{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:45:19Z","timestamp":1790844319310,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.molimm.2014.12.013","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T20:30:36Z","timestamp":1423859436000},"page":"189-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment"],"prefix":"10.1016","volume":"65","author":[{"given":"Md. Anayet","family":"Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Arif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Habibul Hasan","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Uzzal","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.molimm.2014.12.013_bib0330","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1110\/ps.062405906","article-title":"Prediction of residues in discontinuous B-cell epitopes using protein 3D structures","volume":"15","author":"Andersen","year":"2006","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0200","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2014.12.013_bib0445","first-page":"33","article-title":"A novel approach to vaccine design\u2014epitope-based vaccines","volume":"273","author":"Arnon","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.molimm.2014.12.013_bib0190","doi-asserted-by":"crossref","first-page":"120139","DOI":"10.1098\/rsob.120139","article-title":"T-cell epitope vaccine design by immunoinformatics","volume":"3","author":"Atanas","year":"2013","journal-title":"Open Biol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0105","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1128\/JVI.65.3.1496-1506.1991","article-title":"Solubilization and immunoprecipitation of alphavirus replication complexes","volume":"65","author":"Barton","year":"1991","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0380","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/prot.21715","article-title":"QMEAN, a comprehensive scoring function for model quality assessment","volume":"71","author":"Benkert","year":"1998","journal-title":"Proteins Struct. Funct. Bioinform."},{"issue":"9","key":"10.1016\/j.molimm.2014.12.013_bib0515","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1472-6807-9-35","article-title":"QMEANclust: estimation of protein model quality by combining a composite scoring function with structural density information","volume":"20","author":"Benkert","year":"2009","journal-title":"BMC Struct. Biol."},{"issue":"37","key":"10.1016\/j.molimm.2014.12.013_bib0520","doi-asserted-by":"crossref","first-page":"W510","DOI":"10.1093\/nar\/gkp322","article-title":"QMEAN server for protein model quality estimation","volume":"1","author":"Benkert","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.molimm.2014.12.013_bib0505","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/bioinformatics\/btq662","article-title":"Toward the estimation of the absolute quality of individual protein structure models","volume":"27","author":"Benkert","year":"2011","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0290","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"5016","key":"10.1016\/j.molimm.2014.12.013_bib0500","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1126\/science.1853201","article-title":"A method to identify protein sequences that fold into a known three-dimensional structure","volume":"253","author":"Bowie","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.molimm.2014.12.013_bib0055","first-page":"217","article-title":"Chloroquine phosphate treatment of chronic Chikungunya arthritis: an open pilot study","volume":"66","author":"Brighton","year":"1984","journal-title":"S. Afr. Med. J."},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0255","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/1471-2105-8-361","article-title":"Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines","volume":"8","author":"Bui","year":"2007","journal-title":"BMC Bioinform."},{"issue":"9816","key":"10.1016\/j.molimm.2014.12.013_bib0065","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(11)60281-X","article-title":"Chikungunya: a re-emerging virus","volume":"379","author":"Burt","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.molimm.2014.12.013_bib0240","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1034\/j.1399-0039.2003.00112.x","article-title":"Sensitive quantitative predictions of peptide-MHC binding by a \u2018Query by Committee\u2019 artificial neural network approach","volume":"62","author":"Buus","year":"2003","journal-title":"Tissue Antigens"},{"issue":"3","key":"10.1016\/j.molimm.2014.12.013_bib0015","first-page":"211","article-title":"Chikungunya virus infection: an overview","volume":"36","author":"Caglioti","year":"2013","journal-title":"New Microbiol."},{"issue":"5\u20136","key":"10.1016\/j.molimm.2014.12.013_bib0455","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3233\/ISB-2010-0435","article-title":"A computational approach for identification of epitopes in dengue virus envelope protein: a step towards designing a universal dengue vaccine targeting endemic regions","volume":"10","author":"Chakraborty","year":"2010","journal-title":"In Silico Biol."},{"issue":"11","key":"10.1016\/j.molimm.2014.12.013_bib0410","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci300367a","article-title":"admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties","volume":"52","author":"Cheng","year":"2012","journal-title":"J. Chem. Inform. Model."