{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:15:11Z","timestamp":1781198111352,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UGC (RGNF)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.molimm.2018.03.004","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T20:25:27Z","timestamp":1521404727000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Immunomodulation induced through ornithine decarboxylase DNA immunization in Balb\/c mice infected with Leishmania donovani"],"prefix":"10.1016","volume":"97","author":[{"given":"Akhilesh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Ranjan","family":"Dikhit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Amit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Kishor","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi S.","family":"Suman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahab","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya Nand Rabi","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhankar Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirendra kumar","family":"Chourasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiva","family":"Bimal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2018.03.004_bib0005","series-title":"Antimony-Resistant Leishmania donovani in Eastern Sudan: Incidence and In Vitro Correlation","author":"Abdo","year":"2003"},{"issue":"12","key":"10.1016\/j.molimm.2018.03.004_bib0010","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1128\/IAI.70.12.6697-6706.2002","article-title":"Characterization of Leishmania donovani antigens encapsulated in liposomes that induce protective immunity in BALB\/c mice","volume":"70","author":"Afrin","year":"2002","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.molimm.2018.03.004_bib0015","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.micinf.2017.03.002","article-title":"Immuno-informatics based approaches to identify CD8+ T cell epitopes within the Leishmania donovani 3-ectonucleotidase in cured visceral leishmaniasis subjects","volume":"19","author":"Amit","year":"2017","journal-title":"Microbes Infect."},{"key":"10.1016\/j.molimm.2018.03.004_bib0020","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molimm.2016.12.022","article-title":"Immunization with Leishmania donovani protein disulfide isomerase DNA construct induces Th1 and Th17 dependent immune response and protection against experimental visceral leishmaniasis in Balb\/c mice","volume":"82","author":"Amit","year":"2017","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.molimm.2018.03.004_bib0025","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1086\/506624","article-title":"Interferon (IFN)\u2013\u03b3, tumor necrosis factor\u2013\u03b1, interleukin-6, and IFN-\u03b3 receptor 1 are the major immunological determinants associated with post\u2013kala azar dermal leishmaniasis","volume":"194","author":"Ansari","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.molimm.2018.03.004_bib0030","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.4049\/jimmunol.174.11.7160","volume":"174","author":"Basu","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2018.03.004_bib0035","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1128\/IAI.69.3.1499-1507.2001","article-title":"Immunomodulatory role of IL-10 in Visceral Leishmaniasis: defective activation of Protein Kinase C-mediated signal transduction events","volume":"69","author":"Bhattacharya","year":"2001","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.molimm.2018.03.004_bib0040","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pt.2012.05.005","article-title":"Purine salvage in Leishmania: complex or simple by design?","volume":"28","author":"Boitz","year":"2012","journal-title":"Trends Parasitol."},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0045","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2249.1993.tb05931.x","article-title":"Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction","volume":"91","author":"Caceres-Dittmar","year":"1993","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.molimm.2018.03.004_bib0050","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/infdis\/168.4.986","article-title":"Mononuclear cell subpopulations and cytokine levels in human visceral leishmaniasis before and after chemotherapy","volume":"168","author":"Cenini","year":"1993","journal-title":"J. Infect. Dis."},{"issue":"7","key":"10.1016\/j.molimm.2018.03.004_bib0055","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1592","article-title":"Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major","volume":"13","author":"Darrah","year":"2007","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0060","first-page":"130","article-title":"Magnitude of unresponsiveness to sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar","volume":"18","author":"Das","year":"2005","journal-title":"Natl. Med. J. India"},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.actatropica.2011.08.007","article-title":"DNA vaccination with KMP11 and Lutzomyia longipalpis salivary protein protects hamsters against visceral leishmaniasis","volume":"120","author":"da Silva","year":"2011","journal-title":"Acta Trop."