{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:03:44Z","timestamp":1760385824504,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24591490"],"award-info":[{"award-number":["24591490"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.molimm.2020.11.012","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T22:43:04Z","timestamp":1606689784000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Immunomodulatory gene expression analysis in LPS-stimulated human polymorphonuclear leukocytes treated with antibiotics commonly used for multidrug-resistant strains"],"prefix":"10.1016","volume":"129","author":[{"given":"Tsuneyuki","family":"Ubagai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-0911","authenticated-orcid":false,"given":"Go","family":"Kamoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Unno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2020.11.012_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics8020054","article-title":"Intracellular penetration and effects of antibiotics on Staphylococcus aureus inside human neutrophils: a comprehensive review","volume":"8","author":"Bongers","year":"2019","journal-title":"Antibiotics"},{"key":"10.1016\/j.molimm.2020.11.012_bib0010","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/AAC.04934-14","article-title":"Antipseudomonal agents exhibit differential pharmacy interactions with human polymorphonuclear leukocytes against established biofilms of Pseudomonas aeruginosa","volume":"59","author":"Chatzimoschou","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.molimm.2020.11.012_bib0015","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1371\/journal.pbio.0030176","article-title":"Inhibition of mutation and combating the evolution of antibiotic resistance","volume":"3","author":"Cirz","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.molimm.2020.11.012_bib0020","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.CCM.0000117317.18092.E4","article-title":"Surviving sepsis: campaign guidelines for management of severe sepsis and septic shock","volume":"32","author":"Dellinger","year":"2004","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.molimm.2020.11.012_bib0025","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis: current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"year":"2016","series-title":"The Sanford Guide to Antimicrobial Therapy 2016","author":"Gilbert","key":"10.1016\/j.molimm.2020.11.012_bib0030"},{"key":"10.1016\/j.molimm.2020.11.012_bib0035","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1567-5769(01)00194-1","article-title":"Fosfomycin inhibits neutrophil function via a protein kinase C-dependent signaling pathway","volume":"2","author":"Hamada","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2020.11.012_bib0040","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2020.11.012_bib0045","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000330442","article-title":"Anti-tuberculosis drugs and human polymorphonuclear leukocyte functions","volume":"57","author":"Kielland","year":"2011","journal-title":"Chemotherapy"},{"key":"10.1016\/j.molimm.2020.11.012_bib0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"issue":"895","key":"10.1016\/j.molimm.2020.11.012_bib0055","first-page":"1","article-title":"Global dissemination of Carbapenemase-producing Klebsiella pneumoniae: epidemiology, genetic context, treatment options, and detection methods","volume":"7","author":"Lee","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.molimm.2020.11.012_bib0060","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1128\/AAC.45.6.1794-1798.2001","article-title":"Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils","volume":"45","author":"Mandell","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.molimm.2020.11.012_bib0065","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/cpt.582","article-title":"Colistin reduces LPS-triggered inflammation in a human sepsis model in vivo: a randomized controlled trial","volume":"101","author":"Matzneller","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.molimm.2020.11.012_bib0070","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/MPH.0b013e318279eec2","article-title":"Neutrophils engraftment delay during tigecycline treatment in 2 bone marrow-transplanted patients","volume":"35","author":"Maximove","year":"2013","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.molimm.2020.11.012_bib0075","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000358818","article-title":"Effects of erythromycin and rifampicin on immunomodulatory gene expression and cellular function in human polymorphonuclear leukocyte","volume":"59","author":"Mu","year":"2013","journal-title":"Chemotherapy"},{"key":"10.1016\/j.molimm.2020.11.012_bib0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2478\/v10007-011-0024-4","article-title":"Tigecycline attenuates polymorphonuclear leukocyte (PMN) receptors but not functions","volume":"61","author":"Naess","year":"2011","journal-title":"Acta Pharm."},{"key":"10.1016\/j.molimm.2020.11.012_bib0085","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/jac\/dki260","article-title":"Penetration, efflux and intracellular activity of tigecycline in human polymorphonuclear neutrophils (PMNs)","volume":"56","author":"Ong","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.molimm.2020.11.012_bib0090","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00011-016-0999-x","article-title":"Minocycline affects human neutrophil respiratory burst and transendothelial migration","volume":"66","author":"Parenti","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.molimm.2020.11.012_bib0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1086\/426545","article-title":"Nonantimicrobial effects of antibacterial agents","volume":"40","author":"Pasquale","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.molimm.2020.11.012_bib0100","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4161\/viru.26210","article-title":"The clinical impact of multidrug-resistant gram-negative bacilli in the management of septic shock","volume":"5","author":"Pop-Vicas","year":"2015","journal-title":"Virulence"},{"key":"10.1016\/j.molimm.2020.11.012_bib0105","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1473-3099(06)70599-0","article-title":"The worldwide emergence of plasmid mediated quinolone resistance","volume":"6","author":"Robicsek","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molimm.2020.11.012_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19051442","article-title":"A new venue of TNF targeting","volume":"19","author":"Steeland","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2020.11.012_bib0115","doi-asserted-by":"crossref","first-page":"e01195","DOI":"10.1128\/AAC.01195-18","article-title":"Treatment of infections by OXA-48-producing Enterobacteriaceae","volume":"62","author":"Stewart","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.molimm.2020.11.012_bib0120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1874467210801010068","article-title":"Immunomodulatory properties of antibiotics","volume":"1","author":"Tauber","year":"2008","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.molimm.2020.11.012_bib0125","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.tiv.2009.12.022","article-title":"Aflatoxin B1 modulates the insulin-like growth factor-2 dependent signaling axis","volume":"24","author":"Ubagai","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.molimm.2020.11.012_bib0130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1473-3099(07)70265-7","article-title":"Host-pathogen interactions in sepsis","volume":"8","author":"van der Poll","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molimm.2020.11.012_bib0135","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir. Med."},{"year":"2017","series-title":"Adopts Resolution on Sepsis. Jena, Germany: Global Sepsis alliance, 26 May","author":"WHA","key":"10.1016\/j.molimm.2020.11.012_bib0140"},{"key":"10.1016\/j.molimm.2020.11.012_bib0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1586\/14787210.4.1.9","article-title":"Tigecycline: a novel glycylcycline antibiotic","volume":"4","author":"Zhanel","year":"2006","journal-title":"Expert Rev. Anti. Ther."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020305423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020305423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:36:01Z","timestamp":1758980161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589020305423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":29,"alternative-id":["S0161589020305423"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2020.11.012","relation":{},"ISSN":["0161-5890"],"issn-type":[{"type":"print","value":"0161-5890"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory gene expression analysis in LPS-stimulated human polymorphonuclear leukocytes treated with antibiotics commonly used for multidrug-resistant strains","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2020.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}