{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:24:38Z","timestamp":1774535078840,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.molimm.2021.01.020","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T19:10:52Z","timestamp":1612293052000},"page":"60-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Structurally diverse genes encode TLR13 in Nile tilapia: The two receptors can recognize Streptococcus 23S RNA and conduct signal transduction through MyD88"],"prefix":"10.1016","volume":"132","author":[{"given":"Feng-ying","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-cai","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai-xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-meng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-li","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-meng","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2021.01.020_bib0005","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00251-014-0792-3","article-title":"Characterization of Toll-like receptor gene expression and the pathogen agonist response in the antarctic bullhead notothen Notothenia coriiceps","volume":"66","author":"Ahn","year":"2014","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2021.01.020_bib0010","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0952-7915(02)00013-4","article-title":"Mammalian toll-like receptors","volume":"15","author":"Akira","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signaling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0020","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kB by toll-like receptors","volume":"13","author":"Akira","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.molimm.2021.01.020_bib0025","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2021.01.020_bib0030","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.fsi.2006.04.005","article-title":"Structural characterization and expression analysis of toll-like receptor 2 gene from catfish","volume":"22","author":"Baoprasertkul","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0035","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S1471-4906(03)00242-4","article-title":"Leucine-rich repeats and pathogen recognition in Toll-like receptors","volume":"24","author":"Bell","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.cellbio.12.1.393","article-title":"A conserved signaling pathway: the Drosophila toll-dorsal pathway","volume":"12","author":"Belvin","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0045","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nri3284","article-title":"Innate immunity: TLR13, unlucky, but just for some","volume":"12","author":"Bordon","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0050","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.dci.2015.08.012","article-title":"Structurally diverse genes encode Tlr2 in rainbow trout: the conserved receptor cannot be stimulated by classical ligands to activate NF-\u03baB in vitro","volume":"54","author":"Brietzke","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0055","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1016\/j.molimm.2009.06.002","article-title":"Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides","volume":"46","author":"Brownlie","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/emmm.200900014","article-title":"Innate instruction of adaptive immunity revisited: the inflammasome","volume":"1","author":"Eisenbarth","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.molimm.2021.01.020_bib0065","doi-asserted-by":"crossref","first-page":"e0119727","DOI":"10.1371\/journal.pone.0119727","article-title":"Innate immune response to streptococcus pyogenes depends on the combined activation of TLR13 and TLR2","volume":"10","author":"Fieber","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2021.01.020_bib0070","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/intimm\/dxh115","article-title":"The cytoplasmic \u2018linker region\u2019 in Toll-like receptor 3 controls receptor localization and signaling","volume":"16","author":"Funami","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.fsi.2017.12.012","article-title":"Molecular characterization, expression and functional analysis of NOD1, NOD2 and NLRC3 in Nile tilapia (Oreochromis niloticus)","volume":"73","author":"Gao","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.molimm.2021.01.020_bib0080","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.4049\/jimmunol.1200898","article-title":"Cutting edge: TLR13 is a receptor for bacterial RNA","volume":"189","author":"Hidmark","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0085","doi-asserted-by":"crossref","first-page":"e23141","DOI":"10.4161\/onci.23141","article-title":"Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms","volume":"2","author":"Hochrein","year":"2013","journal-title":"Oncoimmunology."},{"key":"10.1016\/j.molimm.2021.01.020_bib0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/ni0202-121","article-title":"Drosophila innate immunity: an evolutionary perspective","volume":"3","author":"Hoffmann","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0095","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.fsi.2005.07.008","article-title":"Carp (Cyprinus carpio L.) innate immune factors are present before hatching","volume":"20","author":"Huttenhuis","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0028500","article-title":"UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling","volume":"6","author":"Itoh","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2021.01.020_bib0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1471-4906(02)00014-5","article-title":"Evolutionary clues to the functions of the Toll-like family as surveillance receptors","volume":"24","author":"Johnson","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2010.01.006","article-title":"Host-microb interactions in the developing zebrafish","volume":"22","author":"Kanther","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0115","first-page":"1","article-title":"UNC93B1 mediates differential