{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:08:45Z","timestamp":1790611725385,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014537","name":"Centre for Food and Allergy Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.molimm.2020.12.033","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T16:12:08Z","timestamp":1610122328000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["IgE and IgG4 epitopes revealed on the major fish allergen Lat c 1"],"prefix":"10.1016","volume":"131","author":[{"given":"Michael F.","family":"Sharp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-4367","authenticated-orcid":false,"given":"Aya C.","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thimo","family":"Ruethers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan N.","family":"Stephen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-6602","authenticated-orcid":false,"given":"Norelle L.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas L.","family":"Lopata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip D.","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 95","key":"10.1016\/j.molimm.2020.12.033_bib0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1398-9995.2011.02628.x","article-title":"The role of IgG antibodies in allergy and immunotherapy","volume":"66","author":"Aalberse","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2020.12.033_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: an odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.molimm.2020.12.033_bib0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2020.12.033_bib0020","doi-asserted-by":"crossref","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2020.12.033_bib0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jprot.2019.04.005","article-title":"Molecular characterization of B-cell epitopes for the major fish allergen, parvalbumin, by shotgun proteomics, protein-based bioinformatics and IgE-reactive approaches","volume":"200","author":"Carrera","year":"2019","journal-title":"J. Proteomics"},{"key":"10.1016\/j.molimm.2020.12.033_bib0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaip.2019.10.019","article-title":"Clinical management of seafood allergy","volume":"8","author":"Davis","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.molimm.2020.12.033_bib0035","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Du Toit","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2020.12.033_bib0040","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.3389\/fimmu.2018.03131","article-title":"Allergen-specific antibodies regulate secondary allergen-specific immune responses","volume":"9","author":"Eckl-Dorna","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1398-9995.1983.tb02353.x","article-title":"Immunochemical analysis of cod fish allergen M: locations of the immunoglobulin binding sites as demonstrated by the native and synthetic peptides","volume":"38","author":"Elsayed","year":"1983","journal-title":"Allergy"},{"issue":"1897\u20131905","key":"10.1016\/j.molimm.2020.12.033_bib0050","first-page":"e1891","article-title":"Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy","volume":"139","author":"Freidl","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0055","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/cea.12117","article-title":"Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens","volume":"43","author":"Kuehn","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.molimm.2020.12.033_bib0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fimmu.2014.00179","article-title":"Fish allergens at a glance: variable allergenicity of parvalbumins, the major fish allergens","volume":"5","author":"Kuehn","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0065","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2020.12.033_bib0070","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/pai.13022","article-title":"A cross-sectional, population-based study on the prevalence of food allergies among children in two different socio-economic regions of Vietnam","volume":"30","author":"Le","year":"2019","journal-title":"Pediatr. Allergy Immunol."},{"issue":"28","key":"10.1016\/j.molimm.2020.12.033_bib0075","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1021\/acs.jafc.8b01967","article-title":"Food allergen epitope mapping","volume":"66","author":"Liu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.molimm.2020.12.033_bib0080","first-page":"60","article-title":"Shellfish allergy diagnosis-gaps and needs","volume":"25","author":"Lopata","year":"2012","journal-title":"Curr. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.aquaculture.2013.04.014","article-title":"Broodstock contribution after mass spawning and size grading in barramundi (Lates calcarifer, Bloch)","volume":"404-405","author":"Loughnan","year":"2013","journal-title":"Aquaculture"},{"issue":"Suppl 23","key":"10.1016\/j.molimm.2020.12.033_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pai.12563","article-title":"EAACI Molecular allergology user\u2019s guide","volume":"27","author":"Matricardi","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"issue":"264\u2013272","key":"10.1016\/j.molimm.2020.12.033_bib0095","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1016\/j.anai.2016.07.015","article-title":"Prevalence of fish and shellfish allergy: a systematic review","volume":"117","author":"Moonesinghe","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0100","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/1521-4141(200202)32:2<576::AID-IMMU576>3.0.CO;2-U","article-title":"Evolution of IgM, IgE and IgG (1-4) antibody responses in early childhood monitored with recombinant allergen components: implications for class switch mechanisms","volume":"32","author":"Niederberger","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000324677","article-title":"Epitope mapping of Atlantic salmon major allergen by peptide microarray immunoassay","volume":"157","author":"Perez-Gordo","year":"2012","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0110","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/mnfr.201200332","article-title":"Epitope