{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:28:29Z","timestamp":1776101309875,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Henan Science and Technology","award":["142300413209"],"award-info":[{"award-number":["142300413209"]}]},{"name":"Ministry of Agriculture of China","award":["2011-G35"],"award-info":[{"award-number":["2011-G35"]}]},{"name":"Ministry of Agriculture of China","award":["2014ZX0801015B"],"award-info":[{"award-number":["2014ZX0801015B"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.molimm.2018.01.008","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T22:26:40Z","timestamp":1519338400000},"page":"56-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Maintenance of cyclic GMP\u2013AMP homeostasis by ENPP1 is involved in pseudorabies virus infection"],"prefix":"10.1016","volume":"95","author":[{"given":"Jiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Li","family":"Ming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Qian","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao-Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shuang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei-Bei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2018.01.008_bib0005","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature12306","article-title":"cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING","volume":"498","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.01.008_bib0010","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature12640","article-title":"Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP","volume":"503","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.01.008_bib0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s11926-003-0071-z","article-title":"Matrix vesicles and calcification","volume":"5","author":"Anderson","year":"2003","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.molimm.2018.01.008_bib0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1432-1033.1975.tb03935.x","article-title":"Nucleotide pyrophosphatase of rat liver: a comparative study on the enzymes solubilized and purified from plasma membrane and endoplasmic reticulum","volume":"51","author":"Bischoff","year":"1975","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.molimm.2018.01.008_bib0025","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.aab3632","article-title":"Viruses transfer the antiviral second messenger cGAMP between cells","volume":"349","author":"Bridgeman","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molimm.2018.01.008_bib0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.01.008_bib0035","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-immunol-051116-052331","article-title":"Intracellular nucleic acid detection in autoimmunity","volume":"35","author":"Crowl","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0045","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.cell.2013.08.014","article-title":"Cyclic dinucleotides and the innate immune response","volume":"154","author":"Danilchanka","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2018.01.008_bib0050","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2012.01.053","article-title":"Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence","volume":"149","author":"Davies","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2018.01.008_bib0055","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.celrep.2013.05.009","article-title":"The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING","volume":"3","author":"Diner","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.molimm.2018.01.008_bib0060","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/BF02658505","article-title":"PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity","volume":"39","author":"Frittitta","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.molimm.2018.01.008_bib0065","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1240933","article-title":"Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses","volume":"341","author":"Gao","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molimm.2018.01.008_bib0070","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.cell.2013.04.046","article-title":"Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase","volume":"153","author":"Gao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2018.01.008_bib0075","doi-asserted-by":"crossref","first-page":"E5699","DOI":"10.1073\/pnas.1516465112","article-title":"Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases","volume":"112","author":"Gao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2018.01.008_bib0080","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aab3628","article-title":"Transmission of innate immune signaling by packaging of cGAMP in viral particles","volume":"349","author":"Gentili","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molimm.2018.01.008_bib0085","doi-asserted-by":"crossref","first-page":"29509","DOI":"10.1074\/jbc.M304059200","article-title":"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine","volume":"278","author":"Guo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.01.008_bib0090","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1073\/pnas.142063399","article-title":"Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization","volume":"99","author":"Hessle","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2018.01.008_bib0095","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature06537","article-title":"TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines","volume":"451","author":"Ishii","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.01.008_bib0100","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.01.008_bib0105","doi-asserted-by":"crossref","first-page":"30069","DOI":"10.1074\/jbc.M005463200","article-title":"The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides","volume":"275","author":"Jedlitschky","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.01.008_bib0110","doi-asserted-by":"crossref","first-page":"988","DOI":"10.2741\/1593","article-title":"Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage","volume":"10","author":"Johnson","year":"2005","journal-title":"Front. Biosci."},{"key":"10.1016\/j.molimm.2018.01.008_bib0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-065X.2011.01052.x","article-title":"RIG-I-like receptors: cytoplasmic sensors for non-self RNA","volume":"243","author":"Kato","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2018.01.008_bib0120","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.it.2011.08.004","article-title":"Cytosolic DNA sensors regulating type I interferon induction","volume":"32","author":"Keating","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0125","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nchembio.2337","article-title":"Versatile modes of cellular regulation via cyclic dinucleotides","volume":"13","author":"Krasteva","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0130","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1128\/JVI.02702-13","article-title":"Adenovirus detection by the cGAS\/STING\/TBK1 DNA sensing cascade","volume":"88","author":"Lam","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0135","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.immuni.2013.10.019","article-title":"Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization","volume":"39","author":"Li","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2018.01.008_bib0140","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nchembio.1661","article-title":"Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs","volume":"10","author":"Li","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0145","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.4049\/jimmunol.1402066","article-title":"Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS","volume":"194","author":"Ma","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2337\/diabetes.49.1.13","article-title":"Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit","volume":"49","author":"Maddux","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.molimm.2018.01.008_bib0155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/373448a0","article-title":"Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus","volume":"373","author":"Maddux","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.01.008_bib0160","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1074\/jbc.M112.395491","article-title":"Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth","volume":"288","author":"Mehne","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.01.008_bib0165","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/ng1604","article-title":"Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes","volume":"37","author":"Meyre","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2018.01.008_bib0170","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1582-4934.2009.00988.x","article-title":"Expression of NPP1 is regulated during atheromatous plaque calcification","volume":"15","author":"Nitschke","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molimm.2018.01.008_bib0175","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/embor.2011.77","article-title":"c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis","volume":"12","author":"Oppenheimer-Shaanan","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molimm.2018.01.008_bib0180","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev.: MMBR"},{"key":"10.1016\/j.molimm.2018.01.008_bib0185","doi-asserted-by":"crossref","first-page":"13348","DOI":"10.1038\/ncomms13348","article-title":"Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS","volume":"7","author":"Reinert","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2018.01.008_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00043-12","article-title":"Cyclic di-GMP: the first 25 years of a universal bacterial second messenger","volume":"77","author":"Romling","year":"2013","journal-title":"Microbiol. Mol. Biol. Rev.: MMBR"},{"key":"10.1016\/j.molimm.2018.01.008_bib0195","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri2314","article-title":"Interferon-inducible antiviral effectors","volume":"8","author":"Sadler","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0200","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molimm.2018.01.008_bib0205","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.molimm.2015.02.002","article-title":"Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase","volume":"65","author":"Wang","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0210","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1099\/jgv.0.000797","article-title":"Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication","volume":"98","author":"Wang","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0215","doi-asserted-by":"crossref","first-page":"17664","DOI":"10.1074\/jbc.M212723200","article-title":"Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells","volume":"278","author":"Wielinga","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.01.008_bib0220","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.dci.2009.10.007","article-title":"Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI)","volume":"34","author":"Xie","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2018.01.008_bib0225","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.molcel.2013.05.022","article-title":"Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molimm.2018.01.008_bib0230","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.dci.2014.07.020","article-title":"Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41)","volume":"47","author":"Zhu","year":"2014","journal-title":"Dev. Comp. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018300154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018300154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T22:21:13Z","timestamp":1535062873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589018300154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":46,"alternative-id":["S0161589018300154"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2018.01.008","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maintenance of cyclic GMP\u2013AMP homeostasis by ENPP1 is involved in pseudorabies virus infection","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2018.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}