{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:47Z","timestamp":1791400607667,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.molimm.2009.11.028","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T07:05:34Z","timestamp":1261551934000},"page":"1299-1305","source":"Crossref","is-referenced-by-count":62,"title":["Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae"],"prefix":"10.1016","volume":"47","author":[{"given":"Johanna","family":"Pietik\u00e4inen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taru","family":"Meri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Meri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2009.11.028_bib1","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.4049\/jimmunol.157.11.4935","article-title":"Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site","volume":"157","author":"Accardo","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib2","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1002\/eji.200526354","article-title":"Expression of complement factor H binding immunoevasion proteins in Borrelia garinii isolated from patients with neuroborreliosis","volume":"35","author":"Alitalo","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib3","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1128\/IAI.69.6.3685-3691.2001","article-title":"Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation","volume":"69","author":"Alitalo","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2009.11.028_bib4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-2958.2001.02664.x","article-title":"Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes","volume":"42","author":"Berggard","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molimm.2009.11.028_bib5","doi-asserted-by":"crossref","first-page":"27136","DOI":"10.1074\/jbc.M102445200","article-title":"Structural requirements for the complement regulatory activities of C4BP","volume":"276","author":"Blom","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2009.11.028_bib6","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.molimm.2003.12.002","article-title":"Complement inhibitor C4b-binding protein-friend or foe in the innate immune system?","volume":"40","author":"Blom","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/08916930410001713098","article-title":"Molecular mimicry to Borrelia burgdorferi: pathway to autoimmunity?","volume":"37","author":"Bolz","year":"2004","journal-title":"Autoimmunity"},{"key":"10.1016\/j.molimm.2009.11.028_bib8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0171-2985(11)80087-2","article-title":"Differences of two Borrelia burgdorferi strains in complement activation and serum resistance","volume":"185","author":"Brade","year":"1992","journal-title":"Immunobiology"},{"key":"10.1016\/j.molimm.2009.11.028_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s004300050038","article-title":"Heterogeneity in the complement-dependent bacteriolysis within the species of Borrelia burgdorferi","volume":"185","author":"Breitner-Ruddock","year":"1997","journal-title":"Med. Microbiol. Immunol. (Berl.)"},{"key":"10.1016\/j.molimm.2009.11.028_bib10","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20030543","article-title":"Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein","volume":"198","author":"Carlsson","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2009.11.028_bib11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1042\/bj2090847","article-title":"Purification of human C4b-binding protein and formation of its complex with vitamin K-dependent protein S","volume":"209","author":"Dahlback","year":"1983","journal-title":"Biochem. J."},{"key":"10.1016\/j.molimm.2009.11.028_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0038-1646373","article-title":"Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulant system","volume":"66","author":"Dahlback","year":"1991","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.molimm.2009.11.028_bib13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1365-2958.2006.05318.x","article-title":"Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1","volume":"61","author":"Hartmann","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molimm.2009.11.028_bib14","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1074\/jbc.M007994200","article-title":"The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi","volume":"276","author":"Hellwage","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2009.11.028_bib15","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.4049\/jimmunol.174.10.6299","article-title":"Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis","volume":"174","author":"Jarva","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib16","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.4049\/jimmunol.157.7.3021","article-title":"A highly variable region in members of the streptococcal M protein family binds the human complement regulator C4BP","volume":"157","author":"Johnsson","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1128\/IAI.56.2.314-321.1988","article-title":"Role of immunoglobulin G in killing of Borrelia burgdorferi by the classical complement pathway","volume":"56","author":"Kochi","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2009.11.028_bib18","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.4049\/jimmunol.160.7.3349","article-title":"Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins","volume":"160","author":"Kotarsky","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib19","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1074\/jbc.M308343200","article-title":"Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins","volume":"279","author":"Kraiczy","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2009.11.028_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/eji.200323571","article-title":"Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family","volume":"33","author":"Kraiczy","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nrmicro1824","article-title":"Complement evasion by human pathogens","volume":"6","author":"Lambris","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.molimm.2009.11.028_bib22","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1128\/IAI.00007-06","article-title":"Relapsing fever spirochetes Borrelia recurrentis and B. duttonii acquire complement regulators C4b-binding protein and factor H","volume":"74","author":"Meri","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2009.11.028_bib23","doi-asserted-by":"crossref","first-page":"17142","DOI":"10.1073\/pnas.0506471102","article-title":"Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection","volume":"102","author":"Ngampasutadol","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2009.11.028_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.micinf.2007.10.016","article-title":"Outer surface protein E antibody response and its effect on complement factor H binding to OspE in Lyme borreliosis","volume":"10","author":"Panelius","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.molimm.2009.11.028_bib25","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1128\/IAI.63.6.2154-2163.1995","article-title":"Characterization of outer membranes isolated from Borrelia burgdorferi, the Lyme disease spirochete","volume":"63","author":"Radolf","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2009.11.028_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0003-2697(81)90703-X","article-title":"Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen)","volume":"117","author":"Salacinski","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molimm.2009.11.028_bib27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM198908313210906","article-title":"Lyme disease","volume":"321","author":"Steere","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2009.11.028_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4049\/jimmunol.154.1.375","article-title":"Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system","volume":"154","author":"Thern","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.immunol.20.103001.114744","article-title":"Phagocytosis of microbes: complexity in action","volume":"20","author":"Underhill","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2009.11.028_bib30","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/IAI.65.4.1228-1236.1997","article-title":"Complement-mediated serum sensitivity among spirochetes that cause Lyme disease","volume":"65","author":"van Dam","year":"1997","journal-title":"Infect. Immun."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589009008554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589009008554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T20:49:21Z","timestamp":1685306961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589009008554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0161589009008554"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2009.11.028","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}