mapping of the major allergen from Atlantic cod in Spanish population reveals different IgE-binding patterns","volume":"57","author":"Perez-Gordo","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.molimm.2020.12.033_bib0115","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.molimm.2020.12.033_bib0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molimm.2018.04.008","article-title":"Seafood allergy: a comprehensive review of fish and shellfish allergens","volume":"100","author":"Ruethers","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0125","first-page":"1","article-title":"IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE","volume":"00","author":"Santos","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.molimm.2020.12.033_bib0130","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.foodchem.2013.10.035","article-title":"Antibody reactivity to the major fish allergen parvalbumin is determined by isoforms and impact of thermal processing","volume":"148","author":"Saptarshi","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.molimm.2020.12.033_bib0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/pai.12186","article-title":"Use of IgE and IgG4 epitope binding to predict the outcome of oral immunotherapy in cow\u2019s milk allergy","volume":"25","author":"Savilahti","year":"2014","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0140","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s12016-013-8363-1","article-title":"Fish allergy: in review","volume":"46","author":"Sharp","year":"2014","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.molimm.2014.05.010","article-title":"Differential IgE binding to isoallergens from Asian seabass (Lates calcarifer) in children and adults","volume":"62","author":"Sharp","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.molimm.2014.09.019","article-title":"Immunological cross-reactivity between four distant parvalbumins-Impact on allergen detection and diagnostics","volume":"63","author":"Sharp","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jaci.2004.04.018","article-title":"Prevalence of seafood allergy in the United States determined by a random telephone survey","volume":"114","author":"Sicherer","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/cea.12892","article-title":"Allergenicity of bony and cartilaginous fish - molecular and immunological properties","volume":"47","author":"Stephen","year":"2017","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.molimm.2020.12.033_bib0165","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.168.9.4576","article-title":"Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy","volume":"168","author":"Swoboda","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0170","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.4049\/jimmunol.178.10.6290","article-title":"A recombinant hypoallergenic parvalbumin mutant for immunotherapy of IgE-mediated fish allergy","volume":"178","author":"Swoboda","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0175","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.anai.2011.02.001","article-title":"Seafood allergy in children: a descriptive study","volume":"106","author":"Turner","year":"2011","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0180","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.molimm.2005.07.038","article-title":"Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen","volume":"43","author":"Untersmayr","year":"2006","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0185","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.jaci.2016.07.022","article-title":"Role of IgG4 in IgE-mediated allergic responses","volume":"138","author":"van de Veen","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0190","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.molimm.2010.11.001","article-title":"Differential responses to natural and recombinant allergens in a murine model of fish allergy","volume":"48","author":"van der Ventel","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0195","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.anai.2011.10.006","article-title":"Selective allergy to the Salmonidae fish family: a selective parvalbumin epitope?","author":"V\u00e0zquez-Cort\u00e9s","year":"2012","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"128\u2013134","key":"10.1016\/j.molimm.2020.12.033_bib0200","first-page":"e121","article-title":"Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens","volume":"131","author":"Vickery","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molimm.2020.12.033_bib0205","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.foodchem.2008.04.062","article-title":"Elucidation of a major IgE epitope of Pacific mackerel parvalbumin","volume":"111","author":"Yoshida","year":"2008","journal-title":"Food Chem."},{"issue":"8","key":"10.1016\/j.molimm.2020.12.033_bib0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182935","article-title":"Identification of a common Ara h 3 epitope recognized by both the capture and the detection monoclonal antibodies in an ELISA detection kit","volume":"12","author":"Zhao","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2020.12.033_bib0215","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000371657","article-title":"Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy","volume":"166","author":"Zuidmeer-Jongejan","year":"2015","journal-title":"Int. Arch. Allergy Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020306003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589020306003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:38:15Z","timestamp":1758980295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589020306003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":43,"alternative-id":["S0161589020306003"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2020.12.033","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IgE and IgG4 epitopes revealed on the major fish allergen Lat c 1","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2020.12.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}