{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:13:14Z","timestamp":1781323994670,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.molimm.2005.07.033","type":"journal-article","created":{"date-parts":[[2005,9,3]],"date-time":"2005-09-03T11:14:19Z","timestamp":1125746059000},"page":"1424-1431","source":"Crossref","is-referenced-by-count":18,"title":["Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies"],"prefix":"10.1016","volume":"43","author":[{"given":"Gregory R.","family":"Moe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurva","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Granoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2005.07.033_bib1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.molimm.2005.07.033_bib2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0882-4010(89)90087-9","article-title":"Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide","volume":"6","author":"Ashton","year":"1989","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.molimm.2005.07.033_bib3","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1128\/IAI.62.5.1776-1786.1994","article-title":"Variable region sequences and idiotypic expression of a protective human immunoglobulin M antibody to capsular polysaccharides of Neisseria meningitidis group B and Escherichia coli K1","volume":"62","author":"Azmi","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2005.07.033_bib4","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: application to microtubules and the ribosome","volume":"98","author":"Baker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2005.07.033_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.molimm.2004.09.002","article-title":"Molecular analysis of monoclonal antibodies to group variant capsular polysaccharide of Neisseria meningitidis: recurrent heavy chains and alternative light chain partners","volume":"42","author":"Berry","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib6","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkg500","article-title":"Multiple sequence alignment with the Clustal series of programs","volume":"31","author":"Chenna","year":"2003","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.molimm.2005.07.033_bib7","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.4049\/jimmunol.141.5.1745","article-title":"V region sequences of anti-DNA and anti-RNA autoantibodies from NZB\/NZW F1 mice","volume":"141","author":"Eilat","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib8","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1021\/bi00020a019","article-title":"Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2\u21928)-polysialic acid","volume":"34","author":"Evans","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.molimm.2005.07.033_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(83)90340-9","article-title":"Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis","volume":"2","author":"Finne","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2005.07.033_bib10","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1073\/pnas.82.4.1194","article-title":"NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B meningococci","volume":"82","author":"Frosch","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2005.07.033_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/infdis\/175.2.364","article-title":"Preclinical evaluation of a novel group B meningococcal conjugate vaccine that elicits bactericidal activity in both mice and nonhuman primates","volume":"175","author":"Fusco","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2005.07.033_bib12","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.4049\/jimmunol.151.3.1353","article-title":"Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines","volume":"151","author":"Gilkeson","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib13","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.4049\/jimmunol.160.10.5028","article-title":"Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid","volume":"160","author":"Granoff","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib14","series-title":"Vaccines","first-page":"959","article-title":"Meningococcal vaccines","author":"Granoff","year":"2004"},{"key":"10.1016\/j.molimm.2005.07.033_bib15","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1084\/jem.165.4.1207","article-title":"N-propionylated group B meningococcal polysaccharide mimics a unique epitope on group B Neisseria meningitidis","volume":"165","author":"Jennings","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.07.033_bib16","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.4049\/jimmunol.127.3.1011","article-title":"Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates","volume":"127","author":"Jennings","year":"1981","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib17","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.4049\/jimmunol.137.5.1708","article-title":"Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine","volume":"137","author":"Jennings","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib18","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.134.4.2651","article-title":"Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis","volume":"134","author":"Jennings","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib19","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0140-6736(02)08416-7","article-title":"Development of vaccines against meningococcal disease","volume":"359","author":"Jodar","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2005.07.033_bib20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1515\/bchm3.1993.374.7-12.993","article-title":"Primary structure of the murine monoclonal IgG2a antibody mAb735 against alpha (2\u20138) polysialic acid. 2. Amino acid sequence of the heavy (H-) chain Fd\u2019 region","volume":"374","author":"Klebert","year":"1993","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"10.1016\/j.molimm.2005.07.033_bib21","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.4049\/jimmunol.157.6.2430","article-title":"Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies","volume":"157","author":"Krishnan","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1365-3083.1998.00426.x","article-title":"Comparison