{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:17:07Z","timestamp":1792880227989,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG050886A"],"award-info":[{"award-number":["P30AG050886A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AR048311"],"award-info":[{"award-number":["P30AR048311"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI27667"],"award-info":[{"award-number":["P30AI27667"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK056336"],"award-info":[{"award-number":["P30DK056336"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK079626"],"award-info":[{"award-number":["P30DK079626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE026465"],"award-info":[{"award-number":["DE026465"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R90 DE023056"],"award-info":[{"award-number":["R90 DE023056"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE022401"],"award-info":[{"award-number":["DE022401"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.molimm.2021.07.004","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T20:55:33Z","timestamp":1626382533000},"page":"187-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells"],"prefix":"10.1016","volume":"137","author":[{"given":"Zhaofei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannet","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Michalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-9893","authenticated-orcid":false,"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2021.07.004_bib0005","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4049\/jimmunol.166.1.678","article-title":"Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer","volume":"166","author":"Almand","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/bonekey.2012.102","article-title":"Aging mechanisms in bone","volume":"1","author":"Almeida","year":"2012","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.molimm.2021.07.004_bib0015","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3389\/fimmu.2018.01122","article-title":"Parameters of the immune system and vitamin d levels in old individuals","volume":"9","author":"Alves","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0020","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.190.12.1741","article-title":"Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors","volume":"190","author":"Arai","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2021.07.004_bib0025","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/eji.201747355","article-title":"Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppresor cell-mediated inhibition of T-cell proliferation","volume":"48","author":"Bian","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0030","doi-asserted-by":"crossref","first-page":"37931","DOI":"10.18632\/oncotarget.9270","article-title":"Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma","volume":"7","author":"Binsfeld","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2021.07.004_bib0035","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/0022034510377791","article-title":"Aging and bone","volume":"89","author":"Boskey","year":"2010","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0040","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/01.bor.0000231913.32364.32","article-title":"Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease","volume":"18","author":"Boyce","year":"2006","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2021.07.004_bib0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11914-012-0104-5","article-title":"Pathways for bone loss in inflammatory disease","volume":"10","author":"Braun","year":"2012","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.molimm.2021.07.004_bib0055","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2021.07.004_bib0060","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0065","first-page":"1","article-title":"Enhanced dual function of osteoclast precursors following calvarial Porphyromonas gingivalis infection","volume":"00","author":"Cai","year":"2020","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0070","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1359\/jbmr.2003.18.2.270","article-title":"Expression of RANKL and OPG correlates with age-related bone loss in male C57BL\/6 mice","volume":"18","author":"Cao","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0075","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1359\/JBMR.050503","article-title":"Aging increases stromal\/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse","volume":"20","author":"Cao","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0080","doi-asserted-by":"crossref","first-page":"21971","DOI":"10.1074\/jbc.M200434200","article-title":"Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B","volume":"277","author":"Cappellen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.07.004_bib0085","doi-asserted-by":"crossref","first-page":"8716","DOI":"10.18632\/oncotarget.2368","article-title":"IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus","volume":"5","author":"Chen","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2021.07.004_bib0090","article-title":"Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cell-mediated liver injury in mice","volume":"6","author":"Cheng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2021.07.004_bib0095","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/jcb.24792","article-title":"Effect of age on regulation of human osteoclast differentiation","volume":"115","author":"Chung","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.molimm.2021.07.004_bib0100","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.4161\/onci.21990","article-title":"Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction","volume":"1","author":"Danilin","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.molimm.2021.07.004_bib0105","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1189\/jlb.0708402","article-title":"Myeloid blasts are the mouse bone marrow cells prone to differentiate into osteoclasts","volume":"85","author":"de