{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:19:44Z","timestamp":1777619984660,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.molimm.2015.11.002","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T10:31:33Z","timestamp":1447929093000},"page":"86-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Cigarette smoke induces mucin hypersecretion and inflammatory response through the p66shc adaptor protein-mediated mechanism in human bronchial epithelial cells"],"prefix":"10.1016","volume":"69","author":[{"given":"J.","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.M.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.D.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.P.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zh.","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.P.","family":"Kolosov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Perelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.molimm.2015.11.002_bib0005","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1210\/me.2010-0189","article-title":"Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta\/p66shc signaling cascade: counter regulation by estrogens or androgens","volume":"24","author":"Almeida","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.molimm.2015.11.002_bib0010","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1074\/jbc.M708799200","article-title":"p66Shc inhibits pro-survival epidermal growth factor receptor\/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells","volume":"283","author":"Arany","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2015.11.002_bib0015","doi-asserted-by":"crossref","first-page":"F1214","DOI":"10.1152\/ajprenal.00639.2009","article-title":"p66Shc-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury","volume":"298","author":"Arany","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0020","doi-asserted-by":"crossref","first-page":"F125","DOI":"10.1152\/ajprenal.00041.2011","article-title":"Chronic nicotine exposure exacerbates acute renal ischemic injury","volume":"301","author":"Arany","year":"2011","journal-title":"Am J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0025","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/ndt\/gfs596","article-title":"Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66Shc","volume":"28","author":"Arany","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.molimm.2015.11.002_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1440-1843.2005.00692.x","article-title":"Global initiative for chronic obstructive lung disease strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: an Asia-Pacific perspective","volume":"10","author":"Asia Pacific COPD Roundtable Group","year":"2005","journal-title":"Respirology"},{"key":"10.1016\/j.molimm.2015.11.002_bib0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1179\/135100099101534945","article-title":"Tobacco smoke induces mitochondrial depolarization along with cell death: effects of antioxidants","volume":"4","author":"Banzet","year":"1999","journal-title":"Redox Rep."},{"key":"10.1016\/j.molimm.2015.11.002_bib0040","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1073\/pnas.0609656104","article-title":"Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress","volume":"104","author":"Camici","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.molimm.2015.11.002_bib0045","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.freeradbiomed.2009.01.006","article-title":"Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-\u03baB in human tracheal smooth muscle cells","volume":"46","author":"Cheng","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.molimm.2015.11.002_bib0050","doi-asserted-by":"crossref","first-page":"F523","DOI":"10.1152\/ajprenal.00215.2006","article-title":"Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidantdependent: FOXO3a regulation and promotes the survival phenotype","volume":"292","author":"Chintapalli","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"6","key":"10.1016\/j.molimm.2015.11.002_bib0055","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2174\/156801005774912806","article-title":"Inflammatory mediators in chronic obstructive pulmonary disease","volume":"4","author":"Chung","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.molimm.2015.11.002_bib0060","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/ATVBAHA.107.156059","article-title":"Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein","volume":"28","author":"Cosentino","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0065","article-title":"Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C","volume":"2013","author":"DeMarchi","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.molimm.2015.11.002_bib0070","doi-asserted-by":"crossref","first-page":"30599","DOI":"10.1074\/jbc.272.49.30599","article-title":"12-O-Tetradecanoylphorbol-13-acetate activates the ras\/extracellular signal-regulated kinase (ERK) signalingpathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells","volume":"49","author":"El-Shemerly","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2015.11.002_bib0075","doi-asserted-by":"crossref","first-page":"39085","DOI":"10.1074\/jbc.M406866200","article-title":"Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK","volume":"279","author":"Gensch","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2015.11.002_bib0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2005.05.011","article-title":"Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis","volume":"122","author":"Giorgio","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2015.11.002_bib0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2007.08.040","article-title":"Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes","volume":"1178","author":"Gonzalez","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.molimm.2015.11.002_bib0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1152\/ajplung.1995.268.3.L347","article-title":"Culture and transformation of human airway epithelial cells","volume":"268","author":"Gruenert","year":"1995","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0095","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1038\/srep08733","article-title":"Mesenchymal stem cells alleviate and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways","volume":"5","author":"Gu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2015.11.002_bib0100","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/CIRCRESAHA.108.186288","article-title":"p66Shc