{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:35:29Z","timestamp":1788896129585,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,3]],"date-time":"2016-12-03T00:00:00Z","timestamp":1480723200000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005621","name":"Kasetsart University Research and Development Institute (KURDI), Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"NRCT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004532","name":"Japan International Cooperation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["MRG-WI545S009"],"award-info":[{"award-number":["MRG-WI545S009"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.molimm.2015.09.012","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T09:37:38Z","timestamp":1445852258000},"page":"585-596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"PC","title":["Molecular characterization of Galectin-8 from Nile tilapia (Oreochromis niloticus Linn.) and its response to bacterial infection"],"prefix":"10.1016","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3242-3978","authenticated-orcid":false,"given":"Sasimanas","family":"Unajak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutthida","family":"Pholmanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napat","family":"Songtawee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornsorn","family":"Srikulnath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapansak","family":"Srisapoome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asama","family":"Kiataramkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Hirono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontawith","family":"Areechon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2015.09.012_bib0005","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature10390","article-title":"The genome of the green anole lizard and a comparative analysis with birds and mammals","volume":"7366","author":"Alfoldi","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.molimm.2015.09.012_bib0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.molimm.2015.09.012_bib0015","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00726-010-0574-7","article-title":"Purification, characterization, structural analysis and protein chemistry of a buffalo heart galectin-1","volume":"39","author":"Ashraf","year":"2010","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.molimm.2015.09.012_bib0020","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(94)90498-7","article-title":"Galectins: a family of animal beta-galactoside-binding lectins","volume":"76","author":"Barondes","year":"1994","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molimm.2015.09.012_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2008.197","article-title":"Protein structure homology modeling using SWISS-MODEL workspace","volume":"4","author":"Bordoli","year":"2008","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.molimm.2015.09.012_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/glycob\/cwm026","article-title":"Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface","volume":"17","author":"Carlsson","year":"2007","journal-title":"Glycobiology"},{"issue":"1","key":"10.1016\/j.molimm.2015.09.012_bib0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/BJ20101691","article-title":"Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation","volume":"434","author":"Cattaneo","year":"2011","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.molimm.2015.09.012_bib0040","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.dci.2012.10.008","article-title":"The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis","volume":"39","author":"Chen","year":"2013","journal-title":"Dev. Comp. Immunol."},{"issue":"2\u20133","key":"10.1016\/j.molimm.2015.09.012_bib0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0304-4165(02)00310-0","article-title":"Galectinomics: finding themes in complexity","volume":"1572","author":"Cooper","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.molimm.2015.09.012_bib0050","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/glycob\/9.10.979","article-title":"God must love galectins; he made so many of them","volume":"9","author":"Cooper","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.molimm.2015.09.012_bib0055","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0076-6879(97)77022-8","article-title":"VERIFY3D: assessment of protein models with three-dimensional profiles","volume":"277","author":"Eisenberg","year":"1997","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.molimm.2015.09.012_bib0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0378-1135(94)00052-X","article-title":"Experimental streptococcal meningo-encephalitis in cultured fish","volume":"43","author":"Eldar","year":"1995","journal-title":"Vet. Microbiol."},{"issue":"3","key":"10.1016\/j.molimm.2015.09.012_bib0065","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1128\/jcm.28.3.628-630.1990","article-title":"Whole-cell protein patterns of nonhemolytic group B, type Ib, streptococci isolated from humans, mice, cattle, frogs, and fish","volume":"28","author":"Elliott","year":"1990","journal-title":"J. Clin. Microbiol."