Vries","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/eji.200939903","article-title":"Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF","volume":"40","author":"Dolcetti","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0115","doi-asserted-by":"crossref","first-page":"27008","DOI":"10.18632\/oncotarget.4714","article-title":"Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer","volume":"6","author":"Edgington-Mitchell","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.molimm.2021.07.004_bib0120","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4049\/jimmunol.1002987","article-title":"A role for immature myeloid cells in immune senescence","volume":"186","author":"Enioutina","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0125","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1359\/jbmr.2001.16.6.1015","article-title":"The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis","volume":"16","author":"Fazzalari","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/15216540500137669","article-title":"RANKing intracellular signaling in osteoclasts","volume":"57","author":"Feng","year":"2005","journal-title":"IUBMB Life"},{"key":"10.1016\/j.molimm.2021.07.004_bib0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4248\/BR201301003","article-title":"Osteoclasts: new insights","volume":"1","author":"Feng","year":"2013","journal-title":"Bone Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fimmu.2018.00095","article-title":"Senescent T-Cells promote bone loss in rheumatoid arthritis","volume":"9","author":"Fessler","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0145","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/acel.12571","article-title":"Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-kappaB-dependent mechanism","volume":"16","author":"Flores","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.molimm.2021.07.004_bib0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/2326-6066.CIR-16-0297","article-title":"Myeloid-derived suppressor cells","volume":"5","author":"Gabrilovich","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nri3433","article-title":"The ageing haematopoietic stem cell compartment","volume":"13","author":"Geiger","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0165","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/00002281-200207000-00013","article-title":"Pathogenesis of bone erosions in rheumatoid arthritis","volume":"14","author":"Goldring","year":"2002","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0170","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcp.22411","article-title":"T cell suppression by osteoclasts in vitro","volume":"226","author":"Grassi","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0175","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.mad.2007.10.003","article-title":"Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice","volume":"128","author":"Grizzle","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.molimm.2021.07.004_bib0180","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1128\/IAI.00759-08","article-title":"Conditions that diminish myeloid-derived suppressor cell activities stimulate cross-protective immunity","volume":"76","author":"Heithoff","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2021.07.004_bib0185","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1158\/0008-5472.CAN-11-3019","article-title":"Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice","volume":"72","author":"Hurez","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0190","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/acel.12062","article-title":"Targeting macrophages rescues age-related immune deficiencies in C57BL\/6J geriatric mice","volume":"12","author":"Jackaman","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.molimm.2021.07.004_bib0195","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41586-019-1105-7","article-title":"Developmental origin, functional maintenance and genetic rescue of osteoclasts","volume":"568","author":"Jacome-Galarza","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2021.07.004_bib0200","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/jor.20623","article-title":"Gene expression analysis of major lineage-defining factors in human bone marrow cells: effect of aging, gender, and age-related disorders","volume":"26","author":"Jiang","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0205","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.3389\/fimmu.2017.01840","article-title":"Interleukin-6 trans-signaling pathway promotes immunosuppressive myeloid-derived suppressor cells via suppression of suppressor of cytokine signaling 3 in breast cancer","volume":"8","author":"Jiang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0210","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5114\/ceji.2019.89601","article-title":"Salivary interleukin 6, interleukin 8, interleukin 17A, and tumour necrosis factor alpha levels in patients with periodontitis and rheumatoid arthritis","volume":"44","author":"Kaczynski","year":"2019","journal-title":"Cent. J. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0215","first-page":"69","article-title":"Age-related bone loss. A hypothesis and initial assessment in mice","author":"Kahn","year":"1995","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0220","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2353\/ajpath.2006.060180","article-title":"B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease","volume":"169","author":"Kawai","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0225","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0047-6374(02)00071-4","article-title":"Osteoclastogenic potential of bone marrow cells increases with age in elderly women with fracture","volume":"123","author":"Koshihara","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.molimm.2021.07.004_bib0230","first-page":"8","article-title":"B cell production of both OPG and RANKL is significantly increased in aged mice","volume":"6","author":"Li","year":"2014","journal-title":"Open Bone J."