},{"key":"10.1016\/j.molimm.2014.12.013_bib0340","first-page":"45","article-title":"Prediction of the secondary structure of proteins from their amino acid sequence","volume":"47","author":"Chou","year":"1978","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0210","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"issue":"9","key":"10.1016\/j.molimm.2014.12.013_bib0370","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures, patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"key":"10.1016\/j.molimm.2014.12.013_bib0145","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.ppat.0040029","article-title":"A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease","volume":"4","author":"Couderc","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2014.12.013_bib0180","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1086\/600381","article-title":"Prophylaxis and therapy for Chikungunya virus infection","volume":"200","author":"Couderc","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0420","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1586\/14760584.3.1.59","article-title":"Genome-derived vaccines","volume":"3","author":"De Groot","year":"2004","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.molimm.2014.12.013_bib0350","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.bpj.2011.10.024","article-title":"Improving the physical realism and structural accuracy of protein models by a two-step atomic-level energy minimization","volume":"101","author":"Dong","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.molimm.2014.12.013_bib0205","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.molimm.2014.12.013_bib0385","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/nar\/gkl282","article-title":"CASTp, computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues","volume":"34","author":"Dundas","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2014.12.013_bib0375","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0076-6879(97)77022-8","article-title":"VERIFY3D, assessment of protein models with three-dimensional profiles","volume":"277","author":"Eisenberg","year":"1997","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.molimm.2014.12.013_bib0320","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0060","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1126\/science.311.5764.1085a","article-title":"Infectious diseases: massive outbreak draws fresh attention to little-known virus","volume":"311","author":"Enesrink","year":"2006","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0430","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2006.02.010","article-title":"Emerging and re-emerging infectious diseases: influenza as a prototype of the host\u2013pathogen balancing act","volume":"124","author":"Fauci","year":"2006","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.molimm.2014.12.013_bib0305","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.1073\/pnas.84.23.8568","article-title":"Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein \u03b1-helix","volume":"84","author":"Fieser","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2014.12.013_bib0175","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya virus arthritis in adult wild-type mice","volume":"84","author":"Gardner","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0170","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virol.2011.12.020","article-title":"Interferon-alpha\/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type Chikungunya virus but not with the cell culture-adapted live-attenuated 181\/25 vaccine candidate","volume":"425","author":"Gardner","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.molimm.2014.12.013_bib0490","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy Server","author":"Gasteiger","year":"2005"},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0215","first-page":"681","article-title":"SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Comput. Appl. Biosci."},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0495","first-page":"681","article-title":"SOPMA, significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Comput. Appl. Biosci."},{"issue":"2","key":"10.1016\/j.molimm.2014.12.013_bib0220","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0003-2697(89)90602-7","article-title":"Calculation of protein extinction coefficients from amino acid sequence data","volume":"182","author":"Gill","year":"1989","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molimm.2014.12.013_bib0095","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1128\/JVI.63.12.5216-5227.1989","article-title":"Cis-acting mutation in the Sindbis virus junction region which affects subgenomicrna-synthesis","volume":"63","author":"Grakoui","year":"1989","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.molimm.2014.12.013_bib0080","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3201\/eid1705.101873","article-title":"Chikungunya virus, southeastern France","volume":"17","author":"Grandadam","year":"2011","journal-title":"Emerg. Infect. Dis."},{"issue":"28","key":"10.1016\/j.molimm.2014.12.013_bib0295","doi-asserted-by":"crossref","first-page":"12599","DOI":"10.1073\/pnas.1007270107","article-title":"Cross reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1 N1-1918 influenza A viruses","volume":"107","author":"Gras","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2014.12.013_bib0355","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer, an environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"issue":"2","key":"10.1016\/j.molimm.2014.12.013_bib0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/protein\/4.2.155","article-title":"Correlation between stability of a protein and its dipeptide composition, a novel approach for predicting in vivo stability of a protein from its primary sequence","volume":"4","author":"Guruprasad","year":"1990","journal-title":"Protein Eng."