{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:01:54Z","timestamp":1792598514346,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.molimm.2020.02.011","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T12:20:28Z","timestamp":1582719628000},"page":"101-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["The unconventional role of HLA-E: The road less traveled"],"prefix":"10.1016","volume":"120","author":[{"given":"Emma J.","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Lobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Szeto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetra S.M.","family":"Chatzileontiadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2020.02.011_bib0005","doi-asserted-by":"crossref","first-page":"e50951","DOI":"10.1371\/journal.pone.0050951","article-title":"HLA-E-restricted cross-recognition of allogeneic endothelial cells by CMV-associated CD8 T cells: a potential risk factor following transplantation","volume":"7","author":"Allard","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.02.011_bib0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/47417","article-title":"Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor","volume":"403","author":"Bennett","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.02.011_bib0015","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001094","article-title":"A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis","volume":"2","author":"Bertholet","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0020","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-immunol-032712-095910","article-title":"Pathways of antigen processing","volume":"31","author":"Blum","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12920-018-0354-x","article-title":"HLA and proteasome expression body map","volume":"11","author":"Boegel","year":"2018","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.molimm.2020.02.011_bib0030","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1084\/jem.187.5.813","article-title":"Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94\/NKG2 confers protection from natural killer cell-mediated lysis","volume":"187","author":"Borrego","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0035","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/eji.1830270517","article-title":"The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9","volume":"27","author":"Braud","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0040","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.02.011_bib0045","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/eji.201445193","article-title":"Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines","volume":"45","author":"Caccamo","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00251-015-0880-z","article-title":"The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch","volume":"68","author":"Celik","year":"2016","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2020.02.011_bib0055","first-page":"474","article-title":"A neo-darwinian commentary on macroevolution","volume":"36","author":"Charlesworth","year":"1982","journal-title":"Evolution"},{"key":"10.1016\/j.molimm.2020.02.011_bib0060","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1073\/pnas.0409676102","article-title":"Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface","volume":"102","author":"Clements","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2020.02.011_bib0065","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1182\/blood-2006-06-030213","article-title":"Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation","volume":"109","author":"Coupel","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2020.02.011_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007567","article-title":"Casting a wider net: immunosurveillance by nonclassical MHC molecules","volume":"15","author":"D\u2019Souza","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2020.02.011_bib0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0039.2010.01599.x","article-title":"Linkage disequilibrium between HLA-G*0104 and HLA-E*0103 alleles in Tswa Pygmies","volume":"77","author":"Di Cristofaro","year":"2011","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.molimm.2020.02.011_bib0080","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/tan.12283","article-title":"Worldwide HLA-E nucleotide and haplotype variability reveals a conserved gene for coding and 3\u2019 untranslated regions","volume":"83","author":"Felicio","year":"2014","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.molimm.2020.02.011_bib0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12967-016-0819-7","article-title":"Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans","volume":"14","author":"Fresnay","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0090","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/42523","article-title":"Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2","volume":"387","author":"Gao","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.02.011_bib0095","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0198-8859(92)90069-Y","article-title":"Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism","volume":"33","author":"Geraghty","year":"1992","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0100","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1038\/s41467-018-07815-5","article-title":"Broad CD8(+) T cell cross-recognition of distinct influenza A strains in humans","volume":"9","author":"Grant","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2020.02.011_bib0105","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4049\/jimmunol.0900556","article-title":"Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope","volume":"183","author":"Gras","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0110","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.4049\/jimmunol.1102462","article-title":"EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail","volume":"190","author":"Griffin","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0198-8859(96)00241-8","article-title":"Population genetic studies of HLA-E: evidence for selection","volume":"52","author":"Grimsley","year":"1997","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1034\/j.1399-0039.2002.600302.x","article-title":"Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data","volume":"60","author":"Grimsley","year":"2002","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.molimm.2020.02.011_bib0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.imlet.2018.08.005","article-title":"Identification of novel HIV-1-derived HLA-E-binding peptides","volume":"202","author":"Hannoun","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.molimm.2020.02.011_bib0130","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1126\/science.aac9475","article-title":"Broadly targeted CD8(+) T cell responses restricted by major histocompatibility complex E","volume":"351","author":"Hansen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molimm.2020.02.011_bib0135","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1038\/s41598-017-04894-0","article-title":"HLA-e presents glycopeptides from the Mycobacterium tuberculosis protein MPT32 to human CD8(+) t cells","volume":"7","author":"Harriff","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2020.02.011_bib0140","doi-asserted-by":"crossref","first-page":"8679","DOI":"10.1074\/jbc.M112.409672","article-title":"Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells","volume":"288","author":"Heatley","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2020.02.011_bib0145","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1084\/jem.20020609","article-title":"HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells","volume":"196","author":"Heinzel","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0150","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00251-019-01112-1","article-title":"HLA-F*01:01 presents peptides with N-terminal flexibility and a preferred length of 16 