{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:18:34Z","timestamp":1789816714818,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500423"],"award-info":[{"award-number":["81500423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370504"],"award-info":[{"award-number":["81370504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600443"],"award-info":[{"award-number":["81600443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502082"],"award-info":[{"award-number":["81502082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370564"],"award-info":[{"award-number":["81370564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400662"],"award-info":[{"award-number":["81400662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Province Natural Science Foundation of China Shaanxi","award":["2015JQ8298"],"award-info":[{"award-number":["2015JQ8298"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.molimm.2017.11.020","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T10:16:59Z","timestamp":1511950619000},"page":"166-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["IL-17 is a protection effector against the adherent-invasive Escherichia coli in murine colitis"],"prefix":"10.1016","volume":"93","author":[{"given":"Hai-jia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-zuo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-fei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-zhan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-chun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-mei","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2017.11.020_bib0005","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2005.06.071","article-title":"Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts","volume":"129","author":"Andoh","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.11.020_bib0010","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2005.06.071","article-title":"Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts","volume":"129","author":"Andoh","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.11.020_bib0015","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058","article-title":"Th17 cell induction by adhesion of microbes to intestinal epithelial cells","volume":"163","author":"Atarashi","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2017.11.020_bib0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume":"14","author":"Aujla","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.molimm.2017.11.020_bib0025","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1046\/j.1365-2958.2003.03468.x","article-title":"Regulatory and functional co-operation of flagella and type 1 pili in adhesive and invasive abilities of AIEC strain LF82 isolated from a patient with Crohn\u2019s disease","volume":"48","author":"Barnich","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0030","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI30504","article-title":"CEACAM6 acts as a receptor for adherent-invasive E coli, supporting ileal mucosa colonization in Crohn disease","volume":"117","author":"Barnich","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2017.11.020_bib0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ismej.2007.52","article-title":"Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn\u2019s disease involving the ileum","volume":"1","author":"Baumgart","year":"2007","journal-title":"ISME J."},{"key":"10.1016\/j.molimm.2017.11.020_bib0040","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1365-2958.2001.02315.x","article-title":"Type 1 pili-mediated adherence of Escherichia coli strain LF82 isolated from Crohn\u2019s disease is involved in bacterial invasion of intestinal epithelial cells","volume":"39","author":"Boudeau","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0045","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nature08949","article-title":"Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology","volume":"464","author":"Buonocore","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2017.11.020_bib0050","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.4049\/jimmunol.1200955","article-title":"Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis","volume":"189","author":"Cao","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0055","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1084\/jem.20090741","article-title":"Crohn\u2019s disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM","volume":"206","author":"Carvalho","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.11.020_bib0060","doi-asserted-by":"crossref","first-page":"e20333","DOI":"10.1371\/journal.pone.0020333","article-title":"IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2017.11.020_bib0065","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.gastro.2004.04.061","article-title":"High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn\u2019s disease","volume":"127","author":"Darfeuille-Michaud","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.11.020_bib0070","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ijmm.2007.05.011","article-title":"Escherichia coli isolated from a Crohn\u2019s disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells","volume":"298","author":"Eaves-Pyles","year":"2008","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/gut.52.1.65","article-title":"Increased expression of interleukin 17 in inflammatory bowel disease","volume":"52","author":"Fujino","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2017.11.020_bib0080","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cyto.2013.07.022","article-title":"IL-17 family: cytokines, receptors and signaling","volume":"64","author":"Gu","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2017.11.020_bib0085","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/gutjnl-2011-301668","article-title":"Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn\u2019s disease: unexpected results of a randomised, double-blind placebo-controlled trial","volume":"61","author":"Hueber","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2017.11.020_bib0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbrc.2008.09.019","article-title":"Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice","volume":"377","author":"Ito","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molimm.2017.11.020_bib0095","doi-asserted-by":"crossref","first-page":"e76520","DOI":"10.1371\/journal.pone.0076520","article-title":"Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis","volume":"8","author":"Kang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2017.11.020_bib0100","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jaci.2004.10.019","article-title":"IL-17 cytokine family","volume":"114","author":"Kawaguchi","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0105","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.11.020_bib0110","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.11.020_bib0115","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/mi.2013.97","article-title":"Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity","volume":"7","author":"Malik","year":"2014","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0120","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1172\/JCI88625","article-title":"IL-33 regulates the IgA-microbiota axis to restrain IL-1alpha-dependent colitis and tumorigenesis","volume":"126","author":"Malik","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2017.11.020_bib0125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2004.03.054","article-title":"Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer","volume":"127","author":"Martin","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.11.020_bib0130","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/ibd.20860","article-title":"Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn\u2019s disease","volume":"15","author":"Martinez-Medina","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molimm.2017.11.020_bib0135","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ni.1736","article-title":"A protective function for interleukin 17A in T cell-mediated intestinal inflammation","volume":"10","author":"O'Connor","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clim.2003.09.013","article-title":"Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice","volume":"110","author":"Ogawa","year":"2004","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2015.09.040","article-title":"A Sledgehammer Breaks glass but forges steel: bacteria adhesion shapes gut immunity","volume":"163","author":"Pedicord","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2017.11.020_bib0150","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"Pickert","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2017.11.020_bib0155","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2011.11.011","article-title":"The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells","volume":"36","author":"Qiu","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2017.11.020_bib0160","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1365-2958.2007.05638.x","article-title":"OmpC and the sigma(E) regulatory pathway are involved in adhesion and invasion of the Crohn\u2019s disease-associated Escherichia coli strain LF82","volume":"63","author":"Rolhion","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0165","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gut.2010.207456","article-title":"Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion","volume":"59","author":"Rolhion","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.molimm.2017.11.020_bib0170","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.4049\/jimmunol.150.12.5445","article-title":"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene","volume":"150","author":"Rouvier","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0175","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2015.08.061","article-title":"An IL-23R\/IL-22 circuit regulates epithelial serum amyloid a to promote local effector th17 responses","volume":"163","author":"Sano","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2017.11.020_bib0180","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/labinvest.3700661","article-title":"Invasive Escherichia coli are a feature of Crohn\u2019s disease","volume":"87","author":"Sasaki","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.molimm.2017.11.020_bib0185","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ni.2002","article-title":"RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota","volume":"12","author":"Sawa","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0190","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1053\/gast.2002.33631","article-title":"Leptin: a pivotal mediator of intestinal inflammation in mice","volume":"122","author":"Siegmund","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2017.11.020_bib0195","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.immuni.2010.12.009","article-title":"CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut","volume":"34","author":"Sonnenberg","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2017.11.020_bib0200","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ibd.20079","article-title":"Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease","volume":"13","author":"Te","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molimm.2017.11.020_bib0205","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ijmm.2011.04.015","article-title":"High prevalence of aggregative adherent Escherichia coli strains in the mucosa-associated microbiota of patients with inflammatory bowel diseases","volume":"301","author":"Thomazini","year":"2011","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0210","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.molimm.2017.11.020_bib0215","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/01.MIB.0000218764.06959.91","article-title":"Critical role of IL-17 receptor signaling in acute TNBS-induced colitis","volume":"12","author":"Zhang","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molimm.2017.11.020_bib0220","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.molimm.2017.11.020_bib0225","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat. Med."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589017305837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589017305837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T13:35:45Z","timestamp":1693316145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589017305837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":45,"alternative-id":["S0161589017305837"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2017.11.020","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-17 is a protection effector against the adherent-invasive Escherichia coli in murine colitis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2017.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}