},{"key":"10.1016\/j.molimm.2014.12.013_bib0470","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4137\/BBI.S13402","article-title":"A computational assay to design an epitope-based peptide vaccine against Saint Louis encephalitis virus","volume":"7","author":"Hasan","year":"2013","journal-title":"Bioinform. Biol. Insights"},{"issue":"8","key":"10.1016\/j.molimm.2014.12.013_bib0510","first-page":"1","article-title":"In silico molecular characterization of cysteine protease YopT from Yersinia pestis by homology modeling and binding site identification","volume":"13","author":"Hasan","year":"2014","journal-title":"Drug Target Insights"},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0530","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5808\/GI.2014.12.4.268","article-title":"Molecular characterization of legionellosis drug target candidate enzyme phosphoglucosamine mutase from Legionella pneumophila (strain Paris): an in silico approach","volume":"12","author":"Hasan","year":"2014","journal-title":"Genomics Inform."},{"key":"10.1016\/j.molimm.2014.12.013_bib0160","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.4049\/jimmunol.0904181","article-title":"Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response","volume":"184","author":"Her","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0465","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1743-422X-10-113","article-title":"Structural analysis and epitope prediction of HCV E1 protein isolated in Pakistan: an in-silico approach","volume":"10","author":"Idrees","year":"2013","journal-title":"Virol. J."},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0230","first-page":"1895","article-title":"Thermostability and aliphatic index of globular proteins","volume":"88","author":"Ikai","year":"1980","journal-title":"J. Biochem."},{"key":"10.1016\/j.molimm.2014.12.013_bib0185","series-title":"Immunobiology","author":"Janeway","year":"2001"},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0405","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.taap.2007.12.037","article-title":"ACToR\u2014aggregated computational toxicology resource","volume":"233","author":"Judson","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0310","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","article-title":"Prediction of chain flexibility in proteins","volume":"72","author":"Karplus","year":"1985","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.molimm.2014.12.013_bib0345","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","article-title":"Protein structure prediction on the web: a case study using the Phyre server","volume":"4","author":"Kelley","year":"2009","journal-title":"Nat. Protoc."},{"issue":"10","key":"10.1016\/j.molimm.2014.12.013_bib0475","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1128\/JVI.63.10.4311-4316.1989","article-title":"Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection","volume":"63","author":"Klavinskis","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0030","first-page":"91","article-title":"Global distribution and continuing spread of Aedes albopictus","volume":"37","author":"Knudsen","year":"1995","journal-title":"Parassitologia"},{"issue":"1\u20132","key":"10.1016\/j.molimm.2014.12.013_bib0315","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of anti-genic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0425","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1371\/journal.pcbi.0020071","article-title":"Immunoinformatics comes of age","volume":"2","author":"Korber","year":"2006","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0130","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1099\/vir.0.83628-0","article-title":"A226V mutation in virus during the 2007 Chikungunya outbreak in Kerala, India","volume":"89","author":"Kumar","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0155","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI40104","article-title":"Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages","volume":"120","author":"Labadie","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0020","first-page":"151","article-title":"Emergence of Chikungunya virus in Indian subcontinent after 32 years: a review","volume":"43","author":"Lahariya","year":"2006","journal-title":"J. Vector Borne Dis."},{"issue":"2","key":"10.1016\/j.molimm.2014.12.013_bib0450","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jmb.2008.10.089","article-title":"In silico vaccine design based on molecular simulations of rhinovirus chimeras presenting HIV-1 gp41 epitopes","volume":"385","author":"Lapelosa","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0235","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2105-8-424","article-title":"Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction","volume":"8","author":"Larsen","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.molimm.2014.12.013_bib0360","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR, programs for checking the quality of protein structures solved by NMR","volume":"8","author":"Laskowski","year":"1996","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.molimm.2014.12.013_bib0140","first-page":"61185","article-title":"Safety and tolerability of Chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial","volume":"14","author":"Lee-Jah","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2014.12.013_bib0090","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(14)60185-9","article-title":"Chikungunya in the Americas","volume":"383","author":"Leparc-Goffart","year":"2014","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0260","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1089\/106652703322756113","article-title":"Combining pairwise sequence similarity and support vector machines for detecting remote protein evolutionary and structural relationships","volume":"10","author":"Liao","year":"2003","journal-title":"J. Comput. Biol."