{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:06:48Z","timestamp":1759018008997,"version":"3.44.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.molimm.2021.10.009","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T18:29:48Z","timestamp":1635272988000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Toll like receptor (2 and 4) expression and cytokine release by human neutrophils during tuberculosis treatment\u2014A longitudinal study"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-937X","authenticated-orcid":false,"given":"Nancy Hilda","family":"J","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Precilla","family":"K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anbalagan","family":"Selvaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saravanan","family":"Chinnaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Luke Elizabeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"September (6)","key":"10.1016\/j.molimm.2021.10.009_bib0005","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.4049\/jimmunol.169.6.3155","article-title":"Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice","volume":"169","author":"Abel","year":"2002","journal-title":"J. Immunol."},{"issue":"November 23","key":"10.1016\/j.molimm.2021.10.009_bib0010","first-page":"145","article-title":"Mycobacterial signaling through toll-like receptors","volume":"2","author":"Basu","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.molimm.2021.10.009_bib0015","first-page":"7789","article-title":"Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g","volume":"97","author":"B\u00f6yum","year":"1968","journal-title":"Scand. J. Clin. Lab. Invest. Suppl."},{"issue":"August (15)","key":"10.1016\/j.molimm.2021.10.009_bib0020","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1128\/JVI.00403-07","article-title":"Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2","volume":"81","author":"Gaudreault","year":"2007","journal-title":"J. Virol."},{"issue":"November (6)","key":"10.1016\/j.molimm.2021.10.009_bib0025","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41385-019-0195-8","article-title":"Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques","volume":"12","author":"Gideon","year":"2019","journal-title":"Mucosal Immunol."},{"issue":"October","key":"10.1016\/j.molimm.2021.10.009_bib0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.coi.2016.06.003","article-title":"Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question","volume":"42","author":"Gopalakrishnan","year":"2016","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2021.10.009_bib0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000494463","article-title":"The role of toll-like receptors in the production of cytokines by human lung macrophages","volume":"12","author":"Grassin-Delyle","year":"2020","journal-title":"J. Innate Immun."},{"issue":"January (1)","key":"10.1016\/j.molimm.2021.10.009_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.humimm.2015.10.005","article-title":"TLR stimulation of human neutrophils lead to increased release of MCP-1, MIP-1\u03b1, IL-1\u03b2, IL-8 and TNF during tuberculosis","volume":"77","author":"Hilda","year":"2016","journal-title":"Hum. Immunol."},{"issue":"8","key":"10.1016\/j.molimm.2021.10.009_bib0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.humimm.2014.06.020","article-title":"Neutrophils from pulmonary tuberculosis patients show augmented levels of chemokines MIP-1\u03b1, IL-8 and MCP-1 which further increase upon in vitro infection with mycobacterial strains","volume":"75","author":"Hilda","year":"2014","journal-title":"Hum. Immunol."},{"issue":"May (4)","key":"10.1016\/j.molimm.2021.10.009_bib0050","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/1753425919881176","article-title":"Role of neutrophils in tuberculosis: a bird\u2019s eye view","volume":"26","author":"Hilda","year":"2020","journal-title":"Innate Immun."},{"issue":"September (5)","key":"10.1016\/j.molimm.2021.10.009_bib0055","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.4049\/jimmunol.173.5.3392","article-title":"IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition","volume":"173","author":"Jang","year":"2004","journal-title":"J. Immunol."},{"issue":"May (7)","key":"10.1016\/j.molimm.2021.10.009_bib0060","doi-asserted-by":"crossref","first-page":"ofz257","DOI":"10.1093\/ofid\/ofz257","article-title":"Plasma proinflammatory cytokines are markers of disease severity and bacterial burden in pulmonary tuberculosis","volume":"6","author":"Kumar","year":"2019","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.molimm.2021.10.009_bib0065","doi-asserted-by":"crossref","first-page":"8619307","DOI":"10.1155\/2017\/8619307","article-title":"Neutrophils in tuberculosis: heterogeneity shapes the way?","volume":"2017","author":"Lyadova","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"May 27","key":"10.1016\/j.molimm.2021.10.009_bib0070","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3389\/fimmu.2020.00962","article-title":"Neutrophils in tuberculosis-associated inflammation and lung pathology","volume":"11","author":"Muefong","year":"2020","journal-title":"Front. Immunol."},{"issue":"July","key":"10.1016\/j.molimm.2021.10.009_bib0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tube.2018.06.010","article-title":"Neutrophil CD64, TLR2 and TLR4 expression increases but phagocytic potential decreases during tuberculosis","volume":"111","author":"Nancy Hilda","year":"2018","journal-title":"Tuberculosis (Edinb.)"},{"issue":"October Suppl. 66-8","key":"10.1016\/j.molimm.2021.10.009_bib0080","article-title":"Toll-like receptor signaling and regulation of cytokine gene expression in the immune system","volume":"70","author":"Ozato","year":"2002","journal-title":"Biotechniques"},{"issue":"December (1)","key":"10.1016\/j.molimm.2021.10.009_bib0085","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/21505594.2020.1766401","article-title":"Toll-like receptor 4 signaling-mediated responses are critically engaged in optimal host protection against highly virulent Mycobacterium tuberculosis K infection","volume":"11","author":"Park","year":"2020","journal-title":"Virulence"},{"issue":"May (5)","key":"10.1016\/j.molimm.2021.10.009_bib0090","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/eji.201344100","article-title":"TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis","volume":"44","author":"Reba","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2021.10.009_bib0095","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cellimm.2009.10.007","article-title":"Role of TLR2- and TLR4-mediated signaling in Mycobacterium tuberculosis-induced macrophage death","volume":"260","author":"S\u00e1nchez","year":"2010","journal-title":"Cell. Immunol."},{"issue":"Septmber (9)","key":"10.1016\/j.molimm.2021.10.009_bib0100","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s10096-012-1572-3","article-title":"Expression of toll-like receptor 2 and plasma level of interleukin-10 are associated with outcome in tuberculosis","volume":"31","author":"Wang","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.molimm.2021.10.009_bib0105","unstructured":"WHO tuberculosis report 2020."},{"issue":"March (3)","key":"10.1016\/j.molimm.2021.10.009_bib0110","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/00365548.2014.982167","article-title":"Latency-associated protein Rv2660c of Mycobacterium tuberculosis augments expression of proinflammatory cytokines in human macrophages by interacting with TLR2","volume":"47","author":"Yihao","year":"2015","journal-title":"Infect. Dis. (Lond)"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021002996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021002996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:41:35Z","timestamp":1758980495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589021002996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":22,"alternative-id":["S0161589021002996"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2021.10.009","relation":{},"ISSN":["0161-5890"],"issn-type":[{"type":"print","value":"0161-5890"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll like receptor (2 and 4) expression and cytokine release by human neutrophils during tuberculosis treatment\u2014A longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2021.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}