{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:47:53Z","timestamp":1792079273888,"version":"4.4.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK107716"],"award-info":[{"award-number":["R01DK107716"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["529257351"],"award-info":[{"award-number":["529257351"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","award":["2023.025.1"],"award-info":[{"award-number":["2023.025.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE033907"],"award-info":[{"award-number":["R01DE033907"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2020_EKEA.91"],"award-info":[{"award-number":["2020_EKEA.91"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001021","name":"Damon Runyon Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011671","name":"G Harold and Leila Y Mathers Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["NIH P30 HD 18655"],"award-info":[{"award-number":["NIH P30 HD 18655"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["NIH P50 HD10531"],"award-info":[{"award-number":["NIH P50 HD10531"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001447","name":"Rita Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.molcel.2026.09.012","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:04:10Z","timestamp":1791299050000},"page":"4291-4309.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNASE1L3 maintains homeostatic levels of mitochondrial DNA on the mammalian cell surface"],"prefix":"10.1016","volume":"86","author":[{"given":"Jennifer","family":"Porat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Poli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Petkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Almahayni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Crompton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson M.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-2299","authenticated-orcid":false,"given":"Francisca Nath\u00e1lia","family":"de Luna Vitorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-4918","authenticated-orcid":false,"given":"Carolina","family":"Bras Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latanya N.","family":"Coke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Humbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep K.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-9063","authenticated-orcid":false,"given":"Fardin","family":"Aryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Tsokos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-3118","authenticated-orcid":false,"given":"Suneet","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard","family":"M\u00f6ckl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Zanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Gewurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim R.","family":"Simpfendorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-0442","authenticated-orcid":false,"given":"Ryan A.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.09.012_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1138625","article-title":"Integrated analysis of circulating cell free nucleic acids for cancer genotyping and immune phenotyping of tumor microenvironment","volume":"14","author":"Chaddha","year":"2023","journal-title":"Front. Genet."},{"key":"10.1016\/j.molcel.2026.09.012_bib2","doi-asserted-by":"crossref","first-page":"E5334","DOI":"10.1073\/pnas.1714397115","article-title":"Human plasma and serum extracellular small RNA reference profiles and their clinical utility","volume":"115","author":"Max","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.012_bib3","article-title":"Diverse human extracellular RNAs are widely detected in human plasma","volume":"7","author":"Freedman","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.012_bib4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2019.02.018","article-title":"exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids","volume":"177","author":"Murillo","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41587-025-02731-8","article-title":"Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples","volume":"44","author":"Ju","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.09.012_bib6","doi-asserted-by":"crossref","first-page":"14888","DOI":"10.1073\/pnas.1408301111","article-title":"Quantitative and stoichiometric analysis of the microRNA content of exosomes","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.012_bib7","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.012_bib8","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1016\/j.cell.2021.04.023","article-title":"Small RNAs are modified with N-glycans and displayed on the surface of living cells","volume":"184","author":"Flynn","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib9","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1016\/j.cell.2024.07.044","article-title":"The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA","volume":"187","author":"Xie","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/s41586-025-09310-6","article-title":"RNA N-glycosylation enables immune evasion and homeostatic efferocytosis","volume":"645","author":"Graziano","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.012_bib11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41587-023-01801-z","article-title":"Spatial imaging of glycoRNA in single cells with ARPLA","volume":"42","author":"Ma","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.09.012_bib12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.cell.2023.12.033","article-title":"Cell surface RNAs control neutrophil recruitment","volume":"187","author":"Zhang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib13","article-title":"FRET imaging of glycoRNA on small extracellular vesicles enabling sensitive cancer diagnostics","volume":"16","author":"Ren","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.012_bib14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41556-025-01682-1","article-title":"Extracellular exosomal RNAs are glyco-modified","volume":"27","author":"Sharma","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s42003-024-06129-1","article-title":"An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release","volume":"7","author":"Davidson","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159590","article-title":"Cell-free DNA topology depends on its subcellular and cellular origins in cancer","volume":"7","author":"Malkin","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.molcel.2026.09.012_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1104732","article-title":"Comparison of the structures and topologies of plasma extracted circulating nuclear and mitochondrial cell-free DNA","volume":"14","author":"Pisareva","year":"2023","journal-title":"Front. Genet."