{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:39:06Z","timestamp":1761946746944},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"Public Health Service","award":["R43AI079999","R01AI06596"],"award-info":[{"award-number":["R43AI079999","R01AI06596"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health, Department of Health and Human Services"},{"name":"NIH Cancer Center Core","award":["5 P30 CA-56036"],"award-info":[{"award-number":["5 P30 CA-56036"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.molimm.2013.09.005","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T15:26:07Z","timestamp":1383319567000},"page":"247-254","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor"],"prefix":"10.1016","volume":"57","author":[{"given":"Rashmi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fetweh H.","family":"Al-Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Syed","family":"Ubaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama Devudu","family":"Puligedda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Segan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Lindorfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Bermudez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad P.","family":"Adekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance L.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald P.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott K.","family":"Dessain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2013.09.005_bib0005","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jim.2008.01.015","article-title":"Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins","volume":"333","author":"Adekar","year":"2008","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.molimm.2013.09.005_bib0010","doi-asserted-by":"crossref","first-page":"e3023","DOI":"10.1371\/journal.pone.0003023","article-title":"Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain","volume":"3","author":"Adekar","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molimm.2013.09.005_bib0015","doi-asserted-by":"crossref","first-page":"e17491","DOI":"10.1371\/journal.pone.0017491","article-title":"Enhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion protein","volume":"6","author":"Adekar","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molimm.2013.09.005_bib0020","doi-asserted-by":"crossref","first-page":"32129","DOI":"10.1074\/jbc.M101299200","article-title":"A protein with characteristics of factor H is present on rodent platelets and functions as the immune adherence receptor","volume":"276","author":"Alexander","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2013.09.005_bib0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1124\/jpet.111.180653","volume":"338","author":"Al-Saleem","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molimm.2013.09.005_bib0030","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jama.285.8.1059","article-title":"Botulinum toxin as a biological weapon: medical and public health management","volume":"285","author":"Arnon","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.molimm.2013.09.005_bib0035","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1128\/IAI.00405-09","article-title":"Antibody protection against botulinum neurotoxin intoxication in mice","volume":"77","author":"Cheng","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2013.09.005_bib0040","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.4049\/jimmunol.144.12.4613","article-title":"A study of in vivo immune complex formation and clearance in man","volume":"144","author":"Davies","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0045","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/protein\/gzq111","article-title":"Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin","volume":"24","author":"Garcia-Rodriguez","year":"2011","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.molimm.2013.09.005_bib0050","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/JB.01180-06","article-title":"Genetic diversity among Botulinum Neurotoxin-producing clostridial strains","volume":"189","author":"Hill","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0055","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/2338","article-title":"Crystal structure of botulinum neurotoxin type A and implications for toxicity","volume":"5","author":"Lacy","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-065x.2001.1830102.x","article-title":"Heteropolymer-mediated clearance of immune complexes via erythrocyte CR1: mechanisms and applications","volume":"183","author":"Lindorfer","year":"2001","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2013.09.005_bib0065","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.4049\/jimmunol.167.4.2240","article-title":"Targeting of Pseudomonas aeruginosa in the bloodstream with bispecific monoclonal antibodies","volume":"167","author":"Lindorfer","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0070","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1128\/JCM.02392-12","article-title":"Toxin detection in patients\u2019 sera by mass spectrometry during two outbreaks of type A Botulism in France","volume":"50","author":"Mazuet","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0075","first-page":"144","article-title":"Heteropolymers: a novel technology against blood-borne infections","volume":"7","author":"Mohamed","year":"2005","journal-title":"Curr. Opin. Mol. Ther."},{"key":"10.1016\/j.molimm.2013.09.005_bib0080","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1182\/blood.V85.4.917.bloodjournal854917","article-title":"Pharmacokinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies","volume":"85","author":"Montero-Julian","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2013.09.005_bib0085","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1073\/pnas.172229899","article-title":"Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody","volume":"99","author":"Nowakowski","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2013.09.005_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/taap.1994.1181","article-title":"Measurement of botulinum toxin activity: evaluation of the lethality assay","volume":"128","author":"Pearce","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0095","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/IAI.00843-07","article-title":"Recombinant holotoxoid vaccine against botulism","volume":"76","author":"Pier","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2013.09.005_bib0100","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1124\/jpet.106.104661","article-title":"An initial assessment of the systemic pharmacokinetics of botulinum toxin","volume":"318","author":"Ravichandran","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molimm.2013.09.005_bib0105","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1128\/IAI.01893-06","article-title":"Trivalent vaccine against botulinum toxin serotypes A, B, and E that can be administered by the mucosal route","volume":"75","author":"Ravichandran","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2013.09.005_bib0110","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.4049\/jimmunol.164.4.1977","article-title":"Transfer of immune complexes from erythrocyte CR1 to mouse macrophages","volume":"164","author":"Reinagel","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2249.2005.02764.x","article-title":"A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1)","volume":"140","author":"Repik","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/IAI.01084-09","article-title":"Efficient serum clearance of botulinum neurotoxin achieved using a pool of small antitoxin binding agents","volume":"78","author":"Sepulveda","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2013.09.005_bib0125","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxicon.2013.02.014","article-title":"The life history of a botulinum toxin molecule","volume":"68","author":"Simpson","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.molimm.2013.09.005_bib0130","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1128\/IAI.73.9.5450-5457.2005","article-title":"Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization","volume":"73","author":"Smith","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2013.09.005_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10875-005-0353-8","article-title":"Fc receptors and their role in immune regulation and autoimmunity","volume":"25","author":"Takai","year":"2005","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/clin.1996.4286","article-title":"Immune complexes bound to the primate erythrocyte complement receptor (CR1) via anti-CR1 mAbs are cleared simultaneously with loss of CR1 in a concerted reaction in a rhesus monkey model","volume":"82","author":"Taylor","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0145","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.4049\/jimmunol.159.8.4035","article-title":"Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model","volume":"159","author":"Taylor","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2013.09.005_bib0150","doi-asserted-by":"crossref","unstructured":"Zhang, X., Goncalves, R., Mosser, D.M., 2008. The Isolation and Characterization of Murine Macrophages. Current Protocols in Immunology, In: John E. Coligan et al. (Ed.). Chapter 14, Unit 14.1.","DOI":"10.1002\/0471142735.im1401s111"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016158901300521X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016158901300521X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T23:12:03Z","timestamp":1688598723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016158901300521X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S016158901300521X"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2013.09.005","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2013.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}