{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:24Z","timestamp":1790352564581,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.molimm.2018.07.013","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T20:05:12Z","timestamp":1532030712000},"page":"276-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Immunomodulatory effect of thymoquinone on atopic dermatitis"],"prefix":"10.1016","volume":"101","author":[{"given":"Hina","family":"Aslam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-8957","authenticated-orcid":false,"given":"Muhammad","family":"Shahzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arham","family":"Shabbir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabeen","family":"Irshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2018.07.013_bib0005","series-title":"The Washington Manual Allergy, Asthma, and Immunology Subspecialty Consult","first-page":"66","article-title":"Atopic dermatitis","author":"Abdel-Hamid","year":"2003"},{"key":"10.1016\/j.molimm.2018.07.013_bib0010","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000323305","article-title":"The role of regulatory T cells in atopic dermatitis","volume":"41","author":"Agrawal","year":"2011","journal-title":"Curr. Probl. Dermatol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0015","article-title":"Topical corticosteroid phobia in atopic dermatitis","author":"Alvin","year":"2017","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0020","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.intimp.2011.10.013","article-title":"Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model","volume":"11","author":"Ammar","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0300-483X(99)00179-1","article-title":"The influence of thymoquinone on doxorubicin induced hyperlipidemic nephropathy in rats","volume":"143","author":"Badary","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.molimm.2018.07.013_bib0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1081\/DCT-120020404","article-title":"Thymoquinone is a potent superoxide anion scavenger","volume":"26","author":"Badary","year":"2003","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0035","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00204-006-0094-0","article-title":"Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis","volume":"80","author":"Budancamanak","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q","article-title":"Antioxidant activity of Nigella sativa essential oil","volume":"14","author":"Burits","year":"2000","journal-title":"Phytother. Res."},{"key":"10.1016\/j.molimm.2018.07.013_bib0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jdermsci.2013.06.015","article-title":"Effect of dehydroepiandrosterone on atopic dermatitis-like skin lesions induced by 1-chloro-2,4-dinitrobenzene in mouse","volume":"72","author":"Chan","year":"2013","journal-title":"J. Dermatol. Sci."},{"issue":"3","key":"10.1016\/j.molimm.2018.07.013_bib0050","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jamadermatol.2016.4467","article-title":"Association of filaggrin loss of function and thymic stromal lymphopoietin variation with treatment use in pediatric atopic dermatitis","volume":"153","author":"Chang","year":"2017","journal-title":"JAMA Dermatol."},{"issue":"6","key":"10.1016\/j.molimm.2018.07.013_bib0055","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.3892\/mmr.2015.3301","article-title":"Role of the complement anaphylatoxin C5a-receptor pathway in atopic dermatitis in mice","volume":"11","author":"Dang","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.molimm.2018.07.013_bib0060","doi-asserted-by":"crossref","first-page":"7201","DOI":"10.4049\/jimmunol.0801772","article-title":"Suppression of NF-kappaB by cyclosporine a and tacrolimus (FK506) via induction of the C\/EBP family: implication for unfolded protein response","volume":"182","author":"Du","year":"2009","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.molimm.2018.07.013_bib0065","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.intimp.2006.02.004","article-title":"Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation","volume":"6","author":"El Gazzar","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.imlet.2006.04.012","article-title":"Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation","volume":"106","author":"El Mezayen","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.molimm.2018.07.013_bib0075","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.biocel.2005.10.009","article-title":"Thymoquinone: a promising anti-cancer drug from natural sources","volume":"38","author":"Gali-Muhtasib","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fct.2015.08.028","article-title":"Immunomodulatory and cytotoxic effects of Nigella sativa and thymoquinone on rat splenocytes","volume":"86","author":"Gholamnezhad","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0085","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jff.2015.06.032","article-title":"Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects of obstructive respiratory diseases: a review of basic and clinical evidence","volume":"17","author":"Gholamnezhad","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.molimm.2018.07.013_bib0090","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jep.2016.06.061","article-title":"Preclinical and clinical effects of Nigella sativa and its constituents, thymoquinone: a review","volume":"190","author":"Gholamnezhad","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0095","series-title":"Black Seed: Nature\u2019s Miracle Remedy","first-page":"1","author":"Goreja","year":"2003"},{"key":"10.1016\/j.molimm.2018.07.013_bib0100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/gb-2003-4-9-117","article-title":"Comparing protein abundance and mRNA expression levels on a genomic scale","volume":"4","author":"Greenbaum","year":"2003","journal-title":"Gen. Biol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0105","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0167-5699(98)01285-7","article-title":"A role for Th1 and Th2 cells in the immuno-pathogenesis of atopic dermatitis","volume":"19","author":"Grewe","year":"1998","journal-title":"Immunol. Today"},{"issue":"5","key":"10.1016\/j.molimm.2018.07.013_bib0110","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1745-7270.2008.00418.x","article-title":"How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes","volume":"40","author":"Guo","year":"2008","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.molimm.2018.07.013_bib0115","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ptr.1390","article-title":"Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug","volume":"18","author":"Hajhashemi","year":"2004","journal-title":"Phytother. Res."