{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:52:29Z","timestamp":1791060749240,"version":"4.1.0"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.molcel.2026.09.032","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:47:55Z","timestamp":1790952475000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events"],"prefix":"10.1016","author":[{"given":"Benjamin I.","family":"Ferman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Azadegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushka","family":"Udara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison A.","family":"Lineberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lautert-Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Sumner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashish","family":"Chetal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zach","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manna","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Umit Kaniskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damayanti","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedona E.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Bellacosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-3192","authenticated-orcid":false,"given":"Hayan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Van Rechem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan I.","family":"Sadreyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan R.","family":"Whetstine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molcel.2026.09.032_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/gim.2015.78","article-title":"Clinical phenotype of the recurrent 1q21.1 copy-number variant","volume":"18","author":"Bernier","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.molcel.2026.09.032_bib2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.288.5466.678","article-title":"Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22","volume":"288","author":"Brzustowicz","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib3","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.annonc.2020.03.303","article-title":"Extrachromosomal DNA-relieving heredity constraints, accelerating tumour evolution","volume":"31","author":"Bailey","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.molcel.2026.09.032_bib4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1128\/MCB.00652-15","article-title":"Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive","volume":"36","author":"Mishra","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.09.032_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/npjgenmed.2016.31","article-title":"The importance of copy number variation in congenital heart disease","volume":"1","author":"Costain","year":"2016","journal-title":"NPJ Genom. Med."},{"key":"10.1016\/j.molcel.2026.09.032_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108454","article-title":"Connecting the dots: Epigenetic regulation of extrachromosomal and inherited DNA amplifications","volume":"301","author":"Azadegan","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.032_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-pathmechdis-051821-114223","article-title":"Extrachromosomal DNA: An Emerging Hallmark in Human Cancer","volume":"17","author":"Wu","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.molcel.2026.09.032_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03369-8","article-title":"Circular DNA elements of chromosomal origin are common in healthy human somatic tissue","volume":"9","author":"M\u00f8ller","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41568-024-00669-8","article-title":"Extrachromosomal DNA in cancer","volume":"24","author":"Yan","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.09.032_bib10","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41588-020-0678-2","article-title":"Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers","volume":"52","author":"Kim","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.032_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-08200-y","article-title":"Exploring the landscape of focal amplifications in cancer using AmpliconArchitect","volume":"10","author":"Deshpande","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00412-022-00773-4","article-title":"Life of double minutes: generation, maintenance, and elimination","volume":"131","author":"Ili\u0107","year":"2022","journal-title":"Chromosoma"},{"key":"10.1016\/j.molcel.2026.09.032_bib13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/327434a0","article-title":"Novel submicroscopic extrachromosomal elements containing amplified genes in human cells","volume":"327","author":"Maurer","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib14","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1073\/pnas.82.4.1126","article-title":"Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line","volume":"82","author":"Hamkalo","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-019-1763-5","article-title":"Circular ecDNA promotes accessible chromatin and high oncogene expression","volume":"575","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba2489","article-title":"ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines","volume":"6","author":"Kumar","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molcel.2026.09.032_bib17","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1073\/pnas.85.13.4804","article-title":"Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules","volume":"85","author":"Von Hoff","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib18","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1073\/pnas.89.17.8165","article-title":"Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity","volume":"89","author":"Von Hoff","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib19","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1158\/2159-8290.CD-21-1376","article-title":"Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer","volume":"12","author":"Yi","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib20","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41588-022-01177-x","article-title":"The evolutionary dynamics of extrachromosomal DNA in human cancers","volume":"54","author":"Lange","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.032_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003099","article-title":"Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification","volume":"3","author":"Lundberg","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.molcel.2026.09.032_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-020-03064-z","article-title":"Chromothripsis drives the evolution of gene amplification in cancer","volume":"591","author":"Shoshani","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41586-024-07861-8","article-title":"Coordinated inheritance of extrachromosomal DNAs in cancer cells","volume":"635","author":"Hung","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1601-5223.1978.tb01606.x","article-title":"Have double minutes functioning centromeres?","volume":"88","author":"Levan","year":"1978","journal-title":"Hereditas"},{"key":"10.1016\/j.molcel.2026.09.032_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0092-8674(81)90204-X","article-title":"Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes","volume":"26","author":"Haber","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib26","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0021-9258(17)34875-5","article-title":"Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells","volume":"253","author":"Alt","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.032_bib27","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1073\/pnas.76.11.5669","article-title":"Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes","volume":"76","author":"Kaufman","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib28","doi-asserted-by":"crossref","first-page":"6674","DOI":"10.1073\/pnas.91.14.6674","article-title":"Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc","volume":"91","author":"Eckhardt","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib29","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41586-021-04116-8","article-title":"ecDNA hubs drive cooperative intermolecular oncogene expression","volume":"600","author":"Hung","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib30","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.cell.2019.10.039","article-title":"Functional Enhancers Shape