{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:51:42Z","timestamp":1768567902288,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Chinese State Key Program in Basic Research","award":["2013CB910802"],"award-info":[{"award-number":["2013CB910802"]}]},{"name":"Pubic Technology Research Project of Zhejiang Province","award":["2015C33120"],"award-info":[{"award-number":["2015C33120"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.molimm.2017.10.008","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:47:49Z","timestamp":1510015669000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Iguratimod ameliorates inflammatory responses by modulating the Th17\/Treg paradigm in dextran sulphate sodium-induced murine colitis"],"prefix":"10.1016","volume":"93","author":[{"given":"Xue-pei","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xie-lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zao-peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-cai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-ming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2017.10.008_bib0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2010.08.010","article-title":"Interleukin-23 drives intestinal inflammation through direct activity on T cells","volume":"33","author":"Ahern","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2017.10.008_bib0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molimm.2017.10.008_bib0015","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s11894-007-0067-3","article-title":"Innate and adaptive immune responses related to IBD pathogenesis","volume":"9","author":"Arseneau","year":"2007","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.molimm.2017.10.008_bib0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ibd.21048","article-title":"World gastroenterology organization practice guidelines for the diagnosis andmanagement of IBD in 2010","volume":"16","author":"Bernstein","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molimm.2017.10.008_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0030","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3","volume":"198","author":"Chen","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.10.008_bib0035","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1007\/s10620-013-2563-7","article-title":"Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production","volume":"58","author":"Chen","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.molimm.2017.10.008_bib0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1124\/jpet.107.127209","article-title":"Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1\/Th17 to a Th2 and regulatory T cell profile","volume":"324","author":"Daniel","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molimm.2017.10.008_bib0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10875-009-9345-1","article-title":"Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease","volume":"30","author":"Eastaff-Leung","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0050","doi-asserted-by":"crossref","DOI":"10.1203\/PDR.0b013e31819e76c7","article-title":"The T(reg)\/Th17 cell balance: a new paradigm for autoimmunity","volume":"65","author":"Eisenstein","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.molimm.2017.10.008_bib0055","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI200423395","article-title":"CD4+ Tregs and immune control","volume":"114","author":"Fehervari","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2017.10.008_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/s10165-006-0542-y","article-title":"Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study","volume":"17","author":"Hara","year":"2007","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0065","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.molimm.2017.10.008_bib0070","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2017.10.008_bib0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2017.10.008_bib0080","first-page":"2591","article-title":"Inhibitory effect of T- 614 on tumor necrosis factor-alpha induced cytokine production and nuclear f actor-kappaB activation in cultured human synovial cells","volume":"28","author":"Kohno","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0085","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cell.2010.02.021","article-title":"Th17 and regulatory T cells in mediating and restraining inflammation","volume":"140","author":"Littman","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2017.10.008_bib0090","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ni0901-816","article-title":"Regulatory T cells in the control of immune pathology","volume":"2","author":"Maloy","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0095","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2017.10.008_bib0100","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ni1320","article-title":"Transcriptional repressor Blimp-1 regulates T cell homeostasis and function","volume":"7","author":"Martins","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0105","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4161\/self.1.4.13560","article-title":"Immunopathogenesis of inflammatory bowel disease","volume":"1","author":"Matricon","year":"2010","journal-title":"Self Nonself"},{"key":"10.1016\/j.molimm.2017.10.008_bib0110","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1053\/j.gastro.2005.03.043","article-title":"Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease","volume":"128","author":"Maul","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.10.008_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0557s47","article-title":"Overview of mouse models of inflammatory bowel disease and their use in drug discovery","author":"Maxwell","year":"2009","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0120","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","article-title":"Interleukin-17 and type 17 helper T cells","volume":"361","author":"Miossec","year":"2009","journal-title":"N Engl. J. Med."},{"key":"10.1016\/j.molimm.2017.10.008_bib0125","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.4049\/jimmunol.170.8.3939","article-title":"Cutting edge: cure of colitis by CD4 + CD25+ regulatory T cells","volume":"170","author":"Mottet","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0130","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nm0804-801","article-title":"Regulatory T cells and mechanisms of immune system control","volume":"10","author":"O'Garra","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.molimm.2017.10.008_bib0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.med.51.1.289","article-title":"Role of cytokines in the pathogenesis of inflammatory bowel disease","volume":"51","author":"Papadakis","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.molimm.2017.10.008_bib0140","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF01540912","article-title":"Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease","volume":"16","author":"Reimund","year":"1996","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0145","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0016-5085(03)00267-1","article-title":"Galectin-1 suppresses experimental colitis in mice","volume":"124","author":"Santucci","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.10.008_bib0150","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/ibd.21248","article-title":"IL-23\/IL-17 axis in IBD","volume":"16","author":"Sarra","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molimm.2017.10.008_bib0155","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/imr.12039","article-title":"CD4(+) T-cell subsets in intestinal inflammation","volume":"252","author":"Shale","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2017.10.008_bib0160","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","article-title":"Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases","volume":"140","author":"Strober","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.10.008_bib0165","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/rheumatology\/keg381","article-title":"Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice","volume":"42","author":"Tanaka","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.molimm.2017.10.008_bib0170","doi-asserted-by":"crossref","first-page":"9394","DOI":"10.1073\/pnas.1511711112","article-title":"Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells","volume":"112","author":"Wan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2017.10.008_bib0175","doi-asserted-by":"crossref","first-page":"34605","DOI":"10.1074\/jbc.M705100200","article-title":"IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner","volume":"282","author":"Wei","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2017.10.008_bib0180","doi-asserted-by":"crossref","first-page":"214683","DOI":"10.1155\/2015\/214683","article-title":"Inhibitory effect of a novel antirheumatic drug T-614 on the IL-6-induced RANKL\/OPG, IL-17, and MMP-3 expression in synovial fibroblasts from rheumatoid arthritis patients","volume":"2015","author":"Wei","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.molimm.2017.10.008_bib0185","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1038\/nprot.2007.315","article-title":"Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue","volume":"2","author":"Weigmann","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molimm.2017.10.008_bib0190","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.it.2011.08.003","article-title":"Deciphering the role of Th17 cells in human disease","volume":"32","author":"Wilke","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2017.10.008_bib0195","doi-asserted-by":"crossref","first-page":"356040","DOI":"10.1155\/2015\/356040","article-title":"(2015), Regulatory effect of iguratimod on the balance of Th subsets and inhibition of inflammatory cytokines in patients with rheumatoid arthritis","author":"Xu","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.molimm.2017.10.008_bib0200","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1182\/blood-2006-02-004747","article-title":"IL-2 regulates FOXP3 expression in human CD4\u2009+\u2009CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo","volume":"108","author":"Zorn","year":"2006","journal-title":"Blood"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016158901730528X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016158901730528X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T22:07:07Z","timestamp":1750975627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016158901730528X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":40,"alternative-id":["S016158901730528X"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2017.10.008","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iguratimod ameliorates inflammatory responses by modulating the Th17\/Treg paradigm in dextran sulphate sodium-induced murine colitis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2017.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}