{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:09:07Z","timestamp":1777262947971,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.molimm.2017.02.008","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T10:49:55Z","timestamp":1487587795000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Inflammatory chemokines and their receptors in human visceral leishmaniasis: Gene expression profile in peripheral blood, splenic cellular sources and their impact on trafficking of inflammatory cells"],"prefix":"10.1016","volume":"85","author":[{"given":"Neetu","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Sundar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2017.02.008_bib0005","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2017.02.008_bib0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0001-706X(02)00260-7","article-title":"Mucosal leishmaniasis: in situ characterization of the host inflammatory response, before and after treatment","volume":"85","author":"Amato","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.molimm.2017.02.008_bib0015","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.4049\/jimmunol.1003588","article-title":"IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis","volume":"186","author":"Ansari","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0020","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jlb.61.6.721","article-title":"Quantitation of surface CD14 on human monocytes and neutrophils","volume":"61","author":"Antal-Szalmas","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0025","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1086\/340820","article-title":"Chemokine-induced leishmanicidal activity in murine macrophages via the generation of nitric oxide","volume":"185","author":"Bhattacharyya","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1084\/jem.187.1.129","article-title":"Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s","volume":"187","author":"Bonecchi","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.02.008_bib0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1179\/2047773213Y.0000000078","article-title":"Serum cytokines associated with severity and complications of kala-azar","volume":"107","author":"Costa","year":"2013","journal-title":"Pathog. Global Health"},{"key":"10.1016\/j.molimm.2017.02.008_bib0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<203::AID-IMMU203>3.0.CO;2-B","article-title":"Leishmania donovani infection initiates T cell-independent chemokine responses, which are subsequently amplified in a T cell-dependent manner","volume":"29","author":"Cotterell","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0045","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1128\/IAI.73.12.8334-8344.2005","article-title":"Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis","volume":"73","author":"Dey","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2017.02.008_bib0050","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0055","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.0022-202X.2005.23841.x","article-title":"Chemokines: key players in innate and adaptive immunity","volume":"125","author":"Esche","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0060","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/infdis\/jir461","article-title":"IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis","volume":"204","author":"Gautam","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0065","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1189\/jlb.0805458","article-title":"The combined CXCR1\/CXCR2 antagonist CXCL8(3-74)K11R\/G31P blocks neutrophil infiltration, pyrexia, and pulmonary vascular pathology in endotoxemic animals","volume":"78","author":"Gordon","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0070","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0075","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1471-2164-9-238","article-title":"Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE","volume":"9","author":"Guerfali","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molimm.2017.02.008_bib0080","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1086\/605895","article-title":"CXC chemokine-mediated protection against visceral leishmaniasis: involvement of the proinflammatory response","volume":"200","author":"Gupta","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4269\/ajtmh.2004.71.561","article-title":"Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis","volume":"71","author":"Hailu","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.molimm.2017.02.008_bib0090","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.4049\/jimmunol.150.12.5556","article-title":"Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide","volume":"150","author":"Haziot","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0095","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1128\/IAI.71.8.4278-4288.2003","article-title":"Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis","volume":"71","author":"Ji","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2017.02.008_bib0100","first-page":"801","article-title":"Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site","volume":"118","author":"Katzman","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2017.02.008_bib0105","doi-asserted-by":"crossref","first-page":"e3198","DOI":"10.1371\/journal.pntd.0003198","article-title":"Leishmania specific CD4 T cells release IFNgamma that limits parasite replication in patients with visceral leishmaniasis","volume":"8","author":"Kumar","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/cyto.a.20256","article-title":"Multiplex analysis of circulating cytokines in the sera of patients with different clinical forms of visceral leishmaniasis","volume":"69","author":"Kurkjian","year":"2006","journal-title":"Cytometry A"},{"key":"10.1016\/j.molimm.2017.02.008_bib0115","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0006-291X(02)00318-2","article-title":"CXCL8((3-73))K11R\/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8\/IL-8","volume":"293","author":"Li","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molimm.2017.02.008_bib0120","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1086\/339260","article-title":"Leishmania-induced cellular recruitment during the early inflammatory response: modulation of proinflammatory mediators","volume":"185","author":"Matte","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0125","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1471-2350-12-162","article-title":"Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India","volume":"12","author":"Mehrotra","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.molimm.2017.02.008_bib0130","doi-asserted-by":"crossref","first-page":"e1566","DOI":"10.1371\/journal.pntd.0001566","article-title":"Higher expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 chemokines in the skin associated with parasite density in canine visceral leishmaniasis","volume":"6","author":"Menezes-Souza","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0135","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1128\/IAI.70.11.6284-6293.2002","article-title":"Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy","volume":"70","author":"Murray","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2017.02.008_bib0140","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20061141","article-title":"Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis","volume":"204","author":"Nylen","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.02.008_bib0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/expr.1996.4139","article-title":"Leishmania major: promastigotes induce expression of a subset of chemokine genes in murine macrophages","volume":"85","author":"Racoosin","year":"1997","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-3024.2002.00467.x","article-title":"Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis","volume":"24","author":"Ritter","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0155","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/infdis\/173.3.699","article-title":"Differential expression of chemokines in patients with localized and diffuse cutaneous American leishmaniasis","volume":"173","author":"Ritter","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2017.02.008_bib0160","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","article-title":"Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells","volume":"22","author":"Rot","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0165","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2174\/1566524043360168","article-title":"Role of chemokines in Leishmania infection","volume":"4","author":"Roychoudhury","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.molimm.2017.02.008_bib0170","doi-asserted-by":"crossref","first-page":"e58129","DOI":"10.1371\/journal.pone.0058129","article-title":"Human chemokines as antimicrobial peptides with direct parasiticidal effect on Leishmania mexicana in vitro","volume":"8","author":"Sobirk","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2017.02.008_bib0175","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/sj.icb7100011","article-title":"Balancing immunity and pathology in visceral leishmaniasis","volume":"85","author":"Stanley","year":"2007","journal-title":"Immunol. Cell Biol."},{"issue":"12","key":"10.1016\/j.molimm.2017.02.008_bib0180","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1128\/JCM.01465-15","article-title":"A correlative study of splenic parasite score and peripheral blood parasite load estimation by qPCR in visceral leishmaniasis","volume":"53","author":"Sudarshan","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.molimm.2017.02.008_bib0185","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.4049\/jimmunol.173.11.6521","article-title":"Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages","volume":"173","author":"van Zandbergen","year":"2004","journal-title":"J. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589017300482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589017300482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:29:23Z","timestamp":1758979763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589017300482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":37,"alternative-id":["S0161589017300482"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2017.02.008","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory chemokines and their receptors in human visceral leishmaniasis: Gene expression profile in peripheral blood, splenic cellular sources and their impact on trafficking of inflammatory cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2017.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}