{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:57:27Z","timestamp":1779191847900,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Grant Council General Research Fund","award":["#466913"],"award-info":[{"award-number":["#466913"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.molimm.2018.12.002","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T01:03:52Z","timestamp":1544663032000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Anti-inflammatory action of HO-1\/CO in human bronchial epithelium in response to cationic polypeptide challenge"],"prefix":"10.1016","volume":"105","author":[{"given":"Rui-Gang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Yin","family":"Yip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-402X","authenticated-orcid":false,"given":"Wing-Hung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2018.12.002_bib0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbamcr.2004.02.002","article-title":"Expression of functional \u03b22-adrenergic receptors in the lung epithelial cell lines 16HBE14o-, Calu-3 and A549","volume":"1691","author":"Abraham","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molimm.2018.12.002_bib0010","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/bph.12632","article-title":"CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation","volume":"172","author":"Babu","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0015","doi-asserted-by":"crossref","first-page":"L470","DOI":"10.1152\/ajplung.90498.2008","article-title":"Virulence factors of Staphylococcus aureus induce Erk-MAP kinase activation and c-Fos expression in S9 and 16HBE14o- human airway epithelial cells","volume":"296","author":"Below","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0020","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jaci.2012.01.059","article-title":"Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines","volume":"129","author":"Bossley","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0025","doi-asserted-by":"crossref","first-page":"F904","DOI":"10.1152\/ajprenal.90377.2008","article-title":"Heme oxygenase induction attenuates afferent arteriolar autoregulatory responses","volume":"295","author":"Botros","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0030","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1038\/emm.2017.193","article-title":"Carbon monoxide prevents TNF-alpha-induced eNOS downregulation by inhibiting NF-kappaB-responsive miR-155-5p biogenesis","volume":"49","author":"Choi","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.molimm.2018.12.002_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012091","article-title":"Polarized secretion of interleukin (IL)-6 and IL-8 by human airway epithelia 16HBE14o- cells in response to cationic polypeptide challenge","volume":"5","author":"Chow","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2018.12.002_bib0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1165\/ajrcmb.10.1.7507342","article-title":"CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells","volume":"10","author":"Cozens","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1165\/ajrcmb.24.3.4001","article-title":"Expression of heme oxygenase in human airway epithelial cells","volume":"24","author":"Donnelly","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1461-5347(99)00231-X","article-title":"Human airway epithelial cell lines for in vitro drug transport and metabolism studies","volume":"3","author":"Forbes","year":"2000","journal-title":"Pharm. Sci. Technol. Today"},{"key":"10.1016\/j.molimm.2018.12.002_bib0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-5173(03)00129-7","article-title":"The human bronchial epithelial cell line 16HBE14o- as a model system of the airways for studying drug transport","volume":"257","author":"Forbes","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.molimm.2018.12.002_bib0060","doi-asserted-by":"crossref","first-page":"L101","DOI":"10.1152\/ajplung.00018.2008","article-title":"LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells","volume":"296","author":"Grumbach","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0065","doi-asserted-by":"crossref","first-page":"L489","DOI":"10.1152\/ajplung.90282.2008","article-title":"EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src","volume":"295","author":"Jeulin","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0070","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fmicb.2013.00263","article-title":"Pathology of asthma","volume":"4","author":"Kudo","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice","volume":"8","author":"Lee","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.molimm.2018.12.002_bib0080","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.toxlet.2016.08.023","article-title":"Inflammatory effects induced by selected limonene oxidation products: 4-OPA, IPOH, 4-AMCH in human bronchial (16HBE14o-) and alveolar (A549) epithelial cell lines","volume":"262","author":"Lipsa","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.molimm.2018.12.002_bib0085","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394C Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molimm.2018.12.002_bib0090","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1074\/jbc.M110939200","article-title":"Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cells","volume":"277","author":"Missiaen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.12.002_bib0095","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/13543784.14.11.1305","article-title":"Therapeutic applications of carbon monoxide-releasing molecules","volume":"14","author":"Motterlini","year":"2005","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.molimm.2018.12.002_bib0100","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1096\/fj.04-2169fje","article-title":"CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule","volume":"19","author":"Motterlini","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.molimm.2018.12.002_bib0105","doi-asserted-by":"crossref","first-page":"L1029","DOI":"10.1152\/ajplung.2000.279.6.L1029","article-title":"Heme oxygenase: colors of defense against cellular stress","volume":"279","author":"Otterbein","year":"2000","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1465-9921-7-84","article-title":"CpG DNA modulates interleukin 1\u03b2-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells","volume":"7","author":"Parilla","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.molimm.2018.12.002_bib0115","doi-asserted-by":"crossref","first-page":"L130","DOI":"10.1152\/ajplung.00070.2014","article-title":"Emerging molecular phenotypes of asthma","volume":"308","author":"Ray","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.molimm.2018.12.002_bib0125","doi-asserted-by":"crossref","first-page":"L596","DOI":"10.1152\/ajplung.00446.2001","article-title":"Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin","volume":"283","author":"Samb","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0130","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.bjp.0706241","article-title":"Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages","volume":"145","author":"Sawle","year":"2005","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/09622935020138172","article-title":"Effects of the cationic protein poly-L-arginine on airway epithelial cells in vitro","volume":"11","author":"Shahana","year":"2002","journal-title":"Med. Inflamm."},{"key":"10.1016\/j.molimm.2018.12.002_bib0140","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1096\/fj.06-6346fje","article-title":"Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin","volume":"20","author":"Shan","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.molimm.2018.12.002_bib0145","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0008-6363(98)00278-8","article-title":"Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?","volume":"41","author":"Siow","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.molimm.2018.12.002_bib0150","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M503512200","article-title":"Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle","volume":"280","author":"Taille","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2018.12.002_bib0155","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1034\/j.1399-3003.2000.01514.x","article-title":"Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o","volume":"15","author":"Wan","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.molimm.2018.12.002_bib0160","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1165\/rcmb.2008-0020OC","article-title":"Apical versus basolateral P2Y6 receptor-mediated Cl\u2212 secretion in immortalized bronchial epithelia","volume":"40","author":"Wong","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.molimm.2018.12.002_bib0165","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon monoxide: endogenous production, physiological functions, and pharmacological applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.molimm.2018.12.002_bib0170","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1159\/000480029","article-title":"Regulation of intracellular calcium by carbon monoxide in human bronchial epithelial cells","volume":"42","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018310046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589018310046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T02:17:47Z","timestamp":1548382667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589018310046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":34,"alternative-id":["S0161589018310046"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2018.12.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory action of HO-1\/CO in human bronchial epithelium in response to cationic polypeptide challenge","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2018.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}