},{"issue":"7","key":"10.1016\/j.molimm.2014.12.013_bib0415","first-page":"556","article-title":"Developing countries face double burden of disease","volume":"82","author":"Marshall","year":"2004","journal-title":"Bull. World Health Organ."},{"issue":"Web Server issue","key":"10.1016\/j.molimm.2014.12.013_bib0275","doi-asserted-by":"crossref","first-page":"W498","DOI":"10.1093\/nar\/gkp323","article-title":"PEP-FOLD: an online resource for de novo peptide structure prediction","volume":"37","author":"Maupetit","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2014.12.013_bib0280","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/jcc.21365","article-title":"A fast and accurate method for large-scale de novo peptide structure prediction","volume":"31","author":"Maupetit","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0265","doi-asserted-by":"crossref","first-page":"e5861","DOI":"10.1371\/journal.pone.0005861","article-title":"AllerHunter: a SVM-pairwise system for assessment of allergenicity and allergic cross-reactivity in proteins","volume":"4","author":"Muh","year":"2009","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.molimm.2014.12.013_bib0025","doi-asserted-by":"crossref","first-page":"e1003172","DOI":"10.1371\/journal.ppat.1003172","article-title":"Random codon re-encoding induces stable reduction of replicative fitness of Chikungunya virus in primate and mosquito cells","volume":"9","author":"Nougairede","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2014.12.013_bib0125","doi-asserted-by":"crossref","first-page":"21899","DOI":"10.1074\/jbc.M802444200","article-title":"Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein","volume":"283","author":"Ozden","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2014.12.013_bib0050","first-page":"2","article-title":"Chikungunya outbreak in reunion: epidemiology and surveillance","volume":"11","author":"Paquet","year":"2006","journal-title":"Euro Surveill."},{"issue":"19","key":"10.1016\/j.molimm.2014.12.013_bib0325","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","article-title":"New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites","volume":"25","author":"Parker","year":"1986","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0390","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10822-014-9709-3","article-title":"Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge","volume":"28","author":"Perryman","year":"2014","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.molimm.2014.12.013_bib0245","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2105-6-132","article-title":"Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method","volume":"6","author":"Peters","year":"2005","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.molimm.2014.12.013_bib0085","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tmaid.2008.10.001","article-title":"An imported case of Chikungunya fever from Madagascar: use of the sentinel traveller for detecting emerging arboviral infections in tropical and European countries","volume":"7","author":"Pistonet","year":"2009","journal-title":"Travel Med. Infect. Dis."},{"issue":"9","key":"10.1016\/j.molimm.2014.12.013_bib0010","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1099\/vir.0.82858-0","article-title":"Changing patterns of Chikungunya virus: re-emergence of a zoonotic arbovirus","volume":"88","author":"Powers","year":"2007","journal-title":"J. Gen. Virol."},{"issue":"5","key":"10.1016\/j.molimm.2014.12.013_bib0435","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrd2224","article-title":"More than one reason to rethink the use of peptides in vaccine design","volume":"6","author":"Purcell","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0485","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1473-3099(07)70294-3","article-title":"Clinical burden of Chikungunya virus infection","volume":"8","author":"Queyriaux","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molimm.2014.12.013_bib0365","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-2836(63)80023-6","article-title":"Stereochemistry of polypeptide chain configurations","volume":"7","author":"Ramachandran","year":"1963","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jmgm.2013.07.001","article-title":"Structure based design towards the identification of novel binding sites and inhibitors for the Chikungunya virus envelope proteins","volume":"44","author":"Rashad","year":"2013","journal-title":"J. Mol. Graph. Modell."},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0100","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/jm400460d","article-title":"Chikungunya virus: emerging targets and new opportunities for medicinal chemistry","volume":"57","author":"Rashad","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.molimm.2014.12.013_bib0075","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0140-6736(07)61779-6","article-title":"Infection with Chikungunya virus in Italy: an outbreak in a temperate region","volume":"370","author":"Rezza","year":"2007","journal-title":"Lancet"},{"issue":"5047","key":"10.1016\/j.molimm.2014.12.013_bib0335","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1546293","article-title":"Structural evidence for induced fit as a mechanism for antibody\u2013antigen recognition","volume":"255","author":"Rini","year":"1992","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.molimm.2014.12.013_bib0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0035-9203(55)90080-8","article-title":"An