of the frequencies of arginines in heavy chain CDR3 of antibodies expressed in the primary B-cell repertoires of autoimmune-prone and normal mice","volume":"48","author":"Krishnan","year":"1998","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib23","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1016\/S0021-9258(19)76560-0","article-title":"Extended polysialic acid chains (n greater than 55) in glycoproteins from human neuroblastoma cells","volume":"263","author":"Livingston","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2005.07.033_bib24","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/infdis\/172.5.1279","article-title":"Complement-mediated bactericidal activity of human antibodies to poly alpha 2\u21928 N-acetylneuraminic acid, the capsular polysaccharide of Neisseria meningitidis serogroup B","volume":"172","author":"Mandrell","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2005.07.033_bib25","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.4049\/jimmunol.129.5.2172","article-title":"Measurement of antibodies to meningococcal group B polysaccharide: low avidity binding and equilibrium binding constants","volume":"129","author":"Mandrell","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0076-6879(91)03008-5","article-title":"Molecular modeling of antibody combining sites","volume":"203","author":"Martin","year":"1991","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.molimm.2005.07.033_bib27","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.123.6.1025","article-title":"Autoimmune disease in NZB\/BL mice. 3. Induction of membranous glomerulonephritis in young mice by the transplantation of spleen cells from old mice","volume":"123","author":"Mellors","year":"1966","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.07.033_bib28","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/IAI.73.4.2123-2128.2005","article-title":"Epitopes recognized by a nonautoreactive murine anti-N-propionyl meningococcal group B polysaccharide monoclonal antibody","volume":"73","author":"Moe","year":"2005","journal-title":"Infect. Immun."},{"issue":"Pt 8","key":"10.1016\/j.molimm.2005.07.033_bib29","first-page":"2451","article-title":"Immunological properties of monoclonal antibodies specific for meningococcal polysaccharides: the protective capacity of IgM antibodies specific for polysaccharide group B","volume":"129","author":"Moreno","year":"1983","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.molimm.2005.07.033_bib30","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0264-410X(01)00410-8","article-title":"Vaccine prevention of meningococcal disease, coming soon?","volume":"20","author":"Morley","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2005.07.033_bib31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/1099-1352(200101\/02)14:1<18::AID-JMR515>3.0.CO;2-2","article-title":"Recognition of DNA by VH and Fv domains of an IgG anti-poly(dC) antibody with a singly mutated VH domain","volume":"14","author":"O\u2019Connor","year":"2001","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.molimm.2005.07.033_bib32","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.185.11.1929","article-title":"N-propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitides","volume":"185","author":"Pon","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.07.033_bib33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/infdis\/163.2.346","article-title":"Comparison of functional activities between IgG1 and IgM class-switched human monoclonal antibodies reactive with group B streptococci or Escherichia coli K1","volume":"163","author":"Raff","year":"1991","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2005.07.033_bib34","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200105033441807","article-title":"Meningococcal disease","volume":"344","author":"Rosenstein","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2005.07.033_bib35","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1128\/IAI.69.5.3335-3342.2001","article-title":"Monoclonal antibodies specific for Neisseria meningitidis group B polysaccharide and their peptide mimotopes","volume":"69","author":"Shin","year":"2001","journal-title":"Infect. Immunol."},{"key":"10.1016\/j.molimm.2005.07.033_bib36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.171.1.265","article-title":"Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation","volume":"171","author":"Shlomchik","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.07.033_bib37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.176.3.761","article-title":"Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB\u00d7NZW)F1 mice","volume":"176","author":"Tillman","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2005.07.033_bib38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1515\/bchm3.1991.372.1.451","article-title":"Primary structure of the murine monoclonal IgG2a antibody mAb735 against alpha (2\u20138) polysialic acid. 1) Amino-acid sequence of the light (L-) chain, kappa-isotype","volume":"372","author":"Vaesen","year":"1991","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"10.1016\/j.molimm.2005.07.033_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0022-1759(99)00184-2","article-title":"Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment of the effect of DNA polymerase 3\u2032\u20135\u2032 exonuclease activity","volume":"233","author":"Wang","year":"2000","journal-title":"J. Immunol. Meth."},{"key":"10.1016\/j.molimm.2005.07.033_bib40","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1172\/JCI109383","article-title":"Complex of meningococcal group B polysaccharide and type 2 outer membrane protein immunogenic in man","volume":"63","author":"Zollinger","year":"1979","journal-title":"J. Clin. Invest."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589005003068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589005003068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:22:18Z","timestamp":1683195738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589005003068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0161589005003068"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2005.07.033","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}