{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:54:10Z","timestamp":1785466450586,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2015R1D1A1A09059345"],"award-info":[{"award-number":["NRF-2015R1D1A1A09059345"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.molimm.2017.09.019","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T16:07:04Z","timestamp":1508170024000},"page":"54-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex"],"prefix":"10.1016","volume":"92","author":[{"given":"Anh Duc","family":"Truong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong Thanh","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeojin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janggeun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungbaek","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun S.","family":"Lillehoj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Ho","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2017.09.019_bib0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cyto.2015.07.026","article-title":"Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines","volume":"76","author":"Abdi","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2017.09.019_bib0010","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(88)90143-2","article-title":"The jun proto-oncogene is positively autoregulated by its product, Jun\/AP-1","volume":"55","author":"Angel","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2017.09.019_bib0015","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1073\/pnas.87.18.6934","article-title":"Structural design and molecular evolution of a cytokine receptor superfamily","volume":"87","author":"Bazan","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2017.09.019_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1084\/jem.20042279","article-title":"IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together","volume":"201","author":"Bettelli","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.09.019_bib0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/ard.2007.082081","article-title":"Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits p19 and p40, in rheumatoid arthritis","volume":"68","author":"Brentano","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2017.09.019_bib0030","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1182\/blood-2010-05-286161","article-title":"Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia","volume":"116","author":"Burbelo","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2017.09.019_bib0035","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0959-440X(98)80069-9","article-title":"Finding the genes in genomic DNA","volume":"8","author":"Burge","year":"1998","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0040","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.4049\/jimmunol.176.9.5652","article-title":"STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice","volume":"176","author":"Cho","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4161\/mabs.2.5.13081","article-title":"A novel class of anti-IL-12p40 antibodies: potent neutralization via inhibition of IL-12-IL-12Rbeta2 and IL-23-IL-23R","volume":"2","author":"Clarke","year":"2010","journal-title":"MAbs"},{"key":"10.1016\/j.molimm.2017.09.019_bib0050","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0898-6568(95)02004-7","article-title":"Regulation of the Jak\/STAT signalling pathway","volume":"7","author":"Finbloom","year":"1995","journal-title":"Cell. Signal."},{"key":"10.1016\/j.molimm.2017.09.019_bib0055","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/MIB.0000000000000013","article-title":"Correlation of genetic risk and messenger RNA expression in a Th17\/IL23 pathway analysis in inflammatory bowel disease","volume":"20","author":"Fransen","year":"2014","journal-title":"Inflamm. Bowel. Dis."},{"key":"10.1016\/j.molimm.2017.09.019_bib0060","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/187152809787582507","article-title":"The IL-12 family of cytokines in infection, inflammation and autoimmune disorders","volume":"8","author":"Gee","year":"2009","journal-title":"Inflamm. Allergy. Drug. Targets"},{"key":"10.1016\/j.molimm.2017.09.019_bib0065","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1189\/jlb.70.3.348","article-title":"Negative regulation of cytokine signaling","volume":"70","author":"Greenhalgh","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0070","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.dci.2005.12.007","article-title":"Molecular cloning and characterization of chicken lipopolysaccharide-induced TNF-alpha factor (LITAF)","volume":"30","author":"Hong","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0075","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.vetimm.2010.06.019","article-title":"Development and characterization of mouse monoclonal antibodies specific for chicken interleukin 18","volume":"138","author":"Hong","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0080","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0145-305X(87)90082-6","article-title":"Influence of cell sources, stimulating agents, and incubation conditions on release of interleukin-1 from chicken macrophages","volume":"11","author":"Klasing","year":"1987","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0085","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1136\/gut.2007.135053","article-title":"IL23 differentially regulates the Th1\/Th17 balance in ulcerative colitis and Crohn's disease","volume":"57","author":"Kobayashi","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2017.09.019_bib0090","doi-asserted-by":"crossref","first-page":"36922","DOI":"10.1074\/jbc.M112.402958","article-title":"Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C\/AATT enhancer-binding protein beta in bone marrow-derived dendritic cells","volume":"287","author":"Kocieda","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2017.09.019_bib0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.09.019_bib0100","doi-asserted-by":"crossref","first-page":"24006","DOI":"10.1074\/jbc.M109.025528","article-title":"AP-1 activated by toll-like receptors regulates expression of IL-23 p19","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2017.09.019_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molimm.2017.09.019_bib0110","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jmb.2008.07.051","article-title":"The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12","volume":"382","author":"Lupardus","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ab.2014.08.020","article-title":"Endotoxin depletion of recombinant protein preparations through their preferential binding to histidine tags","volume":"466","author":"Mack","year":"2014","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.molimm.2017.09.019_bib0120","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/nar\/gkg108","article-title":"TRANSFAC: transcriptional regulation, from patterns to profiles","volume":"31","author":"Matys","year":"2003","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.molimm.2017.09.019_bib0125","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.4049\/jimmunol.179.10.6596","article-title":"A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription","volume":"179","author":"Mise-Omata","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0130","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jbi.2015.01.008","article-title":"HBLAST: Parallelised sequence similarity \u2212 a Hadoop MapReducable basic local alignment search tool","volume":"54","author":"O\u2019Driscoll","year":"2015","journal-title":"J. Biomed. Inf."