{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:07:28Z","timestamp":1779401248808,"version":"3.53.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003993","name":"Ministry of Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.molimm.2020.06.019","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T17:56:51Z","timestamp":1594144611000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Safety and efficacy of rice seed-based oral allergy vaccine for Japanese cedar pollinosis in Japanese monkeys"],"prefix":"10.1016","volume":"125","author":[{"given":"Saburo","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhya","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjirou","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Takaiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2020.06.019_bib0005","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2013.12.1088","article-title":"Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens","volume":"133","author":"Akdis","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0010","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0091-6749(98)70271-4","article-title":"Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper","volume":"102","author":"Bousquet","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1067\/mai.2003.129","article-title":"Noninjection routes for immunotherapy","volume":"111","author":"Canonica","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0020","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jaci.2011.01.047","article-title":"Recombianant allergens for specific immunotherapy","volume":"127","author":"Cromwell","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tplants.2009.09.009","article-title":"Plant-made vaccine antigens and biopharmaceuticals","volume":"14","author":"Daniell","year":"2009","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.molimm.2020.06.019_bib0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000053828","article-title":"Cupressaceae pollinosis: identification, purification and cloning of relevant allergens","volume":"125","author":"Di Felice","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0035","doi-asserted-by":"crossref","first-page":"S306","DOI":"10.1016\/j.jaci.2009.10.064","article-title":"Allergen immunotherapy","author":"Frew","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pep.2010.02.008","article-title":"Extraction and purification of human interleukin-10 from transgenic rice seeds","volume":"72","author":"Fujiwara","year":"2010","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.molimm.2020.06.019_bib0045","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/bjophthalmol-2014-305842","article-title":"Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens","volume":"99","author":"Fukuda","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.alit.2017.06.006","article-title":"Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice","volume":"67","author":"Fukuda","year":"2018","journal-title":"Allergol. Int."},{"key":"10.1016\/j.molimm.2020.06.019_bib0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2332\/allergolint.45.159","article-title":"Effect of pollen exposure on serum IgE and IgG antibody responses in Japanese cedar pollinosis patients","volume":"45","author":"Imaoka","year":"1996","journal-title":"Allergol. Int."},{"key":"10.1016\/j.molimm.2020.06.019_bib0060","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nri1934","article-title":"Immunological mechanisms of allergen-specific immunotherapy","volume":"6","author":"Larche","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0065","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biotechadv.2009.05.005","article-title":"Plant seeds as bioreactors for recombinant protein production","volume":"27","author":"Lau","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.molimm.2020.06.019_bib0070","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1016\/j.vaccine.2011.11.011","article-title":"Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives","volume":"30","author":"Linhart","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2020.06.019_bib0075","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molimm.2005.05.006","article-title":"Structural basis for epitope sharing between group 1 allergens of cedar pollen","volume":"43","author":"Midoro-Horiuti","year":"2006","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0080","doi-asserted-by":"crossref","first-page":"10986","DOI":"10.1073\/pnas.0703766104","article-title":"Rice-based mucosal vaccine as a global strategy for cold-chain-and needle-free vaccination","volume":"104","author":"Nochi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molimm.2020.06.019_bib0085","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1398-9995.1995.tb01183.x","article-title":"Cry j 2, a major allergen of Japanese cedar pollen, shows polymethylgalacturonase activity","volume":"50","author":"Ohtsuki","year":"1995","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2020.06.019_bib0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2332\/allergolint.08-RAI-0074","article-title":"Present situation of cedar pollinosis in Japan and its immune responses","volume":"58","author":"Okamoto","year":"2009","journal-title":"Allergol. Int."},{"key":"10.1016\/j.molimm.2020.06.019_bib0095","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.biotechadv.2011.07.018","article-title":"Delivery of plant-made vaccines and therapeutics","volume":"30","author":"Pelosi","year":"2012","journal-title":"Biotech. Adv."},{"key":"10.1016\/j.molimm.2020.06.019_bib0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1398-9995.1990.tb00501.x","article-title":"Identification of the second major allergen of Japanese cedar pollen","volume":"45","author":"Sakaguchi","year":"1990","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2020.06.019_bib0105","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1365-2567.1999.00792.x","article-title":"The incidence of Japanese cedar pollinosis and sensitization to the pollen allergens among Japanese monkeys in a troop","volume":"97","author":"Sakaguchi","year":"1999","journal-title":"Immunology."