{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:45:47Z","timestamp":1772642747722,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.molimm.2007.07.001","type":"journal-article","created":{"date-parts":[[2007,8,11]],"date-time":"2007-08-11T11:09:27Z","timestamp":1186830567000},"page":"719-727","source":"Crossref","is-referenced-by-count":9,"title":["Rat salivary gland reveals a more restricted IgA repertoire than ileum"],"prefix":"10.1016","volume":"45","author":[{"given":"Maaike","family":"Stoel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem N.H.","family":"Evenhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans G.M.","family":"Kroese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas A.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2007.07.001_bib1","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","article-title":"Defining the normal bacterial flora of the oral cavity","volume":"43","author":"Aas","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.molimm.2007.07.001_bib2","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.molimm.2007.07.001_bib3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.48.6.762","article-title":"T cell control of the gut IgA response against commensal bacteria","volume":"48","author":"Bos","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2007.07.001_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.0105-2896.2005.00283.x","article-title":"Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties","volume":"206","author":"Brandtzaeg","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2007.07.001_bib5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.intimp.2004.03.013","article-title":"Secretion of IgA by rat parotid and submandibular cells in response to autonomimetic stimulation in vitro","volume":"4","author":"Carpenter","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2007.07.001_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/154405910208100111","article-title":"Humans immunized with Streptococcus mutans antigens by mucosal routes","volume":"81","author":"Childers","year":"2002","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molimm.2007.07.001_bib7","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.4049\/jimmunol.163.6.3064","article-title":"Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization","volume":"163","author":"Coffin","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib8","first-page":"448","article-title":"Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice","volume":"22","author":"Crabbe","year":"1970","journal-title":"Lab. Invest."},{"key":"10.1016\/j.molimm.2007.07.001_bib9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s002510100346","article-title":"Evolutionary relationship between rat and mouse immunoglobulin IGHV5 subgroup genes (PC7183) and human IGHV3 subgroup genes","volume":"53","author":"Dammers","year":"2001","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2007.07.001_bib10","first-page":"107","article-title":"Immunoglobulin VH gene analysis in rat: most marginal zone B cells express germline encoded VH genes and are ligand selected","volume":"252","author":"Dammers","year":"2000","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib11","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.4049\/jimmunol.164.3.1595","article-title":"Characteristics of human IgA and IgM genes used by plasma cells in the salivary gland resemble those used in duodenum but not those used in the spleen","volume":"164","author":"Dunn-Walters","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib12","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.molimm.2007.07.001_bib13","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1046\/j.1365-2141.1999.01233.x","article-title":"Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantation","volume":"104","author":"Guikema","year":"1999","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.molimm.2007.07.001_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1046\/j.1365-3083.2003.01226.x","article-title":"Comparison of immunoglobulin heavy chain rearrangements between peripheral and glandular B cells in a patient with primary Sjogren's syndrome","volume":"57","author":"Hansen","year":"2003","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1053\/gast.2000.20219","article-title":"IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated","volume":"119","author":"Holtmeier","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2007.07.001_bib16","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1128\/IAI.69.6.3611-3617.2001","article-title":"Timing, localization, and persistence of colonization by segmented filamentous bacteria in the neonatal mouse gut depend on immune status of mothers and pups","volume":"69","author":"Jiang","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2007.07.001_bib17","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.vaccine.2003.09.002","article-title":"Comparison of different routes of vaccination for eliciting antibody responses in the human stomach","volume":"22","author":"Johansson","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2007.07.001_bib18","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1128\/IAI.69.12.7481-7486.2001","article-title":"Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans","volume":"69","author":"Johansson","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2007.07.001_bib19","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1128\/JVI.75.12.5482-5490.2001","article-title":"B2 but not B1 cells can contribute to CD4+ T-cell-mediated clearance of rotavirus in SCID mice","volume":"75","author":"Kushnir","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2007.07.001_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.micro.51.1.311","article-title":"Interaction of antigens and antibodies at mucosal surfaces","volume":"51","author":"Lamm","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.molimm.2007.07.001_bib21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1679\/aohc.60.493","article-title":"Demonstration and organization of duct-associated lymphoid tissue (DALT) of the main excretory duct in the monkey parotid gland","volume":"60","author":"Matsuda","year":"1997","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.molimm.2007.07.001_bib22","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1073\/pnas.89.15.6901","article-title":"Intracellular neutralization of virus by immunoglobulin A antibodies","volume":"89","author":"Mazanec","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2007.07.001_bib23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/clin.1994.1078","article-title":"Immunoglobulin variable region usage in human intestinal B lymphocytes","volume":"71","author":"McCabe","year":"1994","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.molimm.2007.07.001_bib24","first-page":"171","article-title":"Duct-associated lymphoid tissue (DALT) of minor salivary glands and mucosal immunity","volume":"57","author":"Nair","year":"1986","journal-title":"Immunology"},{"key":"10.1016\/j.molimm.2007.07.001_bib25","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/JVI.74.9.4102-4109.2000","article-title":"Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobulin A","volume":"74","author":"O\u2019Neal","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2007.07.001_bib26","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1073\/pnas.86.10.3833","article-title":"Cloning immunoglobulin variable domains for expression by the polymerase chain reaction","volume":"86","author":"Orlandi","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2007.07.001_bib27","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.4049\/jimmunol.151.8.4164","article-title":"Analysis of Ig H chain gene segment utilization in human fetal liver. Revisiting the \u201cproximal utilization hypothesis\u201d","volume":"151","author":"Pascual","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib28","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1128\/IAI.63.10.3904-3913.1995","article-title":"Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut","volume":"63","author":"Shroff","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2007.07.001_bib29","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.4049\/jimmunol.174.2.1046","article-title":"Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts","volume":"174","author":"Stoel","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib30","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1128\/IAI.67.4.1992-2000.1999","article-title":"Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system","volume":"67","author":"Talham","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2007.07.001_bib31","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.4049\/jimmunol.170.9.4564","article-title":"B1 cells contribute to serum IgM, but not to intestinal IgA. Production in gnotobiotic Ig allotype chimeric mice","volume":"170","author":"Thurnheer","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1525-0016(03)00180-1","article-title":"Systemic and mucosal antibody responses following retroductal gene transfer to the salivary gland","volume":"8","author":"Tucker","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.molimm.2007.07.001_bib33","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.4049\/jimmunol.174.6.3454","article-title":"VH1\u201346 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7","volume":"174","author":"Weitkamp","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1046\/j.1365-3083.1997.d01-159.x","article-title":"Nasal lymphoid tissue (NALT) as a mucosal immune inductive site","volume":"46","author":"Wu","year":"1997","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molimm.2007.07.001_bib35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.0019-2805.2001.01368.x","article-title":"Immunoglobulin A-deficient mice exhibit altered T helper 1-type immune responses but retain mucosal immunity to influenza virus","volume":"105","author":"Zhang","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.molimm.2007.07.001_bib36","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.4049\/jimmunol.168.4.1796","article-title":"Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responses","volume":"168","author":"Zuercher","year":"2002","journal-title":"J. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589007006165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589007006165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T10:18:40Z","timestamp":1708165120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589007006165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0161589007006165"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2007.07.001","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}