},{"key":"10.1016\/j.molcel.2026.09.012_bib18","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.012_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20151876","article-title":"Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus","volume":"213","author":"Caielli","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.012_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.molcel.2026.09.012_bib23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3181\/00379727-96-23544","article-title":"A DNA-reacting factor in serum of a patient with lupus erythematosus diffusus","volume":"96","author":"Ceppellini","year":"1957","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3181\/00379727-96-23545","article-title":"Complement fixation with cell nuclei and DNA in lupus erythematosus","volume":"96","author":"Robbins","year":"1957","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib25","first-page":"243","article-title":"Demonstration in the blood of patients with disseminated lupus erythematosus a substance determining a precipitation reaction with desoxyribonucleic acid","volume":"245","author":"Seligmann","year":"1957","journal-title":"C. R. Hebd. Seances Acad. Sci."},{"key":"10.1016\/j.molcel.2026.09.012_bib26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrrheum.2015.151","article-title":"Anti-DNA antibodies--quintessential biomarkers of SLE","volume":"12","author":"Pisetsky","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.molcel.2026.09.012_bib27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.126.4.607","article-title":"Immunological studies concerning the nephritis of systemic lupus erythematosus","volume":"126","author":"Koffler","year":"1967","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12026-010-8184-8","article-title":"Microparticles as a source of extracellular DNA","volume":"49","author":"Pisetsky","year":"2011","journal-title":"Immunol. Res."},{"key":"10.1016\/j.molcel.2026.09.012_bib29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaut.2011.02.001","article-title":"Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus","volume":"36","author":"Ullal","year":"2011","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molcel.2026.09.012_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/mthe.2002.0625","article-title":"Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection","volume":"6","author":"Wilber","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.molcel.2026.09.012_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cell.2016.05.034","article-title":"Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity","volume":"166","author":"Sisirak","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib32","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/ng.975","article-title":"Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus","volume":"43","author":"Al-Mayouf","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.012_bib33","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jaad.2020.12.031","article-title":"Clinical spectrum of childhood-onset hypocomplementemic urticarial vasculitis in Oman: A retrospective multicenter study","volume":"85","author":"Al Musalhi","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.molcel.2026.09.012_bib34","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1177\/0961203316676382","article-title":"An autosomal recessive DNASE1L3-related autoimmune disease with unusual clinical presentation mimicking systemic lupus erythematosus","volume":"26","author":"Carbonella","year":"2017","journal-title":"Lupus"},{"key":"10.1016\/j.molcel.2026.09.012_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13162","article-title":"Monogenic lupus caused by mutations in DNASE1L3: A rare cause of systemic lupus erythematosus in children","volume":"95","author":"Gezgin Y\u0131ld\u0131r\u0131m","year":"2022","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molcel.2026.09.012_bib36","doi-asserted-by":"crossref","first-page":"e452","DOI":"10.1097\/MPH.0000000000001780","article-title":"Refractory and Fatal Presentation of Severe Autoimmune Hemolytic Anemia in a Child With the DNASE1L3 Mutation Complicated With an Additional DOCK8 Variant","volume":"43","author":"Pa\u00e7 Kisaarslan","year":"2021","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.molcel.2026.09.012_bib37","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1007\/s10875-022-01287-5","article-title":"DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling","volume":"42","author":"Tusseau","year":"2022","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.molcel.2026.09.012_bib38","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/S2665-9913(19)30142-0","article-title":"Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts","volume":"2","author":"Belot","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.molcel.2026.09.012_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2021.104262","article-title":"Monogenic lupus due to DNASE1L3 deficiency in a pediatric patient with urticarial rash, hypocomplementemia, pulmonary hemorrhage, and immune-complex glomerulonephritis","volume":"64","author":"Kisla Ekinci","year":"2021","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.molcel.2026.09.012_bib40","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3899\/jrheum.181232","article-title":"Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis","volume":"47","author":"Bruschi","year":"2020","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.molcel.2026.09.012_bib41","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3899\/jrheum.171358","article-title":"Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus","volume":"45","author":"Batu","year":"2018","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.molcel.2026.09.012_bib42","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201138","article-title":"Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus","volume":"218","author":"Hartl","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib43","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.09.012_bib44","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nmeth.4031","article-title":"ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing","volume":"13","author":"Chen","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.09.012_bib45","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.cell.2025.01.040","article-title":"RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry","volume":"188","author":"Perr","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib46","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41587-025-02648-2","article-title":"Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein","volume":"44","author":"George","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.09.012_bib47","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41586-025-10052-8","article-title":"GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling","volume":"651","author":"Chai","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.012_bib48","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1016\/S0021-9258(18)89237-7","article-title":"Cell