},{"key":"10.1016\/j.molimm.2021.07.004_bib0235","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/hep.30095","article-title":"The immunobiology of receptor activator for nuclear factor kappa B ligand and myeloid-derived suppressor cell activation in immunoglobulin G4-related sclerosing cholangitis","volume":"68","author":"Lian","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.molimm.2021.07.004_bib0240","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4081\/reumatismo.2014.785","article-title":"Osteoporosis and rheumatic diseases","volume":"66","author":"Maruotti","year":"2014","journal-title":"Reumatismo"},{"key":"10.1016\/j.molimm.2021.07.004_bib0245","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.molimm.2021.07.004_bib0250","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fcimb.2016.00037","article-title":"Myeloid-derived suppressor cells in bacterial infections","volume":"6","author":"Ost","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0255","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3389\/fimmu.2019.01099","article-title":"Myeloid-derived suppressor cells: not only in tumor immunity","volume":"10","author":"Pawelec","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0260","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.imbio.2007.09.008","article-title":"Role of arginine metabolism in immunity and immunopathology","volume":"212","author":"Peranzoni","year":"2007","journal-title":"Immunobiology"},{"key":"10.1016\/j.molimm.2021.07.004_bib0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/8756-3282(94)90893-1","article-title":"Age-related bone loss in mice is associated with an increased osteoclast progenitor pool","volume":"15","author":"Perkins","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.molimm.2021.07.004_bib0270","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and age-related diseases: role of inflammation triggers and cytokines","volume":"9","author":"Rea","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.09.001","article-title":"The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process","volume":"48","author":"Salminen","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.molimm.2021.07.004_bib0280","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1158\/0008-5472.CAN-12-2202","article-title":"Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer","volume":"73","author":"Sawant","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.molimm.2021.07.004_bib0285","first-page":"65","article-title":"Osteoclast formation and differentiation: an overview","volume":"59","author":"Soysa","year":"2012","journal-title":"J. Med. Dent. Sci."},{"key":"10.1016\/j.molimm.2021.07.004_bib0290","doi-asserted-by":"crossref","first-page":"e00213","DOI":"10.1128\/IAI.00213-17","article-title":"Phenotype and function of myeloid-derived suppressor cells induced by Porphyromonas gingivalis infection","volume":"85","author":"Su","year":"2017","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2021.07.004_bib0295","first-page":"19","article-title":"STAT3 in tumor-associated myeloid cells: multitasking to disrupt immunity","author":"Su","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2021.07.004_bib0300","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cell.2017.12.026","article-title":"LXR\/ApoE activation restricts innate immune suppression in cancer","volume":"172","author":"Tavazoie","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2021.07.004_bib0305","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.celrep.2012.08.006","article-title":"Immune tolerance to tumor antigens occurs in a specialized environment of the spleen","volume":"2","author":"Ugel","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.molimm.2021.07.004_bib0310","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1172\/JCI60083","article-title":"STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients","volume":"123","author":"Vasquez-Dunddel","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2021.07.004_bib0315","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1189\/jlb.0912461","article-title":"Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer","volume":"93","author":"Verschoor","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0320","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.181.8.5791","article-title":"Subsets of myeloid-derived suppressor cells in tumor-bearing mice","volume":"181","author":"Youn","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0325","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaut.2015.08.010","article-title":"Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts","volume":"65","author":"Zhang","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2021.07.004_bib0330","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1172\/JCI64115","article-title":"TNF signaling drives myeloid-derived suppressor cell accumulation","volume":"122","author":"Zhao","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2021.07.004_bib0335","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/JLB.1HI0620-230R","article-title":"Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection","volume":"108","author":"Zhao","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2021.07.004_bib0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048871","article-title":"Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells","volume":"7","author":"Zhuang","year":"2012","journal-title":"PLoS One"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021002108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021002108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:52:04Z","timestamp":1777492324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589021002108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":68,"alternative-id":["S0161589021002108"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2021.07.004","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2021.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}