{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:59:39Z","timestamp":1790794779771,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.molimm.2018.09.011","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T01:17:59Z","timestamp":1538097479000},"page":"144-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["IDO1 impairs NK cell cytotoxicity by decreasing NKG2D\/NKG2DLs via promoting miR-18a"],"prefix":"10.1016","volume":"103","author":[{"given":"Jiahui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjiao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2018.09.011_bib0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2018.09.011_bib0010","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1002\/eji.201445375","article-title":"Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma","volume":"45","author":"Belting","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0015","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.7150\/thno.11543","article-title":"MicroRNAs: new biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer","volume":"5","author":"Bertoli","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.molimm.2018.09.011_bib0020","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41467-017-01126-x","article-title":"Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq","volume":"8","author":"Bottini","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2018.09.011_bib0025","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/eji.200939937","article-title":"Requirements for control of B-cell lymphoma by NK cells","volume":"40","author":"Brenner","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0030","doi-asserted-by":"crossref","first-page":"905","DOI":"10.4049\/jimmunol.176.2.905","article-title":"IFN-dependent down-regulation of the NKG2D ligand H60 on tumours","volume":"176","author":"Bui","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40425-017-0285-7","article-title":"Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer","volume":"5","author":"Carvajal-Hausdorf","year":"2017","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.molimm.2018.09.011_bib0040","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ijc.2910430410","article-title":"Natural killer cell immunodeficiency in patients with chronic myelogenous leukemia. III. Defective interleukin-2 production by T-helper and natural killer cells","volume":"43","author":"Chang","year":"1989","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.molimm.2018.09.011_bib0045","unstructured":"W. Chen, A.J. Liang X Fau - Peterson, D.H. Peterson Aj Fau - Munn, B.R. Munn Dh Fau - Blazar, B.R. Blazar, The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation, DOI."},{"key":"10.1016\/j.molimm.2018.09.011_bib0050","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1182\/blood-2007-01-068031","article-title":"Tumour-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes","volume":"110","author":"Kuang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2018.09.011_bib0055","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13045-015-0134-4","article-title":"TIM-3\/Gal-9 interaction induces IFNgamma-dependent IDO1 expression in acute myeloid leukemia blast cells","volume":"8","author":"Folgiero","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0060","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ijc.11730","article-title":"Analysis of the natural killer mediated immune response in metastatic renal cell carcinoma patients","volume":"109","author":"Gati","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.molimm.2018.09.011_bib0065","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fimmu.2012.00393","article-title":"Natural killer lytic-associated molecule plays a role in controlling tumour dissemination and metastasis","volume":"3","author":"Hoover","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0070","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jhep.2005.05.026","article-title":"Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas","volume":"43","author":"Jinushi","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0075","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.4049\/jimmunol.139.7.2414","article-title":"Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures","volume":"139","author":"Carlin","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0080","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molonc.2010.04.002","article-title":"The epigenetics of breast cancer","volume":"4","author":"Jovanovic","year":"2010","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0085","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1072-7515(03)00115-7","article-title":"Natural killer cell activity and distant metastasis in rectal cancers treated surgically with and without neoadjuvant chemoradiotherapy","volume":"197","author":"Koda","year":"2003","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.molimm.2018.09.011_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10585-006-9043-9","article-title":"Low expression of CD161 and NKG2D activating NK receptor is associated with impaired NK cell cytotoxicity in metastatic melanoma patients","volume":"24","author":"Konjevic","year":"2007","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.molimm.2018.09.011_bib0095","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.145","article-title":"MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer","volume":"8","author":"Liang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molimm.2018.09.011_bib0100","doi-asserted-by":"crossref","first-page":"68263","DOI":"10.18632\/oncotarget.19293","article-title":"MicroRNA-18a promotes proliferation and metastasis in hepatocellular carcinoma via targeting KLF4","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2018.09.011_bib0105","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1200\/JCO.2005.10.015","article-title":"Social support, psychological distress, and natural killer cell activity in ovarian cancer","volume":"23","author":"Lutgendorf","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0110","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1172\/JCI45816","article-title":"Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumour immunity","volume":"121","author":"Mamessier","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2018.09.011_bib0115","doi-asserted-by":"crossref","first-page":"12892","DOI":"10.1038\/s41598-017-12940-0","article-title":"A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression","volume":"7","author":"Mangaonkar","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2018.09.011_bib0120","first-page":"5610","article-title":"Decreased expression