Extrachromosomal Oncogene Amplifications","volume":"179","author":"Morton","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ccell.2021.03.006","article-title":"Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription","volume":"39","author":"Zhu","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature21356","article-title":"Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity","volume":"543","author":"Turner","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib33","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1158\/2159-8290.CD-22-0796","article-title":"Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes","volume":"13","author":"Pongor","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib34","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/s41588-023-01551-3","article-title":"Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma","volume":"55","author":"Chapman","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.032_bib35","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41586-023-05937-5","article-title":"Extrachromosomal DNA in the cancerous transformation of Barrett\u2019s oesophagus","volume":"616","author":"Luebeck","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11060-010-0289-3","article-title":"Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma","volume":"102","author":"Zitterbart","year":"2011","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.molcel.2026.09.032_bib37","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/sj.leu.2404403","article-title":"Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma","volume":"20","author":"Fonseca","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.molcel.2026.09.032_bib38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9440(10)63276-2","article-title":"Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma","volume":"165","author":"Inoue","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molcel.2026.09.032_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3171\/2008.10.PEDS08105","article-title":"Low-level copy gain versus amplification of myc oncogenes in medulloblastoma: utility in predicting prognosis and survival. Laboratory investigation","volume":"3","author":"Takei","year":"2009","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.molcel.2026.09.032_bib40","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1073\/pnas.1014835108","article-title":"Cyclin E amplification\/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients","volume":"108","author":"Scaltriti","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib41","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nrc2231","article-title":"Reflecting on 25 years with MYC","volume":"8","author":"Meyer","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.09.032_bib42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib43","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cels.2018.03.003","article-title":"Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas","volume":"6","author":"Schaub","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.molcel.2026.09.032_bib44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice","volume":"318","author":"Adams","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib45","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the Catalogue Of Somatic Mutations In Cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.09.032_bib46","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s11523-025-01169-x","article-title":"MYC as a Target for Cancer Treatment: from Undruggable to Druggable?","volume":"20","author":"Duffy","year":"2025","journal-title":"Target. Oncol."},{"key":"10.1016\/j.molcel.2026.09.032_bib47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3390\/genes8060151","article-title":"MYC Deregulation in Primary Human Cancers","volume":"8","author":"Kalkat","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.molcel.2026.09.032_bib48","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nature08822","article-title":"The landscape of somatic copy-number alteration across human cancers","volume":"463","author":"Beroukhim","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/298679a0","article-title":"Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line","volume":"298","author":"Collins","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib50","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1073\/pnas.80.6.1707","article-title":"Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma","volume":"80","author":"Alitalo","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib51","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1101\/gr.106252.110","article-title":"Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure","volume":"20","author":"Storlazzi","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.molcel.2026.09.032_bib52","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.6414084","article-title":"Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma","volume":"222","author":"ar-Rushdi","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib53","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/sj.onc.1202468","article-title":"Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt\u2019s lymphoma","volume":"18","author":"Gerbitz","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.molcel.2026.09.032_bib54","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41586-025-08721-9","article-title":"MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC","volume":"640","author":"Fiorini","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib55","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1002\/1878-0261.13319","article-title":"MYC and therapy resistance in cancer: risks and opportunities","volume":"16","author":"Donati","year":"2022","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.molcel.2026.09.032_bib56","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.4001943","article-title":"Microinjected c-myc as a competence factor","volume":"228","author":"Kaczmarek","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib57","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature05953","article-title":"Non-transcriptional control of DNA replication by c-Myc","volume":"448","author":"Dominguez-Sola","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib58","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.ado0977","article-title":"Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes","volume":"390","author":"Krupina","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib59","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3324\/haematol.2019.223891","article-title":"An increase in MYC copy number has a progressive negative prognostic impact in patients with diffuse large B-cell and high-grade lymphoma, who may benefit from intensified treatment regimens","volume":"105","author":"Schieppati","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.molcel.2026.09.032_bib60","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1016\/j.molcel.2025.07.007","article-title":"Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex","volume":"85","author":"Qin","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib61","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.cell.2018.11.018","article-title":"Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications","volume":"175","author":"Mishra","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib62","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1016\/j.cell.2023.09.009","article-title":"Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement","volume":"186","author":"Gray","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib63","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1158\/2159-8290.CD-19-0463","article-title":"Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification","volume":"10","author":"Clarke","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib64","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1074\/jbc.M115.711648","article-title":"Regulation of Transient Site-specific Copy Gain by MicroRNA","volume":"291","author":"Black","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.032_bib65","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cell.2013.06.051","article-title":"KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors","volume":"154","author":"Black","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib66","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/gad.351444.123","article-title":"Epigenetic