},{"issue":"13","key":"10.1016\/j.molimm.2015.09.012_bib0070","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00018-007-7044-8","article-title":"Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival","volume":"64","author":"Elola","year":"2007","journal-title":"Cell Mol. Life Sci."},{"issue":"Pt 13","key":"10.1016\/j.molimm.2015.09.012_bib0075","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1242\/jcs.113.13.2385","article-title":"Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis","volume":"113","author":"Hadari","year":"2000","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.molimm.2015.09.012_bib0080","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1074\/jbc.270.7.3447","article-title":"Galectin-8. A new rat lectin, related to galectin-4","volume":"270","author":"Hadari","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.molimm.2015.09.012_bib0085","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2761.2008.00981.x","article-title":"Streptococcosis on a red tilapia, Oreochromis sp., farm: a case study","volume":"32","author":"Hernandez","year":"2009","journal-title":"J. Fish Dis."},{"issue":"4","key":"10.1016\/j.molimm.2015.09.012_bib0090","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/glycob\/3.4.297","article-title":"The family of metazoan metal-independent beta-galactoside-binding lectins: structure, function and molecular evolution","volume":"3","author":"Hirabayashi","year":"1993","journal-title":"Glycobiology"},{"issue":"7","key":"10.1016\/j.molimm.2015.09.012_bib0095","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/molbev\/msh082","article-title":"Phylogenetic analysis of the vertebrate galectin family","volume":"21","author":"Houzelstein","year":"2004","journal-title":"Mol. Biol. Evol."},{"issue":"2","key":"10.1016\/j.molimm.2015.09.012_bib0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrmicro3160","article-title":"Bacteria-autophagy interplay: a battle for survival","volume":"12","author":"Huang","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.molimm.2015.09.012_bib0105","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jcc.20634","article-title":"A semiempirical free energy force field with charge-based desolvation","volume":"28","author":"Huey","year":"2007","journal-title":"J. Comput. Chem."},{"issue":"3","key":"10.1016\/j.molimm.2015.09.012_bib0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/fsim.2000.0307","article-title":"Cloning and characterisation of tandem-repeat type galectin in rainbow trout (Oncorhynchus mykiss)","volume":"11","author":"Inagawa","year":"2001","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.molimm.2015.09.012_bib0115","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jcc.20820","article-title":"GLYCAM06: a generalizable biomolecular force field. Carbohydrates","volume":"29","author":"Kirschner","year":"2008","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.molimm.2015.09.012_bib0120","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.fsi.2012.02.003","article-title":"Molecular characterization of a tandem-repeat galectin-9 (RuGlec9) from Korean rose bitterling (Rhodeus uyekii)","volume":"32","author":"Kong","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.molimm.2015.09.012_bib0125","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1590\/1414-431X20143890","article-title":"Increased immunoglobulin production in silver catfish (Rhamdia quelen) exposed to agrichemicals","volume":"47","author":"Kreutz","year":"2014","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2","key":"10.1016\/j.molimm.2015.09.012_bib0130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"issue":"6","key":"10.1016\/j.molimm.2015.09.012_bib0135","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.fsi.2013.03.354","article-title":"Anti-viral activity of galectin-1 from flounder Paralichthys olivaceus","volume":"34","author":"Liu","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"6364","key":"10.1016\/j.molimm.2015.09.012_bib0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/356083a0","article-title":"Assessment of protein models with three-dimensional profiles","volume":"356","author":"Luthy","year":"1992","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.molimm.2015.09.012_bib0145","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.vetmic.2008.10.016","article-title":"Aspects of the natural history and virulence of S. agalactiae infection in Nile tilapia","volume":"136","author":"Mian","year":"2009","journal-title":"Vet. Microbiol."},{"issue":"16","key":"10.1016\/j.molimm.2015.09.012_bib0150","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.molimm.2015.09.012_bib0155","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.fsi.2005.06.004","article-title":"Opsonic effect of congerin, a mucosal galectin of the Japanese conger, Conger myriaster (Brevoort)","volume":"20","author":"Nakamura","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"19","key":"10.1016\/j.molimm.2015.09.012_bib0160","doi-asserted-by":"crossref","first-page":"12670","DOI":"10.1074\/jbc.M808949200","article-title":"Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1\/2 activation supported by protein kinase A down-regulation","volume":"284","author":"Norambuena","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.molimm.2015.09.012_bib0165","doi-asserted-by":"crossref","first-page":"8040","DOI":"10.1128\/JVI.76.16.8040-8049.2002","article-title":"Survey