{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:02:37Z","timestamp":1790938957160,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.molimm.2006.08.004","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T11:30:07Z","timestamp":1159356607000},"page":"1704-1708","source":"Crossref","is-referenced-by-count":41,"title":["Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome"],"prefix":"10.1016","volume":"44","author":[{"given":"G.","family":"Monteferrante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brioschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Caprioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pianetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bettinaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bresin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Remuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Noris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2006.08.004_bib1","doi-asserted-by":"crossref","unstructured":"Abrera-Abeleda, M.A., Nishimura, C., Smith, J.L., Sethi, S., McRae, J.L., Murphy, B.F., Silvestri, G., Skerka, C., Jozsi, M., Zipfel, P.F., Hageman, G.S., Smith, R.J., 2005. Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). J. Med. Genet. (Epub ahead of print).","DOI":"10.1136\/jmg.2005.038315"},{"key":"10.1016\/j.molimm.2006.08.004_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1681\/ASN.V122297","article-title":"Italian Registry of Familial and Recurrent HUS\/TTP. The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20","volume":"12","author":"Caprioli","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molimm.2006.08.004_bib3","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1093\/hmg\/ddg363","article-title":"International Registry of Recurrent and Familial HUS\/TTP. Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease","volume":"12","author":"Caprioli","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molimm.2006.08.004_bib4","doi-asserted-by":"crossref","unstructured":"Caprioli, J., Noris, M., Brioschi, S., Pianetti, G., Castelletti, F., Bettinaglio, P., Mele, C., Bresin, E., Cassis, L., Gamba, S., Porrati, F., Bucchioni, S., Monteferrante, G., Fang, C.J., Liszewski, M.K., Kavanagh, D., Atkinson, J.P., Remuzzi, G., 2006. Genetics of HUS: the impact of MCP, CFH and IF mutations on clinical presentation, response to treatment, and outcome. Blood (Epub ahead of print).","DOI":"10.1182\/blood-2005-10-007252"},{"key":"10.1016\/j.molimm.2006.08.004_bib5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/01.ASN.0000115702.28859.A7","article-title":"Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases","volume":"15","author":"Dragon-Durey","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molimm.2006.08.004_bib6","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1136\/jmg.2004.019083","article-title":"Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome","volume":"41","author":"Fremeaux-Bacchi","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.molimm.2006.08.004_bib7","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1681\/ASN.2005010103","article-title":"Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome","volume":"16","author":"Kavanagh","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molimm.2006.08.004_bib8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molimm.2005.06.041","article-title":"Does complement factor B have a role in the pathogenesis of atypical HUS?","volume":"43","author":"Kavanagh","year":"2006","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2006.08.004_bib9","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1074\/jbc.M007495200","article-title":"Human factor H-related protein 5 (FHR-5). A new complement-associated protein","volume":"276","author":"McRae","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2006.08.004_bib10","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.4049\/jimmunol.174.10.6250","article-title":"Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein","volume":"174","author":"McRae","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2006.08.004_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/ajkd.2002.29873","article-title":"Factor H-related protein-5: a novel component of human glomerular immune deposits","volume":"39","author":"Murphy","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.molimm.2006.08.004_bib12","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0140-6736(03)14742-3","article-title":"Familial haemolytic uraemic syndrome and an CD46 mutation","volume":"362","author":"Noris","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2006.08.004_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1681\/ASN.2004100861","article-title":"Hemolytic uremic syndrome","volume":"16","author":"Noris","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molimm.2006.08.004_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.146.1.257","article-title":"Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution","volume":"146","author":"Pangburn","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2006.08.004_bib15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1086\/318201","article-title":"Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome","volume":"68","author":"Perez-Caballero","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2006.08.004_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1086\/318203","article-title":"Factor H mutations in hemolytic uremic syndrome cluster in exons 18\u201320, a domain important for host cell recognition","volume":"68","author":"Richards","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2006.08.004_bib17","doi-asserted-by":"crossref","first-page":"12966","DOI":"10.1073\/pnas.2135497100","article-title":"Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome","volume":"100","author":"Richards","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2006.08.004_bib18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molimm.2004.02.005","article-title":"The human complement factor H: functional roles, genetic variations and disease associations","volume":"41","author":"Rodriguez de Cordoba","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2006.08.004_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0162-3109(99)00015-6","article-title":"The factor H protein family","volume":"42","author":"Zipfel","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.molimm.2006.08.004_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molimm.2005.06.015","article-title":"Complement and diseases: defective alternative pathway control results in kidney and eye diseases","volume":"43","author":"Zipfel","year":"2006","journal-title":"Mol. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589006005566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589006005566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T16:09:08Z","timestamp":1627834148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589006005566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0161589006005566"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2006.08.004","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}