{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:44:43Z","timestamp":1775159083568,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.molimm.2013.05.231","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T13:01:40Z","timestamp":1375362100000},"page":"540-548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis"],"prefix":"10.1016","volume":"56","author":[{"given":"Juliana","family":"Vitoriano-Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia das Dores","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Menezes-Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Mendes","family":"Roatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Dian","family":"de Oliveira Aguiar-Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Augusto","family":"Siqueira-Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamille Mirelle","family":"de Oliveira Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Cordeiro","family":"Giunchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Guerra","family":"de S\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Corr\u00eaa-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Martins","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Barbosa","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2013.05.231_bib0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/expr.1996.0003","article-title":"Leishmania major: infection of human monocytes induces expression of IL-8 and MCAF","volume":"82","author":"Badolato","year":"1996","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0010","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.vaccine.2003.11.039","article-title":"Effective immunotherapy against canine visceral leishmaniasis with the FML-vaccine","volume":"22","author":"Borja-Cabrera","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1354\/vp.42-2-166","article-title":"Cutaneous leishmaniasis in naturally infected dogs is associated with a T helper-2-biased immune response","volume":"42","author":"Brachelente","year":"2005","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.vetimm.2008.10.310","article-title":"Cytokine profiles in canine visceral leishmaniasis","volume":"128","author":"Carrillo","year":"2009","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.vetimm.2004.08.010","article-title":"Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis","volume":"103","author":"Chamizo","year":"2005","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0030","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0264-410X(00)00339-X","article-title":"A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto, RN)","volume":"19","author":"da Silva","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0035","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.4049\/jimmunol.151.11.6370","article-title":"Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-g or IL-10","volume":"151","author":"de Waal Malefyt","year":"1993","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0040","first-page":"75","article-title":"Leishmaniose visceral urbana (no c\u00e3o e no homem) em Sobral, Cear\u00e1","author":"Deane","year":"1995","journal-title":"Hospital"},{"key":"10.1016\/j.molimm.2013.05.231_bib0045","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Desjeux","year":"2004","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"key":"10.1016\/j.molimm.2013.05.231_bib0050","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1016\/j.vaccine.2007.08.009","article-title":"Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs","volume":"25","author":"Giunchetti","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.rvsc.2007.09.008","article-title":"Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis","volume":"85","author":"Giunchetti","year":"2008","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.molimm.2013.05.231_bib0060","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.vaccine.2007.11.057","article-title":"A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs","volume":"26","author":"Giunchetti","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-4017(01)00486-1","article-title":"An update on antileishmanial vaccine candidates and prospects for a canine Leishmania vaccine","volume":"100","author":"Gradoni","year":"2001","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0070","first-page":"605","article-title":"Role of exogenous chemokines as immunotherapeutic tool against visceral leishmaniasis","author":"Gupta","year":"2011","journal-title":"Science Against Microbial Pathogens: Communicating Current Research and Technological Advances"},{"issue":"Suppl. 1","key":"10.1016\/j.molimm.2013.05.231_bib0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/00034983.1995.11813015","article-title":"Experimental models for leishmaniasis and for testing anti-leishmanial vaccines","volume":"89","author":"Hommel","year":"1995","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0080","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.169.3.1137","article-title":"Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro","volume":"169","author":"Kornbluth","year":"1989","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.vetimm.2006.10.001","article-title":"Analysis of the cytokine profile in spleen cells from dogs naturally infected by Leishmania chagasi","volume":"115","author":"Lage","year":"2007","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0090","first-page":"441","article-title":"Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes","volume":"30","author":"Lasri","year":"1999","journal-title":"Veterinary Research"},{"key":"10.1016\/j.molimm.2013.05.231_bib0095","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.vaccine.2004.11.061","article-title":"Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes","volume":"23","author":"Lemesre","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0100","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.vaccine.2007.02.083","article-title":"Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial","volume":"25","author":"Lemesre","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molimm.2013.05.231_bib0110","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.4049\/jimmunol.159.11.5705","article-title":"Priming with IL-4 and IL-13 during HIV-1 infection restores in vitro IL-12 production by mononuclear cells of HIV-infected patients","volume":"159","author":"Marshall","year":"1997","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0115","first-page":"201","article-title":"Vaccination against Leishmania infections","volume":"2","author":"Mauel","year":"2002","journal-title":"Current Drug Targets: Immune, Endocrine and Metabolic Disorders"},{"key":"10.1016\/j.molimm.2013.05.231_bib0120","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1590\/S0074-02761996000600006","article-title":"Phase I and II open clinical trials of a vaccine against Leishmania chagasi infections in dogs","volume":"91","author":"Mayrink","year":"1996","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.molimm.2013.05.231_bib0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.vetpar.2010.11.025","article-title":"Cytokine and transcription factor profiles in the skin of dogs naturally infected by Leishmania (Leishmania) chagasi presenting