{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:45:05Z","timestamp":1774791905186,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["SS202050"],"award-info":[{"award-number":["SS202050"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["18KJB330005"],"award-info":[{"award-number":["18KJB330005"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473046"],"award-info":[{"award-number":["81473046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872681"],"award-info":[{"award-number":["81872681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401079"],"award-info":[{"award-number":["31401079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.molimm.2020.12.021","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T22:08:54Z","timestamp":1609279734000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Integrative analysis identifies potential causal methylation-mRNA regulation chains for rheumatoid arthritis"],"prefix":"10.1016","volume":"131","author":[{"given":"Xing-Bo","family":"Mo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Feng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2020.12.021_bib0005","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ni.3753","article-title":"BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency","volume":"18","author":"Afzali","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0010","article-title":"Distinctive DNA Methylome Signatures in Early Rheumatoid Arthritis (RA) Synoviocytes Compared with Longstanding (RA) and Other Inflammatory Arthritides","volume":"66","author":"Ai","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11849","article-title":"Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes","volume":"7","author":"Ai","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2020.12.021_bib0020","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2020.12.021_bib0025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nbt.1533","article-title":"Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells","volume":"27","author":"Ball","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0030","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"Battle","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.12.021_bib0035","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/gb-2011-12-1-r10","article-title":"DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines","volume":"12","author":"Bell","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0040","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0045","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(18)31268-6","article-title":"Principles of DNA methylation and their implications for biology and medicine","volume":"392","author":"Dor","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2020.12.021_bib0050","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1002\/art.22860","article-title":"A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52\/anti-Ro 60 autoantibodies","volume":"56","author":"Eloranta","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2020.12.021_bib0055","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ng.2462","article-title":"High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis","volume":"44","author":"Eyre","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0060","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJMra1402513","article-title":"The key role of epigenetics in human disease prevention and mitigation","volume":"378","author":"Feinberg","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2020.12.021_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bax028","article-title":"GeneHancer: genome-wide integration of enhancers and target genes in GeneCards","volume":"2017","author":"Fishilevich","year":"2017","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.molimm.2020.12.021_bib0070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature16490","article-title":"Insulator dysfunction and oncogene activation in IDH mutant gliomas","volume":"529","author":"Flavahan","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.12.021_bib0075","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.3367","article-title":"A gene-based association method for mapping traits using reference transcriptome data","volume":"47","author":"Gamazon","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0085","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.116.023116","article-title":"Altered DNA methylation of long noncoding RNA H19 in calcific aortic valve disease promotes mineralization by silencing NOTCH1","volume":"134","author":"Hadji","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.molimm.2020.12.021_bib0090","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13059-016-1041-x","article-title":"An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation","volume":"17","author":"Hannon","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0095","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ajhg.2017.04.013","article-title":"Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci","volume":"100","author":"Hannon","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0100","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41592-019-0470-3","article-title":"Moving beyond P values: data analysis with estimation graphics","volume":"16","author":"Ho","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2020.12.021_bib0105","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0896-6273(00)81122-8","article-title":"Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I","volume":"24","author":"Janz","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.molimm.2020.12.021_bib0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0168-9525(98)01636-9","article-title":"The DNA methylation paradox","volume":"15","author":"Jones","year":"1999","journal-title":"Trends Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0960-9822(97)70086-1","article-title":"DNA methylation directs a time-dependent repression of transcription initiation","volume":"7","author":"Kass","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0120","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.coph.2013.01.007","article-title":"Epigenetic modifications in rheumatoid arthritis, a review","volume":"13","author":"Klein","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0125","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1186\/ar3317","article-title":"Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molimm.2020.12.021_bib0130","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1038\/sj.emboj.7600771","article-title":"Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule","volume":"24","author":"Li","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.molimm.2020.12.021_bib0135","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/nbt.2487","article-title":"Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis","volume":"31","author":"Liu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0140","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/nbt.2487","article-title":"Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis","volume":"31","author":"Liu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ajhg.2016.12.008","article-title":"The genetic architecture of gene expression in peripheral blood","volume":"100","author":"Lloyd-Jones","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B","article-title":"Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins","volume":"43","author":"MacGregor","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2020.12.021_bib0155","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2217\/rme.10.15","article-title":"Bone marrow- and adipose-derived stem cells show expression of myelin mRNAs and proteins","volume":"5","author":"Mantovani","year":"2010","journal-title":"Regen. Med."},{"key":"10.1016\/j.molimm.2020.12.021_bib0160","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1002\/art.38183","article-title":"Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data","volume":"65","author":"McAllister","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2020.12.021_bib0165","doi-asserted-by":"crossref","first-page":"17605","DOI":"10.1038\/s41598-018-35871-w","article-title":"Identification of 55,000 replicated DNA methylation QTL","volume":"8","author":"McRae","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2020.12.021_bib0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2156-10-23","article-title":"Disentangling molecular relationships with a causal inference test","volume":"10","author":"Millstein","year":"2009","journal-title":"BMC Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0175","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/annrheumdis-2012-201526","article-title":"DNA methylome signature in rheumatoid arthritis","volume":"72","author":"Nakano","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2020.12.021_bib0180","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/03009740802448841","article-title":"Expression of the class I interferon-related MxA protein in temporal arteries in polymyalgia rheumatica and temporal arteritis","volume":"38","author":"Nordborg","year":"2009","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ng.2231","article-title":"Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population","volume":"44","author":"Okada","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0190","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.12.021_bib0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13148-017-0373-z","article-title":"A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients","volume":"9","author":"Park","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.molimm.2020.12.021_bib0200","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13073-016-0338-4","article-title":"Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits","volume":"8","author":"Pavlides","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.molimm.2020.12.021_bib0205","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","article-title":"Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis","volume":"38","author":"Prevoo","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2020.12.021_bib0210","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ng1589","article-title":"An integrative genomics approach to infer causal associations between gene expression and disease","volume":"37","author":"Schadt","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0215","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41576-019-0128-0","article-title":"Long-range enhancer-promoter contacts in gene expression control","volume":"20","author":"Schoenfelder","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u2019Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.molimm.2020.12.021_bib0225","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2020.12.021_bib0230","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ng.582","article-title":"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci","volume":"42","author":"Stahl","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0235","doi-asserted-by":"crossref","first-page":"e6803","DOI":"10.1371\/journal.pone.0006803","article-title":"Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients","volume":"4","author":"Teixeira","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.12.021_bib0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020457","article-title":"Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses","volume":"6","author":"Terao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.12.021_bib0245","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"Westra","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0250","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ccr.2014.07.028","article-title":"Gene body methylation can alter gene expression and is a therapeutic target in cancer","volume":"26","author":"Yang","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molimm.2020.12.021_bib0255","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2020.12.021_bib0260","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/annrheumdis-2018-213970","article-title":"Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells","volume":"78","author":"Zhu","year":"2019","journal-title":"Ann. Rheum. Dis."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020305885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020305885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:37:35Z","timestamp":1758980255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589020305885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":52,"alternative-id":["S0161589020305885"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2020.12.021","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis identifies potential causal methylation-mRNA regulation chains for rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2020.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}