modulators provide a path to understanding disease and therapeutic opportunity","volume":"38","author":"Honer","year":"2024","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib67","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.cell.2025.02.023","article-title":"20 years of histone lysine demethylases: From discovery to the clinic and beyond","volume":"188","author":"Gray","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib68","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1101\/gad.259796.115","article-title":"Hypoxia drives transient site-specific copy gain and drug-resistant gene expression","volume":"29","author":"Black","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib69","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1016\/j.cell.2024.08.001","article-title":"The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance","volume":"187","author":"Engel","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib70","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1158\/2159-8290.CD-23-0656","article-title":"Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs","volume":"14","author":"Pal Choudhuri","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25787-x","article-title":"Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer","volume":"12","author":"Zhou","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib72","first-page":"1171","article-title":"Effects of hydroxyurea on extrachromosomal DNA in patients with advanced ovarian carcinomas","volume":"7","author":"Raymond","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.molcel.2026.09.032_bib73","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/5056","article-title":"Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype","volume":"21","author":"Jiang","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.032_bib74","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1126\/science.1210214","article-title":"Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations","volume":"333","author":"Janssen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib75","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.cell.2015.11.054","article-title":"Chromothripsis and Kataegis Induced by Telomere Crisis","volume":"163","author":"Maciejowski","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib76","doi-asserted-by":"crossref","first-page":"828","DOI":"10.15252\/msb.20156505","article-title":"A cell-based model system links chromothripsis with hyperploidy","volume":"11","author":"Mardin","year":"2015","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.molcel.2026.09.032_bib77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature14493","article-title":"Chromothripsis from DNA damage in micronuclei","volume":"522","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib78","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41419-020-03380-2","article-title":"Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc","volume":"12","author":"Lee","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molcel.2026.09.032_bib79","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/s41588-025-02197-z","article-title":"KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage","volume":"57","author":"Li","year":"2025","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molcel.2026.09.032_bib80","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cell.2006.03.028","article-title":"Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases","volume":"125","author":"Whetstine","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib81","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature04837","article-title":"The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3","volume":"442","author":"Cloos","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib82","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1128\/MCB.00864-13","article-title":"The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development","volume":"34","author":"Pedersen","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.09.032_bib83","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib84","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/acsmedchemlett.7b00220","article-title":"Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models","volume":"8","author":"Chen","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.molcel.2026.09.032_bib85","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1074\/jbc.M115.696864","article-title":"Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C)","volume":"291","author":"Pack","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.032_bib86","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.15252\/embj.201593317","article-title":"Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development","volume":"35","author":"Pedersen","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.09.032_bib87","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.cell.2007.02.003","article-title":"RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3","volume":"128","author":"Christensen","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib88","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2007.03.001","article-title":"PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation","volume":"25","author":"Yamane","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib89","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.cell.2007.02.017","article-title":"The X-linked mental retardation gene SMCX\/JARID1C defines a family of histone H3 lysine 4 demethylases","volume":"128","author":"Iwase","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib90","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/gad.1523007","article-title":"The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth","volume":"21","author":"Secombe","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib91","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.cell.2007.02.013","article-title":"The retinoblastoma binding protein RBP2 is an H3K4 demethylase","volume":"128","author":"Klose","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib92","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nchembio.2087","article-title":"Structural analysis of human KDM5B guides histone demethylase inhibitor development","volume":"12","author":"Johansson","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molcel.2026.09.032_bib93","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/emboj.2011.91","article-title":"KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription","volume":"30","author":"Xie","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.09.032_bib94","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.emboj.7601967","article-title":"Dynamic histone H3 methylation during gene induction: HYPB\/Setd2 mediates all H3K36 trimethylation","volume":"27","author":"Edmunds","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.molcel.2026.09.032_bib95","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/MCB.25.8.3305-3316.2005","article-title":"A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation","volume":"25","author":"Kizer","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molcel.2026.09.032_bib96","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13610","article-title":"Selective suppression of antisense transcription by Set2-mediated H3K36 methylation","volume":"7","author":"Venkatesh","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib97","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/acsmedchemlett.2c00167","article-title":"Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies","volume":"13","author":"Alford","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.molcel.2026.09.032_bib98","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/CAD.0000000000001514","article-title":"TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase","volume":"34","author":"Chandhasin","year":"2023","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.molcel.2026.09.032_bib99","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014407","article-title":"MYC and the control of apoptosis","volume":"4","author":"McMahon","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.molcel.2026.09.032_bib100","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.13.11.1367","article-title":"c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release","volume":"13","author":"Juin","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib101","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1097-2765(00)80350-0","article-title":"Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion","volume":"3","author":"Pelengaris","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib102","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32368-z","article-title":"MYC