{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:32:35Z","timestamp":1789500755733,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.molimm.2013.10.014","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T13:50:45Z","timestamp":1384609845000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dendritic cells promote expansion and survival of aberrant TCR-negative intraepithelial lymphocyte lines from refractory celiac disease type II patients"],"prefix":"10.1016","volume":"58","author":[{"given":"Frederike","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.-L.","family":"Tjon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2013.10.014_bib0005","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/gut.2006.114512","article-title":"Survival in refractory coeliac disease and enteropathyassociated T-cell lymphoma: retrospective evaluation of single-centre experience","volume":"56","author":"Al-Toma","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2013.10.014_bib0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.cyto.2011.04.022","article-title":"Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10","volume":"55","author":"Antonelli","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2013.10.014_bib0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(00)02481-8","article-title":"Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma","volume":"356","author":"Cellier","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2013.10.014_bib0020","first-page":"A358","article-title":"Refractory sprue: histological and phenotypical features and outcome","volume":"114","author":"Cellier","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1182\/blood-2011-02-335216","article-title":"Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project","volume":"118","author":"Delabie","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2013.10.014_bib0030","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/icb.2012.79","article-title":"Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense","volume":"91","author":"Farache","year":"2013","journal-title":"Immunology and Cell Biology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jlb.61.3.246","article-title":"Mig and IP-10: CXC chemokines that target lymphocytes","volume":"61","author":"Farber","year":"1997","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0040","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Medical progress: celiac disease","volume":"357","author":"Green","year":"2007","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.molimm.2013.10.014_bib0045","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00296-012-2459-4","article-title":"Soluble CD163 serum levels are elevated and correlated with IL-12 and CXCL10 in patients with long-standing rheumatoid arthritis","volume":"33","author":"Jude","year":"2013","journal-title":"Rheumatology International"},{"key":"10.1016\/j.molimm.2013.10.014_bib0050","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/gut.34.2.208","article-title":"Numbers of T-cell receptor (Tcr) alpha-beta+ but not of tcr gamma-delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in celiac patients on a long-term normal diet","volume":"34","author":"Kutlu","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2013.10.014_bib0055","first-page":"310","article-title":"CXCR3 inflammation, and autoimmune diseases","volume":"1173","author":"Lacotte","year":"2009","journal-title":"Contemporary Challenges in Autoimmunity"},{"key":"10.1016\/j.molimm.2013.10.014_bib0060","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","article-title":"Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3","volume":"135","author":"Lammers","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0065","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1053\/j.gastro.2011.11.039","article-title":"Peyer's patch dendritic cells sample antigens by extending dendrites through M cell-specific transcellular pores","volume":"142","author":"Lelouard","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1084\/jem.178.1.187","article-title":"Gliadin-specific, Hla-Dq(alpha-1-asterisk-0501, beta-1-asterisk-0201) restricted T-cells isolated from the small-intestinal mucosa of celiac-disease patients","volume":"178","author":"Lundin","year":"1993","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.molimm.2013.10.014_bib0075","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/315672a0","article-title":"Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins","volume":"315","author":"Luster","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2013.10.014_bib0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.gastro.2008.09.069","article-title":"Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II","volume":"136","author":"Malamut","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0085","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1172\/JCI41344","article-title":"IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis","volume":"120","author":"Malamut","year":"2010","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.molimm.2013.10.014_bib0090","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0016-5085(03)01047-3","article-title":"Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease","volume":"125","author":"Mention","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0095","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1182\/blood.V93.10.3531.410k32_3531_3539","article-title":"Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15","volume":"93","author":"Musso","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2013.10.014_bib0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ibd.23034","article-title":"Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal toll-like receptor 3 stimulation","volume":"19","author":"Ostvik","year":"2013","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.molimm.2013.10.014_bib0105","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1053\/j.gastro.2006.06.002","article-title":"A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells","volume":"131","author":"Raki","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","article-title":"Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria","volume":"2","author":"Rescigno","year":"2001","journal-title":"Nature Immunology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0115","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/gutjnl-2012-302265","article-title":"Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II","volume":"62","author":"Schmitz","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2013.10.014_bib0120","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/ibd.21312","article-title":"Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease","volume":"16","author":"Schroepf","year":"2010","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.molimm.2013.10.014_bib0125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaut.2005.09.027","article-title":"Significance of serum CXCL10\/IP-10 level in type 1 diabetes","volume":"26","author":"Shigihara","year":"2006","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/j.molimm.2013.10.014_bib0130","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.4049\/jimmunol.1003382","article-title":"DNAM-1 mediates epithelial cell-specific cytotoxicity of aberrant intraepithelial lymphocyte lines from refractory celiac disease type II patients","volume":"186","author":"Tjon","year":"2011","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0135","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1182\/blood-2008-04-150748","article-title":"Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma","volume":"112","author":"Tjon","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2013.10.014_bib0140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clim.2007.09.002","article-title":"Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in refractory celiac disease","volume":"126","author":"Verbeek","year":"2008","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.molimm.2013.10.014_bib0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/cyto.b.20481","article-title":"Aberrant T-lymphocytes in refractory coeliac disease are not strictly confined to a small intestinal intraepithelial localization","volume":"76B","author":"Verbeek","year":"2009","journal-title":"Cytometry Part B \u2013 Clinical Cytometry"},{"key":"10.1016\/j.molimm.2013.10.014_bib0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.52.2.205","article-title":"Refractory coeliac sprue is a diffuse gastrointestinal disease","volume":"52","author":"Verkarre","year":"2003","journal-title":"Gut"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589013005403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589013005403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T03:10:48Z","timestamp":1596856248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589013005403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0161589013005403"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2013.10.014","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendritic cells promote expansion and survival of aberrant TCR-negative intraepithelial lymphocyte lines from refractory celiac disease type II patients","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2013.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}