},{"key":"10.1016\/j.molimm.2020.06.019_bib0110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1034\/j.1600-0684.2001.300207.x","article-title":"Seasonal changes of humoral and cellular immune responses to Japanese cedar (Cryptomeria japonica) pollen allergens in Japanese monkeys (Macaca fuscata) with pollinosis","volume":"30","author":"Sakaguchi","year":"2001","journal-title":"J. Med. Primatol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0115","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.biotechadv.2009.06.004","article-title":"Plants as bioreactors: recent development and emerging opportunities","volume":"27","author":"Sharma","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.molimm.2020.06.019_bib0120","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-2222.2005.02221.x","article-title":"Identification of human T cell epitopes in Japanese cypress pollen allergen, Cha o 1, elucidates the intrinsic mechanism of cross-allergenicity between Cha o 1 and Cry j1, the major allergen of Japanese cedar pollen, at the T cell level","volume":"35","author":"Sone","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.molimm.2020.06.019_bib0125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.copbio.2005.01.005","article-title":"Sowing the seeds of success: pharmaceutical proteins from plants","volume":"16","author":"Stoger","year":"2005","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ymeth.2005.09.013","article-title":"Mucosal immunization using recombinant plan-based oral vaccines","volume":"38","author":"Streatfield","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.molimm.2020.06.019_bib0135","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1467-7652.2011.00613.x","article-title":"Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression","volume":"9","author":"Suzuki","year":"2011","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.molimm.2020.06.019_bib0140","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1467-7652.2005.00143.x","article-title":"Oral immunotherapy against a pollen allergy using seed-based peptide vaccine","volume":"3","author":"Takagi","year":"2005","journal-title":"Plant Biotech. J."},{"key":"10.1016\/j.molimm.2020.06.019_bib0145","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.peptides.2010.04.032","article-title":"Rice seed ER-derived protein body as an efficient delivery for oral tolerogenic peptides","volume":"33","author":"Takagi","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.molimm.2020.06.019_bib0150","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13601-019-0249-8","article-title":"Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens","volume":"9","author":"Takaishi","year":"2019","journal-title":"Clin. Transl. Allergy"},{"key":"10.1016\/j.molimm.2020.06.019_bib0155","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4161\/hv.7.3.14302","article-title":"Seed-based oral vaccines as allergen-specific immunotherapies","volume":"7","author":"Takaiwa","year":"2011","journal-title":"Hum. Vaccin."},{"key":"10.1016\/j.molimm.2020.06.019_bib0160","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2217\/imt.13.4","article-title":"Update on the use of transgenic rice seeds in oral immunotherapy","volume":"5","author":"Takaiwa","year":"2013","journal-title":"Immunotherapy"},{"key":"10.1016\/j.molimm.2020.06.019_bib0165","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11248-014-9790-3","article-title":"Development of a rice-based peptide vaccine for Japanese cedar and cypress pollen allergies","volume":"23","author":"Takaiwa","year":"2014","journal-title":"Transgenic Res."},{"key":"10.1016\/j.molimm.2020.06.019_bib0170","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/pbi.12423","article-title":"Rice seed for delivery of vaccines to gut mucosal immune tissues","volume":"13","author":"Takaiwa","year":"2015","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.molimm.2020.06.019_bib0175","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.plantsci.2017.07.016","article-title":"An overview on the strategies to exploit rice endosperm as production platform for biopharmaceuticals","volume":"263","author":"Takaiwa","year":"2017","journal-title":"Plant Sci."},{"key":"10.1016\/j.molimm.2020.06.019_bib0180","doi-asserted-by":"crossref","first-page":"13127","DOI":"10.1021\/acs.jafc.9b05421","article-title":"Development of rice-seed-based oral allergy vaccines containing hypoallergenic Japanese cedar pollen allergen derivatives for immunotherapy","volume":"67","author":"Takaiwa","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.molimm.2020.06.019_bib0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1398-9995.1995.tb02489.x","article-title":"Cry j I, a major allergen of Japanese cedar pollen, has pectate lyase enzyme activity","volume":"50","author":"Taniguchi","year":"1995","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2020.06.019_bib0190","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-immunol-030409-101218","article-title":"From allergen genes to allergy vaccines","volume":"28","author":"Valenta","year":"2010","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.molimm.2020.06.019_bib0195","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/biot.201300065","article-title":"The use of rice seeds to produce human pharmaceuticals for oral therapy","volume":"8","author":"Wakasa","year":"2013","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.molimm.2020.06.019_bib0200","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1467-7652.2010.00576.x","article-title":"Antihypertensive activity of transgenic rice seed containing an 18-repeat novokinin peptide localized in the nucleolus of endosperm cell","volume":"9","author":"Wakasa","year":"2011","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.molimm.2020.06.019_bib0205","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/pbi.12007","article-title":"Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis","volume":"11","author":"Wakasa","year":"2013","journal-title":"Plant Biotech. J."},{"key":"10.1016\/j.molimm.2020.06.019_bib0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120209","article-title":"Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy","volume":"10","author":"Wakasa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.06.019_bib0215","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0091-6749(83)90550-X","article-title":"Isolation and partial characterization of major allergen from Japanese cedar (Cryptomeria japonica) pollen","volume":"71","author":"Yasueda","year":"1983","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020303977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020303977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:35:03Z","timestamp":1758980103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589020303977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":43,"alternative-id":["S0161589020303977"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2020.06.019","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of rice seed-based oral allergy vaccine for Japanese cedar pollinosis in Japanese monkeys","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2020.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}