{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:00:28Z","timestamp":1791838828284,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.molimm.2015.03.005","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T17:05:42Z","timestamp":1431191142000},"page":"51-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Paroxysmal nocturnal hemoglobinuria (PNH) and primary p.Cys89Tyr mutation in CD59: Differences and similarities"],"prefix":"10.1016","volume":"67","author":[{"given":"Dror","family":"Mevorach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2015.03.005_bib0005","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1160\/TH07-11-0691","article-title":"Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells","volume":"100","author":"Aharon","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.molimm.2015.03.005_bib0015","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood-2007-06-094136","article-title":"Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria","volume":"111","author":"Brodsky","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0020","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archneur.1980.00500590061010","article-title":"Immunoglobulin and complement deposits in nerves of patients with chronic relapsing polyneuropathy","volume":"37","author":"Dalakas","year":"1980","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0025","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.170.3.637","article-title":"CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells","volume":"170","author":"Davies","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2015.03.005_bib0030","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1182\/blood-2008-01-133918","article-title":"Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories","volume":"112","author":"de Latour","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1172\/JCI112773","article-title":"Interactions of the platelets in paroxysmal nocturnal hemoglobinuria with complement. Relationship to defects in the regulation of complement and to platelet survival in vivo","volume":"79","author":"Devine","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2015.03.005_bib0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/09537105310001657110","article-title":"The platelet function defect of paroxysmal nocturnal haemoglobinuria","volume":"15","author":"Grunewald","year":"2004","journal-title":"Platelets"},{"key":"10.1016\/j.molimm.2015.03.005_bib0045","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/00001721-200310000-00011","article-title":"Plasmatic coagulation and fibrinolytic system alterations in PNH: relation to clone size","volume":"14","author":"Grunewald","year":"2003","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1016\/j.molimm.2015.03.005_bib0050","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.1147103","article-title":"Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense","volume":"317","author":"Hadders","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.molimm.2015.03.005_bib0055","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1182\/blood-2003-01-0009","article-title":"Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria (PNH)","volume":"102","author":"Hall","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0060","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0171-2985(83)80003-5","article-title":"Lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by acid-activated serum","volume":"164","author":"Hansch","year":"1983","journal-title":"Immunobiology"},{"key":"10.1016\/j.molimm.2015.03.005_bib0065","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJM199511093331904","article-title":"Natural history of paroxysmal nocturnal hemoglobinuria","volume":"333","author":"Hillmen","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2015.03.005_bib0070","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1182\/blood-2007-06-095646","article-title":"Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria","volume":"110","author":"Hillmen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0075","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa061648","article-title":"The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria","volume":"355","author":"Hillmen","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2015.03.005_bib0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI114172","article-title":"Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria","volume":"84","author":"Holguin","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2015.03.005_bib0085","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1172\/JCI114311","article-title":"Relationship between the membrane inhibitor of reactive lysis and the erythrocyte phenotypes of paroxysmal nocturnal hemoglobinuria","volume":"84","author":"Holguin","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2015.03.005_bib0090","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1182\/blood.V98.2.442","article-title":"Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria","volume":"98","author":"Holt","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0095","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1182\/blood.V93.10.3451.410k27_3451_3456","article-title":"Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia","volume":"93","author":"Hugel","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0100","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1182\/blood-2006-05-025148","article-title":"Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)","volume":"108","author":"Inoue","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0105","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s002770100350","article-title":"Abnormal platelet adhesion on abdominal vessels in asymptomatic patients with paroxysmal nocturnal hemoglobinuria","volume":"80","author":"Louwes","year":"2001","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0110","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q","article-title":"Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination","volume":"47","author":"Lucchinetti","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0115","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0049-3848(96)00153-3","article-title":"Analysis of the expression of glycosylphosphatidylinositol anchored proteins on platelets from patients with paroxysmal nocturnal hemoglobinuria","volume":"83","author":"Maciejewski","year":"1996","journal-title":"Thromb. Res."