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Lett."},{"key":"10.1016\/j.molimm.2018.06.007_bib0560","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1021\/bi962895r","article-title":"Potent inhibition of terminal complement assembly by clusterin: characterization of its impact on C9 polymerization","volume":"36","author":"McDonald","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.molimm.2018.06.007_bib0565","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.4049\/jimmunol.0900879","article-title":"Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function","volume":"183","author":"Megyeri","year":"2009","journal-title":"J. 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