surface proteoglycan of mammary epithelial cells. Protease releases a heparan sulfate-rich ectodomain from a putative membrane-anchored domain","volume":"260","author":"Rapraeger","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.012_bib49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13059-020-02145-6","article-title":"Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction","volume":"21","author":"Huang","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ab.2014.06.017","article-title":"Influence of trypsinization and alternative procedures for cell preparation before RNA extraction on RNA integrity","volume":"463","author":"Vrta\u010dnik","year":"2014","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molcel.2026.09.012_bib51","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2010.11.012","article-title":"The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers","volume":"12","author":"Williams","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.molcel.2026.09.012_bib52","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1083\/jcb.51.1.116","article-title":"The effect of ethidium bromide on mitochondrial DNA synthesis and mitochondrial DNA structure in HeLa cells","volume":"51","author":"Leibowitz","year":"1971","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib53","doi-asserted-by":"crossref","first-page":"12499","DOI":"10.1039\/D3CC04402E","article-title":"SWAMNA: a comprehensive platform for analysis of nucleic acid modifications","volume":"59","author":"Xie","year":"2023","journal-title":"Chem. Commun."},{"key":"10.1016\/j.molcel.2026.09.012_bib54","article-title":"Accumulation of 8-oxodG within the human mitochondrial genome positively associates with transcription","volume":"5","author":"Scala","year":"2023","journal-title":"NAR Genom. Bioinform."},{"key":"10.1016\/j.molcel.2026.09.012_bib55","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrc3066","article-title":"Cell-free nucleic acids as biomarkers in cancer patients","volume":"11","author":"Schwarzenbach","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.09.012_bib56","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","article-title":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy","volume":"187","author":"Baldwin","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib57","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41586-024-07340-0","article-title":"Mitochondrial transfer mediates endothelial cell engraftment through mitophagy","volume":"629","author":"Lin","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.012_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.012_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21984-w","article-title":"Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs","volume":"12","author":"Todkar","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.012_bib60","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.chembiol.2024.04.015","article-title":"Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology","volume":"31","author":"Kageler","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib61","article-title":"Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters","author":"Floyd","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.molcel.2026.09.012_bib62","doi-asserted-by":"crossref","first-page":"R790","DOI":"10.1016\/j.cub.2020.05.051","article-title":"Scavenger receptors","volume":"30","author":"Alquraini","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105284","article-title":"The role of human ribonuclease A family in health and diseases: A systematic review","volume":"25","author":"Sun","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.molcel.2026.09.012_bib64","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3390\/biom10071036","article-title":"Deoxyribonucleases and Their Applications in Biomedicine","volume":"10","author":"Laukov\u00e1","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.molcel.2026.09.012_bib65","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/annrheumdis-2020-218810","article-title":"Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus","volume":"80","author":"Coke","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molcel.2026.09.012_bib66","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s13075-014-0438-8","article-title":"An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3","volume":"16","author":"Zochling","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molcel.2026.09.012_bib67","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.012_bib68","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ng.81","article-title":"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci","volume":"40","author":"Harley","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.012_bib69","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/s41592-024-02268-9","article-title":"Molecular pixelation: spatial proteomics of single cells by sequencing","volume":"21","author":"Karlsson","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.09.012_bib70","article-title":"Cells as Single-Molecule Protein Proximity Networks","author":"Karlsson","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.molcel.2026.09.012_bib71","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nri1245","article-title":"T-cell-antigen recognition and the immunological synapse","volume":"3","author":"Huppa","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molcel.2026.09.012_bib72","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1158\/2326-6066.CIR-14-0161","article-title":"The immunological synapse","volume":"2","author":"Dustin","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.molcel.2026.09.012_bib73","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41392-025-02332-6","article-title":"Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease","volume":"10","author":"Chao","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molcel.2026.09.012_bib74","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/35078099","article-title":"B