},{"key":"10.1016\/j.molimm.2017.09.019_bib0135","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2017.09.019_bib0140","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1073\/pnas.85.8.2444","article-title":"Improved tools for biological sequence comparison","volume":"85","author":"Pearson","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2017.09.019_bib0145","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.4049\/jimmunol.169.10.5673","article-title":"Regulation of virus-induced IL-12 and IL-23 expression in human macrophages","volume":"169","author":"Pirhonen","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cyto.2013.07.005","article-title":"Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis","volume":"64","author":"Qian","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2017.09.019_bib0155","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.pep.2005.09.027","article-title":"Single step protocol to purify recombinant proteins with low endotoxin contents","volume":"46","author":"Reichelt","year":"2006","journal-title":"Protein. Expr. Purif."},{"key":"10.1016\/j.molimm.2017.09.019_bib0160","doi-asserted-by":"crossref","first-page":"22942","DOI":"10.1074\/jbc.M113.522656","article-title":"The unfolded protein response and the phosphorylations of activating transcription factor 2 in the trans-activation of il23a promoter produced by beta-glucans","volume":"289","author":"Rodriguez","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2017.09.019_bib0165","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.4049\/jimmunol.173.4.2675","article-title":"Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima","volume":"173","author":"Rothwell","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0170","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2307\/1591524","article-title":"Stable transfection of reticuloendotheliosis virus-transformed lymphoblastoid cell lines","volume":"36","author":"Schat","year":"1992","journal-title":"Avian. Dis."},{"key":"10.1016\/j.molimm.2017.09.019_bib0175","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1074\/jbc.M114.617597","article-title":"Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor beta1 via site II and induces p19\/interleukin 23 receptor interaction via site III","volume":"290","author":"Schroder","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2017.09.019_bib0180","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S1074-7613(00)00055-8","article-title":"Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function","volume":"13","author":"Shimoda","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2017.09.019_bib0185","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/eji.200324815","article-title":"Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development","volume":"34","author":"Smits","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0190","first-page":"994","article-title":"Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice","volume":"118","author":"Stirnemann","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2017.09.019_bib0195","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.4049\/jimmunol.181.9.5948","article-title":"IL-23 promotes maintenance but not commitment to the Th17 lineage","volume":"181","author":"Stritesky","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/187152812800392805","article-title":"The IL23\/Th17 pathway as a therapeutic target in chronic inflammatory diseases","volume":"11","author":"Toussirot","year":"2012","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1016\/j.molimm.2017.09.019_bib0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0210","article-title":"Dataset on characterization of recombinant interleukin-23\u03b1, IL-12p40 and IL-23 complex protein, which activates JAK-STAT signaling pathway in chicken cell lines using immunocytochemical staining","author":"Truong","year":"2017","journal-title":"Data in Brief."},{"key":"10.1016\/j.molimm.2017.09.019_bib0215","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.4049\/jimmunol.177.7.4550","article-title":"Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role","volume":"177","author":"Utsugi","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0220","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.4049\/jimmunol.176.12.7768","article-title":"IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production","volume":"176","author":"Vaknin-Dembinsky","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.09.019_bib0225","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2017.09.019_bib0230","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cyto.2012.05.016","article-title":"Up-regulation of IL-23 p19 expression in human periodontal ligament fibroblasts by IL-1beta via concurrent activation of the NF-kappaB and MAPKs\/AP-1 pathways","volume":"60","author":"Zhu","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2017.09.019_bib0235","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/intimm\/dxn132","article-title":"IL-23 modulates CD56+\/CD3- NK cell and CD56+\/CD3+ NK-like t cell function differentially from IL-12","volume":"21","author":"van de Wetering","year":"2009","journal-title":"Int. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589017305187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589017305187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T06:19:47Z","timestamp":1693117187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589017305187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":47,"alternative-id":["S0161589017305187"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2017.09.019","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2017.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}