trafficking of endosomal TLRs","volume":"2013","author":"Lee","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.molimm.2021.01.020_bib0120","doi-asserted-by":"crossref","first-page":"D229","DOI":"10.1093\/nar\/gkn808","article-title":"SMART 6: recent updates and new developments","volume":"37","author":"Letunic","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2021.01.020_bib0125","doi-asserted-by":"crossref","first-page":"e00102","DOI":"10.7554\/eLife.00102","article-title":"Sequence specific detection of bacterial 23S ribosomal RNA by TLR13","volume":"1","author":"Li","year":"2012","journal-title":"Elife"},{"key":"10.1016\/j.molimm.2021.01.020_bib0130","first-page":"1134","article-title":"cDNA isolation, polymorphism analysis, and tissue expression of MHC \u0406\u03b1 of Nile tilapia (Oreochromis niloticus)","volume":"21","author":"Li","year":"2014","journal-title":"J. Fish. Sci. China"},{"key":"10.1016\/j.molimm.2021.01.020_bib0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.fsi.2017.12.054","article-title":"Identification and functional characterization of Toll-like receptor 13 from orange-spotted grouper (Epinephelus coioides)","volume":"74","author":"Liang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0140","first-page":"766","article-title":"Identification and characterizations of Streptococcus agalactiae isolated from tilapia cultured in Guangdong and Hainan Provinces","volume":"37","author":"Lu","year":"2010","journal-title":"Microbiol. China"},{"key":"10.1016\/j.molimm.2021.01.020_bib0145","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1471-2164-8-124","article-title":"Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors","volume":"8","author":"Matsushima","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molimm.2021.01.020_bib0150","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.coi.2009.12.002","article-title":"Localisation and trafficking of Toll-like receptors: an important mode of regulation","volume":"22","author":"McGettrick","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0160","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2021.01.020_bib0165","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.fsi.2011.02.014","article-title":"Ontogeny and tissue-specific expression of innate immune related genes in rohu, Labeo rohita (Hamilton)","volume":"30","author":"Nayak","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0170","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1126\/science.1220363","article-title":"TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification","volume":"337","author":"Oldenburg","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.molimm.2021.01.020_bib0175","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0180","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.fsi.2012.11.048","article-title":"Major histocompatibility complex class IIA and IIB genes of Nile tilapia Oreochromis niloticus: genomic structure, molecular polymorphism and expression patterns","volume":"34","author":"Pang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0185","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1111\/are.13179","article-title":"Isolation and characterization of Toll-like receptor 21 and 22 genes from Nile tilapia, Oreochromis niloticus (Linnaeus)","volume":"48","author":"Pang","year":"2017","journal-title":"Aquac. Res."},{"key":"10.1016\/j.molimm.2021.01.020_bib0190","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.fsi.2016.06.029","article-title":"Identification of Nod like receptor C3 (NLRC3) in Asian seabass, Lates calcarifer: characterisation, ontogeny and expression analysis after experimental infection and ligand stimulation","volume":"55","author":"Paria","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.fsi.2017.01.029","article-title":"Identification, ontogeny and expression analysis of a novel laboratory of genetics and physiology 2 (LGP2) transcript in Asian seabass, Lates calcarifer","volume":"62","author":"Paria","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.dci.2017.09.010","article-title":"Molecular characterisation, ontogeny and expression analysis of melanoma differentiation-associated factor 5 (MDA5) from Asian seabass, Lates calcarifer","volume":"78","author":"Paria","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0205","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.vetimm.2011.09.004","article-title":"In vivo administration of ligands for chicken toll-like receptors 4 and 21 induces the expression of immune system genes in the spleen","volume":"144","author":"Paul","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0210","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/imr.12375","article-title":"Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology","volume":"269","author":"Pelka","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2021.01.020_bib0215","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1074\/jbc.M112.413922","article-title":"The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists","volume":"288","author":"Pohar","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.01.020_bib0220","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00251-013-0694-9","article-title":"Comprehensive survey and genomic characterization of Toll-like receptors (TLRs) in channel catfish, Ictalurus punctatus: identification of novel fish TLRs","volume":"65","author":"Quiniou","year":"2013","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2021.01.020_bib0225","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.169.9.4697","article-title":"Cutting edge: impaired Toll-like receptor expression and function in aging","volume":"169","author":"Renshaw","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0230","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1073\/pnas.0502272102","article-title":"The evolution of vertebrate Toll-like receptors","volume":"102","author":"Roach","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.molimm.2021.01.020_bib0235","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12010-014-1058-0","article-title":"Toll-Like