{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:06:00Z","timestamp":1767211560102,"version":"3.44.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.molimm.2020.02.012","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T09:13:49Z","timestamp":1582881229000},"page":"130-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Serum complement C1q level is associated with acute coronary syndrome"],"prefix":"10.1016","volume":"120","author":[{"given":"Xiao-ning","family":"Ni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen-bo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-wen","family":"Sai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.molimm.2020.02.012_bib0005","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/joim.12296","article-title":"Thrombosis formation on atherosclerotic lesions and plaque rupture","volume":"276","author":"Badimon","year":"2014","journal-title":"J. Intern. Med."},{"issue":"9","key":"10.1016\/j.molimm.2020.02.012_bib0010","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1523\/JNEUROSCI.3932-10.2011","article-title":"Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression","volume":"31","author":"Benoit","year":"2011","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.molimm.2020.02.012_bib0015","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2353\/ajpath.2007.060406","article-title":"Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"170","author":"Bhatia","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molimm.2020.02.012_bib0020","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1038\/ncomms10346","article-title":"C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation","volume":"7","author":"Bulla","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.molimm.2020.02.012_bib0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.amjcard.2018.03.008","article-title":"Usefulness of complement C1q to predict 10-Year mortality in men with diabetes mellitus referred for coronary angiography","volume":"122","author":"Cavusoglu","year":"2018","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.molimm.2020.02.012_bib0030","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1016\/j.ijcard.2013.07.181","article-title":"Coordinated proteomic signature changes in immune response and complement proteins in acute myocardial infarction: The implication of serum amyloid P-component","volume":"168","author":"Cubedo","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.molimm.2020.02.012_bib0035","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3389\/fimmu.2019.02712","article-title":"Binding of von willebrand factor to complement C1q decreases the phagocytosis of cholesterol crystals and subsequent IL-1 secretion in macrophages","volume":"10","author":"Donat","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2020.02.012_bib0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.yexmp.2008.12.005","article-title":"Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells","volume":"86","author":"Fosbrink","year":"2009","journal-title":"Exp. Mol. Pathol."},{"issue":"7","key":"10.1016\/j.molimm.2020.02.012_bib0045","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.1002080","article-title":"Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages","volume":"185","author":"Fraser","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.02.012_bib0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fimmu.2017.00288","article-title":"Lectin pathway of complement activation is associated with vulnerability of atherosclerotic plaques","volume":"8","author":"Fumagalli","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2020.02.012_bib0055","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1253\/circj.CJ-09-0637","article-title":"Coronary score adds prognostic information for patients with acute coronary syndrome","volume":"74","author":"Huang","year":"2010","journal-title":"Circ. J."},{"issue":"1","key":"10.1016\/j.molimm.2020.02.012_bib0060","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.atherosclerosis.2006.06.013","article-title":"Complement regulation in human atherosclerotic coronary lesions. Immunohistochemical evidence that C4b-binding protein negatively regulates the classical complement pathway, and that C5b-9 is formed via the alternative complement pathway","volume":"192","author":"Oksjoki","year":"2007","journal-title":"Atherosclerosis."},{"issue":"8","key":"10.1016\/j.molimm.2020.02.012_bib0065","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molimm.2004.04.020","article-title":"Expression of gC1q-R\/p33 and its major ligands in human atherosclerotic lesions","volume":"41","author":"Peerschke","year":"2004","journal-title":"Mol. Immunol."},{"issue":"49","key":"10.1016\/j.molimm.2020.02.012_bib0070","doi-asserted-by":"crossref","first-page":"29642","DOI":"10.1074\/jbc.M115.690784","article-title":"C1q deficiency promotes pulmonary vascular inflammation and enhances the susceptibility of the lung endothelium to injury","volume":"290","author":"Shah","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.molimm.2020.02.012_bib0075","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1538-7836.2010.04172.x","article-title":"Complement in atherosclerosis: friend or foe?","volume":"9","author":"Speidl","year":"2011","journal-title":"J. Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.molimm.2020.02.012_bib0080","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00011-014-0762-0","article-title":"Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins","volume":"63","author":"Spivia","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.molimm.2020.02.012_bib0085","doi-asserted-by":"crossref","first-page":"14453","DOI":"10.1038\/srep14453","article-title":"Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression","volume":"5","author":"Yabumoto","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2020.02.012_bib0090","first-page":"1","article-title":"Is complement C1q a potential marker for tumor burden and immunodeficiency in multiple myeloma?","author":"Yang","year":"2019","journal-title":"Leuk. Lymphoma"},{"issue":"7","key":"10.1016\/j.molimm.2020.02.012_bib0095","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/hq0701.092160","article-title":"Complement components, but not complement inhibitors, are upregulated in atherosclerotic plaques","volume":"21","author":"Yasojima","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589019306480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589019306480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:34:47Z","timestamp":1758980087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589019306480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":19,"alternative-id":["S0161589019306480"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2020.02.012","relation":{},"ISSN":["0161-5890"],"issn-type":[{"type":"print","value":"0161-5890"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum complement C1q level is associated with acute coronary syndrome","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2020.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}