{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:39Z","timestamp":1760244939980},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.molimm.2007.08.017","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T21:27:33Z","timestamp":1196112453000},"page":"1525-1529","source":"Crossref","is-referenced-by-count":11,"title":["Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia"],"prefix":"10.1016","volume":"45","author":[{"given":"J.","family":"Malcikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Smardova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pekova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cejkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kotaskova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tichy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Francova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Doubek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Brychtova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Janek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pospisilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dvorakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Trbusek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2007.08.017_bib1","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3384::AID-IMMU3384>3.0.CO;2-T","article-title":"Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands","volume":"28","author":"D\u00f6rner","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2007.08.017_bib2","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.molimm.2006.03.018","article-title":"Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations","volume":"44","author":"Epeldegui","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2007.08.017_bib3","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1073\/pnas.92.9.3963","article-title":"A simple p53 functional assay for screening cell lines, blood, and tumors","volume":"92","author":"Flaman","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2007.08.017_bib4","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/sj.leu.2403294","article-title":"High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia","volume":"18","author":"Heintel","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.molimm.2007.08.017_bib5","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/sj.onc.1210279","article-title":"TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer","volume":"26","author":"Hussain","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.molimm.2007.08.017_bib6","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1073\/pnas.0500830102","article-title":"A target selection of somatic hypermutation is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression","volume":"102","author":"Kotani","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2007.08.017_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/ijc.22292","article-title":"Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis","volume":"120","author":"Kou","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.molimm.2007.08.017_bib8","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1182\/blood.V100.4.1410.h81602001410_1410_1416","article-title":"V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia","volume":"100","author":"Kr\u00f6ber","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2007.08.017_bib9","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.0303971101","article-title":"Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes","volume":"101","author":"Machida","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2007.08.017_bib10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm1566","article-title":"Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium","volume":"13","author":"Matsumoto","year":"2007","journal-title":"Nature Med."},{"key":"10.1016\/j.molimm.2007.08.017_bib11","doi-asserted-by":"crossref","first-page":"7781","DOI":"10.4049\/jimmunol.174.12.7781","article-title":"DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes","volume":"174","author":"Mayorov","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2007.08.017_bib12","first-page":"391","article-title":"Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies","volume":"90","author":"Montillo","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.molimm.2007.08.017_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2007.08.017_bib14","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1038\/sj.onc.1208480","article-title":"Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice","volume":"24","author":"Nilsen","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.molimm.2007.08.017_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature00862","article-title":"AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification","volume":"418","author":"Petersen-Mahrt","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2007.08.017_bib16","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/88732","article-title":"Somatic mutation hotspots correlate with DNA polymerase eta error spectrum","volume":"2","author":"Rogozin","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2007.08.017_bib17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/bjc.1998.172","article-title":"Two Li-Fraumeni syndrome families with novel germline p53 mutations: loss of the wild-type p53 allele in only 50% of tumours","volume":"77","author":"Sedlacek","year":"1998","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.molimm.2007.08.017_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000050597","article-title":"Rare somatic p53 mutation identified in breast cancer: a case report","volume":"22","author":"Smardova","year":"2001","journal-title":"Tumour Biol."},{"key":"10.1016\/j.molimm.2007.08.017_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF03036739","article-title":"Determination of optimal conditions for analysis of p53 status in leukemic cells using functional analysis of separated alleles in yeast","volume":"8","author":"Smardova","year":"2002","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.molimm.2007.08.017_bib20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/sj.leu.2404195","article-title":"Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment","volume":"20","author":"Trbusek","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.molimm.2007.08.017_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.onc.1200812","article-title":"Field cancerisation and polyclonal p53 mutation in the upper aero-digestive tract","volume":"14","author":"Waridel","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.molimm.2007.08.017_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1475-2867-6-27","article-title":"Mechanisms of genotoxin-induced transcription and hypermutation in p53","volume":"6","author":"Wright","year":"2006","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.molimm.2007.08.017_bib23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0161-5890(02)00117-7","article-title":"Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational machanisms","volume":"39","author":"Yavuz","year":"2002","journal-title":"Mol. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589007007274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589007007274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T19:18:39Z","timestamp":1588101519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589007007274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0161589007007274"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2007.08.017","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}