{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:23:08Z","timestamp":1791296588045,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.molimm.2005.03.008","type":"journal-article","created":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T17:00:22Z","timestamp":1113411622000},"page":"395-409","source":"Crossref","is-referenced-by-count":13,"title":["Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression"],"prefix":"10.1016","volume":"43","author":[{"given":"Alyssa B.","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parimal","family":"Majumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma M.","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Boss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2005.03.008_bib1","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1073\/pnas.88.10.4285","article-title":"Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis","volume":"88","author":"Benichou","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2005.03.008_bib2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/89810","article-title":"CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter","volume":"2","author":"Beresford","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0952-7915(02)00015-8","article-title":"Transcriptional regulation of the MHC class II antigen presentation pathway","volume":"15","author":"Boss","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib4","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1093\/nar\/26.18.4128","article-title":"The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element","volume":"26","author":"Brown","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2005.03.008_bib5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/jmbi.2000.4028","article-title":"Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter","volume":"302","author":"Caretti","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(00)00161-X","article-title":"Groucho\/TLE family proteins and transcriptional repression","volume":"249","author":"Chen","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.molimm.2005.03.008_bib7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(88)90144-4","article-title":"Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif","volume":"55","author":"Courey","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2005.03.008_bib8","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1128\/MCB.20.17.6587-6599.2000","article-title":"Associations and interactions among the bare lymphocyte syndrome factors","volume":"20","author":"DeSandro","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/emboj\/16.5.1045","article-title":"RFXAP, a novel subunit of the RFX DNA binding complex, is mutated in MHC class II deficiency","volume":"16","author":"Durand","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.molimm.2005.03.008_bib10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0268-960X(96)90008-9","article-title":"Major histocompatibility complex class II deficiency: a clinical review","volume":"10","author":"Elhasid","year":"1996","journal-title":"Blood Rev."},{"key":"10.1016\/j.molimm.2005.03.008_bib11","first-page":"512","article-title":"Analysis of the DNA binding and transcriptional activation properties of the Ets1 oncoprotein","volume":"4","author":"Gegonne","year":"1992","journal-title":"New Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/271459a0","article-title":"Stable variants affecting B cell alloantigens in human lymphoid cells","volume":"271","author":"Gladstone","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2005.03.008_bib13","first-page":"135","article-title":"Combined immunodeficiency with defective expression in MHC class II genes","volume":"1","author":"Griscelli","year":"1989","journal-title":"Immune Defic. Rev."},{"key":"10.1016\/j.molimm.2005.03.008_bib14","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1128\/MCB.20.20.7716-7725.2000","article-title":"CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation","volume":"20","author":"Hake","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib15","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1093\/nar\/19.22.6269","article-title":"Two distinct B cell factors bind the HLA-DRAX box region and recognize different subsets of MHC class II promoters","volume":"19","author":"Hasegawa","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2005.03.008_bib16","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.4049\/jimmunol.150.5.1781","article-title":"Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells","volume":"150","author":"Hasegawa","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1126\/science.1902592","article-title":"In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome","volume":"252","author":"Kara","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.molimm.2005.03.008_bib18","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.4049\/jimmunol.150.11.4934","article-title":"Developmental and cytokine-mediated regulation of MHC class II gene promoter occupancy in vivo","volume":"150","author":"Kara","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0022-3476(05)80388-9","article-title":"Major histocompatibility complex class II deficiency: clinical manifestations, immunologic features, and outcome","volume":"123","author":"Klein","year":"1993","journal-title":"J. Pediatr."},{"key":"10.1016\/j.molimm.2005.03.008_bib20","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1006\/jmbi.1998.2384","article-title":"NF-Y binding to twin CCAAT box: role of Q-rich domains and histone fold helices","volume":"285","author":"Liberati","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib21","doi-asserted-by":"crossref","DOI":"10.1007\/s00251-004-0738-2","article-title":"Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2","author":"Long","year":"2005","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2005.03.008_bib22","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.4049\/jimmunol.159.8.3899","article-title":"Formation of a regulatory factor X\/X2 box-binding protein\/nuclear factor-Y multiprotein complex on the conserved regulatory regions of HLA class II genes","volume":"159","author":"Louis-Plence","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib23","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1002\/j.1460-2075.1992.tb05410.x","article-title":"Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription","volume":"11","author":"Mantovani","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.molimm.2005.03.008_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/3081","article-title":"A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients","volume":"20","author":"Masternak","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2005.03.008_bib25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gad.14.9.1156","article-title":"CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex","volume":"14","author":"Masternak","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.molimm.2005.03.008_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80015-1","article-title":"CREB