Receptor 22 in Labeo rohita: molecular cloning, characterization, 3D modeling, and expression analysis following ligands stimulation and bacterial infection","volume":"174","author":"Samanta","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0240","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1074\/jbc.C200655200","article-title":"Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain","volume":"278","author":"Sarkar","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.01.020_bib0245","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1073\/pnas.95.11.5857","article-title":"SMART, a simple modular architecture research tool: identification of signaling domains","volume":"95","author":"Schultz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2021.01.020_bib0250","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1074\/jbc.M110.159590","article-title":"A novel Toll-like receptor that recognizes vesicular stomatitis virus","volume":"286","author":"Shi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.01.020_bib0255","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1074\/jbc.M110.159590","article-title":"A novel toll-like receptor that recognizes vesicular stomatitis virus","volume":"286","author":"Shi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.01.020_bib0260","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1074\/jbc.275.7.4670","article-title":"Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways","volume":"275","author":"Slack","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.01.020_bib0265","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.dci.2003.09.016","article-title":"The interleukin 1 receptor family","volume":"28","author":"Subramaniam","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0270","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1471-2148-12-256","article-title":"Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua","volume":"12","author":"Sundaram","year":"2012","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0275","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1007\/s11033-012-1765-y","article-title":"Positive selection pressure within teleost toll-like receptors tlr21 and tlr22 subfamilies and their response to temperature stress and microbial components in zebrafish","volume":"39","author":"Sundaram","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.molimm.2021.01.020_bib0280","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.dci.2011.06.018","article-title":"Molecular characterization of nucleotide binding and oligomerization domain (NOD)-2, analysis of its inductive expression and down-stream signaling following ligands exposure and bacterial infection in rohu (Labeo rohita)","volume":"36","author":"Swain","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0285","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-1119(99)00098-0","article-title":"TLR6: a novel member of an expanding toll-like receptor family","volume":"231","author":"Takeuchi","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.molimm.2021.01.020_bib0290","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0295","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2164-9-62","article-title":"Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss","volume":"9","author":"Temperley","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molimm.2021.01.020_bib0300","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.fsi.2016.10.046","article-title":"Comparative immunity of Salmo salar and Oncorhynchus kisutch during infestation with the sea louse Caligus rogercresseyi: an enrichment transcriptome analysis","volume":"59","author":"Valenzuela-Munoz","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0305","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1126\/science.281.5385.1942","article-title":"Fly development genes lead to immune find","volume":"281","author":"Vogel","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.molimm.2021.01.020_bib0310","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.dci.2016.03.005","article-title":"Discovery of toll-like receptor 13 exists in the teleost fish: Miiuy croaker (Perciformes, Sciaenidae)","volume":"61","author":"Wang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0315","first-page":"103837","article-title":"23S rRNA from Vibrio parahaemolyticus regulates the innate immune response via recognition by TLR13 in orange-spotted grouper (Epinephelus coioides) [published online ahead of print, 2020 Aug 22]","author":"Yu","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0320","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1167\/iovs.09-4330","article-title":"Toll-like receptors involved in the pathogenesis of experimental candida albicans keratitis","volume":"51","author":"Yuan","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2021.01.020_bib0325","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.dci.2013.01.009","article-title":"Pathogen recognition receptors in channel catfish: III phylogeny and expression analysis of Toll-like receptors","volume":"40","author":"Zhang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2021.01.020_bib0330","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.fsi.2014.09.022","article-title":"Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways","volume":"41","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021000286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021000286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:38:06Z","timestamp":1758980286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589021000286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":66,"alternative-id":["S0161589021000286"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2021.01.020","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structurally diverse genes encode TLR13 in Nile tilapia: The two receptors can recognize Streptococcus 23S RNA and conduct signal transduction through MyD88","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2021.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}