residues","volume":"71","author":"Ho","year":"2019","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2020.02.011_bib0155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ni1312","article-title":"Structural basis for a major histocompatibility complex class Ib-restricted T cell response","volume":"7","author":"Hoare","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0160","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jmb.2008.01.098","article-title":"Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors","volume":"377","author":"Hoare","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0165","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrg1489","article-title":"Gene map of the extended human MHC","volume":"5","author":"Horton","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molimm.2020.02.011_bib0170","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.4049\/jimmunol.171.3.1376","article-title":"Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition","volume":"171","author":"Ishitani","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000782","article-title":"Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity","volume":"6","author":"Joosten","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2020.02.011_bib0180","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2695396","article-title":"Characteristics of HLA-E restricted T-Cell responses and their role in infectious diseases","volume":"2016","author":"Joosten","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.molimm.2020.02.011_bib0185","doi-asserted-by":"crossref","first-page":"e46120","DOI":"10.1371\/journal.pone.0046120","article-title":"Epstein-Barr virus peptide presented by HLA-E is predominantly recognized by CD8(bright) cells in multiple sclerosis patients","volume":"7","author":"Jorgensen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.02.011_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007041","article-title":"HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition","volume":"14","author":"Jouand","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2020.02.011_bib0195","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.4049\/jimmunol.174.5.2878","article-title":"Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics","volume":"174","author":"Kaiser","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0200","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1073\/pnas.0802736105","article-title":"Structural basis for NKG2A\/CD94 recognition of HLA-E","volume":"105","author":"Kaiser","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2020.02.011_bib0205","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1128\/JVI.76.16.8179-8188.2002","article-title":"The lytic cycle of Epstein-Barr virus is associated with decreased expression of cell surface major histocompatibility complex class I and class II molecules","volume":"76","author":"Keating","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0210","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4049\/jimmunol.141.3.897","article-title":"HLA-E. A novel HLA class I gene expressed in resting T lymphocytes","volume":"141","author":"Koller","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0215","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/352160","article-title":"HLA-E: a novel player for histocompatibility","volume":"2014","author":"Kraemer","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.molimm.2020.02.011_bib0220","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/346714","article-title":"HLA-e: presentation of a broader peptide repertoire impacts the cellular immune response-implications on HSCT outcome","volume":"2015","author":"Kraemer","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.molimm.2020.02.011_bib0225","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1084\/jem.188.5.973","article-title":"Qa-1b binds conserved class I leader peptides derived from several mammalian species","volume":"188","author":"Kurepa","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0230","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molimm.2012.07.009","article-title":"Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2","volume":"53","author":"Lampen","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0235","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0092-8674(00)81151-4","article-title":"Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor","volume":"93","author":"Lebron","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2020.02.011_bib0240","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.4049\/jimmunol.160.10.4951","article-title":"HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences","volume":"160","author":"Lee","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0245","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1073\/pnas.95.9.5199","article-title":"HLA-E is a major ligand for the natural killer inhibitory receptor CD94\/NKG2A","volume":"95","author":"Lee","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2020.02.011_bib0250","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1084\/jem.187.10.1633","article-title":"Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells","volume":"187","author":"Lewinsohn","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0255","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0198-8859(00)00190-7","article-title":"Implications of HLA-E allele expression and different HLA-E ligand diversity for the regulation of NK cells","volume":"61","author":"Maier","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007658","article-title":"Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor","volume":"15","author":"Martinez-Vicente","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2020.02.011_bib0265","first-page":"1150","article-title":"HLA-G and HLA-E polymorphisms in an indigenous African population","volume":"61","author":"Matte","year":"2000","journal-title":"The ZVITAMBO Study Group. Hum Immunol"},{"key":"10.1016\/j.molimm.2020.02.011_bib0270","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1002\/eji.200535343","article-title":"Identification of effector-memory CMV-specific T lymphocytes that kill CMV-infected target cells in an HLA-E-restricted fashion","volume":"35","author":"Mazzarino","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038408","article-title":"Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization","volume":"7","author":"McArthur","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.02.011_bib0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188288","article-title":"T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells","volume":"12","author":"McMurtrey","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.02.011_bib0285","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.4049\/jimmunol.171.3.1369","article-title":"Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94\/NKG2","volume":"171","author":"Miller","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0290","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0002-9440(10)62267-5","article-title":"The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells","volume":"166","author":"Nattermann","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0295","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1097-2765(00)80053-2","article-title":"Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E","volume":"1","author":"O\u2019Callaghan","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molimm.2020.02.011_bib0300","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","author":"O\u2019Leary","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2020.02.011_bib0305","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF02114975","article-title":"Polymorphism in the human class I MHC locus HLA-E in Japanese","volume":"32","author":"Ohya","year":"1990","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2020.02.011_bib0310","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/tan.12965","article-title":"New insights in HLA-E polymorphism by refined analysis of the full-length