},{"issue":"5","key":"10.1016\/j.molimm.2018.03.004_bib0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Desjeux","year":"2004","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"issue":"5","key":"10.1016\/j.molimm.2018.03.004_bib0075","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1073\/pnas.93.5.2192","article-title":"An ATP-dependent As (III)-glutathione transport system in membrane vesicles of Leishmania tarentolae","volume":"93","author":"Dey","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.molimm.2018.03.004_bib0080","first-page":"1753","article-title":"Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl) benzenesulfonamide against Leishmania donovani","volume":"10","author":"Dikhit","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.molimm.2018.03.004_bib0085","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.meegid.2016.08.037","article-title":"Computational prediction and analysis of potential antigenic CTL epitopes in Zika virus: a first step towards vaccine development","volume":"45","author":"Dikhit","year":"2016","journal-title":"Infect. Genet. Evol.: J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"10.1016\/j.molimm.2018.03.004_bib0090","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3389\/fimmu.2017.01763","article-title":"Identification of potential MHC class-II-restricted epitopes derived from Leishmania donovani antigens by reverse vaccinology and evaluation of their CD4+ T-cell responsiveness against visceral leishmaniasis","volume":"8","author":"Dikhit","year":"2017","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.molimm.2018.03.004_bib0095","doi-asserted-by":"crossref","first-page":"A2","DOI":"10.1111\/pim.12451","article-title":"Vaccine potential of HLA- epitopes from Leishmania cysteine protease type III (CPC)","volume":"39","author":"Dikhit","year":"2017","journal-title":"Parasite Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2018.03.004_bib0100","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jcb.26190","article-title":"Mining the proteome of Leishmania donovani for the development of novel MHC class I restricted epitope for the control of visceral leishmaniasis","volume":"119","author":"Dikhit","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0105","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.4049\/jimmunol.162.3.1723","article-title":"A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells","volume":"162","author":"Groux","year":"1999","journal-title":"J. Immunol."},{"issue":"15","key":"10.1016\/j.molimm.2018.03.004_bib0110","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.vaccine.2013.02.025","volume":"31","author":"Guha","year":"2013","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.molimm.2018.03.004_bib0115","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1046\/j.1365-2958.1999.01634.x","article-title":"Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania","volume":"34","author":"Haimeur","year":"1999","journal-title":"Mol. Microbiol."},{"issue":"1","key":"10.1016\/j.molimm.2018.03.004_bib0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0166-6851(00)00187-0","article-title":"Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae","volume":"108","author":"Haimeur","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"issue":"4","key":"10.1016\/j.molimm.2018.03.004_bib0125","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0035-9203(86)90149-5","article-title":"A simple and economical direct agglutination test for serodiagnosis and sero-epidemiological studies of visceral leishmaniasis","volume":"80","author":"Harith","year":"1986","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"1","key":"10.1016\/j.molimm.2018.03.004_bib0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1084\/jem.169.1.59","article-title":"Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets","volume":"169","author":"Heinzel","year":"1989","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.molimm.2018.03.004_bib0135","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1074\/jbc.274.6.3781","article-title":"Ornithine decarboxylase gene deletion mutants of Leishmania donovani","volume":"274","author":"Jiang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.03.004_bib0140","doi-asserted-by":"crossref","first-page":"609289","DOI":"10.1155\/2013\/609289","article-title":"Computational elucidation of structural basis for ligand binding with Leishmania donovani adenosine kinase","volume":"2013","author":"Kar","year":"2013","journal-title":"BioMed Res. Int."},{"issue":"28","key":"10.1016\/j.molimm.2018.03.004_bib0145","doi-asserted-by":"crossref","first-page":"26301","DOI":"10.1074\/jbc.M102351200","article-title":"The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase","volume":"276","author":"L\u00e9gar\u00e9","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.molimm.2018.03.004_bib0150","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02429-16","article-title":"In vitro evaluation of antileishmanial activity of computationally screened compounds against ascorbate peroxidase to combat amphotericin B drug resistance","volume":"61","author":"Mansuri","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.molimm.2018.03.004_bib0155","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s13071-016-1777-x","article-title":"Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery","volume":"9","author":"Mendon\u00e7a","year":"2016","journal-title":"Parasites Vectors"},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0160","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1134\/S0026893312030089","article-title":"DNA vaccine encoding alpha-fetoprotein with fused ornithine decarboxylase degradation signal significantly suppresses hepatocellular carcinoma growth in mice","volume":"46","author":"Morozov","year":"2012","journal-title":"Mol. Biol."