of the signal-transducing zeta chains in tumour-infiltrating T-cells and NK cells of patients with colorectal carcinoma","volume":"53","author":"Nakagomi","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.molimm.2018.09.011_bib0125","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1158\/1078-0432.CCR-07-1731","article-title":"MicroRNA expression profiles in serous ovarian carcinoma","volume":"14","author":"Nam","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.molimm.2018.09.011_bib0130","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1186\/1471-2407-14-738","article-title":"Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction","volume":"14","author":"Peng","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.molimm.2018.09.011_bib0135","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1158\/0008-5472.CAN-11-2544","article-title":"Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity","volume":"72","author":"Pietra","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.molimm.2018.09.011_bib0140","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fimmu.2013.00408","article-title":"Tumour-primed NK cells: waiting for the green light","volume":"4","author":"Sabry","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11010-017-2975-3","article-title":"Kynurenic acid downregulates IL-17\/1L-23 axis in vitro","volume":"431","author":"Salimi Elizei","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.molimm.2018.09.011_bib0150","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.molimm.2008.09.035","article-title":"Murine NKG2D ligands: \u201cdouble, double toil and trouble\u201d","volume":"46","author":"Samarakoon","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0155","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.3892\/or.2012.1984","article-title":"Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumour growth by promoting natural killer cell accumulation","volume":"28","author":"Sato","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.molimm.2018.09.011_bib0160","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/ijc.24098","article-title":"Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells","volume":"124","author":"Schwinn","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.molimm.2018.09.011_bib0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1158\/1940-6207.CAPR-16-0177","article-title":"Expression of miR-18a and miR-210 in normal breast tissue as candidate biomarkers of breast cancer risk","volume":"10","author":"Shidfar","year":"2017","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.molimm.2018.09.011_bib0170","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.intimp.2011.02.005","article-title":"L-kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species","volume":"11","author":"Song","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0175","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ni.1642","article-title":"Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D","volume":"9","author":"Stern-Ginossar","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0180","doi-asserted-by":"crossref","first-page":"54548","DOI":"10.18632\/oncotarget.17408","article-title":"P53 prevent tumour invasion and metastasis by down-regulating IDO in lung cancer","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2018.09.011_bib0185","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/cas.12445","article-title":"Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment","volume":"105","author":"Tanizaki","year":"2014","journal-title":"Cancer Sci."},{"key":"10.1016\/j.molimm.2018.09.011_bib0190","first-page":"167","article-title":"microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells","volume":"5","author":"Tao","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.molimm.2018.09.011_bib0195","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1096\/fasebj.5.11.1907934","article-title":"Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism","volume":"5","author":"Taylor","year":"1991","journal-title":"FASEB J."},{"key":"10.1016\/j.molimm.2018.09.011_bib0200","doi-asserted-by":"crossref","first-page":"25683","DOI":"10.18632\/oncotarget.8361","article-title":"Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages","volume":"7","author":"Teng","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2018.09.011_bib0205","article-title":"Trial watch: IDO inhibitors in cancer therapy","volume":"3","author":"Vacchelli","year":"2014","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.molimm.2018.09.011_bib0210","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3892\/ijo.2011.1295","article-title":"Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy","volume":"40","author":"Wang","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.molimm.2018.09.011_bib0215","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/bjc.2014.547","article-title":"Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma","volume":"112","author":"Yang","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.molimm.2018.09.011_bib0220","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1021\/acsmedchemlett.6b00391","article-title":"INCB24360 (Epacadostat), a highly potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology","volume":"8","author":"Yue","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.molimm.2018.09.011_bib0225","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1158\/1078-0432.CCR-15-0420","article-title":"Molecular pathways: targeting IDO1 and other tryptophan dioxygenases for Cancer immunotherapy","volume":"21","author":"Zhai","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.molimm.2018.09.011_bib0230","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yexcr.2017.09.037","article-title":"The long noncoding RNA CASC2 inhibits tumourigenesis through modulating the expression of PTEN by targeting miR-18a-5p in esophageal carcinoma","volume":"361","author":"Zhang","year":"2017","journal-title":"Exp. Cell Res."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018307879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018307879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:48:59Z","timestamp":1693918139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589018307879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":46,"alternative-id":["S0161589018307879"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2018.09.011","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IDO1 impairs NK cell cytotoxicity by decreasing NKG2D\/NKG2DLs via promoting miR-18a","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2018.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}