epidemic of virus disease in southern province, Tanganyika territory, in 1952\u201353","volume":"49","author":"Robinson","year":"1955","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.molimm.2014.12.013_bib0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1084\/jem.20090851","article-title":"Type I IFN controls Chikungunya virus via its action on nonhematopoietic cells","volume":"207","author":"Schilte","year":"2010","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.molimm.2014.12.013_bib0040","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1371\/journal.pmed.0030263","article-title":"Genome microevolution of Chikungunya viruses causing the Indian Ocean outbreak","volume":"3","author":"Schuffenecker","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.molimm.2014.12.013_bib0525","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.molimm.2014.12.013_bib0460","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-15-161","article-title":"A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design","volume":"15","author":"Sharmin","year":"2014","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.molimm.2014.12.013_bib0110","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1128\/JVI.68.3.1874-1885.1994","article-title":"Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis","volume":"68","author":"Shirako","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0115","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1462-5822.2012.01825.x","article-title":"The cell biology of Chikungunya virus infection","volume":"14","author":"Tang","year":"2012","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.molimm.2014.12.013_bib0250","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00018-005-4528-2","article-title":"Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding","volume":"62","author":"Tenzer","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"D1","key":"10.1016\/j.molimm.2014.12.013_bib0195","doi-asserted-by":"crossref","first-page":"D191","DOI":"10.1093\/nar\/gkt1140","article-title":"Activities at the Universal Protein Resource (UniProt)","volume":"42","author":"The UniProt Consortium","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2014.12.013_bib0270","doi-asserted-by":"crossref","first-page":"W288","DOI":"10.1093\/nar\/gks419","article-title":"PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides","volume":"40","author":"Thevenet","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0005","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1371\/journal.pntd.0000623","article-title":"Chikungunya: a potentially emerging epidemic?","volume":"4","author":"Thiboutot","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"2","key":"10.1016\/j.molimm.2014.12.013_bib0480","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.virol.2006.10.033","article-title":"Mutation analysis of the fusion domain region of St. Louis encephalitis virus envelope protein","volume":"360","author":"Trainor","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.molimm.2014.12.013_bib0285","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDockVina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"4","key":"10.1016\/j.molimm.2014.12.013_bib0300","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.chb.2004.10.039","article-title":"Co-Lab: research and development of an online learning environment for collaborative scientific discovery learning","volume":"21","author":"Van Joolingen","year":"2005","journal-title":"Comput. Hum. Behav."},{"issue":"5","key":"10.1016\/j.molimm.2014.12.013_bib0035","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4269\/ajtmh.2005.72.616","article-title":"Differential infectivities of o\u2019nyong-nyong and Chikungunya virus isolates in Anopheles gambiae and Aedesaegypti mosquitoes","volume":"72","author":"Vanlandingham","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"6","key":"10.1016\/j.molimm.2014.12.013_bib0440","doi-asserted-by":"crossref","first-page":"e2921","DOI":"10.1371\/journal.pntd.0002921","article-title":"Arrival of Chikungunya virus in the new world: prospects for spread and impact on public health","volume":"8","author":"Weaver","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2014.12.013_bib0135","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1586\/erv.12.84","article-title":"Chikungunya virus and prospects for a vaccine","volume":"11","author":"Weaver","year":"2012","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.molimm.2014.12.013_bib0165","doi-asserted-by":"crossref","first-page":"e1002322","DOI":"10.1371\/journal.ppat.1002322","article-title":"ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation","volume":"7","author":"Werneke","year":"2011","journal-title":"PLoS Pathog."},{"issue":"11","key":"10.1016\/j.molimm.2014.12.013_bib0400","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1021\/ol4010118","article-title":"Iron-catalyzed direct synthesis of imines from amines or alcohols and amines via aerobic oxidative reactions under air","volume":"15","author":"Zhang","year":"2013","journal-title":"Org. Lett."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589014003551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589014003551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T02:10:22Z","timestamp":1717726222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589014003551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":104,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0161589014003551"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2014.12.013","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2014.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}