cells acquire antigen from target cells after synapse formation","volume":"411","author":"Batista","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.012_bib75","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","article-title":"CpG motifs in bacterial DNA trigger direct B-cell activation","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.012_bib76","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1073\/pnas.1815031116","article-title":"Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA","volume":"116","author":"Serpas","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.012_bib77","doi-asserted-by":"crossref","first-page":"R406","DOI":"10.1016\/j.cub.2017.11.074","article-title":"Unconventional mechanisms of eukaryotic protein secretion","volume":"28","author":"Dimou","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib78","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1016\/j.molcel.2025.11.020","article-title":"Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors","volume":"85","author":"Li","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib79","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2020.12.015","article-title":"Structure of an activated DNA-PK and its implications for NHEJ","volume":"81","author":"Chen","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.09.012_bib80","doi-asserted-by":"crossref","first-page":"26539","DOI":"10.1074\/jbc.M112.371013","article-title":"Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter","volume":"287","author":"Gallo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.012_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj1008","article-title":"DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia","volume":"13","author":"Lam","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib82","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1164\/rccm.201706-1161OC","article-title":"Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury","volume":"197","author":"Hotz","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.molcel.2026.09.012_bib83","doi-asserted-by":"crossref","DOI":"10.1126\/science.adp3971","article-title":"Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA","volume":"389","author":"Murphy","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.012_bib84","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1038\/s41592-024-02457-6","article-title":"Multiomic characterization of RNA microenvironments by oligonucleotide-mediated proximity-interactome mapping","volume":"21","author":"Tsue","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.09.012_bib85","article-title":"HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution","volume":"54","author":"Trupej","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.09.012_bib86","article-title":"DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci","volume":"13","author":"Liu","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.molcel.2026.09.012_bib87","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s42003-022-03437-2","article-title":"Chemical fixation creates nanoscale clusters on the cell surface by aggregating membrane proteins","volume":"5","author":"Ichikawa","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib88","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molcel.2026.09.012_bib89","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE","volume":"35","author":"Bombardier","year":"1992","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molcel.2026.09.012_bib90","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.09.012_bib91","doi-asserted-by":"crossref","first-page":"E376","DOI":"10.1002\/ajh.27107","article-title":"Successful cord blood transplantation for del7q myelodysplastic syndrome in Pearson marrow pancreas syndrome","volume":"98","author":"Belgacem","year":"2023","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.molcel.2026.09.012_bib92","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/acs.jproteome.9b00640","article-title":"Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics","volume":"19","author":"Adams","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.molcel.2026.09.012_bib93","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.744248","article-title":"Electron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles","volume":"9","author":"Ivanchenko","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib94","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/9780470559277.ch140241","article-title":"Point by Point: An Introductory Guide to Sample Preparation for Single-Molecule, Super-Resolution Fluorescence Microscopy","volume":"7","author":"Halpern","year":"2015","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-2899-7_1","article-title":"Genome-Wide Mapping of Active Regulatory Elements Using ATAC-seq","volume":"2611","author":"Marinov","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib96","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-0716-2899-7_15","article-title":"ATAC-See: A Tn5 Transposase-Mediated Assay for Detection of Chromatin Accessibility with Imaging","volume":"2611","author":"Dang","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib97","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.09.012_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.09.012_bib99","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.4256","article-title":"MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics","volume":"14","author":"Kong","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molcel.2026.09.012_bib100","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","article-title":"Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification","volume":"21","author":"Yanai","year":"2005","journal-title":"Bioinformatics"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526006556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526006556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:21:58Z","timestamp":1792077718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526006556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":100,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1097276526006556"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.09.012","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNASE1L3 maintains homeostatic levels of mitochondrial DNA on the mammalian cell surface","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}