gene","volume":"89","author":"Olieslagers","year":"2017","journal-title":"HLA"},{"key":"10.1016\/j.molimm.2020.02.011_bib0315","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/COH.0b013e32835fd5cd","article-title":"Vaccine and immunotherapeutic interventions","volume":"8","author":"Pantaleo","year":"2013","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.molimm.2020.02.011_bib0320","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20072525","article-title":"CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence","volume":"205","author":"Petrie","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2020.02.011_bib0325","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1073\/pnas.1834449100","article-title":"HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes","volume":"100","author":"Pietra","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2020.02.011_bib0330","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/907092","article-title":"The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors","volume":"2010","author":"Pietra","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0335","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/eji.201747184","article-title":"Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8(+) T cells","volume":"48","author":"Prezzemolo","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0340","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00251-005-0076-z","article-title":"HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes","volume":"58","author":"Pyo","year":"2006","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2020.02.011_bib0345","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gku1161","article-title":"The IPD and IMGT\/HLA database: allele variant databases","volume":"43","author":"Robinson","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2020.02.011_bib0350","doi-asserted-by":"crossref","first-page":"11328","DOI":"10.1073\/pnas.172369799","article-title":"Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells","volume":"99","author":"Romagnani","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2020.02.011_bib0355","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-immunol-032414-112334","article-title":"T cell antigen receptor recognition of antigen-presenting molecules","volume":"33","author":"Rossjohn","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0360","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.immunol.23.021704.115658","article-title":"How TCRs bind MHCs, peptides, and coreceptors","volume":"24","author":"Rudolph","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0365","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fimmu.2019.00257","article-title":"Age-associated heterogeneity of Ty21a-Induced t cell responses to HLA-E restricted Salmonella typhi antigen presentation","volume":"10","author":"Rudolph","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0370","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.4049\/jimmunol.173.9.5852","article-title":"Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine","volume":"173","author":"Salerno-Goncalves","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0375","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/CVI.00234-10","article-title":"Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine","volume":"17","author":"Salerno-Goncalves","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0380","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1086\/605889","article-title":"The HLA-E(R)\/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells","volume":"200","author":"Schulte","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2020.02.011_bib0385","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/jhg.2008.5","article-title":"The HLA genomic loci map: expression, interaction, diversity and disease","volume":"54","author":"Shiina","year":"2009","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.molimm.2020.02.011_bib0390","doi-asserted-by":"crossref","first-page":"10439","DOI":"10.1074\/jbc.M512305200","article-title":"Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer","volume":"281","author":"Shiroishi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2020.02.011_bib0395","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1074\/jbc.M208268200","article-title":"HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities","volume":"278","author":"Strong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2020.02.011_bib0400","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/intimm\/7.4.653","article-title":"HLA-A0201 and HLA-B7 binding peptides in the EBV-encoded EBNA-1, EBNA-2 and BZLF-1 proteins detected in the MHC class I stabilization assay. Low proportion of binding motifs for several HLA class I alleles in EBNA-1","volume":"7","author":"Stuber","year":"1995","journal-title":"Int. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0405","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.it.2006.07.006","article-title":"A structural perspective on MHC class Ib molecules in adaptive immunity","volume":"27","author":"Sullivan","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0410","doi-asserted-by":"crossref","first-page":"21149","DOI":"10.1074\/jbc.M117.807719","article-title":"A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct alphabeta T cell receptors","volume":"292","author":"Sullivan","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2020.02.011_bib0415","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.287.5455.1031","article-title":"Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40","volume":"287","author":"Tomasec","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.molimm.2020.02.011_bib0420","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.4049\/jimmunol.176.10.6130","article-title":"HIV-1 epitope-specific CD8+ T cell responses strongly associated with delayed disease progression cross-recognize epitope variants efficiently","volume":"176","author":"Turnbull","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0425","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<537::AID-IMMU537>3.0.CO;2-6","article-title":"Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences","volume":"29","author":"Ulbrecht","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004671","article-title":"Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset","volume":"11","author":"van Meijgaarden","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2020.02.011_bib0435","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jmb.2010.01.052","article-title":"The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide","volume":"397","author":"Walpole","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2020.02.011_bib0440","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1038\/s41467-018-05459-z","article-title":"Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding","volume":"9","author":"Walters","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2020.02.011_bib0445","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-065X.2008.00693.x","article-title":"Early T-cell responses in tuberculosis immunity","volume":"225","author":"Winslow","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2020.02.011_bib0450","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1073\/pnas.82.6.1785","article-title":"Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes","volume":"82","author":"Yewdell","year":"1985","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589019308442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589019308442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:34:31Z","timestamp":1758980071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589019308442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":90,"alternative-id":["S0161589019308442"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2020.02.011","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The unconventional role of HLA-E: The road less traveled","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2020.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}