{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:59:08Z","timestamp":1774108748907,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.molimm.2021.10.013","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T02:56:46Z","timestamp":1635389806000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Community-acquired methicillin-resistant Staphylococcus aureus provoked cytokine storm causing severe infection on BALB\/c mice"],"prefix":"10.1016","volume":"140","author":[{"given":"Feng","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenpeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-9483","authenticated-orcid":false,"given":"Yunhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2021.10.013_bib0005","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jsb.2012.05.003","article-title":"ClpP: a structurally dynamic protease regulated by AAA+ proteins","volume":"179","author":"Alexopoulos","year":"2012","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2021.10.013_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/sonc.2002.33077","article-title":"Interleukin-2: clinical applications","volume":"29","author":"Atkins","year":"2002","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0020","first-page":"1766","article-title":"Staphylococcal enterotoxin B contributes to Staphylococcus aureus systemic infection","author":"Bae","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2021.10.013_bib0025","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1172\/JCI43157","article-title":"Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice","volume":"121","author":"Behrens","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molimm.2021.10.013_bib0030","doi-asserted-by":"crossref","first-page":"e664","DOI":"10.1097\/CCM.0000000000001639","article-title":"Effects of Tocilizumab on experimental severe acute pancreatitis and associated acute lung injury","volume":"44","author":"Chen","year":"2016","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.molimm.2021.10.013_bib0035","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2021.10.013_bib0040","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1126\/science.270.5238.908.a","article-title":"IL-12 deaths: explanation and a puzzle","volume":"270","author":"Cohen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.molimm.2021.10.013_bib0045","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fimmu.2020.01085","article-title":"A critical blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei infection","volume":"11","author":"De Trez","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0050","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4049\/jimmunol.149.5.1666","article-title":"Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha","volume":"149","author":"Doherty","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0055","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2021.10.013_bib0060","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1046\/j.1365-2958.2003.03524.x","article-title":"Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence","volume":"48","author":"Frees","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0065","doi-asserted-by":"crossref","first-page":"8100","DOI":"10.1128\/IAI.73.12.8100-8108.2005","article-title":"Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar\/agr regulatory network","volume":"73","author":"Frees","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2021.10.013_bib0070","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/meth.2001.1261","article-title":"An overview of real-time quantitative PCR: applications to quantify cytokine gene expression","volume":"25","author":"Giulietti","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molimm.2021.10.013_bib0075","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1215134","article-title":"Chimeric antigen receptor-modified T cells for acute lymphoid leukemia","volume":"368","author":"Grupp","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2021.10.013_bib0080","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1126\/science.1182395","article-title":"Evolution of MRSA during hospital transmission and intercontinental spread","volume":"327","author":"Harris","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.molimm.2021.10.013_bib0085","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0966-842X(01)02175-8","article-title":"The emergence and evolution of methicillin-resistant Staphylococcus aureus","volume":"9","author":"Hiramatsu","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2021.10.013_bib0095","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.immuni.2019.03.026","article-title":"Targeting Interleukin-6 signaling in clinic","volume":"50","author":"Kang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2021.10.013_bib0100","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.0710217105","article-title":"Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification","volume":"105","author":"Kennedy","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molimm.2021.10.013_bib0105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2021.10.013_bib0110","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/infdis\/jiaa251","article-title":"The ClpXP protease contributes to Staphylococcus aureus pneumonia","volume":"222","author":"Kim","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2021.10.013_bib0115","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1021\/acs.jproteome.0c00668","article-title":"Global inventory of ClpP- and ClpX-regulated proteins in Staphylococcus aureus","volume":"20","author":"Kirsch","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.molimm.2021.10.013_bib0120","doi-asserted-by":"crossref","first-page":"e00020","DOI":"10.1128\/CMR.00020-18","article-title":"Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology","volume":"31","author":"Lakhundi","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.molimm.2021.10.013_bib0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2021.10.013_bib0130","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.1038\/nrdp.2018.33","article-title":"Methicillin-resistant Staphylococcus aureus","volume":"4","author":"Lee","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.molimm.2021.10.013_bib0135","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12879-020-4866-6","article-title":"A comparative genomic analysis between methicillin-resistant Staphylococcus aureus strains of hospital acquired and community infections in Yunnan province of China","volume":"20","author":"Liao","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.molimm.2021.10.013_bib0140","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.mib.2012.08.003","article-title":"Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA)","volume":"15","author":"Mediavilla","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0145","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0165-2478(02)00202-X","article-title":"Characterization of anti-mouse interleukin-6 receptor antibody","volume":"84","author":"Okazaki","year":"2002","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.molimm.2021.10.013_bib0150","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/j.1462-5822.2012.01832.x","article-title":"MRSA virulence and spread","volume":"14","author":"Otto","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0155","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.3389\/fimmu.2018.03022","article-title":"Fine tuning the cytokine storm by IFN and IL-10 following neurotropic coronavirus encephalomyelitis","volume":"9","author":"Savarin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00395-014-0449-2","article-title":"Interleukin-6 receptor inhibition modulates the immune reaction and restores titin phosphorylation in experimental myocarditis","volume":"109","author":"Savvatis","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0165","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/infdis\/jiv550","article-title":"Whole-exome sequencing reveals mutations in genes linked to hemophagocytic lymphohistiocytosis and macrophage activation syndrome in fatal cases of H1N1 influenza","volume":"213","author":"Schulert","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molimm.2021.10.013_bib0170","doi-asserted-by":"crossref","first-page":"e632","DOI":"10.1111\/j.1365-2230.2009.03353.x","article-title":"Cytokine profile during the clinical course of toxic shock syndrome","volume":"34","author":"Seishima","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.GPP3-0039-2018","article-title":"Staphylococcus aureus secreted toxins and extracellular enzymes","volume":"7","author":"Tam","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.molimm.2021.10.013_bib0180","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1182\/blood-2013-02-485623","article-title":"Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy","volume":"121","author":"Teachey","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2021.10.013_bib0185","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro3521","article-title":"Staphylococcal manipulation of host immune responses","volume":"13","author":"Thammavongsa","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0190","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1128\/IAI.68.4.2034-2042.2000","article-title":"Cytokine gene expression in innately susceptible BALB\/c mice and relatively resistant C57BL\/6 mice during infection with virulent Burkholderia pseudomallei","volume":"68","author":"Ulett","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2021.10.013_bib0195","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.4049\/jimmunol.1301523","article-title":"Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity?","volume":"191","author":"van der Stegen","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.10.013_bib0200","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1182\/blood.V94.7.2217.419k02_2217_2224","article-title":"Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)","volume":"94","author":"Winkler","year":"1999","journal-title":"Blood"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021003035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021003035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:41:59Z","timestamp":1758980519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589021003035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":40,"alternative-id":["S0161589021003035"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2021.10.013","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Community-acquired methicillin-resistant Staphylococcus aureus provoked cytokine storm causing severe infection on BALB\/c mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2021.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}