sensitises cells to apoptosis by driving energetic demand","volume":"13","author":"Edwards-Hicks","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib103","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1101\/gad928101","article-title":"Deconstructing myc","volume":"15","author":"Eisenman","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib104","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1126\/science.8091232","article-title":"Mediation of c-Myc-induced apoptosis by p53","volume":"265","author":"Hermeking","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib105","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.molcel.2026.09.032_bib106","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41568-020-0262-1","article-title":"p53: 800 million years of evolution and 40 years of discovery","volume":"20","author":"Levine","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molcel.2026.09.032_bib107","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib108","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1101\/gad.8.23.2817","article-title":"Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1\/cip1","volume":"8","author":"Wagner","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib109","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41586-024-08107-3","article-title":"Origins and impact of extrachromosomal DNA","volume":"635","author":"Bailey","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib110","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/j.celrep.2019.08.061","article-title":"Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas","volume":"28","author":"Donehower","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.09.032_bib111","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba0712","article-title":"Mechanisms generating cancer genome complexity from a single cell division error","volume":"368","author":"Umbreit","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib112","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41586-018-0291-z","article-title":"CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions","volume":"559","author":"Zimmermann","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib113","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.celrep.2016.06.020","article-title":"Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients","volume":"16","author":"Semenova","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.09.032_bib114","article-title":"The NFIB\/CARM1 partnership is a driver in preclinical models of small cell lung cancer","volume":"14","author":"Gao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib115","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1101\/gad.2046711","article-title":"Nuclear factor I\/B is an oncogene in small cell lung cancer","volume":"25","author":"Dooley","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.molcel.2026.09.032_bib116","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.celrep.2016.02.091","article-title":"SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability","volume":"15","author":"Huang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.09.032_bib117","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1158\/2159-8290.CD-23-1117","article-title":"Disparate Pathways for Extrachromosomal DNA Biogenesis and Genomic DNA Repair","volume":"15","author":"Rose","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib118","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41586-024-08318-8","article-title":"Engineered extrachromosomal oncogene amplifications promote tumorigenesis","volume":"637","author":"Pradella","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib119","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib120","first-page":"313","article-title":"Mutation and cancer: a model for Wilms\u2019 tumor of the kidney","volume":"48","author":"Knudson","year":"1972","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.molcel.2026.09.032_bib121","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1158\/2159-8290.CD-24-1662","article-title":"Knudson\u2019s \u201cTwo-Hit\u201d Hypothesis and Cancer Predisposition: A Bit More Complicated but Still Going Strong","volume":"15","author":"Brzezinski","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib122","article-title":"Transition from Transient DNA Rereplication to Inherited Gene Amplification Following Prolonged Environmental Stress","author":"Wright","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.molcel.2026.09.032_bib123","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.1190966","article-title":"Loss of DNA replication control is a potent inducer of gene amplification","volume":"329","author":"Green","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.molcel.2026.09.032_bib124","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41586-021-04009-w","article-title":"eccDNAs are apoptotic products with high innate immunostimulatory activity","volume":"599","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molcel.2026.09.032_bib125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2530443123","article-title":"BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance","volume":"123","author":"Chung","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molcel.2026.09.032_bib126","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.cell.2026.03.011","article-title":"A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer","volume":"189","author":"Wong","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib127","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molcel.2026.09.032_bib128","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-4-r41","article-title":"GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers","volume":"12","author":"Mermel","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.molcel.2026.09.032_bib129","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1158\/2159-8290.CD-14-1159","article-title":"A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors","volume":"5","author":"Van Rechem","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.molcel.2026.09.032_bib130","doi-asserted-by":"crossref","first-page":"30462","DOI":"10.1074\/jbc.M111.273508","article-title":"The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)\/Jumonji domain-containing 2A (JMJD2A) protein","volume":"286","author":"Van Rechem","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molcel.2026.09.032_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109799","article-title":"Collective regulation of chromatin modifications predicts replication timing during cell cycle","volume":"37","author":"Van Rechem","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.molcel.2026.09.032_bib132","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molcel.2026.09.032_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2020.194624","article-title":"The lysine demethylase KDM4A controls the cell-cycle expression of replicative canonical histone genes","volume":"1863","author":"Van Rechem","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.molcel.2026.09.032_bib134","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.09.032_bib135","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molcel.2026.09.032_bib136","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molcel.2026.09.032_bib137","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.09.032_bib138","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molcel.2026.09.032_bib139","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/s41588-023-01449-0","article-title":"GATK-gCNV enables the discovery of rare copy number variants from exome sequencing data","volume":"55","author":"Babadi","year":"2023","journal-title":"Nat. Genet."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526006751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276526006751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:55:15Z","timestamp":1791057315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276526006751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":139,"alternative-id":["S1097276526006751"],"URL":"https:\/\/doi.org\/10.1016\/j.molcel.2026.09.032","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}