},{"key":"10.1016\/j.molimm.2018.07.013_bib0120","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.4049\/jimmunol.174.11.6781","article-title":"Regulation of INF-\u03b3 production by B effector 1 cells:essential roles for T-bet and the INF-\u03b3 receptor","volume":"174","author":"Harris","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2010.07.031","article-title":"Comparison of the efficacy of tacrolimus and cyclosporine a in a murine model of dinitrofluorobenzene-induced atopic dermatitis","volume":"645","author":"Hirotaka","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0130","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jaci.2006.03.047","article-title":"Cytokines and chemokines orchestrate atopic skin inflammation","volume":"118","author":"Homey","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.molimm.2018.07.013_bib0135","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/intimm\/dxf044","article-title":"IFN-gamma-inducible expression of thymus and activation-regulated chemokine\/CCL17 and macrophagederived chemokine\/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis","volume":"14","author":"Horikawa","year":"2002","journal-title":"Int. Immunol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0140","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2133.1994.tb08522.x","article-title":"Mast cells are one major source of interleukin-4 in atopic dermatitis","volume":"131","author":"Horsmanheimo","year":"1994","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0145","doi-asserted-by":"crossref","DOI":"10.1038\/srep42995","article-title":"Thymoquinone: an IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities","volume":"7","author":"Hossen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2018.07.013_bib0150","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1472-6882-13-312","article-title":"Modulation of experimental atopic dermatitis by topical application of Gami-Cheongyeul-Sodok-Eum","volume":"13","author":"Hwang","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.molimm.2018.07.013_bib0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jid.2008.106","article-title":"Animal models of atopic dermatitis","volume":"129","author":"Jin","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0160","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.intimp.2008.06.004","article-title":"Inhibition of atopic dermatitis by topical application of silymarin in NC\/Nga mice","volume":"8","author":"Kang","year":"2008","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.molimm.2018.07.013_bib0165","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1055\/s-0029-1186054","article-title":"The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs","volume":"76","author":"Keyhanmanesh","year":"2010","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.molimm.2018.07.013_bib0170","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S1734-1140(10)70351-0","article-title":"Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs","volume":"62","author":"Keyhanmanesh","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.molimm.2018.07.013_bib0175","article-title":"Topical application of herbal mixture extract inhibits ovalbumin- or 2,4-dinitrochlorobenzene-induced atopic dermatitis","volume":"2012","author":"Kim","year":"2012","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"8","key":"10.1016\/j.molimm.2018.07.013_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0104938","article-title":"7,8,4'-trihydroxyisoflavone attenuates DNCB-induced atopic dermatitis-like symptoms in NC\/Nga mice","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2018.07.013_bib0185","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1346-8138.2001.tb00124.x","article-title":"Reduction of serum interleukin-5 levels reflect clinical improvement in patients with atopic dermatitis","volume":"28","author":"Kondo","year":"2001","journal-title":"J. Dermatol."},{"issue":"4","key":"10.1016\/j.molimm.2018.07.013_bib0190","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1542\/peds.2007-2232","article-title":"Management of atopic dermatitis in the pediatric population","volume":"122","author":"Krakowski","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.molimm.2018.07.013_bib0195","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbrc.2013.07.110","article-title":"Thymoquinone inhibits phorbol ester-induced activation of NF-\u0138B and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo","volume":"438","author":"Kundu","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.molimm.2018.07.013_bib0200","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5625\/lar.2010.26.1.95","article-title":"A novel model for human atopic dermatitis: application of repeated DNCB patch in BALB\/c mice, in comparison with NC\/Nga mice","volume":"26","author":"Lee","year":"2010","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.molimm.2018.07.013_bib0205","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(03)12193-9","article-title":"Atopic dermatitis","volume":"361","author":"Leung","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2018.07.013_bib0210","article-title":"Anti-inflammatory effect of qingpeng ointment in atopic dermatitis-like murine model","author":"Li","year":"2013","journal-title":"Evid. Complement. Altern. Med."},{"key":"10.1016\/j.molimm.2018.07.013_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-139","article-title":"Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC\/Nga mice","volume":"14","author":"Lim","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.molimm.2018.07.013_bib0220","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1398-9995.2003.23790.x","article-title":"A mouse model of the atopic eczema\/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farina","volume":"58","author":"Matsuoka","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2018.07.013_bib0225","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1523-1747.2003.12331.x","article-title":"Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A","volume":"121","author":"Meingassner","year":"2003","journal-title":"J. Invest. Dermatol."