{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:03:18Z","timestamp":1782903798189,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.molimm.2013.06.017","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T12:30:28Z","timestamp":1375273828000},"page":"22-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["HLA-B27 and antigen presentation: At the crossroads between immune defense and autoimmunity"],"prefix":"10.1016","volume":"57","author":[{"given":"Rosa","family":"Sorrentino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer A.","family":"B\u00f6ckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Fiorillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2013.06.017_bib0005","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.4049\/jimmunol.162.9.5045","article-title":"Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure","volume":"162","author":"Allen","year":"1999","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0010","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20070784","article-title":"Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover","volume":"204","author":"Almeida","year":"2007","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.molimm.2013.06.017_bib0015","doi-asserted-by":"crossref","first-page":"48740","DOI":"10.1074\/jbc.M108882200","article-title":"The Cys-67 residue of HLA-B27 influences cell surface stability, peptide specificity, and T-cell antigen presentation","volume":"276","author":"Alvarez","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.molimm.2013.06.017_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/art.37885","article-title":"Variants in RUNX3 contribute to susceptibility to psoriatic arthritis exhibiting further common ground with ankylosing spondylitis","author":"Apel","year":"2013","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0025","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.4049\/jimmunol.173.11.6564","article-title":"The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27\/peptide complexes","volume":"173","author":"Appel","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0030","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1002\/art.22060","article-title":"Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis","volume":"54","author":"Appel","year":"2006","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0035","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/art.27257","article-title":"The HLA-B*2705 peptidome","volume":"62","author":"Ben Dror","year":"2010","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0167-5699(90)90051-A","article-title":"Guilt by association: HLA-B27 and ankylosing spondylitis","volume":"11","author":"Benjamin","year":"1990","journal-title":"Immunology Today"},{"key":"10.1016\/j.molimm.2013.06.017_bib0045","doi-asserted-by":"crossref","first-page":"15537","DOI":"10.1128\/JVI.79.24.15537-15546.2005","article-title":"The C terminus of the nucleoprotein of influenza A virus delivers antigens transduced by Tat to the trans-Golgi network and promotes an efficient presentation through HLA class I","volume":"79","author":"Bettosini","year":"2005","journal-title":"Journal of Virology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0050","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.4049\/jimmunol.172.7.4435","article-title":"Preferential HLA usage in the influenza virus-specific CTL response","volume":"172","author":"Boon","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0055","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0140-6736(73)91360-3","article-title":"Ankylosing spondylitis and HL-A 27","volume":"1","author":"Brewerton","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2013.06.017_bib0060","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1084\/jem.178.3.879","article-title":"Different HLA-B27 subtypes present the same immunodominant Epstein\u2013Barr virus peptide","volume":"178","author":"Brooks","year":"1993","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.molimm.2013.06.017_bib0065","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/art.22820","article-title":"Identification of previously unrecognized predisposing factors for ankylosing spondylitis from analysis of HLA-B27 extended haplotypes in Sardinia","volume":"56","author":"Cascino","year":"2007","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0070","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/ni.2342","article-title":"TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection","volume":"13","author":"Chen","year":"2012","journal-title":"Nature Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0075","first-page":"1117","article-title":"Predominance of CD8+ T lymphocytes in psoriatic arthritis","volume":"26","author":"Costello","year":"1999","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0080","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1002\/eji.1830251133","article-title":"Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis","volume":"25","author":"D\u2019Amato","year":"1995","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1399-0039.2012.01944.x","article-title":"Old and new HLA associations with ankylosing spondylitis","volume":"80","author":"D\u00edaz-Pe\u00f1a","year":"2012","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.molimm.2013.06.017_bib0090","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.2422","article-title":"Protective HIV-specific CD8+ T cells evade Treg cell suppression","volume":"17","author":"Elahi","year":"2011","journal-title":"Nature Medicine"},{"key":"10.1016\/j.molimm.2013.06.017_bib0095","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nature Genetics"},{"key":"10.1016\/j.molimm.2013.06.017_bib0100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jmb.2007.12.009","article-title":"HLA-B27 subtypes differentially associated with disease exhibit conformational differences in solution","volume":"376","author":"Fabian","year":"2008","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0105","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/art.27316","article-title":"HLA-B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility","volume":"62","author":"Fabian","year":"2010","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0110","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/eji.1830270205","article-title":"Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes","volume":"27","author":"Fiorillo","year":"1997","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0115","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/art.10948","article-title":"Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis","volume":"48","author":"Fiorillo","year":"2003","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/978-1-4419-0298-6_19","article-title":"T cell responses against viral and self-epitopes and HLA-B27 subtypes differently associated with Ankylosing