{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:09:54Z","timestamp":1792004994024,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603587"],"award-info":[{"award-number":["81603587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603668"],"award-info":[{"award-number":["81603668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC1700400"],"award-info":[{"award-number":["2017YFC1700400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Natural Science Funds for Distinguished Young Scholar","award":["2018B030306027"],"award-info":[{"award-number":["2018B030306027"]}]},{"name":"Science and Technology Development Plan of Guangdong Province","award":["2017A020211016"],"award-info":[{"award-number":["2017A020211016"]}]},{"name":"Youth Medical Talent Fund of Guangzhou University of Chinese Medicine","award":["QNYC20170105"],"award-info":[{"award-number":["QNYC20170105"]}]},{"name":"Science & Technology Award for Young-aged Talents of China Association of Traditional Chinese Medicine","award":["CACM-2017-QNRC2-C12"],"award-info":[{"award-number":["CACM-2017-QNRC2-C12"]}]},{"name":"Project of Guangzhou University of Chinese Medcine","award":["A1-AFD018171Z11020"],"award-info":[{"award-number":["A1-AFD018171Z11020"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["11616334"],"award-info":[{"award-number":["11616334"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.molimm.2018.10.001","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T07:22:08Z","timestamp":1539069728000},"page":"209-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Periodontal ligament fibroblasts migration injury via ROS\/TXNIP\/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide"],"prefix":"10.1016","volume":"103","author":[{"given":"Dawei","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2018.10.001_bib0005","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.molimm.2018.10.001_bib0010","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2015.01.008","article-title":"NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases","volume":"4","author":"Abderrazak","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1753425912444767","article-title":"Down-regulation of NLRP3 inflammasome in gingival fibroblasts by subgingival biofilms: involvement of Porphyromonas gingivalis","volume":"19","author":"Belibasakis","year":"2013","journal-title":"Innate Immun."},{"key":"10.1016\/j.molimm.2018.10.001_bib0020","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbamcr.2014.01.033","article-title":"Activation of inflammasomes in podocyte injury of mice on the high fat diet: effects of ASC gene deletion and silencing","volume":"1843","author":"Boini","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molimm.2018.10.001_bib0025","doi-asserted-by":"crossref","first-page":"19031","DOI":"10.18632\/oncotarget.8023","article-title":"Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene","volume":"7","author":"Boini","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2018.10.001_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","article-title":"Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation","volume":"22","author":"Buckley","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0035","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.freeradbiomed.2011.02.018","article-title":"Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis","volume":"50","author":"Bullon","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.molimm.2018.10.001_bib0040","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1111\/jcmm.12657","article-title":"Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1","volume":"19","author":"Chen","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molimm.2018.10.001_bib0045","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00109-016-1481-5","article-title":"Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction","volume":"94","author":"Chen","year":"2016","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.molimm.2018.10.001_bib0050","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.archoralbio.2014.05.022","article-title":"Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-kappaB signalling in periodontal fibroblasts","volume":"59","author":"Chi","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0055","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1038\/ncomms7574","article-title":"Vimentin regulates activation of the NLRP3 inflammasome","volume":"6","author":"dos Santos","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2018.10.001_bib0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jre.12217","article-title":"The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor-kappa B activation in human gingival fibroblasts","volume":"50","author":"Fu","year":"2015","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.molimm.2018.10.001_bib0065","doi-asserted-by":"crossref","first-page":"986264","DOI":"10.1155\/2014\/986264","article-title":"LPS from P. Gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis","volume":"2014","author":"Golz","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.molimm.2018.10.001_bib0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","article-title":"The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction","volume":"74","author":"Graves","year":"2003","journal-title":"J. Periodontol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0075","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1177\/00220345010800100301","article-title":"Tumor necrosis factor modulates fibroblast apoptosis, PMN recruitment, and osteoclast formation in response to P. gingivalis infection","volume":"80","author":"Graves","year":"2001","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molimm.2018.10.001_bib0080","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s10495-009-0401-3","article-title":"Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells","volume":"14","author":"Guo","year":"2009","journal-title":"Apoptosis : an international journal on programmed cell death"},{"key":"10.1016\/j.molimm.2018.10.001_bib0085","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00795-018-0181-3","article-title":"Effect of systemic administration of lipopolysaccharides derived from Porphyromonas gingivalis on gene expression in mice kidney","volume":"51","author":"Harada","year":"2018","journal-title":"Mol. Morphol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.2041-1014.2012.00638.x","article-title":"Porphyromonas gingivalis and its lipopolysaccharide differentially regulate the expression of cathepsin B in endothelial cells","volume":"27","author":"Huck","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0095","doi-asserted-by":"crossref","first-page":"36617","DOI":"10.1074\/jbc.M112.407130","article-title":"Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation","volume":"287","author":"Juliana","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.10.001_bib0100","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2004.12.041","article-title":"Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases","volume":"120","author":"Kamata","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2018.10.001_bib0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.archoralbio.2013.11.008","article-title":"Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells","volume":"59","author":"Kato","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0022-3913(97)70234-8","article-title":"Periodontal pathogen-related stimulation indicates unique phenotype of primary cultured human fibroblasts from gingiva and periodontal ligament: implications for oral health disease","volume":"77","author":"Koka","year":"1997","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.molimm.2018.10.001_bib0115","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.redox.2017.06.004","article-title":"Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia","volume":"13","author":"Koka","year":"2017","journal-title":"Redox Biol."