links {alpha}1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes","volume":"104","author":"Guo","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.molimm.2015.11.002_bib0105","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molimm.2015.11.002_bib0110","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.molimm.2015.11.002_bib0115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1091\/mbc.E05-06-0570","article-title":"Rac1 leads to phosphorylation-dependent increase in stability of the p66Shc adaptor protein: role in Rac1-induced oxidative stress","volume":"17","author":"Khanday","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molimm.2015.11.002_bib0120","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/CIRCRESAHA.108.181644","article-title":"p53 Impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc","volume":"103","author":"Kim","year":"2008","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.molimm.2015.11.002_bib0125","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jaci.2011.04.032","article-title":"Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism","volume":"128","author":"Li","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0130","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/193095","article-title":"Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction","volume":"2014","author":"Magenta","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"5","key":"10.1016\/j.molimm.2015.11.002_bib0135","doi-asserted-by":"crossref","first-page":"L839","DOI":"10.1152\/ajplung.90570.2008","article-title":"\u03b1 \u03b2-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases","volume":"296","author":"Moretto","year":"2009","journal-title":"Am. J. Physiol.\u2014Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0140","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1126\/science.1069004","article-title":"Redox regulation of forkhead proteins through a p66Shc dependent signaling pathway","volume":"295","author":"Nemoto","year":"2002","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.molimm.2015.11.002_bib0145","doi-asserted-by":"crossref","first-page":"e83429","DOI":"10.1371\/journal.pone.0083429","article-title":"Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats","volume":"8","author":"Ning","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2015.11.002_bib0150","doi-asserted-by":"crossref","first-page":"25689","DOI":"10.1074\/jbc.M401844200","article-title":"The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates transmembrane potential","volume":"279","author":"Orsini","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2015.11.002_bib0155","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4161\/cc.7.3.5360","article-title":"p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria","volume":"7","author":"Pinton","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.molimm.2015.11.002_bib0160","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.1135380","article-title":"Protein kinase C beta and prolylisomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc","volume":"315","author":"Pinton","year":"2007","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.molimm.2015.11.002_bib0165","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/MLG.0b013e31815aedc7","article-title":"Cigarette smoke activates NF-\u03baB and induces Muc5b expression in mouse middle ear cells","volume":"118","author":"Preciado","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.molimm.2015.11.002_bib0170","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ccm.2007.06.003","article-title":"Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity","volume":"28","author":"Remels","year":"2007","journal-title":"Clin. Chest Med."},{"issue":"2","key":"10.1016\/j.molimm.2015.11.002_bib0175","doi-asserted-by":"crossref","first-page":"L420","DOI":"10.1152\/ajplung.00019.2004","article-title":"Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells","volume":"287","author":"Shao","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0180","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/carcin\/bgg078","article-title":"Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of Ikappa-Balpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1","volume":"24","author":"Shishodia","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.molimm.2015.11.002_bib0185","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2015.11.002_bib0190","doi-asserted-by":"crossref","first-page":"L1211","DOI":"10.1152\/ajplung.00291.2006","article-title":"Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosisinto necrosis","volume":"292","author":"van der Toorn","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0195","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.01.026","article-title":"Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling","volume":"69","author":"Wu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"18","key":"10.1016\/j.molimm.2015.11.002_bib0200","first-page":"5171","article-title":"Taxol mediates serine phosphorylation of the 66-kDa Shc isoform","volume":"60","author":"Yang","year":"2000","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.molimm.2015.11.002_bib0205","doi-asserted-by":"crossref","first-page":"L46","DOI":"10.1152\/ajplung.00241.2005","article-title":"Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslationalmodifications of histone deacetylase in macrophages","volume":"291","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molimm.2015.11.002_bib0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mrfmmm.2007.02.010","article-title":"The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis","volume":"621","author":"Yang","year":"2007","journal-title":"Mutat. Res."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589015301127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589015301127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T14:18:22Z","timestamp":1567347502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589015301127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":42,"alternative-id":["S0161589015301127"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2015.11.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cigarette smoke induces mucin hypersecretion and inflammatory response through the p66shc adaptor protein-mediated mechanism in human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2015.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}