Spondylitis","volume":"649","author":"Fiorillo","year":"2009","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0125","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/ard.2005.037465","article-title":"Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis: detection of tumour necrosis factor alpha in two patients with early disease and transforming growth factor beta in three more advanced cases","volume":"65","author":"Fran\u00e7ois","year":"2006","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.molimm.2013.06.017_bib0130","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/0092-8674(90)90512-D","article-title":"Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders","volume":"63","author":"Hammer","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2013.06.017_bib0135","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0707570104","article-title":"Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype","volume":"104","author":"Harari","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.molimm.2013.06.017_bib0140","doi-asserted-by":"crossref","first-page":"10882","DOI":"10.1074\/jbc.M113.455352","article-title":"Natural HLA-B*2705 ligands with glutamine as anchor motif: implications for HLA-B27 association to spondyloarthropathy","volume":"288","author":"Infantes","year":"2013","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.molimm.2013.06.017_bib0145","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et's disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nature Genetics"},{"key":"10.1016\/j.molimm.2013.06.017_bib0150","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.4049\/jimmunol.0900308","article-title":"Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7","volume":"184","author":"Leonhardt","year":"2010","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/353321a0","article-title":"The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation","volume":"353","author":"Madden","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2013.06.017_bib0160","doi-asserted-by":"crossref","first-page":"30358","DOI":"10.1074\/jbc.M112.384339","article-title":"Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules","volume":"287","author":"Magnacca","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.molimm.2013.06.017_bib0165","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1399-0039.2008.01051.x","article-title":"Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis","volume":"71","author":"Marcilla","year":"2008","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.molimm.2013.06.017_bib0170","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.4049\/jimmunol.163.12.6665","article-title":"Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies","volume":"163","author":"Mear","year":"1999","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0175","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jmb.2011.11.021","article-title":"Dynamical characterization of two differentially disease associated MHC class I proteins in complex with viral and self-peptides","volume":"415","author":"Narzi","year":"2012","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0180","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/hep.21049","article-title":"Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution","volume":"43","author":"Neumann-Haefelin","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0185","doi-asserted-by":"crossref","first-page":"e32865","DOI":"10.1371\/journal.pone.0032865","article-title":"Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes","volume":"7","author":"Nurzia","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2013.06.017_bib0190","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/978-1-4419-0298-6_15","article-title":"Biochemical features of HLA-B27 and antigen processing","volume":"649","author":"Powis","year":"2009","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0195","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-4419-0298-6_12","article-title":"Subtypes of HLA-B27: history and implications in the pathogenesis of ankylosing spondylitis","volume":"649","author":"Reveille","year":"2009","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0200","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1056\/NEJM197304052881403","article-title":"High association of an HL-A antigen, W27, with ankylosing spondylitis","volume":"288","author":"Schlosstein","year":"1973","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.molimm.2013.06.017_bib0205","doi-asserted-by":"crossref","first-page":"e1003042","DOI":"10.1371\/journal.ppat.1003042","article-title":"Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope","volume":"8","author":"Schmidt","year":"2012","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.molimm.2013.06.017_bib0210","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Strange","year":"2010","journal-title":"Nature Genetics"},{"key":"10.1016\/j.molimm.2013.06.017_bib0215","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/art.24599","article-title":"Spondylarthritis in HLA-B27\/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8","volume":"60","author":"Taurog","year":"2009","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.molimm.2013.06.017_bib0220","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ni.1728","article-title":"Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance","volume":"10","author":"Tenzer","year":"2009","journal-title":"Nature Immunology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0225","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ejcb.2011.03.003","article-title":"HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system","volume":"91","author":"Uchanska-Ziegler","year":"2012","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/j.molimm.2013.06.017_bib0230","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1073\/pnas.91.4.1534","article-title":"A subset of HLA-B27 molecules contains peptides much longer than nonamers","volume":"91","author":"Urban","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.molimm.2013.06.017_bib0235","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.4049\/jimmunol.1202926","article-title":"KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA Class I and promotes the expansion of T cells in ankylosing spondylitis","volume":"190","author":"Wong-Baeza","year":"2013","journal-title":"Journal of Immunology"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589013004379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589013004379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T19:26:30Z","timestamp":1715801190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589013004379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0161589013004379"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2013.06.017","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-B27 and antigen presentation: At the crossroads between immune defense and autoimmunity","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2013.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}