distinct cutaneous parasite density and clinical status","volume":"177","author":"Menezes-Souza","year":"2011","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0130","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/viro.1993.1121","article-title":"In vitro differentiation of monocytoid THP-1 cells affects their permissiveness for HIV strains: a model system for studying the cellular basis of HIV differential tropism","volume":"193","author":"Meylan","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0135","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.vetimm.2008.11.030","article-title":"Histological study of cell migration in the dermis of hamsters after immunisation with two different vaccines against visceral leishmaniasis","volume":"128","author":"Moreira","year":"2009","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0140","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1128\/IAI.74.4.2487-2490.2006","article-title":"Visceral Leishmania donovani infection in interleukin-13\u2212\/\u2212 mice","volume":"74","author":"Murray","year":"2006","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.molimm.2013.05.231_bib0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0147-9571(00)00026-6","article-title":"Nitric oxide production by macrophages of dogs vaccinated with killed Leishmania infantum promastigotes","volume":"24","author":"Panaro","year":"2001","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"key":"10.1016\/j.molimm.2013.05.231_bib0150","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2249.2006.03171.x","volume":"146","author":"Peruhype-Magalhaes","year":"2006","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0155","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1086\/319869","article-title":"Tissue cytokine responses in canine visceral leishmaniasis","volume":"183","author":"Quinnell","year":"2001","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.molimm.2013.05.231_bib0160","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/infdis\/170.4.1037","article-title":"Immunoregulatory and proinflammatory cytokine production in visceral and cutaneous leishmaniasis","volume":"170","author":"Raziuddin","year":"1994","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.molimm.2013.05.231_bib0165","doi-asserted-by":"crossref","first-page":"e49780","DOI":"10.1371\/journal.pone.0049780","article-title":"Performance of LBSap vaccine after intradermal challenge with L. infantum and saliva of Lu. longipalpis: immunogenicity and parasitological evaluation","volume":"7","author":"Roatt","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molimm.2013.05.231_bib0170","first-page":"7534","article-title":"IL-13 and IFN-g secretion by activated T cells in HIV-1 infection associated with viral suppression and a lack of disease progression","author":"Robert","year":"1999","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0175","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","article-title":"Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells","volume":"22","author":"Rot","year":"2004","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0180","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1128\/IAI.72.8.4918-4923.2004","article-title":"Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major","volume":"72","author":"Santiago","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.molimm.2013.05.231_bib0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-2427(02)00134-4","article-title":"Cytokine expression during the outcome of canine experimental infection by Leishmania infantum","volume":"88","author":"Santos-Gomes","year":"2002","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0190","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1445-2197.1984.tb05447.x","article-title":"Peritoneal neutrophilia: a potential indicator of the surgical acute abdomen","volume":"54","author":"Stewart","year":"1984","journal-title":"Australian and New Zealand Journal of Surgery"},{"key":"10.1016\/j.molimm.2013.05.231_bib0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpara.2004.10.015","article-title":"Interleukin-12 augments a Th1-type immune response manifested as lymphocyte proliferation and interferon gamma production in Leishmania infantum-infected dogs","volume":"35","author":"Strauss-Ayali","year":"2005","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0200","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1051\/vetres:2007015","article-title":"Splenic immune responses during canine visceral leishmaniasis","volume":"38","author":"Strauss-Ayali","year":"2007","journal-title":"Veterinary Research"},{"key":"10.1016\/j.molimm.2013.05.231_bib0205","doi-asserted-by":"crossref","first-page":"8346","DOI":"10.4049\/jimmunol.175.12.8346","article-title":"Saliva from Lutzomyia longipalpis induces CC chemokine ligand 2\/monocyte chemoattractant protein-1 expression and macrophage recruitment","volume":"175","author":"Teixeira","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0210","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pt.2005.11.010","article-title":"Chemokines in host\u2013parasite interactions in leishmaniasis","volume":"22","author":"Teixeira","year":"2006","journal-title":"Trends in Parasitology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0215","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/IAI.70.8.4177-4184.2002","article-title":"Leishmania promastigotes release a granulocyte chemotactic factor and induce interleukin-8 release but inhibit gamma interferon-inducible protein 10 production by neutrophil granulocytes","volume":"70","author":"van Zandbergen","year":"2002","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.molimm.2013.05.231_bib0220","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.4049\/jimmunol.173.11.6521","article-title":"Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages","volume":"173","author":"van Zandbergen","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0225","doi-asserted-by":"crossref","first-page":"920","DOI":"10.4049\/jimmunol.169.2.920","article-title":"Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth","volume":"169","author":"Venuprasad","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.05.231_bib0230","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1016\/j.vaccine.2008.04.084","article-title":"Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin","volume":"26","author":"Vitoriano-Souza","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2013.05.231_bib0235","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/AAC.40.1.253","article-title":"Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the l-arginine nitric oxide pathway","volume":"40","author":"Vouldoukis","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589013003994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589013003994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T16:11:56Z","timestamp":1688400716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589013003994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0161589013003994"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2013.05.231","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2013.05.231","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}