of transcript expression in rainbow trout leukocytes reveals a major contribution of interferon-responsive genes in the early response to a rhabdovirus infection","volume":"76","author":"O'Farrell","year":"2002","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.molimm.2015.09.012_bib0170","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.4049\/jimmunol.0801726","article-title":"Nodavirus infection of sea bass (Dicentrarchus labrax) induces up-regulation of galectin-1 expression with potential anti-inflammatory activity","volume":"183","author":"Poisa-Beiro","year":"2009","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2015.09.012_bib0175","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nri2536","article-title":"Turning \u2018sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation","volume":"9","author":"Rabinovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2015.09.012_bib0180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.dci.2013.02.002","article-title":"Localization and functional properties of two galectin-1 proteins in Atlantic cod (Gadus morhua) mucosal tissues","volume":"40","author":"Rajan","year":"2013","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2015.09.012_bib0185","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/prot.22879","article-title":"Automated minimization of steric clashes in protein structures","volume":"79","author":"Ramachandran","year":"2011","journal-title":"Proteins: Struct. Func. Bioinform."},{"issue":"13","key":"10.1016\/j.molimm.2015.09.012_bib0190","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL: an automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.molimm.2015.09.012_bib0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000230005","article-title":"Karyological characterization of the butterfly lizard (Leiolepis reevesii rubritaeniata, Agamidae, Squamata) by molecular cytogenetic approach","volume":"125","author":"Srikulnath","year":"2009","journal-title":"Cytogenet Genome Res"},{"issue":"2","key":"10.1016\/j.molimm.2015.09.012_bib0200","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1189\/jlb.4RI0214-090R","article-title":"Intracellular immunity: finding the enemy within\u2014how cells recognize and respond to intracellular pathogens","volume":"96","author":"Tam","year":"2014","journal-title":"J. Leukoc. Biol."},{"issue":"7385","key":"10.1016\/j.molimm.2015.09.012_bib0205","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature10744","article-title":"Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion","volume":"482","author":"Thurston","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.molimm.2015.09.012_bib0210","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1189\/jlb.0908529","article-title":"Galectin-8 provides costimulatory and proliferative signals to T lymphocytes","volume":"86","author":"Tribulatti","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"12","key":"10.1016\/j.molimm.2015.09.012_bib0215","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/glycob\/cwm104","article-title":"Galectin-8 induces apoptosis in the CD4(high)CD8(high) thymocyte subpopulation","volume":"17","author":"Tribulatti","year":"2007","journal-title":"Glycobiology"},{"issue":"4","key":"10.1016\/j.molimm.2015.09.012_bib0220","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.4049\/jimmunol.1100297","article-title":"Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation","volume":"187","author":"Tsai","year":"2011","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2015.09.012_bib0225","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1128\/iai.7.3.496-498.1973","article-title":"Nonhemolytic group B streptococci of human, bovine, and ichthyic origin","volume":"7","author":"Wilkinson","year":"1973","journal-title":"Infect. Immunol."},{"issue":"0","key":"10.1016\/j.molimm.2015.09.012_bib0230","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.aquaculture.2014.02.027","article-title":"Protection of Nile tilapia (Oreochromis niloticus L.) against Streptococcus agalactiae following immunization with recombinant FbsA and \u03b1-enolase","volume":"428\u2013429","author":"Yi","year":"2014","journal-title":"Aquaculture"},{"issue":"20","key":"10.1016\/j.molimm.2015.09.012_bib0235","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1111\/j.1742-4658.2012.08753.x","article-title":"X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains","volume":"279","author":"Yoshida","year":"2012","journal-title":"FEBS J."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589015300742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589015300742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:28:33Z","timestamp":1758979713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589015300742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0161589015300742"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2015.09.012","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization of Galectin-8 from Nile tilapia (Oreochromis niloticus Linn.) and its response to bacterial infection","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2015.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}