},{"issue":"52","key":"10.1016\/j.molimm.2018.10.001_bib0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0757.2009.00311.x","article-title":"Subgingival biofilm formation","volume":"2000","author":"Kuboniwa","year":"2010","journal-title":"Periodontology"},{"key":"10.1016\/j.molimm.2018.10.001_bib0125","first-page":"397","article-title":"Activation and regulation of the inflammasomes. Nature reviews","volume":"13","author":"Latz","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.molimm.2018.10.001_bib0130","doi-asserted-by":"crossref","first-page":"e87552","DOI":"10.1371\/journal.pone.0087552","article-title":"Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2018.10.001_bib0135","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fphys.2017.00439","article-title":"The role of reactive oxygen species and autophagy in periodontitis and their potential linkage","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0140","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.coviro.2015.02.007","article-title":"Inflammasome control of viral infection","volume":"12","author":"Lupfer","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0145","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1189\/jlb.3CE0915-443R","article-title":"Editorial: NLRP3: immune activator or modulator?","volume":"99","author":"Ma","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0150","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0155","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ni.2550","article-title":"Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome","volume":"14","author":"Misawa","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2018.10.001_bib0160","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/jre.12120","article-title":"Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor -alpha and Porphyromonas gingivalis lipopolysaccharides","volume":"49","author":"Padial-Molina","year":"2014","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.molimm.2018.10.001_bib0165","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/1933719112459240","article-title":"Bacterial LPS differently modulates inflammasome gene expression and IL-1beta secretion in trophoblast cells, decidual stromal cells, and decidual endothelial cells","volume":"20","author":"Pontillo","year":"2013","journal-title":"Reprod. Sci."},{"issue":"40","key":"10.1016\/j.molimm.2018.10.001_bib0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0757.2005.00144.x","article-title":"Host responses in maintaining periodontal health and determining periodontal disease","volume":"2000","author":"Schenkein","year":"2006","journal-title":"Periodontology"},{"key":"10.1016\/j.molimm.2018.10.001_bib0175","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2018.10.001_bib0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/omi.12217","article-title":"Historical aspects of studies on roles of the inflammasome in the pathogenesis of periodontal diseases","volume":"33","author":"Shibata","year":"2018","journal-title":"Mol. Oral Microbiol."},{"issue":"38","key":"10.1016\/j.molimm.2018.10.001_bib0185","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0757.2005.00107.x","article-title":"Periodontal microbial ecology","volume":"2000","author":"Socransky","year":"2005","journal-title":"Periodontology"},{"key":"10.1016\/j.molimm.2018.10.001_bib0190","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2018.10.001_bib0195","doi-asserted-by":"crossref","first-page":"24233","DOI":"10.1074\/jbc.M212389200","article-title":"Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase","volume":"278","author":"Takada","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.10.001_bib0200","first-page":"210","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nature reviews","volume":"10","author":"Tschopp","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.molimm.2018.10.001_bib0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbagen.2004.12.008","article-title":"Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells","volume":"1722","author":"Vejrazka","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molimm.2018.10.001_bib0210","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1159\/000363046","article-title":"Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by NLRP3 gene deletion","volume":"34","author":"Xia","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.molimm.2018.10.001_bib0215","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","article-title":"NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke","volume":"34","author":"Yang","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.molimm.2018.10.001_bib0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12974-017-0895-5","article-title":"Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and\/or NF-kappaB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway","volume":"14","author":"Zeng","year":"2017","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.molimm.2018.10.001_bib0225","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1089\/ars.2014.5978","article-title":"Coronary endothelial dysfunction induced by nucleotide oligomerization domain-like receptor protein with pyrin domain containing 3 inflammasome activation during hypercholesterolemia: beyond inflammation","volume":"22","author":"Zhang","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.molimm.2018.10.001_bib0230","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12974-017-1052-x","article-title":"Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL\/6 mice","volume":"15","author":"Zhang","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.molimm.2018.10.001_bib0235","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018305066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018305066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T06:26:04Z","timestamp":1589955964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589018305066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":47,"alternative-id":["S0161589018305066"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2018.10.001","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periodontal ligament fibroblasts migration injury via ROS\/TXNIP\/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2018.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 University of Chinese Medicine. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}