},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0165","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0738-081X(99)00049-8","article-title":"Treatment of cutaneous leishmaniasis: retrospectives and advances for the 21st century","volume":"17","author":"Moskowitz","year":"1999","journal-title":"Clin. Dermatol."},{"issue":"2","key":"10.1016\/j.molimm.2018.03.004_bib0170","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/jac\/dkl494","article-title":"Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani","volume":"59","author":"Mukherjee","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"issue":"19","key":"10.1016\/j.molimm.2018.03.004_bib0175","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1073\/pnas.93.19.10383","article-title":"Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania","volume":"93","author":"Mukhopadhyay","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.molimm.2018.03.004_bib0180","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.189.4.741","article-title":"Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani","volume":"189","author":"Murray","year":"1999","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.molimm.2018.03.004_bib0185","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/eji.1830220217","article-title":"Preferential positive selection of V\u03b12+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V\u03b1a haplotypes: determination with a V\u03b12-specific monoclonal antibody","volume":"22","author":"Pircher","year":"1992","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2018.03.004_bib0190","first-page":"251","article-title":"Wild and synanthropic reservoirs of Leishmania species in the Americas","volume":"3","author":"Roque","year":"2014","journal-title":"Int. J. Parasitol.: Parasites Wildl."},{"issue":"2","key":"10.1016\/j.molimm.2018.03.004_bib0195","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jcb.20187","article-title":"The role of stathmin in the regulation of the cell cycle","volume":"93","author":"Rubin","year":"2004","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.molimm.2018.03.004_bib0200","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1074-7613(00)80479-3","article-title":"Upstream-downstream: CD28 cosignaling pathways and T cell function","volume":"4","author":"Rudd","year":"1996","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.molimm.2018.03.004_bib0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40249-016-0112-2","article-title":"Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective","volume":"5","author":"Singh","year":"2016","journal-title":"Infect. Dis. Poverty"},{"issue":"2","key":"10.1016\/j.molimm.2018.03.004_bib0210","doi-asserted-by":"crossref","first-page":"133","DOI":"10.7326\/0003-4819-127-2-199707150-00007","article-title":"Short-course, low-dose amphotericin B lipid complex therapy for visceral leishmaniasis unresponsive to antimony","volume":"127","author":"Sundar","year":"1997","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.molimm.2018.03.004_bib0215","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1179\/000349804225003154","article-title":"A comparative evaluation of amphotericin B and sodium antimony gluconate, as first-line drugs in the treatment of Indian visceral leishmaniasis","volume":"98","author":"Thakur","year":"2004","journal-title":"Ann. Trop. Med. Parasitol."},{"issue":"6","key":"10.1016\/j.molimm.2018.03.004_bib0220","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.micinf.2017.03.002","article-title":"Immuno-informatics based approaches to identify CD8+ T cell epitopes within the Leishmania donovani 3-ectonucleotidase in cured visceral leishmaniasis subjects","volume":"19","author":"Vijayamahantesh","year":"2017","journal-title":"Microbes Infect."},{"issue":"38","key":"10.1016\/j.molimm.2018.03.004_bib0225","doi-asserted-by":"crossref","first-page":"39925","DOI":"10.1074\/jbc.M405635200","article-title":"Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani","volume":"279","author":"Wyllie","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.molimm.2018.03.004_bib0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijpara.2014.08.013","article-title":"Leishmania donovani: impairment of the cellular immune response against recombinant ornithine decarboxylase protein as a possible evasion strategy of Leishmania in visceral leishmaniasis","volume":"45","author":"Yadav","year":"2015","journal-title":"Int. J. Parasitol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018300555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018300555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:32:16Z","timestamp":1693575136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589018300555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":46,"alternative-id":["S0161589018300555"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2018.03.004","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulation induced through ornithine decarboxylase DNA immunization in Balb\/c mice infected with Leishmania donovani","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2018.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}