baiyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-1581","authenticated-orcid":false,"given":"Ning","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.08.024_bib1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41586-026-10790-3","article-title":"Metabolite glues as a means of purine sensing and chemotherapeutic response","volume":"655","author":"Witus","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.024_bib2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature05731","article-title":"Mechanism of auxin perception by the TIR1 ubiquitin ligase","volume":"446","author":"Tan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.08.024_bib3","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.chembiol.2024.04.002","article-title":"Molecular glues for protein-protein interactions: Progressing toward a new dream","volume":"31","author":"Konstantinidou","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2026.08.024_bib4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1039\/D2CB00207H","article-title":"Protein-protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction","volume":"4","author":"Rui","year":"2023","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.molcel.2026.08.024_bib5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41467-022-28507-1","article-title":"Defining molecular glues with a dual-nanobody cannabidiol sensor","volume":"13","author":"Cao","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.08.024_bib6","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.adv4257","article-title":"A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis","volume":"390","author":"Nguyen","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.08.024_bib7","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.adx9717","article-title":"NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT","volume":"390","author":"Wu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.08.024_bib8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nchembio.2329","article-title":"Structural basis of PROTAC cooperative recognition for selective protein degradation","volume":"13","author":"Gadd","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.08.024_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41589-023-01409-z","article-title":"Design principles for cyclin K molecular glue degraders","volume":"20","author":"Kozicka","year":"2024","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.08.024_bib10","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1038\/s41467-021-26546-8","article-title":"Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526005939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526005939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:58:19Z","timestamp":1791017899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526005939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1097276526005939"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.08.024","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular glue everywhere: Metabolites join the party","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}