regulates MHC class II expression in a CIITA-dependent manner","volume":"10","author":"Moreno","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2005.03.008_bib27","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.4049\/jimmunol.158.12.5841","article-title":"Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoproteinn complex","volume":"158","author":"Moreno","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4049\/jimmunol.173.1.410","article-title":"A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression","volume":"173","author":"Nagarajan","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1074-7613(00)80016-3","article-title":"RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, a MHC class II immunodeficiency","volume":"10","author":"Nagarajan","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2005.03.008_bib30","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1128\/MCB.20.12.4455-4461.2000","article-title":"Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex","volume":"20","author":"Nekrep","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1084\/jem.173.3.629","article-title":"An isotype-specific transacting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP","volume":"173","author":"Ono","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.03.008_bib32","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1074\/jbc.270.11.6396","article-title":"Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box","volume":"270","author":"Ono","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2005.03.008_bib33","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1128\/MCB.21.17.5699-5709.2001","article-title":"Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP","volume":"21","author":"Peretti","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib34","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.4049\/jimmunol.136.11.4311","article-title":"Differential expression of HLA-DR, -DQ and -DP antigens on malignant B cells","volume":"136","author":"Pesando","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib35","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.4049\/jimmunol.137.6.1932","article-title":"HLA-DP can be expressed with or without -DR molecules on a malignant B cell line","volume":"137","author":"Pesando","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib36","doi-asserted-by":"crossref","first-page":"33026","DOI":"10.1074\/jbc.271.51.33026","article-title":"Products of the grg (Groucho-related gene) family can dimerize through the amino-teiminal Q domain","volume":"271","author":"Pinto","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2005.03.008_bib37","first-page":"101","article-title":"The acidic amino-terminal region of the HIV-1 Tat protein constitutes an essential activating domain","volume":"1","author":"Rappaport","year":"1989","journal-title":"New Biol."},{"key":"10.1016\/j.molimm.2005.03.008_bib38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2370.1998.00116.x","article-title":"Differential expression of MHC class II genes in lung tumour cell lines","volume":"25","author":"Redondo","year":"1998","journal-title":"Eur. J. Immunogenet."},{"key":"10.1016\/j.molimm.2005.03.008_bib39","doi-asserted-by":"crossref","first-page":"20020","DOI":"10.1016\/S0021-9258(17)32121-X","article-title":"Cooperative binding between factors RFX and X2BP to the X and X2 boxes of MHC class II promoters","volume":"269","author":"Reith","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2005.03.008_bib40","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1073\/pnas.91.2.554","article-title":"Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y","volume":"91","author":"Reith","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2005.03.008_bib41","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.immunol.19.1.331","article-title":"The bare lymphocyte syndrome and the regulation of MHC expression","volume":"19","author":"Reith","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib42","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1073\/pnas.94.12.6330","article-title":"Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5","volume":"94","author":"Scholl","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2005.03.008_bib43","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.4049\/jimmunol.148.5.1576","article-title":"Genetic complexity of regulatory mutants defective for HLA class II expression","volume":"148","author":"Seidl","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.03.008_bib44","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1101\/gad.9.9.1021","article-title":"A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)","volume":"9","author":"Steimle","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.molimm.2005.03.008_bib45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0092-8674(05)80090-X","article-title":"Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)","volume":"75","author":"Steimle","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2005.03.008_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF02935505","article-title":"Locus-and allele-specific DNA-protein interactions in the HLA-DQB1 X box","volume":"12","author":"Sukiennicki","year":"1993","journal-title":"Immunol. Res."},{"key":"10.1016\/j.molimm.2005.03.008_bib47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10126-002-0063-4","article-title":"Isolation of the promoters of Atlantic salmon MHCII genes","volume":"5","author":"Syed","year":"2003","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.molimm.2005.03.008_bib48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(90)90589-7","article-title":"Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation","volume":"60","author":"Tanaka","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2005.03.008_bib49","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2005.03.008_bib50","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/nar\/27.7.1635","article-title":"Orientation and positional mapping of the subunits of the multicomponent transcription factors RFX and X2BP to the major histocompatibility complex class II transcriptional enhancer","volume":"27","author":"Westerheide","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2005.03.008_bib51","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1128\/MCB.20.16.6051-6061.2000","article-title":"Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter","volume":"20","author":"Zhu","year":"2000","journal-title":"Mol. Cell. Biol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589005000660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589005000660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T20:33:33Z","timestamp":1706128413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589005000660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0161589005000660"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2005.03.008","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}