},{"key":"10.1016\/j.molimm.2015.03.005_bib0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/labinvest.3700015","article-title":"Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis","volume":"84","author":"Mead","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.molimm.2015.03.005_bib0125","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1073\/pnas.82.9.2980","article-title":"Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor","volume":"82","author":"Medof","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2015.03.005_bib0130","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1365-2141.1989.tb00260.x","article-title":"Studies on the sensitivity to complement-mediated lysis of erythrocytes (Inab phenotype) with a deficiency of DAF (decay accelerating factor)","volume":"73","author":"Merry","year":"1989","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0135","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.7680492","article-title":"The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis","volume":"259","author":"Miyata","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.molimm.2015.03.005_bib0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2141.2004.04992.x","article-title":"Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays","volume":"126","author":"Moyo","year":"2004","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1182\/blood-2012-07-441857","article-title":"CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy","volume":"121","author":"Nevo","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/intimm\/1.2.205","article-title":"A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement","volume":"1","author":"Okada","year":"1989","journal-title":"Int. Immunol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0155","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/CIRCRESAHA.110.233056","article-title":"Microparticles in hemostasis and thrombosis","volume":"108","author":"Owens","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.molimm.2015.03.005_bib0160","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1160\/TH07-04-0316","article-title":"Stroke in paroxysmal nocturnal haemoglobinuria: patterns of disease and outcome","volume":"98","author":"Poulou","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.molimm.2015.03.005_bib0165","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0609.2011.01615.x","article-title":"Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia","volume":"87","author":"Pu","year":"2011","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0170","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","article-title":"The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease","volume":"293","author":"Rother","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.molimm.2015.03.005_bib0175","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3324\/haematol.2009.017889","article-title":"Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine","volume":"95","author":"Scheinberg","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.molimm.2015.03.005_bib0180","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2141.2004.04974.x","article-title":"Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria","volume":"125","author":"Simak","year":"2004","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.molimm.2015.03.005_bib0185","doi-asserted-by":"crossref","first-page":"19228","DOI":"10.1016\/S0021-9258(19)47291-8","article-title":"Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex","volume":"264","author":"Sims","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2015.03.005_bib0190","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0167-5699(91)90012-I","article-title":"The response of human platelets to activated components of the complement system","volume":"12","author":"Sims","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/j.molimm.2015.03.005_bib0195","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/oxfordjournals.jbchem.a122524","article-title":"Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels","volume":"104","author":"Sugita","year":"1988","journal-title":"J. Biochem."},{"key":"10.1016\/j.molimm.2015.03.005_bib0200","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0092-8674(93)90250-T","article-title":"Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria","volume":"73","author":"Takeda","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2015.03.005_bib0205","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1084\/jem.185.9.1619","article-title":"The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity","volume":"185","author":"Tedesco","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2015.03.005_bib0210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1182\/blood.V74.1.437.437","article-title":"The Inab phenotype: characterization of the membrane protein and complement regulatory defect","volume":"74","author":"Telen","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0215","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1084\/jem.167.6.1993","article-title":"Identification of human erythrocyte blood group antigens on decay-accelerating factor (DAF) and an erythrocyte phenotype negative for DAF","volume":"167","author":"Telen","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2015.03.005_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1538-7836.2011.04562.x","article-title":"Mechanisms and clinical implications of thrombosis in paroxysmal nocturnal hemoglobinuria","volume":"10","author":"Van Bijnen","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.molimm.2015.03.005_bib0225","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1182\/blood.V98.6.1802","article-title":"Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase","volume":"98","author":"Wagener","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0230","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/brain\/awg207","article-title":"Distinct time pattern of complement activation and cytotoxic T cell response in Guillain-Barre syndrome","volume":"126","author":"Wanschitz","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.molimm.2015.03.005_bib0235","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V82.4.1192.1192","article-title":"Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria","volume":"82","author":"Wiedmer","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0240","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1182\/blood.V78.3.820.820","article-title":"Molecular basis of the enhanced susceptibility of the erythrocytes of paroxysmal nocturnal hemoglobinuria to hemolysis in acidified serum","volume":"78","author":"Wilcox","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2015.03.005_bib0245","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1538-7836.2007.02379.x","article-title":"Thrombosis in paroxysmal nocturnal hemoglobinuria: sites, risks, outcome. An overview","volume":"5","author":"Ziakas","year":"2007","journal-title":"J. Thromb. Haemost."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589015001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589015001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T19:06:40Z","timestamp":1651950400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589015001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0161589015001030"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2015.03.005","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paroxysmal nocturnal hemoglobinuria (PNH) and primary p.Cys89Tyr mutation in CD59: Differences and similarities","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2015.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}