{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:16:53Z","timestamp":1791206213437,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.molimm.2005.06.041","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T03:13:47Z","timestamp":1123125227000},"page":"856-859","source":"Crossref","is-referenced-by-count":37,"title":["Does complement factor B have a role in the pathogenesis of atypical HUS?"],"prefix":"10.1016","volume":"43","author":[{"given":"David","family":"Kavanagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mayland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Goodship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.J.","family":"Goodship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2005.06.041_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1681\/ASN.V122297","article-title":"The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20","volume":"12","author":"Caprioli","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molimm.2005.06.041_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/01.ASN.0000115702.28859.A7","article-title":"Heterozygous and homozygous factor H deficiencies associated with haemolytic uraemic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases","volume":"15","author":"Dragon-Durey","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molimm.2005.06.041_bib3","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1136\/jmg.2004.019083","article-title":"Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome.","volume":"41","author":"Fremeaux-Bacchi","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.molimm.2005.06.041_bib4","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/0161-5890(93)90231-Y","article-title":"Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression","volume":"30","author":"Horiuchi","year":"1993","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2005.06.041_bib5","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1074\/jbc.M109322200","article-title":"Decay-accelerating factor (DAF), complement receptor 1 (CR1) and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb","volume":"277","author":"Hourcade","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2005.06.041_bib6","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1681\/ASN.2005010103","article-title":"Mutations in complement factor I (IF) predispose to the development of atypical HUS","volume":"16","author":"Kavanagh","year":"2005","journal-title":"JASN"},{"key":"10.1016\/j.molimm.2005.06.041_bib7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1172\/JCI16651","article-title":"Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in haemolytic uraemic syndrome","volume":"111","author":"Manuelin","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2005.06.041_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0171-2985(80)80045-3","article-title":"Serum concentration and functional efficiency of factor B alleles","volume":"158","author":"Mauff","year":"1980","journal-title":"Immunobiology"},{"key":"10.1016\/j.molimm.2005.06.041_bib9","first-page":"505","article-title":"Quantitative differences between complement factor B phenotypes","volume":"42","author":"Mortensen","year":"1981","journal-title":"Immunology"},{"key":"10.1016\/j.molimm.2005.06.041_bib10","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0140-6736(03)14742-3","article-title":"Familial haemolytic uraemic syndrome and an MCP mutation","volume":"362","author":"Noris","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2005.06.041_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.146.1.257","article-title":"Human complement C3b inactivator: Isolation, characterisation, and demonstration of an absolute requirement for the serum protein \u03b21H for cleavage of C3b and C4b in solution","volume":"146","author":"Pangburn","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.06.041_bib12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1086\/318201","article-title":"Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome","volume":"68","author":"Perez-Caballero","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2005.06.041_bib13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1086\/318203","article-title":"Factor H mutations in hemolytic uremic syndrome cluster in exons 18\u201320, a domain important for host cell recognition","volume":"68","author":"Richards","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2005.06.041_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00041552-200207000-00010","article-title":"The genetics and pathogenesis of haemolytic uraemic syndrome and thrombocytopenic purpura","volume":"11","author":"Richards","year":"2002","journal-title":"Curr. Opin. Nephrol. Hyperten."},{"key":"10.1016\/j.molimm.2005.06.041_bib15","doi-asserted-by":"crossref","first-page":"12966","DOI":"10.1073\/pnas.2135497100","article-title":"Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome","volume":"100","author":"Richards","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2005.06.041_bib16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1086\/344515","article-title":"Structural and functional characterization of factor H mutations associated with atypical haemolytic uraemic syndrome","volume":"71","author":"Sanchez-Corral","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2005.06.041_bib17","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1523-1755.1998.00824.x","article-title":"Genetic studies into inherited and sporadic hemolytic uremic syndrome","volume":"53","author":"Warwicker","year":"1998","journal-title":"Kidney Int."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589005002257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589005002257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T19:35:17Z","timestamp":1626291317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589005002257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0161589005002257"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2005.06.041","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}