},{"issue":"1-2","key":"10.1016\/j.molimm.2018.07.013_bib0230","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s12016-007-0029-4","article-title":"Mast cells and immunological skin diseases","volume":"33","author":"Navi","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0235","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1398-9995.2008.01922.x","article-title":"New insights into the mechanism and management of allergic diseases: atopic dermatitis","volume":"64","author":"Novak","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2018.07.013_bib0240","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jaci.2003.09.032","article-title":"Immune mechanisms leading to atopic dermatitis","volume":"112","author":"Novak","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0245","series-title":"What's New in Dermatology","author":"Ofori","year":"2017"},{"key":"10.1016\/j.molimm.2018.07.013_bib0250","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11882-996-0008-5","article-title":"Immune dysregulation in atopic dermatitis","volume":"6","author":"Ong","year":"2006","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.molimm.2018.07.013_bib0255","doi-asserted-by":"crossref","first-page":"99","DOI":"10.18773\/austprescr.2006.064","article-title":"Immunosuppressive mechanisms of action and monitoring","volume":"29","author":"Pillans","year":"2006","journal-title":"Aust. Prescr."},{"key":"10.1016\/j.molimm.2018.07.013_bib0260","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1067\/mai.2000.104575","article-title":"The role of lymphocytes in allergic disease","volume":"105","author":"Romagnani","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0265","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu. Rev. Immunol."},{"issue":"738","key":"10.1016\/j.molimm.2018.07.013_bib0270","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejphar.2014.05.045","article-title":"Anti-arthiritic activity of N-(2,4- dihydroxyphenyl] methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolol[4,3-][1,2]benzothiazin-1(4H)-yl) acetohydrazide","author":"Shabbir","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.molimm.2018.07.013_bib0275","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1398-9995.1989.tb02449.x","article-title":"Morphology of atopic eczema","volume":"44","author":"Soter","year":"1989","journal-title":"Allergy"},{"issue":"Suppl. 6","key":"10.1016\/j.molimm.2018.07.013_bib0280","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jaci.2003.09.033","article-title":"Atopic dermatitis and the atopic march","volume":"112","author":"Spergel","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0285","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1172\/JCI5669","article-title":"Role of Th1 and Th2 cytokines in a murine model of allergic dermatitis","volume":"103","author":"Spergel","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2018.07.013_bib0290","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/ptr.2143","article-title":"Effects of thymoquinone (Volatile Oil of Black Cumin) on rheumatoid arthritis in rat models","volume":"21","author":"Tekeoglu","year":"2007","journal-title":"Phytother. Res."},{"issue":"6","key":"10.1016\/j.molimm.2018.07.013_bib0295","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00007691-199512000-00007","article-title":"Mode of action of tacrolimus (FK506): molecular and cellular mechanisms","volume":"17","author":"Thomson","year":"1995","journal-title":"Ther. Drug Monit."},{"issue":"1","key":"10.1016\/j.molimm.2018.07.013_bib0300","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI9199","article-title":"T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis","volume":"106","author":"Trautmann","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2018.07.013_bib0305","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/1523-1747.ep12331164","article-title":"Allergen specificity of skin-infiltrating T cells is not restricted to type-2 cytokine pattern in chronic skin lesions of atopic dermatitis","volume":"107","author":"Werfel","year":"1996","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molimm.2018.07.013_bib0310","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijpharm.2013.08.015","article-title":"Inhibitory effects of cultured Dendrobium tosaense on atopic dermatitis murine model","volume":"463","author":"Wu","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.molimm.2018.07.013_bib0315","first-page":"471","article-title":"Topical tacrolimus: an effective therapy for facial psoriasis","volume":"13","author":"Yamamoto","year":"2003","journal-title":"Eur. J. Dermatol."},{"issue":"2","key":"10.1016\/j.molimm.2018.07.013_bib0320","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/77811","article-title":"IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6","volume":"1","author":"Yoshimoto","year":"2000","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2018.07.013_bib0325","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000442353","article-title":"Comparison of histopathological effects of thymoquinone and local nasal corticosteroids in allergic rhinitis in a rabbit model","volume":"78","author":"Yurtta\u015f","year":"2016","journal-title":"ORL"},{"key":"10.1016\/j.molimm.2018.07.013_bib0330","first-page":"140","article-title":"Sanpao herbs inhibit development of atopic dermatitis in Balb\/c mice, 2018 inhibit development of atopic dermatitis in Balb\/c mice","volume":"32","author":"Zhou","year":"2014","journal-title":"Asian Pac. J. Allergy Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018305534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018305534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:33:54Z","timestamp":1758980034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589018305534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":66,"alternative-id":["S0161589018305534"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2018.07.013","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory effect of thymoquinone on atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2018.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}